Women with Preeclampsia Have Increased Serum Levels of Pregnancy‐Associated Plasma Protein A (PAPP‐A), Inhibin A, Activin A and Soluble E‐selectin

References

• Roberts J M, Taylor R N, Musci T J, Rodgers G M, Hubel C A, McLaughlin M K. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161: 1200–1204
   PubMed Web of Science ®Google Scholar
• Hughes G, Bischof P, Wilson G, Smith R, Klopper A. Assay of placental protein to determine fetal risk. Brit J Med 1980; 280: 671–673
   Google Scholar
• Toop K, Klopper A. Concentration of pregnancy‐assocated plasma protein A (PAPP‐A) in patients with pre‐eclamptic toxaemia. Placenta 1981; 4: 167–174, (Suppl.)
   Google Scholar
• Westergaard J G, Teisner B. Pregnancy‐associated plasma protein A in normal and abnormal late pregnancy. Pregnancy Proteins, J G Grudzinskas, B Teisner, M Seppala. Academic Press, Sydney 1982; 345–354
   Google Scholar
• Bischof P. Placental proteins: pregnancy‐associated plasma protein A. Contrib Gynecol Obstet 1984; 12: 41–73
   Google Scholar
• Oxvig C, Sand O, Kristensen T, Kristensen L, Sottrup‐Jensen L. Isolation and characterisation of circulating complex between human pregnancy‐associated plasma protein‐A and proform of eosinophil major basic protein. Biochim Biophys Acta 1994; 1201: 415–423
   PubMed Web of Science ®Google Scholar
• Overgaard M T, Haaning J, Boldt H B, Olsen I M, Laursen L S, Christiansen M, et al. Expression of recombinant human pregnancy‐associated plasma protein A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J Biol Chem 2000; 275: 31128–31133
   PubMed Web of Science ®Google Scholar
• Bersinger N A, Altermatt H J, Birkhäuser M H, Brizot M L, Kappeler A, Muller M D, et al. Non‐placental production of pregnancy‐associated placental protein A (PAPP‐A): old and new evidence. Early Preg Biol Med 1997; 3: 96–101
   Google Scholar
• Lawrence J B, Oxvig C, Overgaard M T, Sottrup‐Jensen L, Gleich G J, Hays L G, et al. The insulin‐like growth factor (IGF)‐dependent IGF binding protein‐4 protease secreted by human fibroblasts is pregnancy‐associated plasma protein A. Proc Natl Acad Sci USA 1999; 96: 3149–3153
   PubMed Web of Science ®Google Scholar
• Bischof P. Placental proteins: schwangerschaftsprotein 1. Contrib Gynecol Obstet 1984; 12: 6–22
   Google Scholar
• Chapman M G, O'Shea R T, Jones W R, Hillier R. Pregnancy‐specific β1‐glycoprotein as a screening test for at‐risk pregnancies. Am J Obstet Gynecol 1981; 141: 499–502
   PubMed Web of Science ®Google Scholar
• Muttukrishna S, Child T J, Groome N P, Ledger W L. Source of circulating levels of inhibin A, pro alpha C‐containing inhibins and activin A in early pregnancy. Hum Reprod 1997; 12: 1089–1093
   PubMedGoogle Scholar
• Muttukrishna S, Knight P G, Groome N P, Redman C W, Ledger W L. Activin A and inhibin A as possible endocrine markers for preeclampsia. Lancet 1997; 349: 1285–1288
   PubMed Web of Science ®Google Scholar
• Silver H M, Lambert G M, Star J A, Hogan J, Canick J A. Comparison of maternal serum total activin A and inhibin A in normal, pre‐eclamptic, and non‐proteinuric gestationally hypertensive pregnancies. Am J Obstet Gynecol 1999; 180: 1131–1137
   PubMed Web of Science ®Google Scholar
• Aquilina J, Barnett A, Thompson O, Harrington K. Second‐trimester maternal serum inhibin A concentration as an early marker for preeclampsia. Am J Obstet Gynecol 1999; 181: 131–136
   PubMed Web of Science ®Google Scholar
• Cuckle H, Sehmi I, Jones R. Maternal serum inhibin A can predict preeclampsia. Brit J Obstet Gynaecol 1998; 105: 1101–1103
   PubMedGoogle Scholar
• Muttukrishna S, North R A, Morris J, Schellenberg J C, Taylor R S, Asselin J, et al. Serum inhibin A and activin A are elevated prior to the onset of preeclampsia. Hum Reprod 2000; 15: 1640–1645
   PubMed Web of Science ®Google Scholar
• Sebire N J, Roberts L, Noble P, Wallace E, Nicolaides K H. Raised maternal serum inhibin A concentration at 10 to 14 weeks gestation is associated with preeclampsia. Brit J Obstet Gynaecol 2000; 107: 795–797
   Google Scholar
• Raty R, Koskinen P, Alanen A, Irjala K, Matinlauri I, Ekblad U. Prediction of preeclampsia with maternal mid‐trimester total renin, inhibin A, AFP and free β‐hCG levels. Prenat Diagn 1999; 19: 122–127
   PubMed Web of Science ®Google Scholar
• Redman C W, Sacks G P, Sargent I L. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999; 180: 499–506
   PubMed Web of Science ®Google Scholar
• Suefuiji H, Ogawa H, Yasue H, Sakamoto T, Miyao Y, Kaikita K, et al. Increased plasma level of soluble E‐selectin in acute myocardial infarction. Am Heart J 2000; 140: 243–248
   Google Scholar
• Austgulen R, Lien E, Vince G, Redman C W. Increased maternal plasma levels of soluble adhesion molecues (ICAM‐1, VCAM‐1, E‐selectin) in preeclampsia. Eur J Obstet Gynecol Reprod Biol 1997; 71: 53–58
   PubMed Web of Science ®Google Scholar
• Krauss T, Kuhn W, Lakoma C, Augustin H G. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia. Am J Obstet Gynecol 1997; 177: 443–449
   PubMed Web of Science ®Google Scholar
• Heyl W, Handt S, Reister F, Gehlen J, Schroder W, Mittermayer C, et al. Elevated soluble adhesion molecules in women with preeclampsia. Do cytokines like tumour necrosis factor‐alpha and interleukin‐1beta cause endothelial activation. Eur J Obstet Gynecol Reprod Biol 1999; 86: 35–41
   PubMed Web of Science ®Google Scholar
• Fickling S A, Whitley G S, Nussey S S. The cell adhesion molecule, VCAM‐1, is selectively elevated in serum in preeclampsia: does this indicate the mechanism of leucocyte activation?. Brit J Obstet Gynaecol 1995; 102: 173
   PubMedGoogle Scholar
• Lyall F, Greer I A, Boswell F, Macara L M, Walker J J, Kingdom J C. The cell adhesion molecule, VCAM‐1, is selectively elevated in serum in preeclampsia: does this indicate the mechanism of leucocyte activation. Brit J Obstet Gynaecol 1994; 101: 485–487
   PubMedGoogle Scholar
• Halim A, Kanayama N, El Maradny E, Nakashima A, Bhuiyan A B, Khatun S, Terao T. Plasma P selectin (GMP‐140) and glycocalicin are elevated in preeclampsia and eclampsia: their significances. Am J Obstet Gynecol 1996; 174: 272–277
   PubMed Web of Science ®Google Scholar
• Daniel Y, Kupferminc M J, Baram A, Jaffa A J, Wolman I, Shenhav M, et al. Plasma soluble endothelial selectin is elevated in women with preeclampsia. Hum Reprod 1998; 13: 3537–3541
   PubMed Web of Science ®Google Scholar
• Bersinger N A, Zakher A, Huber U, Pescia G, Schneider H. A sensitive immunoassay for pregnancy‐associated plasma protein A (PAPP‐A): a possible first trimester method of screening for Down syndrome and other trisomies. Arch Gynecol Obstet 1995; 256: 185–192
   PubMed Web of Science ®Google Scholar
• Bersinger N A, Brandenberger A W, Birkhäuser M H. Endometrial and placental protein markers and ovarian steroids in serum during in‐vitro fertilisation cycles. Hum Reprod 1995; 10: 2149–2154
   Google Scholar
• Bueler M, Bersinger N A. Antiserum to pregnancy‐associated plasma protein A (PAPP‐A) recognizes human haptoglobin. Brit J Obstet Gynaecol 1989; 96: 867–869
   PubMedGoogle Scholar
• Groome N P, Illingworth P J, O'Brien M, Cooke I, Ganesan T S, Baird D T, et al. Detection of dimeric inhibin throughout the human menstrual cycle by two‐site immunoassay. Clin Endocrinol 1994; 40: 717–723
   PubMedGoogle Scholar
• Knight P G, Muttukrishna S, Groome N P. Development and application of a two‐site enzyme immunoassay for the determination of ‘total’ activin A concentrations in serum and follicular fluid. J Endocrinol 1996; 148: 267–279
   PubMed Web of Science ®Google Scholar
• Muttukrishna S, Tannetta D, Groome N, Redman C, Sargent I. Secretion of activin A by peripheral blood mononuclear cells (PBMCs) in culture and flowcytometric detection of intra cytoplasmic inhibin/activin subunits and activin receptors. International workshop on inhibins, activins, and follistatins, Melbourne, Australia, October 2000. Mol Cell Endocrinol 2001; 180: 194, (special edition)
   Google Scholar
• Brauman J N, Smith A I, Scheerlinck J P, de Kretser D M, Phillips D J. Activin A and follistatin responses to inflammatory mediators in the endothelium. Proceedings of the 11th International Congress of Endocrinology. The International Society for Endocrinology, Sydney 2000, Abstract P.512
   Google Scholar
• Lyall F, Greer I A. Reply to “The cell adhesion molecule, VCAM‐1, is selectively elevated in serum in preeclampsia: does this indicate the mechanism of leucocyte activation? by S.A. Fickling, G.S. Whitley, and S.S. Nussey”. Brit J Obstet Gynaecol 1995; 102: 173–174
   PubMedGoogle Scholar
• Kvasnicka J, Skrha J, Perusicova J, Kvasnicka T, Markova M, Umlaufova A, et al. Haemostasis, cytoadhesive molecules (sE‐selectin and sICAM‐1) and inflammatory markers in non‐insulin dependent diabetes mellitus (NIDDM). Sb Lek 1998; 99: 97–101
   Google Scholar
• Szepietowski J, Wasik F, Bielicka E, Nockowski P, Noworolska A. Soluble E‐selectin serum levels correlate with disease activity in psoriatic patients. Clin Exp Dermatol 1999; 24: 33–36
   PubMed Web of Science ®Google Scholar
• Galley H F, Blaylock M G, Dubbles A M, Webster N R. Variability in E‐selectin expression, mRNA levels and sE‐selectin release between endothelial cell lines and primary endothelial cells. Cell Biol Int 2000; 24: 91–99
   Google Scholar
• Ong C Y, Liao A W, Spencer K, Munim S, Nicolaides K H. First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. Brit J Obstet Gynaecol 2000; 107: 1265–1270
   Google Scholar
• Smith G C, Stenhouse E J, Crossley J A, Aitken D A, Cameron A D, Connor J M. Early pregnancy levels of pregnancy‐associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab 2002; 87: 1762–1767
   PubMed Web of Science ®Google Scholar
• Bersinger N A, Marguerat P, Pescia G, Schneider H. Pregnancy‐associated plasma protein A (PAPP‐A): measurement by highly sensitive and specific enzyme immunoassay, importance of first trimester serum determinations, and stability studies. Reprod Fertil Dev 1995; 7: 1419–1423
   Google Scholar