Advanced search
Publication Cover
Science and Technology of Advanced Materials Volume 14, 2013 - Issue 4
Submit an article Journal homepage
2,626
Views
61
CrossRef citations to date
0
Altmetric
Focus Articles

Non-metallic nanomaterials in cancer theranostics: a review of silica- and carbon-based drug delivery systems

Yu-Cheng ChenDepartment of Applied Chemistry and Institute of Molecular Science, National Chiao-Tung University, Tin-Ka-Pin Building R615B, No. 1001, Ta-Hsueh Road, Hsinchu30010, Taiwan
,
Xin-Chun HuangDepartment of Applied Chemistry and Institute of Molecular Science, National Chiao-Tung University, Tin-Ka-Pin Building R615B, No. 1001, Ta-Hsueh Road, Hsinchu30010, Taiwan
,
Yun-Ling LuoDepartment of Applied Chemistry and Institute of Molecular Science, National Chiao-Tung University, Tin-Ka-Pin Building R615B, No. 1001, Ta-Hsueh Road, Hsinchu30010, Taiwan
,
Yung-Chen ChangDepartment of Applied Chemistry and Institute of Molecular Science, National Chiao-Tung University, Tin-Ka-Pin Building R615B, No. 1001, Ta-Hsueh Road, Hsinchu30010, Taiwan
,
You-Zung HsiehDepartment of Applied Chemistry and Institute of Molecular Science, National Chiao-Tung University, Tin-Ka-Pin Building R615B, No. 1001, Ta-Hsueh Road, Hsinchu30010, Taiwan
&
Hsin-Yun HsuDepartment of Applied Chemistry and Institute of Molecular Science, National Chiao-Tung University, Tin-Ka-Pin Building R615B, No. 1001, Ta-Hsueh Road, Hsinchu30010, Taiwan;Institute of Molecular Science, National Chiao-Tung University, No. 1001, Ta-Hsueh Road, Hsinchu30010, TaiwanCorrespondence[email protected]
Article: 044407 | Received 07 Jun 2013, Accepted 16 Jul 2013, Published online: 16 Aug 2013

References

  • DeanMFojoTBatesS 2005 Tumour stem cells and drug resistance Nature Rev. Cancer 5 275 284 275–84 10.1038/nrc1590
  • PaciottiG FKingstonD G ITamarkinL 2006 Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors Drug Dev. Res. 67 47 54 47–54 10.1002/ddr.20066
  • SlowingI ITrewynB GGiriSLinV S Y 2007 Mesoporous silica nanoparticles for drug delivery and biosensing applications Adv. Funct. Mater. 17 1225 1236 1225–36 10.1002/adfm.200601191
  • NasonklaNBeyERenJAiHKhemtongCGuthiJ SChinS FSherryA DBoothmanD AGaoJ 2006 Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems Nano Lett. 6 2427 2430 2427–30 10.1021/nl061412u
  • SoppimathK STanD CYangY Y 2005 pH-triggered thermally responsive polymer core–shell nanoparticles for drug delivery Adv. Mater. 17 318 323 318–23 10.1002/adma.200401057
  • DromiSFrenkelVLukATraughberBAngstadtMBurMPoffJXieJLibuttiS KLiK CWoodB J 2007 Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect Clin. Cancer Res. 13 2722 2727 2722–7 10.1158/1078-0432.CCR-06-2443
  • YangHKaoW J 2007 Synthesis and characterization of nanoscale dendritic RGD clusters for potential applications in tissue engineering and drug delivery Int. J. Nanomed. 1 89 99 89–99 10.2147/nano.2007.2.1.89
  • ArigaKJiQMcShaneM JLvovY MVinuAHillJ P 2011 Inorganic nanoarchitectonics for biological applications Chem. Mater. 24 728 737 728–37 10.1021/cm202281m
  • UboldiCGiudettiGBroggiFGillilandDPontiJRossiF 2012 Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts Mutat. Res. 745 11 20 11–20 10.1016/j.mrgentox.2011.10.010
  • XiaoQ GTaoXZouH KChenJ F 2008 Comparative study of solid silica nanoparticles and hollow silica nanoparticles for the immobilization of lysozyme Chem. Eng. J. 137 38 44 38–44 10.1016/j.cej.2007.09.012
  • StöberWFinkABohnE 1968 Controlled growth of monodisperse silica spheres in the micron size range J. Colloid Interface Sci. 26 62 69 62–9 10.1016/0021-9797(68)90272-5
  • GrünMLauerIUngerK K 1997 The synthesis of micrometer-and submicrometer-size spheres of ordered mesoporous oxide MCM-41 Adv. Mater. 9 254 257 254–7 10.1002/adma.19970090317
  • BeckJ Set al 1992 A new family of mesoporous molecular-sieves prepared with liquid-crystal templats J. Am. Chem. Soc. 114 10834 10843 10834–43 10.1021/ja00053a020
  • KresgeC TLeonowiczM ERothW JVartuliJ CBeckJ S 1992 Ordered mesoporous molecular-sieves synthesized by a liquid-crystal template mechanism Nature 359 710 712 710–2 10.1038/359710a0
  • HuoQMargoleseD IStuckyG D 1996 Surfactant control of phases in the synthesis of mesoporous silica-based materials Chem. Mater. 8 1147 1160 1147–60 10.1021/cm960137h
  • VartuliJSchmittKKresgeCRothWLeonowiczMMcCullenSHellringSBeckJSchlenkerJ 1994 Effect of surfactant/silica molar ratios on the formation of mesoporous molecular sieves: inorganic mimicry of surfactant liquid-crystal phases and mechanistic implications Chem. Mater. 6 2317 2326 2317–26 10.1021/cM0048a018
  • CaiQLuoZ-SPangW-QFanY-WChenX-HCuiF-Z 2001 Dilute solution routes to various controllable morphologies of MCM-41 silica with a basic medium Chem. Mater. 13 258 263 258–63 10.1021/cm990661z
  • SuzukiKIkariKImaiH 2004 Synthesis of silica nanoparticles having a well-ordered mesostructure using a double surfactant system J. Am. Chem. Soc. 126 462 463 462–3 10.1021/ja038250d
  • SlowingI IVivero-EscotoJ LTrewynB GLinV S Y 2010 Mesoporous silica nanoparticles: structural design and applications J. Mater. Chem. 20 7924 7937 7924–37 10.1039/c0jm00554a
  • AmbrogioM WThomasC RZhaoY-LZinkJ IStoddartJ F 2011 Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine Acc. Chem. Res. 44 903 913 903–13 10.1021/ar200018x
  • ArigaKVinuAYamauchiYJiQHillJ P 2012 Nanoarchitectonics for mesoporous materials Bull. Chem. Soc. Japan 85 1 32 1–32 10.1246/bcsj.20110162
  • LiZBarnesJ CBosoyAStoddartJ FZinkJ I 2012 Mesoporous silica nanoparticles in biomedical applications Chem. Soc. Rev. 41 2590 2605 2590–605 10.1039/c1cs15246g
  • TarnDAshleyC EXueMCarnesE CZinkJ IBrinkerC J 2013 Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility Acc. Chem. Res. 46 792 801 792–801 10.1021/ar3000986
  • WuK C WJiangXYamauchiY 2011 New trend on mesoporous films: precise controls of one-dimensional (1D) mesochannels toward innovative applications J. Mater. Chem. 21 8934 8939 8934–9 10.1039/c1jm10548e
  • WuK C WYamauchiY 2012 Controlling physical features of mesoporous silica nanoparticles (MSNs) for emerging applications J. Mater. Chem. 22 1251 1256 1251–6 10.1039/c1jm13811a
  • FerrisD PZhaoY-LKhashabN MKhatibH AStoddartJ FZinkJ I 2009 Light-operated mechanized nanoparticles J. Am. Chem. Soc. 131 1686 1688 1686–8 10.1021/ja807798g
  • WangYLiBZhangLSongHZhangL 2012 Targeted delivery system based on magnetic mesoporous silica nanocomposites with light-controlled release character ACS App. Mater. Interfaces 5 11 15 11–5 10.1021/am302492e
  • YuanQZhangYChenTLuDZhaoZZhangXLiZYanC-HTanW 2012 Photon-manipulated drug release from a mesoporous nanocontainer controlled by azobenzene-modified nucleic acid ACS Nano 6 6337 6344 6337–44 10.1021/nn3018365
  • ParkCLeeKKimC 2009 Photoresponsive cyclodextrin-covered nanocontainers and their sol–gel transition induced by molecular recognition Angew. Chem. Int. Edn. Engl. 48 1275 1278 1275–8 10.1002/anie.200803880
  • MalN KFujiwaraMTanakaY 2003 Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica Nature 421 350 353 350–3 10.1038/nature01362
  • KnezevicN ZTrewynB GLinV S Y 2011 Functionalized mesoporous silica nanoparticle-based visible light responsive controlled release delivery system Chem. Commun. 47 2817 2819 2817–9 10.1039/c0cc04424e
  • Vivero-EscotoJ LSlowingI IWuC-WLinV S Y 2009 Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere J. Am. Chem. Soc. 131 3462 3463 3462–3 10.1021/ja900025f
  • LinQHuangQLiCBaoCLiuZLiFZhuL 2010 Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one- or two-photon process J. Am. Chem. Soc. 132 10645 10647 10645–7 10.1021/ja103415t
  • SchwarzAStänderSBerneburgMBöhmMKulmsDvan SteegHGrosse-HeitmeyerKKrutmannJSchwarzT 2001 Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair Nature Cell Biol. 4 26 31 26–31 10.1038/ncb717
  • JuzenasPJuzenieneAKaalhusOIaniVMoanJ 2002 Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo Photochem. Photobiol. Sci. 1 745 748 745–8 10.1039/b203459j
  • LiuHChenDLiLLiuTTanLWuXTangF 2011 Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity Angew. Chem. 123 921 925 921–5 10.1002/ange.201002820
  • FangWYangJGongJZhengN 2012 Photo-and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@ Ag nanoparticles Adv. Funct. Mater. 22 842 848 842–8 10.1002/adfm.201101960
  • TangHShenSGuoJChangBJiangXYangW 2012 Gold nanorods@mSiO2 with a smart polymer shell responsive to heat/near-infrared light for chemo-photothermal therapy J. Mater. Chem. 22 16095 16103 16095–103 10.1039/c2jm32599c
  • HelmlingerGYuanFDellianMJainR K 1997 Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nature Med. 3 177 182 177–82 10.1038/nm0297-177
  • SilvaA SYunesJ AGilliesR JGatenbyR A 2009 The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion Cancer Res. 69 2677 2684 2677–84 10.1158/0008-5472.CAN-08-2394
  • MaxfieldF RMcGrawT E 2004 Endocytic recycling Nature Rev. Mol. Cell Biol. 5 121 132 121–32 10.1038/nrm1315
  • ZhaoY-LLiZKabehieSBotrosY YStoddartJ FZinkJ I 2010 pH-operated nanopistons on the surfaces of mesoporous silica nanoparticles J. Am. Chem. Soc. 132 13016 13025 13016–25 10.1021/ja105371u
  • MengHXueMXiaTZhaoY-LTamanoiFStoddartJ FZinkJ INelA E 2010 Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves J. Am. Chem. Soc. 132 12690 12697 12690–7 10.1021/ja104501a
  • LinC-HChengS-HLiaoW-NWeiP-RSungP-JWengC-FLeeC-H 2012 Mesoporous silica nanoparticles for the improved anticancer efficacy of cis-platin Int. J. Pharm. 429 138 147 138–47 10.1016/j.ijpharm.2012.03.026
  • LeeC HChengS HHuangISourisJ SYangC SMouC YLoL W 2010 Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics Angew. Chem. 122 8390 8395 8390–5 10.1002/ange.201002639
  • LiuRZhangYZhaoXAgarwalAMuellerL JFengP 2010 pH-responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker J. Am. Chem. Soc. 132 1500 1501 1500–1 10.1021/ja907838s
  • GanQLuXYuanYQianJZhouHLuXShiJLiuC 2011 A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica Biomaterials 32 1932 1942 1932–42 10.1016/j.biomaterials.2010.11.020
  • AznarEMarcosM DMartiánez-MaánñezR NSancenónFSotoJAmoroásPGuillemC 2009 pH-and photo-switched release of guest molecules from mesoporous silica supports J. Am. Chem. Soc. 131 6833 6843 6833–43 10.1021/ja810011p
  • GaoCZhengHXingLShuMCheS 2010 Designable coordination bonding in mesopores as a pH-responsive release system Chem. Mater. 22 5437 5444 5437–44 10.1021/cm100667u
  • PopatALiuJLuG Q MQiaoS Z 2012 A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles J. Mater. Chem. 22 11173 11178 11173–8 10.1039/c2jm30501a
  • ChenFZhuY 2012 Chitosan enclosed mesoporous silica nanoparticles as drug nano-carriers: sensitive response to the narrow pH range Micropor. Mesopor. Mater. 150 83 89 83–9 10.1016/j.micromeso.2011.07.023
  • TangHGuoJSunYChangBRenQYangW 2011 Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery Int. J. Pharm. 421 388 396 388–96 10.1016/j.ijpharm.2011.10.013
  • MuhammadFGuoMQiWSunFWangAGuoYZhuG 2011 pH-Triggered controlled drug release from mesoporous silica nanoparticles via intracelluar dissolution of ZnO nanolids J. Am. Chem. Soc. 133 8778 8781 8778–81 10.1021/ja200328s
  • SchaferF QBuettnerG R 2001 Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radi. Biol. Med. 30 1191 1212 1191–212 10.1016/S0891-5849(01)00480-4
  • WuGFangY-ZYangSLuptonJ RTurnerN D 2004 Glutathione metabolism and its implications for health J. Nutr. 134 489 492 489–92
  • ArunachalamBPhanU TGeuzeH JCresswellP 2000 Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT) Proc. Nat. Acad. Sci. 97 745 750 745–50 10.1073/pnas.97.2.745
  • TrachoothamDAlexandreJHuangP 2009 Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature reviews. Drug Disc. 8 579 591 579–91 10.1038/nrd2803
  • LuoZCaiKHuYZhaoLLiuPDuanLYangW 2011 Mesoporous silica nanoparticles end-capped with collagen: redox-responsive nanoreservoirs for targeted drug delivery Angew. Chem. Int. Edn. 50 640 643 640–3 10.1002/anie.201005061
  • CuiYDongHCaiXWangDLiY 2012 Mesoporous silica nanoparticles capped with disulfide-linked peg gatekeepers for glutathione-mediated controlled release ACS Appl. Mater. Interfaces 4 3177 3183 3177–83 10.1021/am3005225
  • KimHKimSParkCLeeHParkH JKimC 2010 Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers Adv. Mater. 22 4280 4283 4280–3 10.1002/adma.201001417
  • ZhangQLiuFNguyenK TMaXWangXXingBZhaoY 2012 Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery Adv. Funct. Mater. 22 5144 5156 5144–56 10.1002/adfm.201201316
  • SauerA MSchlossbauerARuthardtNCaudaVBeinTBraäuchleC 2010 Role of endosomal escape for disulfide-based drug delivery from colloidal mesoporous silica evaluated by live-cell imaging Nano Lett. 10 3684 3691 3684–91 10.1021/nl102180s
  • ZongSWangZChenHYangJCuiY 2013 Surface enhanced Raman scattering traceable and glutathione responsive nanocarrier for the intracellular drug delivery Anal. Chem. 85 2223 2230 2223–30 10.1021/ac303028v
  • ZhuC-LSongX-YZhouW-HYangH-HWenY-HWangX-R 2009 An efficient cell-targeting and intracellular controlled-release drug delivery system based on MSN-PEM-aptamer conjugates J. Mater. Chem. 19 7765 7770 7765–70 10.1039/b907978e
  • WanXWangDLiuS 2010 Fluorescent pH-sensing organic/inorganic hybrid mesoporous silica nanoparticles with tunable redox-responsive release capability Langmuir 26 15574 15579 15574–9 10.1021/la102148x
  • DavisJ JHuangW-YDaviesG-L 2012 Location-tuned relaxivity in Gd-doped mesoporous silica nanoparticles J. Mater. Chem. 22 22848 22850 22848–50 10.1039/c2jm35116a
  • CarniatoFTeiLCossiMMarcheseLBottaM 2010 A chemical strategy for the relaxivity enhancement of GdIII chelates anchored on mesoporous silica nanoparticles Chemistry-A Eur. J. 16 10727 10734 10727–34 10.1002/chem.201000499
  • LinW-ILinC-YLinY-SWuS-HHuangY-RHungYChangCMouC-Y 2013 High payload Gd (iii) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging J. Mater. Chem. B 1 639 645 639–45 10.1039/c2tb00283c
  • LiuJBuWZhangSChenFXingHPanLZhouLPengWShiJ 2012 Controlled synthesis of uniform and monodisperse upconversion core/mesoporous silica shell nanocomposites for bimodal imaging Chemistry-A Eur. J. 18 2335 2341 2335–41 10.1002/chem.201102599
  • Guillet-NicolasRBridotJ LSeoYFortinM AKleitzF 2011 Enhanced relaxometric properties of MRI ‘Positive’ contrast agents confined in three-dimensional cubic mesoporous silica nanoparticles Adv. Funct. Mater. 21 4653 4662 4653–62 10.1002/adfm.201101766
  • KimTMominEChoiJYuanKZaidiHKimJParkMLeeNMcMahonM TQuinones-HinojosaA 2011 Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T 1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells J. Am. Chem. Soc. 133 2955 2961 2955–61 10.1021/ja1084095
  • ChenYYinQJiXZhangSChenHZhengYSunYQuHWangZLiY 2012 Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells Biomaterials 33 7126 7137 7126–37 10.1016/j.biomaterials.2012.06.059
  • ChenP-JHuS-HHsiaoC-SChenY-YLiuD-MChenS-Y 2011 Multifunctional magnetically removable nanogated lids of Fe3O4–capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging J. Mater. Chem. 21 2535 2543 2535–43 10.1039/c0jm02590a
  • LeeJ ELeeNKimHKimJChoiS HKimJ HKimTSongI CParkS PMoonW K 2009 Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery J. Am. Chem. Soc. 132 552 557 552–7 10.1021/ja905793q
  • ChenYChenHZengDTianYChenFFengJShiJ 2010 Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery ACS Nano 4 6001 6013 6001–13 10.1021/nn1015117
  • ThomasC RFerrisD PLeeJ-HChoiEChoM HKimE SStoddartJ FShinJ-SCheonJZinkJ I 2010 Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles J. Am. Chem. Soc. 132 10623 10625 10623–5 10.1021/ja1022267
  • BaezaAGuisasolaERuiz-HernaándezEVallet-RegiáM a 2012 Magnetically triggered multidrug release by hybrid mesoporous silica nanoparticles Chem. Mater. 24 517 524 517–24 10.1021/cm203000u
  • BringasEKöysürenÖQuachD VMahmoudiMAznarERoehlingJ DMarcosM DMartínez-MáñezRStroeveP 2012 Triggered release in lipid bilayer-capped mesoporous silica nanoparticles containing SPION using an alternating magnetic field Chem. Commun. 48 5647 5649 5647–9 10.1039/c2cc31563g
  • SchrandAHensS A CShenderovaO 2009 Nanodiamond particles: properties and perspectives for bioapplications Crit. Rev. Solid State Mater. Sci. 34 18 74 18–74 10.1080/10408430902831987
  • CaoLWangXMezianiM JLuFWangHLuoP GLinYHarruffB AVecaMMurrayDXieS YSunY P 2007 Carbon dots for multiphoton bioimaging J. Am. Chem. Soc. 129 11318 11319 11318–19 10.1021/ja073527l
  • YangKZhangSZhangGSunXLeeS TLiuZ 2010 Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy Nano Lett. 10 3318 3323 3318–23 10.1021/nl100996u
  • KimJ WGalanzhaE IShashkovE VMoonH MZharovV P 2009 Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents Nature Nanotechnol. 4 688 694 688–94 10.1038/nnano.2009.231
  • MrozPTegosG PGaliHWhartonTSarnaTHamblinM R 2007 Photodynamic therapy with fullerenes Photochem. Photobiol. Sci. 6 1139 1149 1139–49 10.1039/b711141j
  • HuangHPierstorffEOsawaEHoD 2008 Protein-mediated assembly of nanodiamond hydrogels into a biocompatible and biofunctional multilayer nanofilm ACS Nano 2 203 212 203–12 10.1021/nn7000867
  • LiuXTaoHYangKZhangSLeeS TLiuZ 2011 Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors Biomaterials 32 144 151 144–51 10.1016/j.biomaterials.2010.08.096
  • JiaNLianQShenHWangCLiXYangZ 2007 Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes Nano Lett. 7 2976 2980 2976–80 10.1021/nl071114c
  • LamRChenMPierstorffEHuangHOsawaEHoD 2008 Nanodiamond-embedded microfilm devices for localized chemotherapeutic elution ACS Nano 2 2095 2102 2095–102 10.1021/nn800465x
  • KimT WChungP WSlowingI ITsunodaMYeungE SLinV S 2008 Structurally ordered mesoporous carbon nanoparticles as transmembrane delivery vehicle in human cancer cells Nano Lett. 8 3724 3727 3724–27 10.1021/nl801976m
  • BhirdeA APatelVGavardJZhangGSousaA AMA.LeapmanR DWeigertRGutkindJ SRuslingJ F 2009 Targeted killing of cancer cells in Vivo and in Vitro with EGF ACS Nano 3 307 316 307–16 10.1021/nn800551s
  • KrotoH WHeathJ RO'BriemS CCurlR FSmalleyR E 1985 C-60: Buckminsterfullerene Nature 318 162 163 162–63 10.1038/318162a0
  • IijimaS 1991 HELICAL Microtubules of graphitic carbon Nature 354 56 58 56–8 10.1038/354056a0
  • BaughmanR HZakhidovA Ade HeerW A 2002 Carbon nanotubes—the route toward applications Science 297 787 792 787–92 10.1126/science.1060928
  • GeimA KNovoselovK S 2007 the rise of graphene Nature Mater. 6 183 191 183–91 10.1038/nmat1849
  • ZhangYNayakT RHongHCaiW 2012 Graphene: a versatile nanoplatform for biomedical applications Nanoscale 4 3833 3842 3833–42 10.1039/c2nr31040f
  • YangKFengLShiXLiuZ 2013 Nano-graphene in biomedicine: theranostic applications Chem. Soc. Rev. 42 530 547 530–47 10.1039/c2cs35342c
  • XuXRayRGuYPloehnH JGearheartLRakerKScrivensW A 2004 Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments J. Am. Chem. Soc. 126 12736 12737 12736–7 10.1021/ja040082h
  • LiuHYeTMaoC 2007 Fluorescent carbon nanoparticles derived from candle soot Angew. Chem. Int. Edn Engl. 46 6473 6475 6473–5 10.1002/anie.200701271
  • RayS CSahaAJanaN RSarkarR 2009 Fluorescent carbon nanoparticles: synthesis, characterization, and bioimaging application J. Phys. Chem. C 113 18546 18551 18546–51 10.1021/jp905912n
  • KamN W SLiuZ ADaiH J 2006 Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway Angew. Chem. Int. Edn. Engl. 45 577 581 577–81 10.1002/anie.200503389
  • KatzEWillnerI 2004 Biomolecule-functionalized carbon nanotubes: applications in nanobioelectronics ChemPhysChem 5 1084 1104 1084–104 10.1002/cphc.200400193
  • FriebelMMeinkeM 2005 Determination of the complex refractive index of highly concentrated hemoglobin solutions using transmittance and reflectance measurements J. Biomed. opt. 10 064019 10.1117/1.2138027
  • ShiDGuoYDongZLianJWangWLiuGWangLEwingR C 2007 Quantum-dot-activated luminescent carbon nanotubes via a nano scale surface functionalization for in vivo imaging Adv. Mater. 19 4033 4037 4033–7 10.1002/adma.200700035
  • WelsherKLiuZDaraciangDDaiH 2008 Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules Nano Lett. 8 586 590 586–90 10.1021/nl072949q
  • de la ZerdaALiuZBodapatiSTeedRVaithilingamSKhuri-YakubB TChenXDaiHGambhirS S 2010 Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice Nano Lett. 10 2168 2172 2168–72 10.1021/nl100890d
  • GuoYet al 2008 In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes Adv. Funct. Mater. 18 2489 2497 2489–97 10.1002/adfm.200800406
  • HartmanK BLausSBolskarR DMuthupollaiRHelmLTothEMebrachA EWilsonL J 2008 Gadonanotubes as ultrasensitive pH-smart probes for magnetic resonance imaging Nano Lett. 8 415 419 415–19 10.1021/nl0720408
  • HeisterENevesVTîlmaciuCLipertKBeltránV SColeyH MSilvaS R PMcFaddenJ 2009 Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy Carbon 47 2152 2160 2152–60 10.1016/j.carbon.2009.03.057
  • ChenJChenSZhaoXKuznetsovaL VWongS SOjimaL 2008 Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery J. Am. Chem. Soc. 130 16778 16785 16778–85 10.1021/ja805570f
  • DharSLiuZThomaleJDaiHLippardS J 2008 Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device J. Am. Chem. Soc. 130 11467 11476 11467–76 10.1021/ja803036e
  • LiuZSunXRatchfordN NDaiH 2007 Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery ACS Nano 1 50 56 50–6 10.1021/nn700040t
  • LiRWuRZhaoLWuMYangLZouH 2010 P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells ACS Nano 4 1399 1408 1399–408 10.1021/nn9011225
  • GhoshSDuttaSGnomesECarrollDJrR DOlsonJGutholdMGmeinerW H 2009 Increased heating efficiency and selective thermal ablation of malignant tissue with dna-encased multiwalled carbon nanotubes ACS Nano 3 2667 2673 2667–73 10.1021/nn900368b
  • MoonH KLeeS HChoiH C 2009 In vivo near-infrared mediated tumor destruction by photothermal effect of carbon nanotubes ACS Nano 3 3707 3713 3707–13 10.1021/nn900904h
  • ChakravartyPMarchesRZimmermanN SSwaffordA DBajajPMusselmanI HPantanoPDraperR KVitettaE S 2008 Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes Proc. Natl Acad. Sci. USA 105 8697 8702 8697–702 10.1073/pnas.0803557105
  • CarlsonL JKraussT D 2008 Photophysics of individual single-walled carbon nanotubes Acc. Chem. Res. 41 235 243 235–43 10.1021/ar700136v
  • RobinsonJ TWelsherKTabakmanS MSherlockS PWangHLuongRDaiH 2010 High performance in vivo near-IR (> 1 mum) imaging and photothermal cancer therapy with carbon nanotubes Nano Research 3 779 793 779–93 10.1007/s12274-010-0045-1
  • ZhouFXingDOuZWuBResascoD EChenW R 2009 Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes J. Biomed. Opt. 14 021009 10.1117/1.3078803
  • KlingelerRHampelSBuchnerB 2008 Carbon nanotube based biomedical agents for heating, temperature sensoring and drug delivery Int. J. Hyperth. 24 496 505 496–505 10.1080/02656730802154786
  • HatakeyamaHAkitaHKogureKOishiMNagasakiYKihiraYUenoMKobayashiHKikuchiHHarashimaH 2007 Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid Gene Ther. 14 68 77 68–77 10.1038/sj.gt.3302843
  • MorilleMPassiraniCVonarbourgAClavreulABenoitJ P 2008 Progress in developing cationic vectors for non-viral systemic gene therapy against cancer Biomaterials 29 3477 3496 3477–96 10.1016/j.biomaterials.2008.04.036
  • WaehlerRRussellS JCurielD T 2007 Engineering targeted viral vectors for gene therapy Nature Rev. Genetics 8 573 587 573–87 10.1038/nrg2141
  • Ferrer-MirallesNVazquezEVillaverdeA 2008 Membrane-active peptides for non-viral gene therapy: making the safest easier Trends Biotechnol. 26 267 275 267–75 10.1016/j.tibtech.2008.02.003
  • DassC RChoongP F 2006 Selective gene delivery for cancer therapy using cationic liposomes: in vivo proof of applicability J. Control. Release 113 155 163 155–63 10.1016/j.jconrel.2006.04.009
  • HerreroM ATomaF MAl-jamalK TKosrarelosKBiancoARosT DBanoFCasalisLScolesGPratoM 2009 Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery J. Am. Chem. Soc. 131 9843 9848 9843–48 10.1021/ja903316z
  • YangXZhangXMaYHuangYWangYChenY 2009 Superparamagnetic graphene oxide–Fe3O4 nanoparticles hybrid for controlled targeted drug carriers J. Mater. Chem. 19 2710 10.1039/b821416f
  • LuC HZhuC LLiJLiuJ JChenXYangH H 2010 Using graphene to protect DNA from cleavage during cellular delivery Chem. Commun. (Camb.) 46 3116 3118 3116–8 10.1039/b926893f
  • MarkovicZ MHarhaji-TrajkovicL MTodorovic-MarkovicB MKepicD PArsikinK MJovanovicS PPantovicA CDramicaninM DTrajkovicV S 2011 In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes Biomaterials 32 1121 1129 1121–9 10.1016/j.biomaterials.2010.10.030
  • RobinsonJ TTabakmanS MLiangYWangHCasalongueH SVinhDDaiH 2011 Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy J. Am. Chem. Soc. 133 6825 6831 6825–31 10.1021/ja2010175
  • YangXWangYHuangXMaYHuangYYangRDuanHChenY 2011 Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity J. Mater. Chem. 21 3448 10.1039/c0jm02494e
  • BottiniMBalasubramanianCDawsonM IBergamaschiABellucciSMustelinT 2006 Isolation and characterization of fluorescent nanoparticles from pristine and oxidized electric arc-produced single-walled carbon nanotubes J. Phys. Chem. B 110 831 836 831–6 10.1021/jp055503b
  • FangYGuoSLiDZhuCRenWDongSWangE 2012 Easy synthesis and imaging applications of cross-linked green fluorescent hollow carbon nanoparticles ACS Nano 6 400 409 400–9 10.1021/nn2046373
  • SunY Pet al 2006 Quantum-sized carbon dots for bright and colorful photoluminescence J. Am. Chem. Soc. 128 7756 7757 7756–7 10.1021/ja062677d
  • HuangHPierstorffEOsawaEHoD 2007 Active nanodiamond hydrogels for chemotherapeutic delivery Nano Lett. 7 3305 3314 3305–14 10.1021/nl071521o
  • ChenMPierstorffE DLamRLiS YHuangHOsawaEHoD 2009 Nanodiamond-mediated delivery of water-insoluble therapeutics ACS Nano 3 2016 2022 2016–22 10.1021/nn900480m
  • ZhangX QChenMLamRXuXOsawaEHoD 2009 Polymer-functionalized nanodiamond platforms as vehicles for gene delivery ACS Nano 3 2609 2616 2609–16 10.1021/nn900865g
  • ZhaoQ-LZhangZ-LHuangB-HPengJZhangMPangD-W 2008 Facile preparation of low cytotoxicity fluorescent carbon nanocrystals by electrooxidation of graphite Chem. Commun. (Camb.) 5116 5118 5116–8 10.1039/b812420e
  • ZhangSHeQLiRWangQHuZLiuXChangX 2011 Study on the fluorescence carbon nanoparticles Mater. Lett. 65 2371 2373 2371–3 10.1016/j.matlet.2011.05.025
  • LuWQinXLiuSChangGZhangYLuoYAsiriA MAl-YoubiA OSunX 2012 Economical, green synthesis of fluorescent carbon nanoparticles and their use as probes for sensitive and selective detection of mercury(II) ions Anal. Chem. 84 5351 5357 5351–7 10.1021/ac3007939
  • MrozPPawlakASattiMLeeHWhartonTGaliHSarnaTHamblinM R 2007 Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism Free Rad. Biol. Med. 43 711 719 711–9 10.1016/j.freeradbiomed.2007.05.005
  • ShanbhagP PJogS VChogaleM MGaikwadS S 2013 Theranostics for cancer therapy Curr. Drug. Deliv. 10 357 362 357–62 10.2174/1567201811310030013
  • PovoskiS PHatzarasI SMojzisikC MMartinE WJr. 2011 Oncologic theranostics: recognition of this concept in antigen-directed cancer therapy for colorectal cancer with anti-TAG-72 monoclonal antibodies Expert Rev. Mol. Diagn. 11 667 670 667–70 10.1586/erm.11.54
  • OmidiY 2011 Smart multifunctional theranostics: simultaneous diagnosis and therapy of cancer Bioimpacts 1 145 147 145–7
  • ChenWXuNXuLWangLLiZMaWZhuYXuCKotovN A 2010 Multifunctional magnetoplasmonic nanoparticle assemblies for cancer therapy and diagnostics (theranostics) Macromol. Rapid Commun. 31 228 236 228–36
  • BanghamA DStandishM MWatkinsJ C 1965 Diffusion of univalent ions across the lamellae of swollen phospholipids J. Mol. Biol. 13 238 252 238–52 10.1016/S0022-2836(65)80093-6
  • TorchilinV 2009 Multifunctional and stimuli-sensitive pharmaceutical nanocarriers Eur. J. Pharm. Biopharm. 71 431 444 431–44 10.1016/j.ejpb.2008.09.026
  • LangerRFolkmanJ 1976 Polymers for the sustained release of proteins and other macromolecules Nature 263 797 800 797–800 10.1038/263797a0
  • HarriesMEllisPHarperP 2005 Nanoparticle albumin-bound paclitaxel for metastatic breast cancer J. Clin. Oncol. 23 7768 7771 7768–71 10.1200/JCO.2005.08.002
  • KhoeeSRahmatolahzadehR 2012 Synthesis and characterization of pH-responsive and folated nanoparticles based on self-assembled brush-like PLGA/PEG/AEMA copolymer with targeted cancer therapy properties: a comprehensive kinetic study Eur. J. Med. Chem. 50 416 427 416–27 10.1016/j.ejmech.2012.02.027
  • AsteteC ESabliovC M 2006 Synthesis and characterization of PLGA nanoparticles J. Biomater. Sci. Polym. Ed. 17 247 289 247–89 10.1163/156856206775997322
  • KlibanovA LMaruyamaKTorchilinV PHuangL 1990 Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett. 268 235 237 235–7 10.1016/0014-5793(90)81016-H
  • PapahadjopoulosDet al 1991 Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy Proc. Natl Acad. Sci. USA 88 11460 11464 11460–4 10.1073/pnas.88.24.11460
  • LiuZRobinsonJ TSunXDaiH 2008 PEGylated nanographene oxide for delivery of water-insoluble cancer drugs J. Am. Chem. Soc. 130 10876 10877 10876–77 10.1021/ja803688x
  • BuningH 2013 Gene therapy enters the pharma market: the short story of a long journey EMBO Mol. Med. 5 1 3 1–3 10.1002/emmm.201202291
  • WenYPanSLuoXZhangXZhangWFengM 2009 A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector Bioconjug. Chem. 20 322 332 322–32 10.1021/bc800428y
  • Cavazzana-CalvoMet al 2000 Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease Science 288 669 672 669–72 10.1126/science.288.5466.669
  • ThomasC EEhrhardtAKayM A 2003 Progress and problems with the use of viral vectors for gene therapy Nature Rev. Genetics 4 346 358 346–58 10.1038/nrg1066
  • FarokhzadO CLangerR 2006 Nanomedicine: developing smarter therapeutic and diagnostic modalities Adv. Drug. Deliv. Rev. 58 1456 1459 1456–9 10.1016/j.addr.2006.09.011
  • AndersonD GPengWAkincAHossainNKohnAPaderaRLangerRSawickiJ A 2004 A polymer library approach to suicide gene therapy for cancer Proc. Natl Acad. Sci. USA 101 16028 16033 16028–33 10.1073/pnas.0407218101
  • Maurer-JonesM AHaynesC L 2012 Toward correlation in in vivo and in vitro nanotoxicology studies J. Law Med. Ethics 40 795 801 795–801
  • Maurer-JonesM ABantzK CLoveS AMarquisB JHaynesC L 2009 Toxicity of therapeutic nanoparticles Nanomedicine 4 219 241 219–41 10.2217/17435889.4.2.219
  • Slowing,IIWuC WVivero-EscotoJ LLinV S 2009 Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells Small 5 57 62 57–62 10.1002/smll.200800926
  • LinY SHaynesC L 2009 Synthesis and characterization of biocompatible and size-tunable multifunctional porous silica nanoparticles Chem. Mater. 21 3979 3986 3979–86 10.1021/cm901259n
  • JiS RLiuCZhangBYangFXuJLongJJinCFuD LNiQ XYuX J 2010 Carbon nanotubes in cancer diagnosis and therapy Biochim. Biophys. Acta. 1806 29 35 29–35
  • HanS-oMahatoR IKimS W 2001 Water-soluble lipopolymer for gene delivery Bioconjug. Chem. 12 337 345 337–45 10.1021/bc000120w
  • De la ZerdaAet al 2008 Carbon nanotubes as photoacoustic molecular imaging agents in living mie Nature Nanotechnol. 3 557 562 557–62 10.1038/nnano.2008.231
  • ZavaletaCZerdaA D LLiuSKerenSChengZSchipperMChenXDaiHGambhirS S 2008 Noninvasive raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes Nano Lett. 8 2800 2805 2800–05 10.1021/nl801362a
  • ShiXWangS HShenMAntwerpM EChenXLiCPetersenE JHuangQWeberW JJrBakerJ RJr 2009 Multifunctional dendrimer-modified multiwalled carbon nanotubes synthesis, characterization and in vitro cancer cell targeting and imaging Biomacromolecules 10 1744 1750 1744–50 10.1021/bm9001624
  • WuWLiRBianXZhuZDingDLiXJiaZJiangXHuY 2009 Covalently combining carbon nanotubes with anticancer agent preparation and antitumor activity ACS Nano 3 2740 2750 2740–50 10.1021/nn9005686
  • ZhangXMengLLuQFeiZDysonP J 2009 Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes Biomaterials 30 6041 6047 6041–7 10.1016/j.biomaterials.2009.07.025
  • LiuZFanA CRakhraKSherlockSGoodwinAChenXYangQFelsherD WDaiH 2009 Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy Angew. Chem. Int. Edn. Engl. 48 7668 7672 7668–72 10.1002/anie.200902612
  • FeazellR PRatchfordN NDaiHLippardS J 2007 Soluble single-walled carbon nanotubes as longboat delivery systems for platinum (IV) anticancer drug design J. Am. Chem. Soc. 129 8438 8439 8438–39 10.1021/ja073231f
  • Ali-BoucettaHAl-JamalK TMcCarthyDPratoMBiancoAKostarelosK 2008 Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics Chem. Commun. (Camb.) 459 461 459–61 10.1039/b712350g
  • KimJ WShashkovE VGalanzhaE IKotagiriNZharovV P 2007 Photothermal antimicrobial nanotherapy and nanodiagnostics with self-assembling carbon nanotube clusters Lasers Surg. Med. 39 622 634 622–34 10.1002/lsm.20534
  • GannonC Jet al 2007 Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field Cancer 110 2654 2665 2654–65 10.1002/cncr.23155

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.