The usefulness of multimodal imaging for differentiating pseudopapilloedema and true swelling of the optic nerve head: a review and case series

References

• Sadun AA, Wang MY. Abnormalities of the optic disc. Handb Clin Neurol 2011; 102: 117–157.
   PubMedGoogle Scholar
• Johnson LN, Hepler RS, Bartholomew MJ. Accuracy of papilledema and pseudopapilledema detection: a multispecialty study. J Fam Pract 1991; 33: 381–386.
   PubMed Web of Science ®Google Scholar
• Whiting AS, Johnson LN. Papilledema: clinical clues and differential diagnosis. Am Fam Physician 1992; 45: 1125–1134.
   PubMed Web of Science ®Google Scholar
• Jonas JB, Gusek GC, Guggenmoos‐holzmann I, Naumann GO. Pseudopapilledema associated with abnormally small optic discs. Acta Ophthalmol (Copenh) 1988; 66: 190–193.
   Web of Science ®Google Scholar
• Jonas JB, Gusek GC, Naumann GO. Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci 1988; 29: 1151–1158.
   PubMed Web of Science ®Google Scholar
• Frisen L, Holmegaard L. Spectrum of optic nerve hypoplasia. Br J Ophthalmol 1978; 62: 7–15.
   PubMed Web of Science ®Google Scholar
• Oliveira C, Harizman N, Girkin CA, Xie A, Tello C, Liebmann JM, Ritch R. Axial length and optic disc size in normal eyes. Br J Ophthalmol 2007; 91: 37–39.
   Web of Science ®Google Scholar
• Apple DJ, Rabb MF, Walsh PM. Congenital anomalies of the optic disc. Surv Ophthalmol 1982; 27: 3–41.
   PubMed Web of Science ®Google Scholar
• Witmer MT, Margo CE, Drucker M. Tilted optic disks. Surv Ophthalmol 2010; 55: 403–428.
   PubMed Web of Science ®Google Scholar
• Brito PN, Vieira MP, Falcao MS, Faria OS, Falcao‐reis F. Optical coherence tomography study of peripapillary retinal nerve fiber layer and choroidal thickness in eyes with tilted optic disc. J Glaucoma 2013; February 19. [Epub ahead of print].
   Google Scholar
• Vongphanit J, Mitchell P, Wang JJ. Population prevalence of tilted optic disks and the relationship of this sign to refractive error. Am J Ophthalmol 2002; 133: 679–685.
   PubMed Web of Science ®Google Scholar
• Brazitikos PD, Safran AB, Simona F, Zulauf M. Threshold perimetry in tilted disc syndrome. Arch Ophthalmol 1990; 108: 1698–1700.
   Google Scholar
• Nakanishi H, Tsujikawa A, Gotoh N, Hayashi H, Iwama D, Tamura H, Otani A et al. Macular complications on the border of an inferior staphyloma associated with tilted disc syndrome. Retina 2008; 28: 1493–1501.
   Web of Science ®Google Scholar
• Lam BL, Morais CG Jr, Pasol J. Drusen of the optic disc. Curr Neurol Neurosci Rep 2008; 8: 404–408.
   PubMed Web of Science ®Google Scholar
• Auw‐haedrich C, Staubach F, Witschel H. Optic disk drusen. Surv Ophthalmol 2002; 47: 515–532.
   PubMed Web of Science ®Google Scholar
• Tso MO, Hayreh SS. Optic disc edema in raised intracranial pressure. III. A pathologic study of experimental papilledema. Arch Ophthalmol 1977; 95: 1448–1457.
   PubMedGoogle Scholar
• Passi N, Degnan AJ, Levy LM. MR imaging of papilledema and visual pathways: effects of increased intracranial pressure and pathophysiologic mechanisms. AJNR Am J Neuroradiol 2012; 34: 919–924.
   Web of Science ®Google Scholar
• Killer HE, Laeng HR, Flammer J, Groscurth P. Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations. Br J Ophthalmol 2003; 87: 777–781.
   PubMed Web of Science ®Google Scholar
• Lee AG, Wall M. Papilledema: are we any nearer to a consensus on pathogenesis and treatment? Curr Neurol Neurosci Rep 2012; 12: 334–339.
   PubMed Web of Science ®Google Scholar
• Radhakrishnan K, Thacker AK, Bohlaga NH, Maloo JC, Gerryo SE. Epidemiology of idiopathic intracranial hypertension: a prospective and case‐control study. J Neurol Sci 1993; 116: 18–28.
   PubMed Web of Science ®Google Scholar
• Trobe JD. Papilledema: the vexing issues. J Neuroophthalmol 2011; 31: 175–186.
   PubMed Web of Science ®Google Scholar
• Sergott RC. Headaches associated with papilledema. Curr Pain Headache Rep 2012; 16: 354–358.
   Web of Science ®Google Scholar
• Thambisetty M, Lavin PJ, Newman NJ, Biousse V. Fulminant idiopathic intracranial hypertension. Neurology 2007; 68: 229–232.
   PubMed Web of Science ®Google Scholar
• Carta A, Favilla S, Prato M, Bianchi‐marzoli S, Sadun AA, Mora P. Accuracy of funduscopy to identify true edema versus pseudoedema of the optic disc. Invest Ophthalmol Vis Sci 2012; 53: 1–6.
   Web of Science ®Google Scholar
• Scott CJ, Kardon RH, Lee AG, Frisen L, Wall M. Diagnosis and grading of papilledema in patients with raised intracranial pressure using optical coherence tomography vs clinical expert assessment using a clinical staging scale. Arch Ophthalmol 2010; 128: 705–711.
   PubMedGoogle Scholar
• Kerr NM, Chew SS, Danesh‐meyer HV. Non‐arteritic anterior ischaemic optic neuropathy: a review and update. J Clin Neurosci 2009; 16: 994–1000.
   PubMed Web of Science ®Google Scholar
• Kiernan DF, Mieler WF, Hariprasad SM. Spectral‐domain optical coherence tomography: a comparison of modern high‐resolution retinal imaging systems. Am J Ophthalmol 2010; 149: 18–31.
   PubMed Web of Science ®Google Scholar
• Jaffe GJ, Caprioli J. Optical coherence tomography to detect and manage retinal disease and glaucoma. Am J Ophthalmol 2004; 137: 156–169.
   PubMed Web of Science ®Google Scholar
• Sakata LM, Deleon‐ortega J, Sakata V, Girkin CA. Optical coherence tomography of the retina and optic nerve—a review. Clin Experiment Ophthalmol 2009; 37: 90–99.
   PubMed Web of Science ®Google Scholar
• Chen TC, Cense B, Miller JW, Rubin PA, Deschler DG, Gragoudas ES, de Boer JF. Histologic correlation of in vivo optical coherence tomography images of the human retina. Am J Ophthalmol 2006; 141: 1165–1168.
   Web of Science ®Google Scholar
• Strouthidis NG, Grimm J, Williams GA, Cull GA, Wilson DJ, Burgoyne CF. A comparison of optic nerve head morphology viewed by spectral domain optical coherence tomography and by serial histology. Invest Ophthalmol Vis Sci 2010; 51: 1464–1474.
   PubMed Web of Science ®Google Scholar
• Gabriele ML, Wollstein G, Bilonick RA, Burgansky‐eliash Z, Ishikawa H, Kagemann LE, Schuman JS. Comparison of parameters from Heidelberg Retina Tomographs 2 and 3. Ophthalmology 2008; 115: 673–677.
   PubMed Web of Science ®Google Scholar
• Wollstein G, Garway‐heath DF, Hitchings RA. Identification of early glaucoma cases with the scanning laser ophthalmoscope. Ophthalmology 1998; 105: 1557–1563.
   PubMed Web of Science ®Google Scholar
• Webb RH, Hughes GW, Delori FC. Confocal scanning laser ophthalmoscope. Appl Opt 1987; 26: 1492–1499.
   PubMed Web of Science ®Google Scholar
• Vizzeri G, Weinreb RN, Martinez de la casa JM, Alencar LM, Bowd C, Balasubramanian M, Medeiros FA et al. Clinicians agreement in establishing glaucomatous progression using the Heidelberg retina tomograph. Ophthalmology 2009; 116: 14–24.
   Web of Science ®Google Scholar
• Deleon ortega JE, Sakata LM, Kakati B, Mcgwin G Jr, Monheit BE, Arthur SN, Girkin CA. Effect of glaucomatous damage on repeatability of confocal scanning laser ophthalmoscope, scanning laser polarimetry, and optical coherence tomography. Invest Ophthalmol Vis Sci 2007; 48: 1156–1163.
   PubMed Web of Science ®Google Scholar
• von Ruckmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol 1995; 79: 407–412.
   PubMed Web of Science ®Google Scholar
• Jorzik JJ, Bindewald A, Dithmar S, Holz FG. Digital simultaneous fluorescein and indocyanine green angiography, autofluorescence, and red‐free imaging with a solid‐state laser‐based confocal scanning laser ophthalmoscope. Retina 2005; 25: 405–416.
   PubMed Web of Science ®Google Scholar
• Schmitz‐valckenberg S, Holz FG, Bird AC, Spaide RF. Fundus autofluorescence imaging: review and perspectives. Retina 2008; 28: 385–409.
   PubMed Web of Science ®Google Scholar
• Schmitz‐valckenberg S, Fleckenstein M, Gobel AP, Sehmi K, Fitzke FW, Holz FG, Tufail A. Evaluation of autofluorescence imaging with the scanning laser ophthalmoscope and the fundus camera in age‐related geographic atrophy. Am J Ophthalmol 2008; 146: 183–192.
   PubMed Web of Science ®Google Scholar
• Mundt GH Jr, Hughes WF Jr. Ultrasonics in ocular diagnosis. Am J Ophthalmol 1956; 41: 488–498.
   PubMed Web of Science ®Google Scholar
• Ossoinig KC. Standardized echography: basic principles, clinical applications and results. Int Ophthalmol Clin 1979; 19: 127–210.
   PubMedGoogle Scholar
• Fledelius HC. Ultrasound in ophthalmology. Ultrasound Med Biol 1997; 23: 365–375.
   PubMed Web of Science ®Google Scholar
• Atta HR. Imaging of the optic nerve with standardised echography. Eye (Lond) 1988; 2: 358–366.
   Web of Science ®Google Scholar
• Karam EZ, Hedges TR. Optical coherence tomography of the retinal nerve fibre layer in mild papilloedema and pseudopapilloedema. Br J Ophthalmol 2005; 89: 294–298.
   PubMed Web of Science ®Google Scholar
• Mendoza‐santiesteban CE, Gonzalez‐garcia A, Hedges TR 3rd, Hernandez‐silva Y, Columbie‐garbey Y, Fernández‐cherkasova L, Santiesteban‐freixas R et al. Optical coherence tomography for neuro‐ophthalmologic diagnoses. Semin Ophthalmol 2010; 25: 144–154.
   PubMed Web of Science ®Google Scholar
• Mardin CY, Horn FK. Influence of optic disc size on the sensitivity of the Heidelberg Retina Tomograph. Graefes Arch Clin Exp Ophthalmol 1998; 236: 641–645.
   PubMed Web of Science ®Google Scholar
• Moschos MM, Triglianos A, Rotsos T, Papadimitriou S, Margetis I, Minogiannis P, Moschos M. Tilted disc syndrome: an OCT and mfERG study. Doc Ophthalmol 2009; 119: 23–28.
   Web of Science ®Google Scholar
• Law SK, Tamboli DA, Giaconi J, Caprioli J. Characterization of retinal nerve fiber layer in nonglaucomatous eyes with tilted discs. Arch Ophthalmol 2010; 128: 141–142.
   Google Scholar
• Rauscher FM, Sekhon N, Feuer WJ, Budenz DL. Myopia affects retinal nerve fiber layer measurements as determined by optical coherence tomography. J Glaucoma 2009; 18: 501–505.
   PubMed Web of Science ®Google Scholar
• Hwang YH, Yoo C, Kim YY. Myopic optic disc tilt and the characteristics of peripapillary retinal nerve fiber layer thickness measured by spectral‐domain optical coherence tomography. J Glaucoma 2012; 21: 260–265.
   PubMed Web of Science ®Google Scholar
• Park CY, Kim YT, Kee C. Evaluation of the influence of tilt of optic disc on the measurement of optic disc variables obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy. J Glaucoma 2005; 14: 210–214.
   PubMed Web of Science ®Google Scholar
• Takasaki H, Higashide T, Takeda H, Ohkubo S, Sugiyama K. Relationship between optic disc ovality and horizontal disc tilt in normal young subjects. Jpn J Ophthalmol 2013; 57: 34–40.
   Web of Science ®Google Scholar
• Hosseini H, Nassiri N, Azarbod P, Giaconi J, Chou T, Caprioli J, Nouri‐mahdavi K. Measurement of the optic disc vertical tilt angle with spectral‐domain optical coherence tomography and influencing factors. Am J Ophthalmol 2013; 156: 737–744.
   Web of Science ®Google Scholar
• Tong L, Chan YH, Gazzard G, Loon SC, Fong A, Selvaraj P, Healey PR et al. Heidelberg retinal tomography of optic disc and nerve fiber layer in singapore children: variations with disc tilt and refractive error. Invest Ophthalmol Vis Sci 2007; 48: 4939–4944.
   Web of Science ®Google Scholar
• Singh J. Echographic features of tilted optic disk. Ann Ophthalmol 1985; 17: 382–384.
   Google Scholar
• Kurz‐levin MM, Landau K. A comparison of imaging techniques for diagnosing drusen of the optic nerve head. Arch Ophthalmol 1999; 117: 1045–1049.
   PubMedGoogle Scholar
• Gili P, Flores‐rodríguez P, Yangüela J, Orduña‐azcona J, Martín‐ríos MD. Sensitivity and specificity of monochromatic photography of the ocular fundus in differentiating optic nerve head drusen and optic disc oedema: optic disc drusen and oedema. Graefes Arch Clin Exp Ophthalmol 2013; 251: 923–928.
   Web of Science ®Google Scholar
• Gili P, Flores‐rodríguez P, Yangüela J, Herreros fernández ML. Using autofluorescence to detect optic nerve head drusen in children. J AAPOS 2013; 17: 568–571.
   Web of Science ®Google Scholar
• Lee KM, Woo SJ, Hwang JM. Morphologic characteristics of optic nerve head drusen on spectral‐domain optical coherence tomography. Am J Ophthalmol 2013; 155: 1139–1147.
   PubMed Web of Science ®Google Scholar
• Johnson LN, Diehl ML, Hamm CW, Sommerville DN, Petroski GF. Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography. Arch Ophthalmol 2009; 127: 45–49.
   PubMedGoogle Scholar
• Flores‐rodríguez P, Gili P, Martin‐rios MD. Sensitivity and specificity of time‐domain and spectral‐domain optical coherence tomography in differentiating optic nerve head drusen and optic disc oedema. Ophthalmic Physiol Opt 2012; 32: 213–221.
   Web of Science ®Google Scholar
• Lee KM, Woo SJ, Hwang JM. Differentiation of optic nerve head drusen and optic disc edema with spectral‐domain optical coherence tomography. Ophthalmology 2011; 118: 971–977.
   Web of Science ®Google Scholar
• Martinez MR, Ophir A. Optical coherence tomography as an adjunctive tool for diagnosing papilledema in young patients. J Pediatr Ophthalmol Strabismus 2011; 48: 174–181.
   Web of Science ®Google Scholar
• Ophir A, Karatas M, Ramirez JA, Inzelberg R. OCT and chronic papilledema. Ophthalmology 2005; 112: 2238.
   PubMed Web of Science ®Google Scholar
• Vartin CV, Nguyen AM, Balmitgere T, Bernard M, Tilikete C, Vighetto A. Detection of mild papilloedema using spectral domain optical coherence tomography. Br J Ophthalmol 2012; 96: 375–379.
   PubMed Web of Science ®Google Scholar
• Costello F. Evaluating the use of optical coherence tomography in optic neuritis. Mult Scler Int 2011; 2011: 148394.
   Google Scholar
• Sato T, Mrejen S, Spaide RF. Multimodal imaging of optic disc drusen. Am J Ophthalmol 2013; 156: 275–282.
   Web of Science ®Google Scholar
• Trick GL, Bhatt SS, Dahl D, Skarf B. Optic disc topography in pseudopapilledema: a comparison to pseudotumor cerebri. J Neuroophthalmol 2001; 21: 240–244.
   PubMed Web of Science ®Google Scholar
• Chen JY, Taranath DA, Chappell AJ, Brophy BP, Craig JE. Objective monitoring of papilloedema using confocal scanning laser ophthalmoscopy. Clin Experiment Ophthalmol 2007; 35: 863–865.
   PubMed Web of Science ®Google Scholar
• Catrambone JE, He W, Prestigiacomo CJ, Carmel PW. Monitoring papilledema with Heidelberg Retina Tomograph in a patient with ruptured aneurysm: a case report. Surg Neurol 2008; 70: 79–81.
   Google Scholar
• Mulholland DA, Craig JJ, Rankin SJ. Use of scanning laser ophthalmoscopy to monitor papilloedema in idiopathic intracranial hypertension. Br J Ophthalmol 1998; 82: 1301–1305.
   PubMed Web of Science ®Google Scholar
• Neudorfer M, Ben‐haim MS, Leibovitch I, Kesler A. The efficacy of optic nerve ultrasonography for differentiating papilloedema from pseudopapilloedema in eyes with swollen optic discs. Acta Ophthalmol 2011.
   Web of Science ®Google Scholar
• Tamburrelli C, Salgarello T, Caputo CG, Giudiceandrea A, Scullica L. Ultrasonographic evaluation of optic disc swelling: comparison with CSLO in idiopathic intracranial hypertension. Invest Ophthalmol Vis Sci 2000; 41: 2960–2966.
   Web of Science ®Google Scholar
• Shuper A, Snir M, Barash D, Yassur Y, Mimouni M. Ultrasonography of the optic nerves: clinical application in children with pseudotumor cerebri. J Pediatr 1997; 131: 734–740.
   Web of Science ®Google Scholar