41
Views
76
CrossRef citations to date
0
Altmetric
Article

The Small Molecule Phenamil Induces Osteoblast Differentiation and Mineralization

, , , , , & show all
Pages 3905-3914 | Received 01 Jan 2009, Accepted 14 Apr 2009, Published online: 21 Mar 2023

REFERENCES

  • Aghaloo, T. L., C. M. Amantea, C. M. Cowan, J. A. Richardson, B. M. Wu, F. Parhami, and S. Tetradis. 2007. Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo. J. Orthop. Res. 25:1488–1497.
  • Benos, D. J. 1982. Amiloride: a molecular probe of sodium transport in tissues and cells. Am. J. Physiol. 242:C131–C145.
  • Beresford, J. N. 1989. Osteogenic stem cells and the stromal system of bone and marrow. Clin. Orthop. Relat. Res. 1989:270–280.
  • Bezy, O., C. Vernochet, S. Gesta, S. R. Farmer, and C. R. Kahn. 2007. TRB3 blocks adipocyte differentiation through the inhibition of C/EBPβ transcriptional activity. Mol. Cell. Biol. 27:6818–6831.
  • Blazer-Yost, B. L., and S. I. Helman. 1997. The amiloride-sensitive epithelial Na+ channel: binding sites and channel densities. Am. J. Physiol. 272:C761–C769.
  • Bobkov, Y. V., and B. W. Ache. 2007. Block by amiloride derivatives of odor-evoked discharge in lobster olfactory receptor neurons through action on a presumptive TRP channel. Chem. Senses 32:149–159.
  • Caplan, A. I. 1991. Mesenchymal stem cells. J. Orthop. Res. 9:641–650.
  • Centrella, M., M. C. Horowitz, J. M. Wozney, and T. L. McCarthy. 1994. Transforming growth factor-beta gene family members and bone. Endocrinol. Rev. 15:27–39.
  • Chan, M. C., P. H. Nguyen, B. N. Davis, N. Ohoka, H. Hayashi, K. Du, G. Lagna, and A. Hata. 2007. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol. Cell. Biol. 27:5776–5789.
  • Chao, L. C., S. J. Bensinger, C. J. Villanueva, K. Wroblewski, and P. Tontonoz. 2008. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol. Endocrinol. 22:2596–2608.
  • Chen, T. L., M. A. Hirst, and D. Feldman. 1979. A receptor-like binding macromolecule for 1 alpha, 25-dihydroxycholecalciferol in cultured mouse bone cells. J. Biol. Chem. 254:7491–7494.
  • Dezawa, M., H. Ishikawa, Y. Itokazu, T. Yoshihara, M. Hoshino, S. Takeda, C. Ide, and Y. Nabeshima. 2005. Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 309:314–317.
  • Dezawa, M., H. Kanno, M. Hoshino, H. Cho, N. Matsumoto, Y. Itokazu, N. Tajima, H. Yamada, H. Sawada, H. Ishikawa, T. Mimura, M. Kitada, Y. Suzuki, and C. Ide. 2004. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J. Clin. Investig. 113:1701–1710.
  • Du, K., S. Herzig, R. N. Kulkarni, and M. Montminy. 2003. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300:1574–1577.
  • Dwyer, J. R., N. Sever, M. Carlson, S. F. Nelson, P. A. Beachy, and F. Parhami. 2007. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J. Biol. Chem. 282:8959–8968.
  • Fleet, J. C., K. Cashman, K. Cox, and V. Rosen. 1996. The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Endocrinology 137:4605–4610.
  • Frelin, C., P. Barbry, P. Vigne, O. Chassande, E. J. Cragoe, Jr., and M. Lazdunski. 1988. Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. Biochimie 70:1285–1290.
  • Fulfaro, F., A. Casuccio, C. Ticozzi, and C. Ripamonti. 1998. The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials. Pain 78:157–169.
  • Gangji, V., and T. Appelboom. 1999. Analgesic effect of intravenous pamidronate on chronic back pain due to osteoporotic vertebral fractures. Clin. Rheumatol. 18:266–267.
  • Giannobile, W. V., R. A. Hernandez, R. D. Finkelman, S. Ryan, C. P. Kiritsy, M. D'Andrea, and S. E. Lynch. 1996. Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macaca fascicularis. J. Periodontal Res. 31:301–312.
  • Gong, Y., R. B. Slee, N. Fukai, G. Rawadi, S. Roman-Roman, A. M. Reginato, H. Wang, T. Cundy, F. H. Glorieux, D. Lev, M. Zacharin, K. Oexle, J. Marcelino, W. Suwairi, S. Heeger, G. Sabatakos, S. Apte, W. N. Adkins, J. Allgrove, M. Arslan-Kirchner, J. A. Batch, P. Beighton, G. C. Black, R. G. Boles, L. M. Boon, C. Borrone, H. G. Brunner, G. F. Carle, B. Dallapiccola, A. De Paepe, B. Floege, M. L. Halfhide, B. Hall, R. C. Hennekam, T. Hirose, A. Jans, H. Juppner, C. A. Kim, K. Keppler-Noreuil, A. Kohlschuetter, D. LaCombe, M. Lambert, E. Lemyre, T. Letteboer, L. Peltonen, R. S. Ramesar, M. Romanengo, H. Somer, E. Steichen-Gersdorf, B. Steinmann, B. Sullivan, A. Superti-Furga, W. Swoboda, M. J. van den Boogaard, W. Van Hul, M. Vikkula, M. Votruba, B. Zabel, T. Garcia, R. Baron, B. R. Olsen, and M. L. Warman. 2001. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513–523.
  • Govender, P. V., Y. R. Rampersaud, L. Rickards, and M. G. Fehlings. 2002. Use of osteogenic protein-1 in spinal fusion: literature review and preliminary results in a prospective series of high-risk cases. Neurosurg. Focus 13:e4.
  • Govender, S., C. Csimma, H. K. Genant, A. Valentin-Opran, Y. Amit, R. Arbel, H. Aro, D. Atar, M. Bishay, M. G. Borner, P. Chiron, P. Choong, J. Cinats, B. Courtenay, R. Feibel, B. Geulette, C. Gravel, N. Haas, M. Raschke, E. Hammacher, D. van der Velde, P. Hardy, M. Holt, C. Josten, R. L. Ketterl, B. Lindeque, G. Lob, H. Mathevon, G. McCoy, D. Marsh, R. Miller, E. Munting, S. Oevre, L. Nordsletten, A. Patel, A. Pohl, W. Rennie, P. Reynders, P. M. Rommens, J. Rondia, W. C. Rossouw, P. J. Daneel, S. Ruff, A. Ruter, S. Santavirta, T. A. Schildhauer, C. Gekle, R. Schnettler, D. Segal, H. Seiler, R. B. Snowdowne, J. Stapert, G. Taglang, R. Verdonk, L. Vogels, A. Weckbach, A. Wentzensen, and T. Wisniewski. 2002. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J. Bone Joint Surg. Am. 84A:2123–2134.
  • Horwitz, E. M., P. L. Gordon, W. K. Koo, J. C. Marx, M. D. Neel, R. Y. McNall, L. Muul, and T. Hofmann. 2002. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc. Natl. Acad. Sci. USA 99:8932–8937.
  • Hu, H., M. J. Hilton, X. Tu, K. Yu, D. M. Ornitz, and F. Long. 2005. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132:49–60.
  • Iynedjian, P. B. 2005. Lack of evidence for a role of TRB3/NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes. Biochem. J. 386:113–118.
  • Johnson, E. E., and M. R. Urist. 2000. Human bone morphogenetic protein allografting for reconstruction of femoral nonunion. Clin. Orthop. Relat. Res. 2000:61–74.
  • Kha, H. T., B. Basseri, D. Shouhed, J. Richardson, S. Tetradis, T. J. Hahn, and F. Parhami. 2004. Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J. Bone Miner. Res. 19:830–840.
  • Kleyman, T. R., and E. J. Cragoe, Jr. 1988. Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol. 105:1–21.
  • Lant, A. F., A. J. Smith, and G. M. Wilson. 1969. Clinical evaluation of amiloride, a potassium-sparing diuretic. Clin. Pharmacol. Ther. 10:50–63.
  • Masereel, B., L. Pochet, and D. Laeckmann. 2003. An overview of inhibitors of Na(+)/H(+) exchanger. Eur. J. Med. Chem. 38:547–554.
  • Minamide, A., M. Yoshida, M. Kawakami, S. Yamasaki, H. Kojima, H. Hashizume, and S. D. Boden. 2005. The use of cultured bone marrow cells in type I collagen gel and porous hydroxyapatite for posterolateral lumbar spine fusion. Spine 30:1134–1138.
  • Murakami, G., T. Watabe, K. Takaoka, K. Miyazono, and T. Imamura. 2003. Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol. Biol. Cell 14:2809–2817.
  • Nohe, A., E. Keating, P. Knaus, and N. O. Petersen. 2004. Signal transduction of bone morphogenetic protein receptors. Cell Signal. 16:291–299.
  • Ohoka, N., S. Yoshii, T. Hattori, K. Onozaki, and H. Hayashi. 2005. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24:1243–1255.
  • Owen, M. 1988. Marrow stromal stem cells. J. Cell Sci. Suppl. 10:63–76.
  • Padilla, M. C., M. J. Armas-Hernandez, R. H. Hernandez, Z. H. Israili, and M. Valasco. 2007. Update of diuretics in the treatment of hypertension. Am. J. Ther. 14:154–160.
  • Papanikolaou, G., M. E. Samuels, E. H. Ludwig, M. L. MacDonald, P. L. Franchini, M. P. Dube, L. Andres, J. MacFarlane, N. Sakellaropoulos, M. Politou, E. Nemeth, J. Thompson, J. K. Risler, C. Zaborowska, R. Babakaiff, C. C. Radomski, T. D. Pape, O. Davidas, J. Christakis, P. Brissot, G. Lockitch, T. Ganz, M. R. Hayden, and Y. P. Goldberg. 2004. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 36:77–82.
  • Pittenger, M. F., and B. J. Martin. 2004. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ. Res. 95:9–20.
  • Prockop, D. J. 1997. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71–74.
  • Qi, L., J. E. Heredia, J. Y. Altarejos, R. Screaton, N. Goebel, S. Niessen, I. X. Macleod, C. W. Liew, R. N. Kulkarni, J. Bain, C. Newgard, M. Nelson, R. M. Evans, J. Yates, and M. Montminy. 2006. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312:1763–1766.
  • Rorth, P., K. Szabo, and G. Texido. 2000. The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Mol. Cell 6:23–30.
  • Shore, E. M., M. Xu, G. J. Feldman, D. A. Fenstermacher, T. J. Cho, I. H. Choi, J. M. Connor, P. Delai, D. L. Glaser, M. LeMerrer, R. Morhart, J. G. Rogers, R. Smith, J. T. Triffitt, J. A. Urtizberea, M. Zasloff, M. A. Brown, and F. S. Kaplan. 2006. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat. Genet. 38:525–527.
  • Spinella-Jaegle, S., G. Rawadi, S. Kawai, S. Gallea, C. Faucheu, P. Mollat, B. Courtois, B. Bergaud, V. Ramez, A. M. Blanchet, G. Adelmant, R. Baron, and S. Roman-Roman. 2001. Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J. Cell Sci. 114:2085–2094.
  • Takahashi, Y., N. Ohoka, H. Hayashi, and R. Sato. 2008. TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity. J. Lipid Res. 49:880–892.
  • van der Horst, G., H. Farih-Sips, C. W. Lowik, and M. Karperien. 2003. Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells. Bone 33:899–910.
  • Waite, K. A., and C. Eng. 2003. From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family. Nat. Rev. Genet. 4:763–773.
  • Winn, S. R., Y. Hu, C. Sfeir, and J. O. Hollinger. 2000. Gene therapy approaches for modulating bone regeneration. Adv. Drug Deliv. Rev. 42:121–138.
  • Yamaguchi, A., T. Komori, and T. Suda. 2000. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocrinol. Rev. 21:393–411.
  • Yu, P. B., C. C. Hong, C. Sachidanandan, J. L. Babitt, D. Y. Deng, S. A. Hoyng, H. Y. Lin, K. D. Bloch, and R. T. Peterson. 2008. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 4:33–41.
  • Zhu, H., P. Kavsak, S. Abdollah, J. L. Wrana, and G. H. Thomsen. 1999. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400:687–693.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.