62
Views
9
CrossRef citations to date
0
Altmetric
Research Article

CEBPA-AS1 Knockdown Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Neuron Cell Damage by the MicroRNA 24-3p/BOK Axis

, , , & ORCID Icon
Article: e00065-21 | Received 13 Feb 2021, Accepted 07 May 2021, Published online: 03 Mar 2023

REFERENCES

  • Kanazawa M, Ninomiya I, Hatakeyama M, Takahashi T, Shimohata T. 2017. Microglia and monocytes/macrophages polarization reveal novel therapeutic mechanism against stroke. Int J Mol Sci 18:2135. https://doi.org/10.3390/ijms18102135.
  • Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, Isasi CR, Jiménez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Mackey RH, Matsushita K, Mozaffarian D, Mussolino ME, Nasir K, Neumar RW, Palaniappan L, Pandey DK, Thiagarajan RR, Reeves MJ, Ritchey M, Rodriguez CJ, Roth GA, Rosamond WD, Sasson C, Towfighi A, Tsao CW, Turner MB, Virani SS, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P. 2017. Heart disease and stroke statistics—2017 update: a report from the American Heart Association. Circulation 135:e146–e603. https://doi.org/10.1161/CIR.0000000000000485.
  • Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. 2009. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol 8:355–369. https://doi.org/10.1016/S1474-4422(09)70025-0.
  • Du K, Zhao C, Wang L, Wang Y, Zhang KZ, Shen XY, Sun HX, Gao W, Lu X. 2019. MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1. Aging (Albany, NY) 11:2762–2786. https://doi.org/10.18632/aging.101948.
  • Culman J, Nguyen-Ngoc M, Glatz T, Gohlke P, Herdegen T, Zhao Y. 2012. Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: a preclinical stroke trial. Exp Neurol 238:243–253. https://doi.org/10.1016/j.expneurol.2012.09.003.
  • Riverol M, Becker JT, López OL, Raji CA, Thompson PM, Carmichael OT, Gach HM, Longstreth WT, Jr, Fried L, Tracy RP, Kuller LH. 2015. Relationship between systemic and cerebral vascular disease and brain structure integrity in normal elderly individuals. J Alzheimers Dis 44:319–328. https://doi.org/10.3233/JAD-141077.
  • Zhang W, Chen Y, Liu P, Chen J, Song L, Tang Y, Wang Y, Liu J, Hu FB, Hui R. 2012. Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population. Stroke 43:14–21. https://doi.org/10.1161/STROKEAHA.111.625442.
  • Yan X, Yu A, Zheng H, Wang S, He Y, Wang L. 2019. Calycosin-7-O-β-d-glucoside attenuates OGD/R-induced damage by preventing oxidative stress and neuronal apoptosis via the SIRT1/FOXO1/PGC-1α pathway in HT22 cells. Neural Plast 2019:8798069. https://doi.org/10.1155/2019/8798069.
  • Gong L, Tang Y, An R, Lin M, Chen L, Du J. 2017. RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Cell Death Dis 8:e3080. https://doi.org/10.1038/cddis.2017.465.
  • Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER, III, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB. 2016. Executive summary: heart disease and stroke statistics—2016 update: a report from the American Heart Association. Circulation 133:447–454. https://doi.org/10.1161/CIR.0000000000000366.
  • Geisler S, Coller J. 2013. RNA in unexpected places: long noncoding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol 14:699–712. https://doi.org/10.1038/nrm3679.
  • Kornienko AE, Guenzl PM, Barlow DP, Pauler FM. 2013. Gene regulation by the act of long noncoding RNA transcription. BMC Biol 11:59. https://doi.org/10.1186/1741-7007-11-59.
  • Wang KC, Chang HY. 2011. Molecular mechanisms of long noncoding RNAs. Mol Cell 43:904–914. https://doi.org/10.1016/j.molcel.2011.08.018.
  • Mercer TR, Dinger ME, Mattick JS. 2009. Long noncoding RNAs: insights into functions. Nat Rev Genet 10:155–159. https://doi.org/10.1038/nrg2521.
  • Wan P, Su W, Zhuo Y. 2017. The role of long noncoding RNAs in neurodegenerative diseases. Mol Neurobiol 54:2012–2021. https://doi.org/10.1007/s12035-016-9793-6.
  • Deng Y, Chen D, Wang L, Gao F, Jin B, Lv H, Zhang G, Sun X, Liu L, Mo D, Ma N, Song L, Huo X, Yan T, Miao Z. 2019. Silencing of long noncoding RNA Nespas aggravates microglial cell death and neuroinflammation in ischemic stroke. Stroke 50:1850–1858. https://doi.org/10.1161/STROKEAHA.118.023376.
  • Zhang X, Tang X, Liu K, Hamblin MH, Yin KJ. 2017. Long noncoding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke. J Neurosci 37:1797–1806. https://doi.org/10.1523/JNEUROSCI.3389-16.2017.
  • Miao SY, Miao SM, Cui RT, Yu AL, Miao ZJ. 2018. SETD5-AS1 stimulates neuron death in stroke via promoting PTEN expression. Eur Rev Med Pharmacol Sci 22:6035–6041. https://doi.org/10.26355/eurrev_201809_15940.
  • He W, Wei D, Cai D, Chen S, Li S, Chen W. 2018. Altered long non-coding RNA transcriptomic profiles in ischemic stroke. Hum Gene Ther 29:719–732. https://doi.org/10.1089/hum.2017.064.
  • Ma H, Hao Y, Dong X, Gong Q, Chen J, Zhang J, Tian W. 2012. Molecular mechanisms and function prediction of long noncoding RNA. Sci World J 2012:541786. https://doi.org/10.1100/2012/541786.
  • Chen JY, Chen H, Li T, Yang L, Ye XM, Gao WY, Zhang SP, Zong L. 2020. LncRNA LncOGD-1006 alleviates OGD-induced ischemic brain injury regulating apoptosis through miR-184-5p/CAAP1 axis. Eur Rev Med Pharmacol Sci 24:12324–12333. https://doi.org/10.26355/eurrev_202012_24025.
  • Pan H, Zhao F, Yang Y, Chang N. 2020. Overexpression of long noncoding RNA SNHG16 against cerebral ischemia-reperfusion injury through miR-106b-5p/LIMK1 axis. Life Sci 254:117778. https://doi.org/10.1016/j.lfs.2020.117778.
  • O’Brien J, Hayder H, Zayed Y, Peng C. 2018. Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https://doi.org/10.3389/fendo.2018.00402.
  • Ge XL, Wang JL, Liu X, Zhang J, Liu C, Guo L. 2019. Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis. Cell Mol Biol Lett 24:37. https://doi.org/10.1186/s11658-019-0160-2.
  • Huang L, Ma Q, Li Y, Li B, Zhang L. 2018. Inhibition of microRNA-210 suppresses proinflammatory response and reduces acute brain injury of ischemic stroke in mice. Exp Neurol 300:41–50. https://doi.org/10.1016/j.expneurol.2017.10.024.
  • Li B, Huang Z, Meng J, Yu W, Yang H. 2020. MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro-2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3β pathway. Mol Cell Probes 51:101497. https://doi.org/10.1016/j.mcp.2019.101497.
  • Zhou J, Chen L, Chen B, Huang S, Zeng C, Wu H, Chen C, Long F. 2018. Increased serum exosomal miR-134 expression in the acute ischemic stroke patients. BMC Neurol 18:198. https://doi.org/10.1186/s12883-018-1196-z.
  • Jiang H, Toscano JF, Song SS, Schlick KH, Dumitrascu OM, Pan J, Lyden PD, Saver JL, Gonzalez NR. 2019. Differential expression of circulating exosomal microRNAs in refractory intracranial atherosclerosis associated with antiangiogenesis. Sci Rep 9:19429. https://doi.org/10.1038/s41598-019-54542-y.
  • Wen Y, Yu Y, Fu X. 2017. LncRNA Gm4419 contributes to OGD/R injury of cerebral microglial cells via IκB phosphorylation and NF-κB activation. Biochem Biophys Res Commun 487:923–929. https://doi.org/10.1016/j.bbrc.2017.05.005.
  • Bai M, Liu B, Peng M, Jia J, Fang X, Miao M. 2019. Effect of Sargentodoxa cuneata total phenolic acids on focal cerebral ischemia reperfusion injury rats model. Saudi J Biol Sci 26:569–576. https://doi.org/10.1016/j.sjbs.2018.11.019.
  • Zhang X, Hamblin MH, Yin KJ. 2019. Noncoding RNAs and stroke. Neuroscientist 25:22–26. https://doi.org/10.1177/1073858418769556.
  • Xia P, Gu R, Zhang W, Sun YF. 2020. lncRNA CEBPA-AS1 overexpression inhibits proliferation and migration and stimulates apoptosis of OS cells via Notch signaling. Mol Ther Nucleic Acids 19:1470–1481. https://doi.org/10.1016/j.omtn.2019.10.017.
  • Guo Y, Ma Y, Hu X, Song R, Zhu L, Zhong M. 2018. Long noncoding RNA CEBPA-AS1 correlates with poor prognosis and promotes tumorigenesis via CEBPA/Bcl2 in oral squamous cell carcinoma. Cancer Biol Ther 19:205–213. https://doi.org/10.1080/15384047.2017.1416276.
  • Sun S, Hu F, Wu J, Zhang S. 2017. Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons. Redox Biol 11:577–585. https://doi.org/10.1016/j.redox.2016.12.029.
  • Chen N, Zhou Z, Li J, Li B, Feng J, He D, Luo Y, Zheng X, Luo J, Zhang J. 2018. 3-n-Butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke. Drug Des Devel Ther 12:4261–4271. https://doi.org/10.2147/DDDT.S189472.
  • Zhao L, Zhang M, Yan F, Cong Y. 2021. Knockdown of RMST impedes neuronal apoptosis and oxidative stress in OGD/R-induced ischemic stroke via depending on the miR-377/SEMA3A signal network. Neurochem Res 46:584–594. https://doi.org/10.1007/s11064-020-03194-w.
  • Wan H, Yang Y, Li M, Liu X, Sun Y, Wang K, Zhang C, Zheng Q, Wang C. 2019. Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21. Aging (Albany, NY) 11:5108–5123. https://doi.org/10.18632/aging.102106.
  • de la Mata M, Gaidatzis D, Vitanescu M, Stadler MB, Wentzel C, Scheiffele P, Filipowicz W, Grosshans H. 2015. Potent degradation of neuronal miRNAs induced by highly complementary targets. EMBO Rep 16:500–511. https://doi.org/10.15252/embr.201540078.
  • Ghini F, Rubolino C, Climent M, Simeone I, Marzi MJ, Nicassio F. 2018. Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation. Nat Commun 9:3119. https://doi.org/10.1038/s41467-018-05182-9.
  • Sheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA, MacRae IJ. 2019. Structural basis for target-directed microRNA degradation. Mol Cell 75:1243–1255. https://doi.org/10.1016/j.molcel.2019.06.019.
  • Kang SH, Perales O, Michaud M, Katz SG. 2019. BOK promotes erythropoiesis in a mouse model of myelodysplastic syndrome. Ann Hematol 98:2089–2096. https://doi.org/10.1007/s00277-019-03726-7.
  • Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE, 2nd, Yule DI, Wojcikiewicz RJH. 2019. Bok regulates mitochondrial fusion and morphology. Cell Death Differ 26:2682–2694. https://doi.org/10.1038/s41418-019-0327-4.
  • Kantari C, Walczak H. 2011. Caspase-8 and bid: caught in the act between death receptors and mitochondria. Biochim Biophys Acta 1813:558–563. https://doi.org/10.1016/j.bbamcr.2011.01.026.
  • Hu X, Xiang Z, Zhang W, Yu Z, Xin X, Zhang R, Deng Y, Yuan Q. 2020. Protective effect of DLX6-AS1 silencing against cerebral ischemia/reperfusion induced impairments. Aging (Albany, NY) 12:23096–23113. https://doi.org/10.18632/aging.104070.
  • Nakajima Y, Shimazawa M, Mishima S, Hara H. 2009. Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phytother Res 23:1431–1438. https://doi.org/10.1002/ptr.2797.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.