RNA m6A Methyltransferase Mettl3 Regulates Spatial Neural Patterning in Xenopus laevis

REFERENCES

• Weil TT. 2015. Post-transcriptional regulation of early embryogenesis. F1000Prime Rep 7:31. https://doi.org/10.12703/P7-31.
   PubMedGoogle Scholar
• Schieweck R, Kiebler MA. 2019. Posttranscriptional gene regulation of the GABA receptor to control neuronal inhibition. Front Mol Neurosci 12:152. https://doi.org/10.3389/fnmol.2019.00152.
   PubMed Web of Science ®Google Scholar
• Frye M, Blanco S. 2016. Post-transcriptional modifications in development and stem cells. Development 143:3871–3881. https://doi.org/10.1242/dev.136556.
   PubMed Web of Science ®Google Scholar
• Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C. 2014. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol 10:93–95. https://doi.org/10.1038/nchembio.1432.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, Weng X, Chen K, Shi H, He C. 2015. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell 161:1388–1399. https://doi.org/10.1016/j.cell.2015.05.014.
   PubMed Web of Science ®Google Scholar
• Xiao W, Adhikari S, Dahal U, Chen YS, Hao YJ, Sun BF, Sun HY, Li A, Ping XL, Lai WY, Wang X, Ma HL, Huang CM, Yang Y, Huang N, Jiang GB, Wang HL, Zhou Q, Wang XJ, Zhao YL, Yang YG. 2016. Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Mol Cell 61:507–519. https://doi.org/10.1016/j.molcel.2016.01.012.
   PubMed Web of Science ®Google Scholar
• Ping XL, Sun BF, Wang L, Xiao W, Yang X, Wang WJ, Adhikari S, Shi Y, Lv Y, Chen YS, Zhao X, Li A, Yang Y, Dahal U, Lou XM, Liu X, Huang J, Yuan WP, Zhu XF, Cheng T, Zhao YL, Wang X, Rendtlew Danielsen JM, Liu F, Yang YG. 2014. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res 24:177–189. https://doi.org/10.1038/cr.2014.3.
   PubMed Web of Science ®Google Scholar
• Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. 2011. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 7:885–887. https://doi.org/10.1038/nchembio.687.
   PubMed Web of Science ®Google Scholar
• Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C. 2013. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell 49:18–29. https://doi.org/10.1016/j.molcel.2012.10.015.
   PubMed Web of Science ®Google Scholar
• Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C. 2014. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505:117–120. https://doi.org/10.1038/nature12730.
   PubMed Web of Science ®Google Scholar
• Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY. 2014. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell 15:707–719. https://doi.org/10.1016/j.stem.2014.09.019.
   PubMed Web of Science ®Google Scholar
• Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B, He C. 2017. Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res 27:1115–1127. https://doi.org/10.1038/cr.2017.99.
   PubMed Web of Science ®Google Scholar
• Ivanova I, Much C, Di Giacomo M, Azzi C, Morgan M, Moreira PN, Monahan J, Carrieri C, Enright AJ, O’Carroll D. 2017. The RNA m(6)A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence. Mol Cell 67:1059–1067.e1054. https://doi.org/10.1016/j.molcel.2017.08.003.
   PubMed Web of Science ®Google Scholar
• Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, Wang X, Dore LC, Jin P, Regot S, Zhuang X, Canzar S, He C, Ming GL, Song H. 2017. Temporal control of mammalian cortical neurogenesis by m(6)A methylation. Cell 171:877–889.e817. https://doi.org/10.1016/j.cell.2017.09.003.
   PubMed Web of Science ®Google Scholar
• Zhang C, Chen Y, Sun B, Wang L, Yang Y, Ma D, Lv J, Heng J, Ding Y, Xue Y, Lu X, Xiao W, Yang YG, Liu F. 2017. m(6)A modulates haematopoietic stem and progenitor cell specification. Nature 549:273–276. https://doi.org/10.1038/nature23883.
   PubMed Web of Science ®Google Scholar
• Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, Eyal E, Yunger S, Pinto Y, Jaitin DA, Viukov S, Rais Y, Krupalnik V, Chomsky E, Zerbib M, Maza I, Rechavi Y, Massarwa R, Hanna S, Amit I, Levanon EY, Amariglio N, Stern-Ginossar N, Novershtern N, Rechavi G, Hanna JH. 2015. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science 347:1002–1006. https://doi.org/10.1126/science.1261417.
   PubMed Web of Science ®Google Scholar
• Wang CX, Cui GS, Liu X, Xu K, Wang M, Zhang XX, Jiang LY, Li A, Yang Y, Lai WY, Sun BF, Jiang GB, Wang HL, Tong WM, Li W, Wang XJ, Yang YG, Zhou Q. 2018. METTL3-mediated m6A modification is required for cerebellar development. PLoS Biol 16:e2004880. https://doi.org/10.1371/journal.pbio.2004880.
   PubMed Web of Science ®Google Scholar
• Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, Jiang Y, Ye L, Chen Q, Zhou X, Lin S, Yuan Q. 2018. Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nat Commun 9:4772. https://doi.org/10.1038/s41467-018-06898-4.
   PubMed Web of Science ®Google Scholar
• Kiecker C, Niehrs C. 2001. A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus. Development 128:4189–4201. https://doi.org/10.1242/dev.128.21.4189.
   PubMed Web of Science ®Google Scholar
• Du H, Zhao Y, He J, Zhang Y, Xi H, Liu M, Ma J, Wu L. 2016. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nat Commun 7:12626. https://doi.org/10.1038/ncomms12626.
   PubMed Web of Science ®Google Scholar
• Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN. 2014. Uridylation by TUT4 and TUT7 marks mRNA for degradation. Cell 159:1365–1376. https://doi.org/10.1016/j.cell.2014.10.055.
   PubMed Web of Science ®Google Scholar
• Chang H, Yeo J, Kim JG, Kim H, Lim J, Lee M, Kim HH, Ohk J, Jeon HY, Lee H, Jung H, Kim KW, Kim VN. 2018. Terminal uridylyltransferases execute programmed clearance of maternal transcriptome in vertebrate embryos. Mol Cell 70:72–82.e77. https://doi.org/10.1016/j.molcel.2018.03.004.
   PubMed Web of Science ®Google Scholar
• Ha M, Kim VN. 2014. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15:509–524. https://doi.org/10.1038/nrm3838.
   PubMed Web of Science ®Google Scholar
• Wu J, Yang J, Klein PS. 2005. Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus. Dev Biol 279:220–232. https://doi.org/10.1016/j.ydbio.2004.12.016.
   PubMed Web of Science ®Google Scholar
• Garcia-Morales C, Liu CH, Abu-Elmagd M, Hajihosseini MK, Wheeler GN. 2009. Frizzled-10 promotes sensory neuron development in Xenopus embryos. Dev Biol 335:143–155. https://doi.org/10.1016/j.ydbio.2009.08.021.
   PubMed Web of Science ®Google Scholar
• Polevoy H, Gutkovich YE, Michaelov A, Volovik Y, Elkouby YM, Frank D. 2019. New roles for Wnt and BMP signaling in neural anteroposterior patterning. EMBO Rep 20:e45842. https://doi.org/10.15252/embr.201845842.
   Google Scholar
• Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. 1998. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391:357–362. https://doi.org/10.1038/34848.
   PubMed Web of Science ®Google Scholar
• Ding Y, Colozza G, Sosa EA, Moriyama Y, Rundle S, Salwinski L, De Robertis EM. 2018. Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis. Proc Natl Acad Sci U S A 115:E9135–E9144. https://doi.org/10.1073/pnas.1812117115.
   PubMed Web of Science ®Google Scholar
• Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, He X. 2015. Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation. Dev Cell 32:719–730. https://doi.org/10.1016/j.devcel.2015.02.014.
   PubMed Web of Science ®Google Scholar
• Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. 2012. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell 149:1565–1577. https://doi.org/10.1016/j.cell.2012.04.039.
   PubMed Web of Science ®Google Scholar
• Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C. 2013. RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling. Science 339:1436–1441. https://doi.org/10.1126/science.1231499.
   PubMed Web of Science ®Google Scholar
• Kim WT, Kim H, Katanaev VL, Joon Lee S, Ishitani T, Cha B, Han JK, Jho EH. 2012. Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. EMBO J 31:3384–3397. https://doi.org/10.1038/emboj.2012.181.
   PubMed Web of Science ®Google Scholar
• Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Munoz N, Albrecht LV, Sosa EA, Wohlschlegel JA, De Robertis EM. 2020. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway. Sci Rep 10:21555. https://doi.org/10.1038/s41598-020-78019-5.
   PubMed Web of Science ®Google Scholar
• Sokol SY. 1999. Wnt signaling and dorso-ventral axis specification in vertebrates. Curr Opin Genet Dev 9:405–410. https://doi.org/10.1016/S0959-437X(99)80061-6.
   PubMed Web of Science ®Google Scholar
• Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J. 2005. Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120:857–871. https://doi.org/10.1016/j.cell.2005.01.013.
   PubMed Web of Science ®Google Scholar
• Ramel MC, Lekven AC. 2004. Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development 131:3991–4000. https://doi.org/10.1242/dev.01277.
   PubMed Web of Science ®Google Scholar
• Kim H, Cheong SM, Ryu J, Jung HJ, Jho EH, Han JK. 2009. Xenopus Wntless and the retromer complex cooperate to regulate XWnt4 secretion. Mol Cell Biol 29:2118–2128. https://doi.org/10.1128/MCB.01503-08.
   PubMed Web of Science ®Google Scholar
• Nieuwkoop PD, Faber J (ed). 1967. Normal table of Xenopus laevis (Daudin): a systematical and chronological survey of the development from the fertilized egg till the end of metamorphosis. North-Holland Publishing Company, Amsterdam, The Netherlands.
   Google Scholar
• Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN. 2021. RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis. Dev Cell 56:1118–1130. https://doi.org/10.1016/j.devcel.2021.03.006.
   PubMed Web of Science ®Google Scholar