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Article

The Locus Control Region Activates Serpin Gene Expression through Recruitment of Liver-Specific Transcription Factors and RNA Polymerase II

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Pages 5286-5295 | Received 30 Jan 2007, Accepted 16 May 2007, Published online: 27 Mar 2023

REFERENCES

  • Baxter, E. W., W. J. Cummings, and R. E. Fournier. 2005. Formation of a large, complex domain of histone hyperacetylation at human 14q32.1 requires the serpin locus control region. Nucleic Acids Res. 33:3313–3322.
  • Bender, M. A., M. Bulger, J. Close, and M. Groudine. 2000. Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol. Cell 5:387–393.
  • Costa, R. H., D. R. Grayson, and J. E. Darnell, Jr. 1989. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol. Cell. Biol. 9:1415–1425.
  • Dean, A. 2006. On a chromosome far, far away: LCRs and gene expression. Trends Genet. 22:38–45.
  • Derman, E., K. Krauter, L. Walling, C. Weinberger, M. Ray, and J. E. Darnell, Jr. 1981. Transcriptional control in the production of liver-specific mRNAs. Cell 23:731–739.
  • Dieken, E. S., E. M. Epner, S. Fiering, R. E. Fournier, and M. Groudine. 1996. Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. Nat. Genet. 12:174–182.
  • Fang, X., J. Sun, P. Xiang, M. Yu, P. A. Navas, K. R. Peterson, G. Stamatoyannopoulos, and Q. Li. 2005. Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5′HS3 deletion mutations: implication for LCR chromatin architecture. Mol. Cell. Biol. 25:7033–7041.
  • Gribnau, J., K. Diderich, S. Pruzina, R. Calzolari, and P. Fraser. 2000. Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus. Mol. Cell 5:377–386.
  • Haussecker, D., and N. J. Proudfoot. 2005. Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster. Mol. Cell. Biol. 25:9724–9733.
  • Hayashi, Y., W. Wang, T. Ninomiya, H. Nagano, K. Ohta, and H. Itoh. 1999. Liver enriched transcription factors and differentiation of hepatocellular carcinoma. Mol. Pathol. 52:19–24.
  • Ho, Y., F. Elefant, N. Cooke, and S. Liebhaber. 2002. A defined locus control region determinant links chromatin domain acetylation with long-range gene activation. Mol. Cell 9:291–302.
  • Ho, Y., F. Elefant, S. A. Liebhaber, and N. E. Cooke. 2006. Locus control region transcription plays an active role in long-range gene activation. Mol. Cell 23:365–375.
  • Hu, C., and D. H. Perlmutter. 1999. Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4. Am. J. Physiol. 276:G1181–G1194.
  • Johnson, K. D., and E. H. Bresnick. 2002. Dissecting long-range transcriptional mechanisms by chromatin immunoprecipitation. Methods (Duluth) 26:27–36.
  • Johnson, K. D., J. A. Grass, C. Park, H. Im, K. Choi, and E. H. Bresnick. 2003. Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain. Mol. Cell. Biol. 23:6484–6493.
  • Johnson, P. F. 2005. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J. Cell Sci. 118:2545–2555.
  • Kim, A., and A. Dean. 2004. Developmental stage differences in chromatin subdomains of the beta-globin locus. Proc. Natl. Acad. Sci. USA 101:7028–7033.
  • Li, Q., K. R. Peterson, X. Fang, and G. Stamatoyannopoulos. 2002. Locus control regions. Blood 100:3077–3086.
  • Ling, J., B. Baibakov, W. Pi, B. M. Emerson, and D. Tuan. 2005. The HS2 enhancer of the beta-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter. J. Mol. Biol. 350:883–896.
  • Litt, M. D., M. Simpson, F. Recillas-Targa, M. N. Prioleau, and G. Felsenfeld. 2001. Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J. 20:2224–2235.
  • Louie, M. C., H. Q. Yang, A. H. Ma, W. Xu, J. X. Zou, H. J. Kung, and H. W. Chen. 2003. Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc. Natl. Acad. Sci. USA 100:2226–2230.
  • Marsden, M. D., and R. E. Fournier. 2003. Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1. Mol. Cell. Biol. 23:3516–3526.
  • Marsden, M. D., and R. E. Fournier. 2005. Organization and expression of the human serpin gene cluster at 14q32.1. Front. Biosci. 10:1768–1778.
  • Masternak, K., N. Peyraud, M. Krawczyk, E. Barras, and W. Reith. 2003. Chromatin remodeling and extragenic transcription at the MHC class II locus control region. Nat. Immunol. 4:132–137.
  • Maston, G. A., S. K. Evans, and M. R. Green. 2006. Transcriptional regulatory elements in the human genome. Annu. Rev. Genomics Hum. Genet. 7:29–59.
  • Matsuda, S., Y. Ichigotani, T. Okuda, T. Irimura, S. Nakatsugawa, and M. Hamaguchi. 2000. Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. Biochim. Biophys. Acta 1490:163–169.
  • Namciu, S. J., R. D. Friedman, M. D. Marsden, L. M. Sarausad, C. L. Jasoni, and R. E. Fournier. 2004. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Mamm. Genome 15:162–178.
  • Osborne, C. S., L. Chakalova, K. E. Brown, D. Carter, A. Horton, E. Debrand, B. Goyenechea, J. A. Mitchell, S. Lopes, W. Reik, and P. Fraser. 2004. Active genes dynamically colocalize to shared sites of ongoing transcription. Nat. Genet. 36:1065–1071.
  • Plant, K. E., S. J. Routledge, and N. J. Proudfoot. 2001. Intergenic transcription in the human beta-globin gene cluster. Mol. Cell. Biol. 21:6507–6514.
  • Ragoczy, T., M. A. Bender, A. Telling, R. Byron, and M. Groudine. 2006. The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation. Genes Dev. 20:1447–1457.
  • Rausa, F. M., Y. Tan, and R. H. Costa. 2003. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol. Cell. Biol. 23:437–449.
  • Rollini, P., and R. E. Fournier. 1997. A 370-kb cosmid contig of the serpin gene cluster on human chromosome 14q32.1: molecular linkage of the genes encoding alpha 1-antichymotrypsin, protein C inhibitor, kallistatin, alpha 1-antitrypsin, and corticosteroid-binding globulin. Genomics 46:409–415.
  • Rollini, P., and R. E. Fournier. 1999. The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1. Proc. Natl. Acad. Sci. USA 96:10308–10313.
  • Rollini, P., and R. E. Fournier. 1999. Long-range chromatin reorganization of the human serpin gene cluster at 14q32.1 accompanies gene activation and extinction in microcell hybrids. Genomics 56:22–30.
  • Samadani, U., and R. H. Costa. 1996. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell. Biol. 16:6273–6284.
  • Schubeler, D., M. Groudine, and M. A. Bender. 2001. The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes. Proc. Natl. Acad. Sci. USA 98:11432–11437.
  • Soutoglou, E., and I. Talianidis. 2002. Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Science 295:1901–1904.
  • Spicuglia, S., S. Kumar, J. H. Yeh, E. Vachez, L. Chasson, S. Gorbatch, J. Cautres, and P. Ferrier. 2002. Promoter activation by enhancer-dependent and -independent loading of activator and coactivator complexes. Mol. Cell 10:1479–1487.
  • Tolhuis, B., R. J. Palstra, E. Splinter, F. Grosveld, and W. de Laat. 2002. Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol. Cell 10:1453–1465.
  • Vandesompele, J., K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe, and F. Speleman. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3: RESEARCH0034.
  • Vieira, K. F., P. P. Levings, M. A. Hill, V. J. Crusselle, S. H. Kang, J. D. Engel, and J. Bungert. 2004. Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro. J. Biol. Chem. 279:50350–50357.
  • Wakamiya, M., J. A. Rivera-Perez, A. Baldini, and R. R. Behringer. 1997. Goosecoid and goosecoid-related genes in mouse embryogenesis. Cold Spring Harbor Symp. Quant. Biol. 62:145–149.
  • West, A. G., and P. Fraser. 2005. Remote control of gene transcription. Hum. Mol. Genet. 14(Spec. no. 1):R101–R111.
  • Yoshida, Y., D. E. Hughes, F. M. Rausa III, I. M. Kim, Y. Tan, G. J. Darlington, and R. H. Costa. 2006. C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells. Hepatology 43:276–286.

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