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Article

DRONC Coordinates Cell Death and Compensatory Proliferation

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Pages 7258-7268 | Received 01 Feb 2006, Accepted 17 Jul 2006, Published online: 27 Mar 2023

REFERENCES

  • Abrams, J. M. 1999. An emerging blueprint for apoptosis in Drosophila. Trends. Cell. Biol. 9:435–440.
  • Bellen, H. J., R. W. Levis, G. Liao, Y. He, J. W. Carlson, G. Tsang, M. Evans-Holm, P. R. Hiesinger, K. L. Schulze, G. M. Rubin, R. A. Hoskins, and A. C. Spradling. 2004. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167:761–781.
  • Brachmann, C. B., and R. L. Cagan. 2003. Patterning the fly eye: the role of apoptosis. Trends Genet. 19:91–96.
  • Brodsky, M. H., J. J. Sekelsky, G. Tsang, R. S. Hawley, and G. M. Rubin. 2000. mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Genes Dev. 14:666–678.
  • Brodsky, M. H., W. Nordstrom, G. Tsang, E. Kwan, G. M. Rubin, and J. M. Abrams. 2000. Drosophila p53 binds a damage response element at the reaper locus. Cell 101:103–113.
  • Chen, P., W. Nordstrom, B. Gish, and J. M. Abrams. 1996. grim, a novel cell death gene in Drosophila. Genes Dev. 10:1773–1782.
  • Chen, P., A. Rodriguez, R. Erskine, T. Thach, and J. M. Abrams. 1998. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Dev. Biol. 201:202–216.
  • Chew, S. K., F. Akdemir, P. Chen, W. J. Lu, K. Mills, T. Daish, S. Kumar, A. Rodriguez, and J. M. Abrams. 2004. The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev. Cell 7:897–907.
  • Chou, T. B., and N. Perrimon. 1996. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics 144:1673–1679.
  • Daish, T. J., K. Mills, and S. Kumar. 2004. Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev. Cell 7:909–915.
  • Dorstyn, L., P. A. Colussi, L. M. Quinn, H. Richardson, and S. Kumar. 1999. DRONC, an ecdysone-inducible Drosophila caspase. Proc. Natl. Acad. Sci. USA 96:4307–4312.
  • Dorstyn, L., S. H. Read, L. M. Quinn, H. Richardson, and S. Kumar. 1999. DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7. J. Biol. Chem. 274:30778–30783.
  • Doumanis, J., L. Quinn, H. Richardson, and S. Kumar. 2001. STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Cell Death Differ. 8:387–394.
  • Fraser, A. G., and G. I. Evan. 1997. Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE. EMBO J. 16:2805–2813.
  • Fraser, A. G., N. J. McCarthy, and G. I. Evan. 1997. drICE is an essential caspase required for apoptotic activity in Drosophila cells. EMBO J. 16:6192–6199.
  • Graves, J. D., Y. Gotoh, K. E. Draves, D. Ambrose, D. K. Han, M. Wright, J. Chernoff, E. A. Clark, and E. G. Krebs. 1998. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 17:2224–2234.
  • Grether, M. E., J. M. Abrams, J. Agapite, K. White, and H. Steller. 1995. The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 14:1694–1708.
  • Golic, K. G., and S. Lindquist. 1989. The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59:499–509.
  • Harvey, N. L., T. Daish, K. Mills, L. Dorstyn, L. M. Quinn, S. H. Read, H. Richardson, and S. Kumar. 2001. Characterization of the Drosophila caspase, DAMM. J. Biol. Chem. 276:25342–25350.
  • Hawkins, C. J., S. J. Yoo, E. P. Peterson, S. L. Wang, S. Y. Vernooy, and B. A. Hay. 2000. The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM. J. Biol. Chem. 275:27084–27093.
  • Hay, B. A., T. Wolff, and G. M. Rubin. 1994. Expression of baculovirus P35 prevents cell death in Drosophila. Development 120:2121–2129.
  • Haynie, J. L., and P. J. Bryant. 1977. The effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc of Drosophila melanogaster. Roux's Arch. Dev. Biol. 183:85–100.
  • Hays, R., L. Wickline, and R. Cagan. 2002. Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1. Nat. Cell. Biol. 4:425–431.
  • Higashijima, S., T. Kojima, T. Michiue, S. Ishimaru, Y. Emori, and K. Saigo. 1992. Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development. Genes Dev. 6:50–60.
  • Huh, J. R., M. Guo, and B. A. Hay. 2004. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr. Biol. 14:1262–1266.
  • Jaklevic, B. R., and T. T. Su. 2004. Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae. Curr. Biol. 14:23–32.
  • Kanuka, H., S. Hisahara, K. Sawamoto, S. Shoji, H. Okano, and M. Miura. 1999. Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation. Proc. Natl. Acad. Sci. USA 96:145–150.
  • Kanuka, H., K. Sawamoto, N. Inohara, K. Matsuno, H. Okano, and M. Miura. 1999. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator. Mol. Cell 4:757–769.
  • Kuranaga, E., H. Kanuka, T. Igaki, K. Sawamoto, H. Ichijo, H. Okano, and M. Miura. 2002. Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat. Cell Biol. 4:705–710.
  • Kuranaga, E., H. Kanuka, A. Tonoki, K. Takemoto, T. Tomioka, M. Kobayashi, S. Hayashi, and M. Miura. Drosophila IKK-related kinase regulates non-apoptotic function of caspases via degradation of IAPs. Cell 126:583–596.
  • Laundrie, B., J. S. Peterson, J. S. Baum, J. C. Chang, D. Fileppo, S. R. Thompson, and K. McCall. 2003. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Genetics 65:1881–1888.
  • Lee, K. K., M. Murakawa, E. Nishida, S. Tsubuki, S. Kawashima, K. Sakamaki, and S. Yonehara. 1998. Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16:3029–3037.
  • Leulier, F, P. S. Ribeiro, E. Palmer, T. Tenev, K. Takahashi, D. Robertson, A. Zachariou, F. Pichaud, R. Ueda, and P. Meier. Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ., in press.
  • Leulier, F., A. Rodriguez, R. S. Khush, J. M. Abrams, and B. Lemaitre. 2000. The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep. 1:353–358.
  • Maeda, S., H. Kamata, J. L. Luo, H. Leffert, and M. Karin. 2005. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977–990.
  • Martin, S. J. 2002. Destabilizing influences in apoptosis: sowing the seeds of IAP destruction. Cell 109:793–796.
  • McCall, K., and H. Steller. 1997. Facing death in the fly: genetic analysis of apoptosis in Drosophila. Trends Genet. 13:222–226.
  • McEwen, D. G., and M. Peifer. 2005. Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132:3935–3946.
  • Meier, P., J. Silke, S. J. Leevers, and G. I. Evan. 2000. The Drosophila caspase DRONC is regulated by DIAP1. EMBO J. 19:598–611.
  • Milan, M., S. Campuzano, and A. Garcia-Bellido. 1997. Developmental parameters of cell death in the wing disc of Drosophila. Proc. Natl. Acad. Sci. USA 94:5691–5696.
  • Newsome, T. P., B. Asling, and B. J. Dickson. 2000. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127:851–860.
  • Nordstrom, W., P. Chen, H. Steller, and J. M. Abrams. 1996. Activation of the reaper gene during ectopic cell killing in Drosophila. Dev. Biol. 180:213–226.
  • Ollmann, M., L. M. Young, C. J. Di Como, F. Karim, M. Belvin, S. Robertson, K. Whittaker, M. Demsky, W. W. Fisher, A. Buchman, G. Duyk, L. Friedman, C. Prives, and C. Kopczynski. 2000. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 101:91–101.
  • Oren, M. 2003. Decision making by p53: life, death, and cancer. Cell Death Differ. 10:431–442.
  • Perez-Garijo, A., F. A. Martin, and G. Morata. 2004. Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila. Development 131:5591–5598.
  • Perez-Garijo, A., F. A. Martin, G. Struhl, and G. Morata. 2005. Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila. Proc. Natl. Acad. Sci. USA 102:17664–17669.
  • Preiss, A., B. Johannes, A. C. Nagel, D. Maier, N. Peters, and H. Wajant. 2001. Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development. Mech. Dev. 100:109–113.
  • Quinn, L. M., L. Dorstyn, K. Mills, P. A. Colussi, P. Chen, M. Coombe, J. Abrams, S. Kumar, and H. Richardson. 2000. An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. J. Biol. Chem. 275:40416–40424.
  • Roberts, D. B. 1998. Drosophila: a practical approach, 2nd ed. Oxford University Press, Oxford, United Kingdom.
  • Ryoo, H. D., A. Bergmann, H. Gonen, A. Ciechanover, and H. Steller. 2002. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell. Biol. 4:432–438.
  • Ryoo, H. D., T. Gorenc, and H. Steller. 2004. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev. Cell 7:491–501.
  • Song, Z., K. McCall, and H. Steller. 1997. DCP-1, a Drosophila cell death protease essential for development. Science 275:536–540.
  • Stowers, R. S., and T. L. Schwarz. 1999. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 152:1631–1639.
  • Tomioka, M., K. Shirotani, N. Iwata, H. J. Lee, F. Yang, G. M. Cole, Y. Seyama, and T. C. Saido. 2002. In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons. Brain Res. Mol. Brain Res. 108:18–32.
  • Waldhuber, M., K. Emoto, and C. Petritsch. 2005. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech. Dev. 122:914–927.
  • White, K., M. E. Grether, J. M. Abrams, L. Young, K. Farrell, and H. Steller. 1994. Genetic control of programmed cell death in Drosophila. Science 264:677–683.
  • White, K., E. Tahaoglu, and H. Steller. 1996. Cell killing by the Drosophila gene reaper. Science 271:805–807.
  • Wilson, R., L. Goyal, M. Ditzel, A. Zachariou, D. A. Baker, J. Agapite, H. Steller, and P. Meier. 2002. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat. Cell. Biol. 4:445–450.
  • Wing, J. P., B. A. Schreader, T. Yokokura, Y. Wang, P. S. Andrews, N. Huseinovic, C. K. Dong, J. L. Ogdahl, L. M. Schwartz, K. White, and J. R. Nambu. 2002. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat. Cell. Biol. 4:451–456.
  • Xu, D., Y. Li, M. Arcaro, M. Lackey, and A. Bergmann. 2005. The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132:2125–2134.
  • Yoo, S. J., J. R. Huh, I. Muro, H. Yu, L. Wang, S. L. Wang, R. M. Feldman, R. J. Clem, H. A. Muller, and B. A. Hay. 2002. Hid, Rpr, and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat. Cell. Biol. 4:416–424.
  • Zhou, L., A. Schnitzler, J. Agapite, L. M. Schwartz, H. Steller, and J. R. Nambu. 1997. Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc. Natl. Acad. Sci. USA 94:5131–5136.

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