Regulation of H-ras Splice Variant Expression by Cross Talk between the p53 and Nonsense-Mediated mRNA Decay Pathways

REFERENCES

• Amrani, N., M. S. Sachs, and A. Jacobson. 2006. Early nonsense: mRNA decay solves a translational problem. Nat. Rev. Mol. Cell Biol. 7:415–425.
   PubMed Web of Science ®Google Scholar
• Azzalin, C. M., and J. Lingner. 2006. The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr. Biol. 16:433–439.
   PubMedGoogle Scholar
• Blencowe, B. J. 2006. Alternative splicing: new insights from global analyses. Cell 126:37–47.
   PubMed Web of Science ®Google Scholar
• Brumbaugh, K. M., D. M. Otterness, C. Geisen, V. Oliveira, J. Brognard, X. Li, F. Lejeune, R. S. Tibbetts, L. E. Maquat, and R. T. Abraham. 2004. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol. Cell 14:585–598.
   PubMed Web of Science ®Google Scholar
• Candeias, M. M., D. J. Powell, E. Roubalova, S. Apcher, K. Bourougaa, B. Vojtesek, H. Bruzzoni-Giovanelli, and R. Fahraeus. 2006. Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene 25:6936–6947.
   PubMed Web of Science ®Google Scholar
• Cartegni, L., J. Wang, Z. Zhu, M. Q. Zhang, and A. R. Krainer. 2003. ESEfinder: a web resource to identify exonic splicing enhancers. Nucleic Acids Res. 31:3568–3571.
   PubMed Web of Science ®Google Scholar
• Carter, M. S., J. Doskow, P. Morris, S. Li, R. P. Nhim, S. Sandstedt, and M. F. Wilkinson. 1995. A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro. J. Biol. Chem. 270:28995–29003.
   PubMed Web of Science ®Google Scholar
• Deguin-Chambon, V., M. Vacher, M. Jullien, E. May, and J. C. Bourdon. 2000. Direct transactivation of c-Ha-Ras gene by p53: evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis. Oncogene 19:5831–5841.
   PubMedGoogle Scholar
• de la Grange, P., M. Dutertre, N. Martin, and D. Auboeuf. 2005. FAST DB: a website resource for the study of the expression regulation of human gene products. Nucleic Acids Res. 33:4276–4284.
   PubMedGoogle Scholar
• Deptala, A., X. Li, E. Bedner, W. Cheng, F. Traganos, and Z. Darzynkiewicz. 1999. Differences in induction of p53, p21WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin. Int. J. Oncol. 15:861–871.
   PubMed Web of Science ®Google Scholar
• Dreumont, N., A. Maresca, E. W. Khandjian, F. Baklouti, and R. M. Tanguay. 2004. Cytoplasmic nonsense-mediated mRNA decay for a nonsense (W262X) transcript of the gene responsible for hereditary tyrosinemia, fumarylacetoacetate hydrolase. Biochem. Biophys. Res. Commun. 324:186–192.
   PubMedGoogle Scholar
• Elias, E., N. Lalun, M. Lorenzato, L. Blache, P. Chelidze, M. F. O'Donohue, D. Ploton, and H. Bobichon. 2003. Cell-cycle-dependent three-dimensional redistribution of nuclear proteins, P 120, pKi-67, and SC 35 splicing factor, in the presence of the topoisomerase I inhibitor camptothecin. Exp. Cell Res. 291:176–188.
   PubMedGoogle Scholar
• Ferbeyre, G., E. de Stanchina, A. W. Lin, E. Querido, M. E. McCurrach, G. J. Hannon, and S. W. Lowe. 2002. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol. Cell. Biol. 22:3497–3508.
   PubMed Web of Science ®Google Scholar
• Gehring, N. H., J. B. Kunz, G. Neu-Yilik, S. Breit, M. H. Viegas, M. W. Hentze, and A. E. Kulozik. 2005. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol. Cell 20:65–75.
   PubMed Web of Science ®Google Scholar
• Guil, S., N. de La Iglesia, J. Fernandez-Larrea, D. Cifuentes, J. C. Ferrer, J. J. Guinovart, and M. Bach-Elias. 2003. Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus. Cancer Res. 63:5178–5187.
   PubMed Web of Science ®Google Scholar
• Guil, S., R. Gattoni, M. Carrascal, J. Abián, J. Stévenin, and M. Bach-Elias. 2003. Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Mol. Cell. Biol. 23:2927–2941.
   PubMed Web of Science ®Google Scholar
• Hanamura, A., J. F. Caceres, A. Mayeda, B. R. Franza, Jr., and A. R. Krainer. 1998. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA 4:430–444.
   PubMed Web of Science ®Google Scholar
• Harms, K. L., and X. Chen. 2006. p19ras brings a new twist to the regulation of p73 by Mdm2. Sci. STKE 2006:pe24.
   PubMedGoogle Scholar
• Hoh, J., S. Jin, T. Parrado, J. Edington, A. J. Levine, and J. Ott. 2002. The p53MH algorithm and its application in detecting p53-responsive genes. Proc. Natl. Acad. Sci. USA 99:8467–8472.
   PubMed Web of Science ®Google Scholar
• Holbrook, J. A., G. Neu-Yilik, M. W. Hentze, and A. E. Kulozik. 2004. Nonsense-mediated decay approaches the clinic. Nat. Genet. 36:801–808.
   PubMed Web of Science ®Google Scholar
• Jaks, V., A. Joers, A. Kristjuhan, and T. Maimets. 2001. p53 protein accumulation in addition to the transactivation activity is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin. Oncogene 20:1212–1219.
   PubMed Web of Science ®Google Scholar
• Jeong, M. H., J. Bae, W. H. Kim, S. M. Yoo, J. W. Kim, P. I. Song, and K. H. Choi. 2006. p19ras interacts with and activates p73 by involving the MDM2 protein. J. Biol. Chem. 281:8707–8715.
   PubMed Web of Science ®Google Scholar
• Jiang, Z. H., W. J. Zhang, Y. Rao, and J. Y. Wu. 1998. Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors. Proc. Natl. Acad. Sci. USA 95:9155–9160.
   PubMedGoogle Scholar
• Koivusalo, R., A. Mialon, H. Pitkanen, J. Westermarck, and S. Hietanen. 2006. Activation of p53 in cervical cancer cells by human papillomavirus E6 RNA interference is transient, but can be sustained by inhibiting endogenous nuclear export-dependent p53 antagonists. Cancer Res. 66:11817–11824.
   PubMed Web of Science ®Google Scholar
• Lewis, B. P., R. E. Green, and S. E. Brenner. 2003. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc. Natl. Acad. Sci. USA 100:189–192.
   PubMed Web of Science ®Google Scholar
• Lim, S. K., and L. E. Maquat. 1992. Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5′ termini. EMBO J. 11:3271–3278.
   PubMed Web of Science ®Google Scholar
• Liu, W., and R. Zhang. 1998. Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways. Int. J. Oncol. 12:793–804.
   PubMed Web of Science ®Google Scholar
• Lykke-Andersen, J., M. D. Shu, and J. A. Steitz. 2000. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103:1121–1131.
   PubMed Web of Science ®Google Scholar
• Malumbres, M., and M. Barbacid. 2003. RAS oncogenes: the first 30 years. Nat. Rev. Cancer 3:459–465.
   PubMed Web of Science ®Google Scholar
• Maquat, L. E. 2004. Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev. Mol. Cell Biol. 5:89–99.
   PubMed Web of Science ®Google Scholar
• Meek, D. W. 2004. The p53 response to DNA damage. DNA Repair 3:1049–1056.
   PubMed Web of Science ®Google Scholar
• Narita, M., and S. W. Lowe. 2005. Senescence comes of age. Nat. Med. 11:920–922.
   PubMed Web of Science ®Google Scholar
• Pal, M., Y. Ishigaki, E. Nagy, and L. E. Maquat. 2001. Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. RNA 7:5–15.
   PubMedGoogle Scholar
• Pan, Q., A. L. Saltzman, Y. K. Kim, C. Misquitta, O. Shai, L. E. Maquat, B. J. Frey, and B. J. Blencowe. 2006. Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev. 20:153–158.
   PubMed Web of Science ®Google Scholar
• Pilch, B., E. Allemand, M. Facompre, C. Bailly, J. F. Riou, J. Soret, and J. Tazi. 2001. Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506. Cancer Res. 61:6876–6884.
   PubMed Web of Science ®Google Scholar
• Pommier, Y. 2006. Topoisomerase I inhibitors: camptothecins and beyond. Nat. Rev. Cancer 6:789–802.
   PubMed Web of Science ®Google Scholar
• Rajavel, K. S., and E. F. Neufeld. 2001. Nonsense-mediated decay of human HEXA mRNA. Mol. Cell. Biol. 21:5512–5519.
   PubMedGoogle Scholar
• Rehwinkel, J., J. Raes, and E. Izaurralde. 2006. Nonsense-mediated mRNA decay: target genes and functional diversification of effectors. Trends Biochem. Sci. 31:639–646.
   PubMedGoogle Scholar
• Rossi, F., E. Labourier, T. Forne, G. Divita, J. Derancourt, J. F. Riou, E. Antoine, G. Cathala, C. Brunel, and J. Tazi. 1996. Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I. Nature 381:80–82.
   PubMed Web of Science ®Google Scholar
• Solier, S., A. Lansiaux, E. Logette, J. Wu, J. Soret, J. Tazi, C. Bailly, L. Desoche, E. Solary, and L. Corcos. 2004. Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells. Mol. Cancer Res. 2:53–61.
   PubMed Web of Science ®Google Scholar
• Solier, S., E. Logette, L. Desoche, E. Solary, and L. Corcos. 2005. Nonsense-mediated mRNA decay among human caspases: the caspase-2S putative protein is encoded by an extremely short-lived mRNA. Cell Death Differ. 12:687–689.
   PubMedGoogle Scholar
• Soret, J., M. Gabut, C. Dupon, G. Kohlhagen, J. Stevenin, Y. Pommier, and J. Tazi. 2003. Altered serine/arginine-rich protein phosphorylation and exonic enhancer-dependent splicing in mammalian cells lacking topoisomerase I. Cancer Res. 63:8203–8211.
   PubMed Web of Science ®Google Scholar
• Sun, X., P. M. Moriarty, and L. E. Maquat. 2000. Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position. EMBO J. 19:4734–4744.
   PubMedGoogle Scholar
• Sureau, A., R. Gattoni, Y. Dooghe, J. Stevenin, and J. Soret. 2001. SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs. EMBO J. 20:1785–1796.
   PubMed Web of Science ®Google Scholar
• van der Houven van Oordt, W., M. T. Diaz-Meco, J. Lozano, A. R. Krainer, J. Moscat, and J. F. Caceres. 2000. The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J. Cell Biol. 149:307–316.
   PubMed Web of Science ®Google Scholar
• Wang, J., P. J. Smith, A. R. Krainer, and M. Q. Zhang. 2005. Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Res. 33:5053–5062.
   PubMedGoogle Scholar
• Wang, J., V. M. Vock, S. Li, O. R. Olivas, and M. F. Wilkinson. 2002. A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation. J. Biol. Chem. 277:18489–18493.
   PubMed Web of Science ®Google Scholar
• Weil, D., S. Boutain, A. Audibert, and F. Dautry. 2000. Mature mRNAs accumulated in the nucleus are neither the molecules in transit to the cytoplasm nor constitute a stockpile for gene expression. RNA 6:962–975.
   PubMedGoogle Scholar
• Wu, Y., Y. Zhang, and J. Zhang. 2005. Distribution of exonic splicing enhancer elements in human genes. Genomics 86:329–336.
   PubMedGoogle Scholar
• You, K. T., L. S. Li, N. G. Kim, H. J. Kang, K. H. Koh, Y. J. Chwae, K. M. Kim, Y. K. Kim, S. M. Park, S. K. Jang, and H. Kim. 2007. Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLoS Biol. 5:e109.
   PubMedGoogle Scholar