Direct Protein Interactions Are Responsible for Ikaros-GATA and Ikaros-Cdk9 Cooperativeness in Hematopoietic Cells

REFERENCES

• Pertea M. 2012. The human transcriptome: an unfinished story. Genes 3:344–360.
   PubMed Web of Science ®Google Scholar
• Dillon N. 2012. Factor mediated gene priming in pluripotent stem cells sets the stage for lineage specification. Bioessays 34:194–204.
   PubMedGoogle Scholar
• Bresnick EH, Lee HY, Fujiwara T, Johnson KD, Keles S. 2010. GATA switches as developmental drivers. J. Biol. Chem. 285:31087–31093.
   PubMed Web of Science ®Google Scholar
• Hosoya T, Maillard I, Engel JD. 2010. From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation. Immunol. Rev. 238:110–125.
   PubMedGoogle Scholar
• John LB, Ward AC. 2011. The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity. Mol. Immunol. 48:1272–1278.
   PubMed Web of Science ®Google Scholar
• Patient RK, McGhee JD. 2002. The GATA family (vertebrates and invertebrates). Curr. Opin. Genet. Dev. 12:416–422.
   PubMed Web of Science ®Google Scholar
• Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:257–260.
   PubMed Web of Science ®Google Scholar
• Weiss MJ, Orkin SH. 1995. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc. Natl. Acad. Sci. U. S. A. 92:9623–9627.
   PubMed Web of Science ®Google Scholar
• Whyatt D, Lindeboom F, Karis A, Ferreira R, Milot E, Hendriks R, de Bruijn M, Langeveld A, Gribnau J, Grosveld F, Philipsen S. 2000. An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells. Nature 406:519–524.
   PubMed Web of Science ®Google Scholar
• Whyatt DJ, Karis A, Harkes IC, Verkerk A, Gillemans N, Elefanty AG, Vairo G, Ploemacher R, Grosveld F, Philipsen S. 1997. The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery. Genes Funct. 1:11–24.
   PubMedGoogle Scholar
• Yamamoto M, Takahashi S, Onodera K, Muraosa Y, Engel JD. 1997. Upstream and downstream of erythroid transcription factor GATA-1. Genes Cells 2:107–115.
   PubMed Web of Science ®Google Scholar
• Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH. 2008. Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J. Exp. Med. 205:611–624.
   PubMedGoogle Scholar
• Ku CJ, Hosoya T, Maillard I, Engel JD. 2012. GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. Blood 119:2242–2251.
   PubMedGoogle Scholar
• Crossley M, Merika M, Orkin SH. 1995. Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains. Mol. Cell. Biol. 15:2448–2456.
   PubMedGoogle Scholar
• Martin DI, Orkin SH. 1990. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev. 4:1886–1898.
   PubMed Web of Science ®Google Scholar
• Tsiftsoglou AS, Vizirianakis IS, Strouboulis J. 2009. Erythropoiesis: model systems, molecular regulators, and developmental programs. IUBMB Life 61:800–830.
   PubMed Web of Science ®Google Scholar
• Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J. 2005. GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 24:2354–2366.
   PubMed Web of Science ®Google Scholar
• Bresnick EH, Martowicz ML, Pal S, Johnson KD. 2005. Developmental control via GATA factor interplay at chromatin domains. J. Cell Physiol. 205:1–9.
   PubMed Web of Science ®Google Scholar
• Weiss MJ, Orkin SH. 1995. GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol. 23:99–107.
   PubMed Web of Science ®Google Scholar
• Bottardi S, Ross J, Bourgoin V, Fotouhi-Ardakani N, Affar EB, Trudel BM, Milot E. 2009. Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes. Mol. Cell. Biol. 29:1526–1537.
   PubMedGoogle Scholar
• Bottardi S, Zmiri FA, Bourgoin V, Ross J, Mavoungou L, Milot E. 2011. Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation. Nucleic Acids Res. 39:3505–3519.
   PubMed Web of Science ®Google Scholar
• Koipally J, Georgopoulos K. 2000. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J. Biol. Chem. 275:19594–19602.
   PubMedGoogle Scholar
• Koipally J, Renold A, Kim J, Georgopoulos K. 1999. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. 18:3090–3100.
   PubMedGoogle Scholar
• Sun L, Liu A, Georgopoulos K. 1996. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 15:5358–5369.
   PubMed Web of Science ®Google Scholar
• Molnar A, Georgopoulos K. 1994. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol. Cell. Biol. 14:8292–8303.
   PubMed Web of Science ®Google Scholar
• Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST. 1994. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol. Cell. Biol. 14:7111–7123.
   PubMedGoogle Scholar
• Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. 1996. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 5:537–549.
   PubMed Web of Science ®Google Scholar
• Avitahl N, Winandy S, Friedrich C, Jones B, Ge Y, Georgopoulos K. 1999. Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 10:333–343.
   PubMedGoogle Scholar
• Winandy S, Wu P, Georgopoulos K. 1995. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83:289–299.
   PubMed Web of Science ®Google Scholar
• Ng SY, Yoshida T, Georgopoulos K. 2007. Ikaros and chromatin regulation in early hematopoiesis. Curr. Opin. Immunol. 19:116–122.
   PubMedGoogle Scholar
• Ross J, Mavoungou L, Bresnick EH, Milot E. 2012. GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis. Mol. Cell. Biol. 32:3624–3638.
   PubMed Web of Science ®Google Scholar
• Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K. 1997. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 7:483–492.
   PubMed Web of Science ®Google Scholar
• Dumortier A, Kirstetter P, Kastner P, Chan S. 2003. Ikaros regulates neutrophil differentiation. Blood 101:2219–2226.
   PubMedGoogle Scholar
• Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG. 1997. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91:845–854.
   PubMed Web of Science ®Google Scholar
• Georgopoulos K. 2002. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat. Rev. Immunol. 2:162–174.
   PubMed Web of Science ®Google Scholar
• Harker N, Naito T, Cortes M, Hostert A, Hirschberg S, Tolaini M, Roderick K, Georgopoulos K, Kioussis D. 2002. The CD8α gene locus is regulated by the Ikaros family of proteins. Mol. Cell 10:1403–1415.
   PubMedGoogle Scholar
• Sabbattini P, Lundgren M, Georgiou A, Chow C, Warnes G, Dillon N. 2001. Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J. 20:2812–2822.
   PubMedGoogle Scholar
• Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST. 2001. Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes Dev. 15:1817–1832.
   PubMedGoogle Scholar
• Keys JR, Tallack MR, Zhan Y, Papathanasiou P, Goodnow CC, Gaensler KM, Crossley M, Dekker J, Perkins AC. 2008. A mechanism for Ikaros regulation of human globin gene switching. Br. J. Haematol. 141:398–406.
   PubMed Web of Science ®Google Scholar
• Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K. 1999. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10:345–355.
   PubMed Web of Science ®Google Scholar
• Yoshida T, Ng SY, Georgopoulos K. 2010. Awakening lineage potential by Ikaros-mediated transcriptional priming. Curr. Opin. Immunol. 22:154–160.
   PubMedGoogle Scholar
• Zhou Q, Li T, Price DH. 2012. RNA polymerase II elongation control. Annu. Rev. Biochem. 81:119–143.
   PubMed Web of Science ®Google Scholar
• Doubeikovskaia Z, Aries A, Jeannesson P, Morle F, Doubeikovski A. 2001. Purification of human recombinant GATA-1 from bacteria: implication for protein-protein interaction studies. Protein Express. Purif. 23:426–431.
   PubMedGoogle Scholar
• Cheng Y, Wu W, Kumar SA, Yu D, Deng W, Tripic T, King DC, Chen KB, Zhang Y, Drautz D, Giardine B, Schuster SC, Miller W, Chiaromonte F, Zhang Y, Blobel GA, Weiss MJ, Hardison RC. 2009. Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res. 19:2172–2184.
   PubMed Web of Science ®Google Scholar
• Welch JJ, Watts JA, Vakoc CR, Yao Y, Wang H, Hardison RC, Blobel GA, Chodosh LA, Weiss MJ. 2004. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 104:3136–3147.
   PubMed Web of Science ®Google Scholar
• Weiss MJ, Yu C, Orkin SH. 1997. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol. Cell. Biol. 17:1642–1651.
   PubMed Web of Science ®Google Scholar
• Nakatani Y, Ogryzko V. 2003. Immunoaffinity purification of mammalian protein complexes. Methods Enzymol. 370:430–444.
   PubMed Web of Science ®Google Scholar
• Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, Soverini S, Astolfi A, Chiaretti S, Vitale A, Messa F, Impera L, Baldazzi C, D'Addabbo P, Papayannidis C, Lonoce A, Colarossi S, Vignetti M, Piccaluga PP, Paolini S, Russo D, Pane F, Saglio G, Baccarani M, Foa R, Martinelli G. 2009. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 114:2159–2167.
   PubMed Web of Science ®Google Scholar
• Klein F, Feldhahn N, Herzog S, Sprangers M, Mooster JL, Jumaa H, Muschen M. 2006. BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 25:1118–1124.
   PubMed Web of Science ®Google Scholar
• Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH, Relling MV, Shurtleff SA, Downing JR. 2008. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 453:110–114.
   PubMed Web of Science ®Google Scholar
• Nakayama H, Ishimaru F, Avitahl N, Sezaki N, Fujii N, Nakase K, Ninomiya Y, Harashima A, Minowada J, Tsuchiyama J, Imajoh K, Tsubota T, Fukuda S, Sezaki T, Kojima K, Hara M, Takimoto H, Yorimitsu S, Takahashi I, Miyata A, Taniguchi S, Tokunaga Y, Gondo H, Niho Y, Harada M, et al. 1999. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. Cancer Res. 59:3931–3934.
   PubMed Web of Science ®Google Scholar
• Sun L, Goodman PA, Wood CM, Crotty ML, Sensel M, Sather H, Navara C, Nachman J, Steinherz PG, Gaynon PS, Seibel N, Vassilev A, Juran BD, Reaman GH, Uckun FM. 1999. Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia. J. Clin. Oncol. 17:3753–3766.
   PubMed Web of Science ®Google Scholar
• Crossley M, Orkin SH. 1994. Phosphorylation of the erythroid transcription factor GATA-1. J. Biol. Chem. 269:16589–16596.
   PubMed Web of Science ®Google Scholar
• Romano G, Giordano A. 2008. Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases. Cell Cycle 7:3664–3668.
   PubMed Web of Science ®Google Scholar
• Elagib KE, Mihaylov IS, Delehanty LL, Bullock GC, Ouma KD, Caronia JF, Gonias SL, Goldfarb AN. 2008. Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation. Blood 112:4884–4894.
   PubMedGoogle Scholar
• Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K. 2011. Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. J. Cell Physiol. 226:248–254.
   PubMed Web of Science ®Google Scholar
• Meier N, Krpic S, Rodriguez P, Strouboulis J, Monti M, Krijgsveld J, Gering M, Patient R, Hostert A, Grosveld F. 2006. Novel binding partners of Ldb1 are required for haematopoietic development. Development 133:4913–4923.
   PubMedGoogle Scholar
• Song SH, Kim A, Ragoczy T, Bender MA, Groudine M, Dean A. 2010. Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood 116:2356–2364.
   PubMed Web of Science ®Google Scholar
• Claudio PP, Cui J, Ghafouri M, Mariano C, White MK, Safak M, Sheffield JB, Giordano A, Khalili K, Amini S, Sawaya BE. 2006. Cdk9 phosphorylates p53 on serine 392 independently of CKII. J. Cell Physiol. 208:602–612.
   PubMed Web of Science ®Google Scholar
• Garriga J, Mayol X, Grana X. 1996. The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes. Biochem. J. 319:293–298.
   PubMedGoogle Scholar
• Lopez RA, Schoetz S, DeAngelis K, O'Neill D, Bank A. 2002. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc. Natl. Acad. Sci. U. S. A. 99:602–607.
   PubMedGoogle Scholar
• Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, Yamamoto M. 2007. GATA-1 self-association controls erythroid development in vivo. J. Biol. Chem. 282:15862–15871.
   PubMedGoogle Scholar
• Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH. 1991. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc. Natl. Acad. Sci. U. S. A. 88:10638–10641.
   PubMed Web of Science ®Google Scholar
• Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. 2002. A stem cell molecular signature. Science 298:601–604.
   PubMed Web of Science ®Google Scholar
• Mansson R, Hultquist A, Luc S, Yang L, Anderson K, Kharazi S, Al-Hashmi S, Liuba K, Thoren L, Adolfsson J, Buza-Vidas N, Qian H, Soneji S, Enver T, Sigvardsson M, Jacobsen SE. 2007. Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 26:407–419.
   PubMed Web of Science ®Google Scholar
• Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. 2002. “Stemness”: transcriptional profiling of embryonic and adult stem cells. Science 298:597–600.
   PubMed Web of Science ®Google Scholar
• Subramaniam VN, Summerville L, Wallace DF. 2002. Molecular and cellular characterization of transferrin receptor 2. Cell. Biochem. Biophys. 36:235–239.
   PubMedGoogle Scholar
• Wargnier A, Lafaurie C, Legros-Maida S, Bourge JF, Sigaux F, Sasportes M, Paul P. 1998. Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter. J. Biol. Chem. 273:35326–35331.
   PubMed Web of Science ®Google Scholar
• Wilson BJ. 2008. Does GATA3 act in tissue-specific pathways? A meta-analysis-based approach. J. Carcinog. 7:6.
   PubMedGoogle Scholar
• Ronni T, Payne KJ, Ho S, Bradley MN, Dorsam G, Dovat S. 2007. Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms. J. Biol. Chem. 282:2538–2547.
   PubMedGoogle Scholar
• Lahlil R, Lecuyer E, Herblot S, Hoang T. 2004. SCL assembles a multifactorial complex that determines glycophorin A expression. Mol. Cell. Biol. 24:1439–1452.
   PubMedGoogle Scholar
• Yoshida T, Ng SY, Zuniga-Pflucker JC, Georgopoulos K. 2006. Early hematopoietic lineage restrictions directed by Ikaros. Nat. Immunol. 7:382–391.
   PubMed Web of Science ®Google Scholar
• Ptashne M. 2005. Regulation of transcription: from lambda to eukaryotes. Trends Biochem. Sci. 30:275–279.
   PubMedGoogle Scholar
• Gregory GD, Raju SS, Winandy S, Brown MA. 2006. Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J. Clin. Invest. 116:1327–1336.
   PubMed Web of Science ®Google Scholar
• Hatton RD, Harrington LE, Luther RJ, Wakefield T, Janowski KM, Oliver JR, Lallone RL, Murphy KM, Weaver CT. 2006. A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity 25:717–729.
   PubMedGoogle Scholar
• Malinge S, Thiollier C, Chlon TM, Dore LC, Diebold L, Bluteau O, Mabialah V, Vainchenker W, Dessen P, Winandy S, Mercher T, Crispino JD. 2013. Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood 121:2440–2451.
   PubMed Web of Science ®Google Scholar
• Quirion MR, Gregory GD, Umetsu SE, Winandy S, Brown MA. 2009. Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J. Immunol. 182:741–745.
   PubMedGoogle Scholar
• Umetsu SE, Winandy S. 2009. Ikaros is a regulator of Il10 expression in CD4+ T cells. J. Immunol. 183:5518–5525.
   PubMedGoogle Scholar
• Yang L, Luo Y, Wei J. 2010. Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis. Oncol. Rep. 24:571–577.
   PubMedGoogle Scholar
• Jager R, Gisslinger H, Passamonti F, Rumi E, Berg T, Gisslinger B, Pietra D, Harutyunyan A, Klampfl T, Olcaydu D, Cazzola M, Kralovics R. 2010. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia 24:1290–1298.
   PubMed Web of Science ®Google Scholar
• Rebollo A, Schmitt C. 2003. Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies. Immunol. Cell Biol. 81:171–175.
   PubMed Web of Science ®Google Scholar
• Rooke HM, Orkin SH. 2006. Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood 107:3527–3530.
   PubMedGoogle Scholar
• Ferreira R, Wai A, Shimizu R, Gillemans N, Rottier R, von Lindern M, Ohneda K, Grosveld F, Yamamoto M, Philipsen S. 2007. Dynamic regulation of Gata factor levels is more important than their identity. Blood 109:5481–5490.
   PubMed Web of Science ®Google Scholar
• Grass JA, Boyer ME, Pal S, Wu J, Weiss MJ, Bresnick EH. 2003. GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc. Natl. Acad. Sci. U. S. A. 100:8811–8816.
   PubMed Web of Science ®Google Scholar
• Jing H, Vakoc CR, Ying L, Mandat S, Wang H, Zheng X, Blobel GA. 2008. Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol. Cell 29:232–242.
   PubMed Web of Science ®Google Scholar
• Hung HL, Lau J, Kim AY, Weiss MJ, Blobel GA. 1999. CREB-binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol. Cell. Biol. 19:3496–3505.
   PubMed Web of Science ®Google Scholar
• Koipally J, Georgopoulos K. 2002. Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. J. Biol. Chem. 277:23143–23149.
   PubMedGoogle Scholar
• Georgopoulos K, Moore DD, Derfler B. 1992. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 258:808–812.
   PubMed Web of Science ®Google Scholar
• O'Neill D, Yang J, Erdjument-Bromage H, Bornschlegel K, Tempst P, Bank A. 1999. Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. Proc. Natl. Acad. Sci. U. S. A. 96:349–354.
   PubMedGoogle Scholar
• O'Neill DW, Schoetz SS, Lopez RA, Castle M, Rabinowitz L, Shor E, Krawchuk D, Goll MG, Renz M, Seelig HP, Han S, Seong RH, Park SD, Agalioti T, Munshi N, Thanos D, Erdjument-Bromage H, Tempst P, Bank A. 2000. An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol. Cell. Biol. 20:7572–7582.
   PubMedGoogle Scholar
• Nichogiannopoulou A, Trevisan M, Neben S, Friedrich C, Georgopoulos K. 1999. Defects in hemopoietic stem cell activity in Ikaros mutant mice. J. Exp. Med. 190:1201–1214.
   PubMed Web of Science ®Google Scholar
• Saunders A, Core LJ, Lis JT. 2006. Breaking barriers to transcription elongation. Nat. Rev. Mol. Cell Biol. 7:557–567.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Yik JH. 2006. The yin and yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation. Microbiol. Mol. Biol. Rev. 70:646–659.
   PubMed Web of Science ®Google Scholar
• Zheng R, Blobel GA. 2010. GATA Transcription factors and cancer. Genes Cancer 1:1178–1188.
   PubMedGoogle Scholar
• Greene ME, Mundschau G, Wechsler J, McDevitt M, Gamis A, Karp J, Gurbuxani S, Arceci R, Crispino JD. 2003. Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. Blood Cells Mol. Dis. 31:351–356.
   PubMed Web of Science ®Google Scholar
• Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM, Crispino JD. 2002. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat. Genet. 32:148–152.
   PubMed Web of Science ®Google Scholar
• Zipursky A. 2003. Transient leukaemia: a benign form of leukaemia in newborn infants with trisomy 21. Br. J. Haematol. 120:930–938.
   PubMed Web of Science ®Google Scholar
• Bresnick EH, Katsumura KR, Lee HY, Johnson KD, Perkins AS. 2012. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res. 40:5819–5831.
   PubMed Web of Science ®Google Scholar
• Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. 2012. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481:157–163.
   PubMed Web of Science ®Google Scholar
• Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.
   PubMed Web of Science ®Google Scholar