35
Views
41
CrossRef citations to date
0
Altmetric
Article

Phosphorylation of TPL-2 on Serine 400 Is Essential for Lipopolysaccharide Activation of Extracellular Signal-Regulated Kinase in Macrophages

, , , &
Pages 7355-7364 | Received 19 Feb 2007, Accepted 10 Aug 2007, Published online: 27 Mar 2023

REFERENCES

  • Aoki, M., F. Hamada, T. Sugimoto, S. Sumida, T. Akiyama, and K. Toyoshima. 1993. The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. J. Biol. Chem. 268:22723–22732.
  • Babu, G. R., W. Jin, L. Norman, M. Waterfield, M. Chang, X. Wu, M. Zhang, and S. C. Sun. 2006. Phosphorylation of NF-κB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation. Biochim. Biophys. Acta 1763:174–181.
  • Beinke, S., M. P. Belich, and S. C. Ley. 2002. The death domain of NF-κB1 p105 is essential for signal-induced p105 proteolysis. J. Biol. Chem. 277:24162–24168.
  • Beinke, S., J. Deka, V. Lang, M. P. Belich, P. A. Walker, S. Howell, S. J. Smerdon, S. J. Gamblin, and S. C. Ley. 2003. NF-κB p105 negatively regulates TPL-2 MEK kinase activity. Mol. Cell. Biol. 23:4739–4752.
  • Beinke, S., M. J. Robinson, A. Salmeron, M. Hugunin, H. Allen, and S. C. Ley. 2004. Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105. Mol. Cell. Biol. 24:9658–9667.
  • Belich, M. P., A. Salmeron, L. H. Johnston, and S. C. Ley. 1999. TPL-2 kinase regulates the proteolysis of the NF-κB inhibitory protein NF-κB1 p105. Nature 397:363–368.
  • Ceci, J. D., C. P. Patriotis, C. Tsatsanis, A. M. Makris, R. Kovatch, D. A. Swing, N. A. Jenkins, P. N. Tsichlis, and N. G. Copeland. 1997. TPL-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev. 11:688–700.
  • Chan, A. M.-L., M. Chedid, E. S. McGovern, N. C. Popescu, T. Miki, and S. A. Aaronson. 1993. Expression cDNA cloning of a serine kinase transforming gene. Oncogene 8:1329–1333.
  • Chiariello, M., M. J. Marinissen, and J. S. Gutkind. 2000. Multiple mitogen-activated protein kinase signaling pathways connect the Cot oncoprotein to the c-Jun promoter and to cellular transformation. Mol. Cell. Biol. 20:1747–1758.
  • Cho, J., M. Melnick, G. P. Solidakis, and P. N. Tsichlis. 2005. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an IκB kinase-β-dependent pathway and is required for Tpl2 activation by external signals. J. Biol. Chem. 280:20442–20448.
  • Cho, J., and P. N. Tsichlis. 2005. Phosphorylation at T290 regulates Tpl2 binding to NF-κB1/p105 and Tpl2 activation and degradation by lipopolysaccharide. Proc. Natl. Acad. Sci. USA 102:2350–2355.
  • Das, S., J. Cho, I. Lambertz, M. A. Kelliher, A. G. Eliopoulos, K. Du, and P. N. Tsichlis. 2005. Tpl2/Cot signals activate ERK, JNK and NF-κB in a cell-type and stimulus-specific manner. J. Biol. Chem. 280:23748–23757.
  • Dumitru, C. D., J. D. Ceci, C. Tsatsanis, D. Kontoyiannis, K. Stamatakis, J.-H. Lin, C. Patriotis, N. A. Jenkins, N. G. Copeland, G. Kollias, and P. N. Tsichlis. 2000. TNFα induction by LPS is regulated post-transcriptionally via a TPL2/ERK-dependent pathway. Cell 103:1071–1083.
  • Eliopoulos, A. G., C. D. Dumitru, C.-C. Wang, J. Cho, and P. N. Tsichlis. 2002. Induction of COX-2 by LPS in macrophages is regulated by TPL2-dependent CREB activation signals. EMBO J. 21:4831–4840.
  • Eliopoulos, A. G., C.-C. Wang, C. D. Dumitru, and P. N. Tsichlis. 2003. TPL-2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J. 22:3855–3864.
  • Erny, K. M., J. Peli, J.-F. Lambert, V. Muller, and H. Diggelmann. 1996. Involvement of the TPL-2/COT oncogene in MMTV tumorigenesis. Oncogene 13:2015–2020.
  • Gandara, M. L., P. Lopez, R. Hernando, J. G. Castano, and S. Alemany. 2003. The COOH-terminal domain of wild-type Cot regulates its stability and kinase-specific activity. Mol. Cell. Biol. 23:7377–7390.
  • Guha, M., and N. Mackman. 2002. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277:32124–32132.
  • Kabouridis, P. S., A. I. Magee, and S. C. Ley. 1997. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:4983–4998.
  • Kane, L. P., M. N. Mollenauer, Z. Xu, C. W. Turck, and A. Weiss. 2002. Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB-dependent transcription. Mol. Cell. Biol. 22:5962–5974.
  • Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621–663.
  • Lang, V., J. Janzen, G. Z. Fischer, Y. Soneji, S. Beinke, A. Salmeron, H. Allen, R. T. Hay, Y. Ben-Neriah, and S. C. Ley. 2003. βTrCP-mediated proteolysis of NF-κB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol. Cell. Biol. 23:402–413.
  • Lang, V., A. Symons, S. J. Watton, J. Janzen, Y. Soneji, S. Beinke, S. Howell, and S. C. Ley. 2004. ABIN-2 forms a ternary complex with TPL-2 and NF-κB1 p105 and is essential for TPL-2 protein stability. Mol. Cell. Biol. 24:5235–5248.
  • Luciano, B. S., S. Hsu, P. L. Channavajhala, L.-L. Lin, and J. W. Cuozzo. 2004. Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity. J. Biol. Chem. 279:52117–52123.
  • Lund, A. H., G. Turner, A. Trubetskoy, E. Verhoeven, E. Wientjens, D. Hulsman, R. Russell, R. A. DePinho, J. Lenz, and M. van Lohuizen. 2002. Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat. Gene 32:160–165.
  • Mikkers, H., J. Allen, P. Knipscheer, L. Romeyn, A. Hart, E. Vink, and A. Berns. 2002. High throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat. Gene 32:153–159.
  • Morita, S., T. Kojima, and T. Kitamura. 2000. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7:1063–1066.
  • Nolen, B., S. Taylor, and G. Ghosh. 2004. Regulation of protein kinases: controlling activity through activation segment conformation. Mol. Cell 15:661–675.
  • Ojaniemi, M., V. Glumoff, K. Harju, M. Liljeroos, K. Vuori, and M. Hallman. 2003. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur. J. Immunol. 33:597–605.
  • Papoutsopoulou, S., A. Symons, T. Tharmalingham, M. P. Belich, F. Kaiser, D. Kioussis, A. O'Garra, V. Tybulewicz, and S. C. Ley. 2006. ABIN-2 is required for optimal activation of the TPL-2/ERK MAP kinase pathway in innate immune responses. Nat. Immunol. 7:606–615.
  • Patriotis, C., A. Makris, S. E. Bear, and P. N. Tsichlis. 1993. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T cell lymphomas and in T cell activation. Proc. Natl. Acad. Sci. USA 90:2251–2255.
  • Patriotis, C., A. Makris, J. Chernoff, and P. N. Tsichlis. 1994. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 91:9755–9759.
  • Salmeron, A., T. B. Ahmad, G. W. Carlile, D. Pappin, R. P. Narsimhan, and S. C. Ley. 1996. Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J. 15:817–826.
  • Sha, W. C., H.-C. Lious, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321–330.
  • Sugimoto, K., M. Ohata, J. Miyoshi, H. Ishizaki, N. Tsuboi, A. Masuda, Y. Yoshikai, M. Takamoto, K. Sugane, S. Matsuo, Y. Shimada, and T. Matsuguchi. 2004. A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J. Clin. Investig. 114:857–866.
  • Symons, A., S. Beinke, and S. C. Ley. 2006. MAP kinase kinase kinases and innate immunity. Trends Immunol. 27:40–48.
  • Warren, M. K., and S. N. Vogel. 1985. Bone marrow-derived macrophages: development and regulation of differentiation markers by colony-stimulating factor and interferons. J. Immunol. 134:982–989.
  • Waterfield, M., W. Jin, W. Reiley, M. Y. Zhang, and S.-C. Sun. 2004. IKKβ is an essential component of the TPL-2 signaling pathway. Mol. Cell. Biol. 24:6040–6048.
  • Waterfield, M. R., M. Zhang, L. P. Norman, and S.-C. Sun. 2003. NF-κB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the TPL-2 kinase. Mol. Cell 11:685–694.
  • Yeung, K. T., P. Janosch, B. McFerran, D. W. Rose, H. Mischak, J. M. Sedivy, and W. Kolch. 2000. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the Raf kinase inhibitor protein. Mol. Cell. Biol. 20:3079–3085.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.