A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling

REFERENCES

• Alimohamad, H., N. Rajakumar, Y. H. Seah, and W. Rushlow. 2005. Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum. Biol. Psych. 57:533–542.
   PubMed Web of Science ®Google Scholar
• Alimohamad, H., L. Sutton, J. Mouyal, N. Rajakumar, and W. J. Rushlow. 2005. The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats. J. Neurochem. 95:513–525.
   PubMedGoogle Scholar
• Armogida, M., A. Petit, B. Vincent, S. Scarzello, C. A. da Costa, and F. Checler. 2001. Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts. Nat. Cell Biol 3:1030–1033.
   PubMed Web of Science ®Google Scholar
• Cadigan, K. M., and Y. I. Liu. 2006. Wnt signaling: complexity at the surface. J. Cell Sci. 119:395–402.
   PubMed Web of Science ®Google Scholar
• Castelo-Branco, G., and E. Arenas. 2006. Function of Wnts in dopaminergic neuron development. Neurodegener. Dis. 3:5–11.
   PubMedGoogle Scholar
• Castelo-Branco, G., K. M. Sousa, V. Bryja, L. Pinto, J. Wagner, and E. Arenas. 2006. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol. Cell. Neurosci. 31:251–262.
   PubMedGoogle Scholar
• Castelo-Branco, G., J. Wagner, F. J. Rodriguez, J. Kele, K. Sousa, N. Rawal, H. A. Pasolli, E. Fuchs, J. Kitajewski, and E. Arenas. 2003. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc. Natl. Acad. Sci. USA 100:12747–12752.
   PubMed Web of Science ®Google Scholar
• Castro, D. S., M. Arvidsson, M. Bondesson Bolin, and T. Perlmann. 1999. Activity of the Nurr1 carboxyl-terminal domain depends on cell type and integrity of the activation function 2. J. Biol. Chem. 274:37483–37490.
   PubMedGoogle Scholar
• Chan, H. M., and N. B. La Thangue. 2001. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci. 114:2363–2373.
   PubMed Web of Science ®Google Scholar
• Chu, Y., K. Kompoliti, E. J. Cochran, E. J. Mufson, and J. H. Kordower. 2002. Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. J. Comp. Neurol. 450:203–214.
   PubMed Web of Science ®Google Scholar
• Chu, Y., W. Le, K. Kompoliti, J. Jankovic, E. J. Mufson, and J. H. Kordower. 2006. Nurr1 in Parkinson's disease and related disorders. J. Comp. Neurol. 494:495–514.
   PubMed Web of Science ®Google Scholar
• Codina, A., G. Benoit, J. T. Gooch, D. Neuhaus, T. Perlmann, and J. W. Schwabe. 2004. Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting. J. Biol. Chem. 279:53338–53345.
   PubMed Web of Science ®Google Scholar
• Danielian, P. S., and A. P. McMahon. 1996. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383:332–334.
   PubMedGoogle Scholar
• Daniels, D. L., and W. I. Weis. 2005. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat. Struct. Mol. Biol. 12:364–371.
   PubMed Web of Science ®Google Scholar
• Darragh, J., A. Soloaga, V. A. Beardmore, A. D. Wingate, G. R. Wiggin, M. Peggie, and J. S. Arthur. 2005. MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling. Biochem. J. 390:749–759.
   PubMedGoogle Scholar
• Dean, B. 2002. Understanding the pathology of schizophrenia: recent advances from the study of the molecular architecture of postmortem CNS tissue. Postgrad. Med. J. 78:142–148.
   PubMed Web of Science ®Google Scholar
• Forman, B. M., K. Umesono, J. Chen, and R. M. Evans. 1995. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81:541–550.
   PubMed Web of Science ®Google Scholar
• Galleguillos, D., A. Vecchiola, J. A. Fuentealba, V. Ojeda, K. Alvarez, A. Gomez, and M. E. Andres. 2004. PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1. J. Biol. Chem. 279:2005–2011.
   PubMed Web of Science ®Google Scholar
• Gould, T. D., and H. K. Manji. 2002. The Wnt signaling pathway in bipolar disorder. Neuroscientist 8:497–511.
   PubMed Web of Science ®Google Scholar
• Hermanson, E., B. Joseph, D. Castro, E. Lindqvist, P. Aarnisalo, A. Wallen, G. Benoit, B. Hengerer, L. Olson, and T. Perlmann. 2003. Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Exp. Cell Res. 288:324–334.
   PubMed Web of Science ®Google Scholar
• Holla, V. R., J. R. Mann, Q. Shi, and R. N. DuBois. 2006. Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. J. Biol. Chem. 281:2676–2682.
   PubMed Web of Science ®Google Scholar
• Jiang, C., X. Wan, Y. He, T. Pan, J. Jankovic, and W. Le. 2005. Age-dependent dopaminergic dysfunction in Nurr1 knockout mice. Exp. Neurol. 191:154–162.
   PubMedGoogle Scholar
• Joseph, B., A. Wallen-Mackenzie, G. Benoit, T. Murata, E. Joodmardi, S. Okret, and T. Perlmann. 2003. p57(Kip2) cooperates with Nurr1 in developing dopamine cells. Proc. Natl. Acad. Sci. USA 100:15619–15624.
   PubMedGoogle Scholar
• Kang, D. E., S. Soriano, X. Xia, C. G. Eberhart, B. De Strooper, H. Zheng, and E. H. Koo. 2002. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 110:751–762.
   PubMed Web of Science ®Google Scholar
• Killick, R., C. C. Pollard, A. A. Asuni, A. K. Mudher, J. C. Richardson, H. T. Rupniak, P. W. Sheppard, I. M. Varndell, J. P. Brion, A. I. Levey, O. A. Levy, M. Vestling, R. Cowburn, S. Lovestone, and B. H. Anderton. 2001. Presenilin 1 independently regulates beta-catenin stability and transcriptional activity. J. Biol. Chem. 276:48554–48561.
   PubMed Web of Science ®Google Scholar
• Kim, K. S., C. H. Kim, D. Y. Hwang, H. Seo, S. Chung, S. J. Hong, J. K. Lim, T. Anderson, and O. Isacson. 2003. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. J. Neurochem. 85:622–634.
   PubMed Web of Science ®Google Scholar
• Kim, S. Y., K. C. Choi, M. S. Chang, M. H. Kim, Y. S. Na, J. E. Lee, B. K. Jin, B. H. Lee, and J. H. Baik. 2006. The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr1 activation. J. Neurosci. 26:4567–4576.
   PubMedGoogle Scholar
• Kitagawa, H., R. Fujiki, K. Yoshimura, Y. Mezaki, Y. Uematsu, D. Matsui, S. Ogawa, K. Unno, M. Okubo, A. Tokita, T. Nakagawa, T. Ito, Y. Ishimi, H. Nagasawa, T. Matsumoto, J. Yanagisawa, and S. Kato. 2003. The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell 113:905–917.
   PubMed Web of Science ®Google Scholar
• Kouzmenko, A. P., K. Takeyama, S. Ito, T. Furutani, S. Sawatsubashi, A. Maki, E. Suzuki, Y. Kawasaki, T. Akiyama, T. Tabata, and S. Kato. 2004. Wnt/beta-catenin and estrogen signaling converge in vivo. J. Biol. Chem. 279:40255–40258.
   PubMed Web of Science ®Google Scholar
• Kozlovsky, N., S. Amar, R. H. Belmaker, and G. Agam. 2006. Psychotropic drugs affect Ser9-phosphorylated GSK-3 beta protein levels in rodent frontal cortex. Int. J. Neuropsychopharmacol. 9:337–342.
   PubMed Web of Science ®Google Scholar
• Le, W. D., P. Xu, J. Jankovic, H. Jiang, S. H. Appel, R. G. Smith, and D. K. Vassilatis. 2003. Mutations in NR4A2 associated with familial Parkinson disease. Nat. Genet. 33:85–89.
   PubMed Web of Science ®Google Scholar
• Liu, J., H. Wang, Y. Zuo, and S. R. Farmer. 2006. Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin. Mol. Cell. Biol. 26:5827–5837.
   PubMed Web of Science ®Google Scholar
• Maira, M., C. Martens, E. Batsche, Y. Gauthier, and J. Drouin. 2003. Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol. Cell. Biol. 23:763–776.
   PubMed Web of Science ®Google Scholar
• Morohashi, Y., N. Hatano, S. Ohya, R. Takikawa, T. Watabiki, N. Takasugi, Y. Imaizumi, T. Tomita, and T. Iwatsubo. 2002. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J. Biol. Chem. 277:14965–14975.
   PubMed Web of Science ®Google Scholar
• Mulholland, D. J., S. Dedhar, G. A. Coetzee, and C. C. Nelson. 2005. Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr. Rev. 26:898–915.
   PubMed Web of Science ®Google Scholar
• Murphy, E. P., and O. M. Conneely. 1997. Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors. Mol. Endocrinol. 11:39–47.
   PubMed Web of Science ®Google Scholar
• Nantermet, P. V., J. Xu, Y. Yu, P. Hodor, D. Holder, S. Adamski, M. A. Gentile, D. B. Kimmel, S. Harada, D. Gerhold, L. P. Freedman, and W. J. Ray. 2004. Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland. J. Biol. Chem. 279:1310–1322.
   PubMed Web of Science ®Google Scholar
• Nordzell, M., P. Aarnisalo, G. Benoit, D. S. Castro, and T. Perlmann. 2004. Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1. Biochem. Biophys. Res. Commun. 313:205–211.
   PubMedGoogle Scholar
• Palacino, J. J., M. P. Murphy, O. Murayama, K. Iwasaki, M. Fujiwara, A. Takashima, T. E. Golde, and B. Wolozin. 2001. Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion. J. Biol. Chem. 276:38563–38569.
   PubMed Web of Science ®Google Scholar
• Perissi, V., and M. G. Rosenfeld. 2005. Controlling nuclear receptors: the circular logic of cofactor cycles. Nat. Rev. Mol. Cell. Biol. 6:542–554.
   PubMed Web of Science ®Google Scholar
• Porfiri, E., B. Rubinfeld, I. Albert, K. Hovanes, M. Waterman, and P. Polakis. 1997. Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. Oncogene 15:2833–2839.
   PubMedGoogle Scholar
• Powzaniuk, M., S. McElwee-Witmer, R. L. Vogel, T. Hayami, S. J. Rutledge, F. Chen, S. Harada, A. Schmidt, G. A. Rodan, L. P. Freedman, and C. Bai. 2004. The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. Mol. Endocrinol. 18:2011–2023.
   PubMedGoogle Scholar
• Sacchetti, P., R. Carpentier, P. Segard, C. Olive-Cren, and P. Lefebvre. 2006. Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1. Nucleic Acids Res. 34:5515–5527.
   PubMed Web of Science ®Google Scholar
• Sacchetti, P., T. R. Mitchell, J. G. Granneman, and M. J. Bannon. 2001. Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism. J. Neurochem. 76:1565–1572.
   PubMed Web of Science ®Google Scholar
• Sakurada, K., M. Ohshima-Sakurada, T. D. Palmer, and F. H. Gage. 1999. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development 126:4017–4026.
   PubMed Web of Science ®Google Scholar
• Salthun-Lassalle, B., E. C. Hirsch, J. Wolfart, M. Ruberg, and P. P. Michel. 2004. Rescue of mesencephalic dopaminergic neurons in culture by low-level stimulation of voltage-gated sodium channels. J. Neurosci. 24:5922–5930.
   PubMedGoogle Scholar
• Satoh, J., and Y. Kuroda. 2002. The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines. Neuropathology 22:219–232.
   PubMedGoogle Scholar
• Saucedo-Cardenas, O., J. D. Quintana-Hau, W. D. Le, M. P. Smidt, J. J. Cox, F. De Mayo, J. P. Burbach, and O. M. Conneely. 1998. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95:4013–4018.
   PubMed Web of Science ®Google Scholar
• Sierra, J., T. Yoshida, C. A. Joazeiro, and K. A. Jones. 2006. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 20:586–600.
   PubMed Web of Science ®Google Scholar
• Singh, R., J. N. Artaza, W. E. Taylor, M. Braga, X. Yuan, N. F. Gonzalez-Cadavid, and S. Bhasin. 2006. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147:141–154.
   PubMed Web of Science ®Google Scholar
• Soriano, S., D. E. Kang, M. Fu, R. Pestell, N. Chevallier, H. Zheng, and E. H. Koo. 2001. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J. Cell Biol. 152:785–794.
   PubMed Web of Science ®Google Scholar
• Takayama, S., I. Rogatsky, L. E. Schwarcz, and B. D. Darimont. 2006. The glucocorticoid receptor represses cyclin D1 by targeting the Tcf-beta-catenin complex. J. Biol. Chem. 281:17856–17863.
   PubMed Web of Science ®Google Scholar
• Volakakis, N., M. Malewicz, B. Kadkhodai, T. Perlmann, and G. Benoit. 2006. Characterization of the Nurr1 ligand-binding domain co-activator interaction surface. J. Mol. Endocrinol. 37:317–326.
   PubMedGoogle Scholar
• Volpicelli, F., C. Perrone-Capano, P. Da Pozzo, L. Colucci-D'Amato, and U. di Porzio. 2004. Modulation of nurr1 gene expression in mesencephalic dopaminergic neurones. J. Neurochem. 88:1283–1294.
   PubMedGoogle Scholar
• Wang, Z., G. Benoit, J. Liu, S. Prasad, P. Aarnisalo, X. Liu, H. Xu, N. P. Walker, and T. Perlmann. 2003. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 423:555–560.
   PubMed Web of Science ®Google Scholar
• Wansa, K. D., J. M. Harris, and G. E. Muscat. 2002. The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. J. Biol. Chem. 277:33001–33011.
   PubMed Web of Science ®Google Scholar
• Xia, X., S. Qian, S. Soriano, Y. Wu, A. M. Fletcher, X. J. Wang, E. H. Koo, X. Wu, and H. Zheng. 2001. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. USA 98:10863–10868.
   PubMed Web of Science ®Google Scholar
• Yanagisawa, J., H. Kitagawa, M. Yanagida, O. Wada, S. Ogawa, M. Nakagomi, H. Oishi, Y. Yamamoto, H. Nagasawa, S. B. McMahon, M. D. Cole, L. Tora, N. Takahashi, and S. Kato. 2002. Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol. Cell 9:553–562.
   PubMed Web of Science ®Google Scholar
• Zetterstrom, R. H., L. Solomin, L. Jansson, B. J. Hoffer, L. Olson, and T. Perlmann. 1997. Dopamine neuron agenesis in Nurr1-deficient mice. Science 276:248–250.
   PubMed Web of Science ®Google Scholar