Interleukin-10-Induced Neutrophil Gelatinase-Associated Lipocalin Production in Macrophages with Consequences for Tumor Growth

REFERENCES

• Barra V, Kuhn AM, von Knethen A, Weigert A, Brune B. 2011. Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB. Cell. Mol. Life Sci. 68:1815–1827.
   PubMedGoogle Scholar
• Bauer M, et al. 2008. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res. Treat. 108:389–397.
   PubMed Web of Science ®Google Scholar
• Bingle L, Brown NJ, Lewis CE. 2002. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196:254–265.
   PubMed Web of Science ®Google Scholar
• Bolignano D, et al. 2010. Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 288:10–16.
   PubMed Web of Science ®Google Scholar
• Cowland JB, Muta T, Borregaard N. 2006. IL-1 beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by I kappa B-xi. J. Immunol. 176:5559–5566.
   PubMed Web of Science ®Google Scholar
• Cowland JB, Sorensen OE, Sehested M, Borregaard N. 2003. Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha. J. Immunol. 171:6630–6639.
   PubMed Web of Science ®Google Scholar
• Devireddy LR, Teodoro JG, Richard FA, Green MR. 2001. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 293:829–834.
   PubMed Web of Science ®Google Scholar
• Du ZP, Zhuo LV, Wu BL, Xu LY. 2011. Neutrophil gelatinase-associated lipocalin and its receptor: independent prognostic factors of oesophageal squamous cell carcinoma. J. Clin. Pathol. 64:69–74. [Correction, 64:113.].
   PubMed Web of Science ®Google Scholar
• Ernst M, Putoczki TL. 2012. Stat3: linking inflammation to (gastrointestinal) tumourigenesis. Clin. Exp. Pharmacol. Physiol. 39:711–718.
   PubMedGoogle Scholar
• Farre D, et al. 2003. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res. 31:3651–3653.
   PubMed Web of Science ®Google Scholar
• Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, Ogarra A. 1991. Il-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815–3822.
   PubMed Web of Science ®Google Scholar
• Fujino RS, et al. 2006. Spermatogonial cell-mediated activation of an I kappa B zeta-independent nuclear factor-kappa B pathway in Sertoli cells induces transcription of the lipocalin-2 gene. Mol. Endocrinol. 20:904–915.
   PubMed Web of Science ®Google Scholar
• Fusek M, Vetvickova J, Vetvicka V. 2007. Secretion of cytokines in breast cancer cells: the molecular mechanism of procathepsin D proliferative effects. J. Interferon Cytokine Res. 27:191–199.
   PubMedGoogle Scholar
• Goetz DH, et al. 2002. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 10:1033–1043.
   PubMed Web of Science ®Google Scholar
• Jung M, et al. 2012. Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. Kidney Int. 81:969–982.
   PubMed Web of Science ®Google Scholar
• Lau KW, Tian YM, Raval RR, Ratcliffe PJ, Pugh CW. 2007. Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br. J. Cancer 96:1284–1292.
   PubMed Web of Science ®Google Scholar
• LeClair KP, Blanar MA, Sharp PA. 1992. The P50 subunit of NF-kappa-B associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. U. S. A. 89:8145–8149.
   PubMedGoogle Scholar
• Leng XH, et al. 2009. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res. 69:8579–8584.
   PubMed Web of Science ®Google Scholar
• Lewis CE, Pollard JW. 2006. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66:605–612.
   PubMed Web of Science ®Google Scholar
• Li S, Wang N, Brodt P.22 December 2011. Metastatic cells can escape the pro-apoptotic effects of TNF-alpha through increased autocrine IL-6/STAT3 signalling. Cancer Res.https://doi.org/10.1158/0008-5472.CAN-11-1357.
   Google Scholar
• Lin EY, et al. 2006. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66:11238–11246.
   PubMed Web of Science ®Google Scholar
• Malefyt RD, Abrams J, Bennett B, Figdor CG, Devries JE. 1991. Interleukin-10 (Il-10) inhibits cytokine synthesis by human monocytes - an autoregulatory role of Il-10 produced by monocytes. J. Exp. Med. 174:1209–1220.
   PubMed Web of Science ®Google Scholar
• Mantovani A, Sica A, Locati M. 2005. Macrophage polarization comes of age. Immunity 23:344–346.
   PubMed Web of Science ®Google Scholar
• Mantovani A, et al. 2004. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25:677–686.
   PubMed Web of Science ®Google Scholar
• Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. 2002. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549–555.
   PubMed Web of Science ®Google Scholar
• Matsuo S, Yamazaki S, Takeshige K, Muta T. 2007. Crucial roles of binding sites for NF-kappa B and C/EBPs in I kappa B-zeta-mediated transcriptional activation. Biochem. J. 405:605–615.
   PubMedGoogle Scholar
• Matsusaka T, et al. 1993. Transcription factors NF-IL6 and NF-kappa-B synergistically activate transcription of the inflammatory cytokines, interleukin-6 and interleukin-8. Proc. Natl. Acad. Sci. U. S. A. 90:10193–10197.
   PubMed Web of Science ®Google Scholar
• Messeguer X, et al. 2002. PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics 18:333–334.
   PubMed Web of Science ®Google Scholar
• Mishra J, et al. 2004. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J. Am. Soc. Nephrol. 15:3073–3082.
   PubMed Web of Science ®Google Scholar
• Moore KW, Malefyt RD, Coffman RL, O'Garra A. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19:683–765.
   PubMed Web of Science ®Google Scholar
• Murdoch C, Giannoudis A, Lewis CE. 2004. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104:2224–2234.
   PubMed Web of Science ®Google Scholar
• Murray PJ. 2006. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr. Opin. Pharmacol. 6:379–386.
   PubMed Web of Science ®Google Scholar
• Numata A, et al. 2005. Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J. Biol. Chem. 280:12621–12629.
   PubMedGoogle Scholar
• Rahimi AA, Gee K, Mishra S, Lim W, Kumar A. 2005. STAT-1 mediates the stimulatory effect of IL-10 on CD14 expression in human monocytic cells. J. Immunol. 174:7823–7832.
   PubMed Web of Science ®Google Scholar
• Robb BW, Hershko DD, Paxton JH, Luo GJ, Hasselgren PO. 2002. Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells. Surgery 132:226–231.
   PubMedGoogle Scholar
• Schmidt-Ott KM, et al. 2007. Dual action of neutrophil gelatinase-associated lipocalin. J. Am. Soc. Nephrol. 18:407–413.
   PubMed Web of Science ®Google Scholar
• Schottelius AJG, Mayo MW, Sartor RB, Badwin AS. 1999. Interleukin-10 signaling blocks inhibitor of kappa B kinase activity and nuclear factor kappa B DNA binding. J. Biol. Chem. 274:31868–31874.
   PubMed Web of Science ®Google Scholar
• Sica A, Allavena P, Mantovani A. 2008. Cancer related inflammation: the macrophage connection. Cancer Lett. 267:204–215.
   PubMed Web of Science ®Google Scholar
• Sola A, et al. 2011. Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration. J. Pathol. 225:597–608.
   PubMed Web of Science ®Google Scholar
• Stein B, Cogswell PC, Baldwin AS. 1993. Functional and physical associations between NF-kappa-B and C/Ebp family members—a Rel domain-Bzip interaction. Mol. Cell. Biol. 13:3964–3974.
   PubMed Web of Science ®Google Scholar
• Stoesz SP, et al. 1998. Heterogeneous expression of the lipocalin NGAL in primary breast cancers. Int. J. Cancer 79:565–572.
   PubMed Web of Science ®Google Scholar
• Stout RD, et al. 2005. Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J. Immunol. 175:342–349.
   PubMed Web of Science ®Google Scholar
• Tanaka N, et al. 2005. Interleukin-10 induces inhibitory C/EBP beta through STAT-3 and represses HIV-1 transcription in macrophages. Am. J. Respir. Cell Mol. 33:406–411.
   Google Scholar
• Tausendschon M, Dehne N, Brune B. 2011. Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity. Cytokine 53:256–262.
   PubMed Web of Science ®Google Scholar
• von Knethen A, Lotero A, Brune B. 1998. Etoposide and cisplatin induced apoptosis in activated RAW264.7 macrophages is attenuated by cAMP-induced gene expression. Oncogene 17:387–394.
   PubMedGoogle Scholar
• Weber-Nordt RM, Gabler A, Janson C, Weber F, Ho AD. 1999. Constitutive STAT3-DNA binding coincides with a single amino acid exchange in the aminoterminal domain of the STAT3 protein in acute meyloid leukemia. Blood 94:75a.
   Google Scholar
• Wen H, Andrejka L, Ashton J, Karess R, Lipsick JS. 2008. Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF via the Myb-MuvB/dREAM complex. Genes Dev. 22:601–614.
   PubMed Web of Science ®Google Scholar
• Williams L, Bradley L, Smith A, Foxwell B. 2004. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J. Immunol. 172:567–576.
   PubMed Web of Science ®Google Scholar
• Xiong H, et al. 2012. Roles of STAT3 and ZEB1 in E-cadherin downregulation and human colorectal cancer epithelial-mesenchymal transition. J. Biol. Chem. 287:5819–5832.
   PubMedGoogle Scholar
• Yan QW, et al. 2007. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 56:2533–2540.
   PubMed Web of Science ®Google Scholar
• Yu JL, Rak JW. 2003. Host microenvironment in breast cancer development—inflammatory and immune cells in tumour angiogenesis and arteriogenesis. Breast Cancer Res. 5:83–88.
   PubMed Web of Science ®Google Scholar
• Zhang KM, Guo W, Yang Y, Wu JR. 2011. JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBP beta transcription. J. Cell Biochem. 112:488–497.
   PubMed Web of Science ®Google Scholar