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Article

Genetic Evidence of an Evolutionarily Conserved Role for Nrf2 in the Protection against Oxidative Stress

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Pages 4455-4461 | Received 11 Apr 2012, Accepted 25 Aug 2012, Published online: 20 Mar 2023

REFERENCES

  • Aleström P, Holter JL, Nourizadeh-Lillabadi R. 2006. Zebrafish in functional genomics and aquatic biomedicine. Trends Biotechnol. 24:15–21.
  • An JH, Blackwell TK. 2003. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 17:1882–1893.
  • Anderson ME. 1998. Glutathione: an overview of biosynthesis and modulation. Chem. Biol. Interact. 111–112:1–14.
  • Berggren MI, et al. 2001. Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin. Arch. Biochem. Biophys. 392:103–109.
  • Bowerman B, Eaton BA, Priess JR. 1992. skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell 68:1061–1075.
  • Chan K, Lu R, Chang JC, Kan YW. 1996. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl. Acad. Sci. U. S. A. 93:13943–13948.
  • Chan K, Han XD, Kan YW. 2001. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. U. S. A. 98:4611–4616.
  • Chen Y, Chan PH, Swanson RA. 2001. Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury. Glia 33:343–347.
  • Cortes-Wanstreet MM, Giedzinski E, Limoli CL, Luderer U. 2009. Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and γ-radiation-induced cell death. Mutagenesis 24:211–224.
  • Enomoto A, et al. 2001. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci. 59:169–177.
  • Fahey JW, et al. 2002. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. U. S. A. 99:7610–7615.
  • Gerhard GS. 2007. Small laboratory fish as models for aging research. Ageing Res. Rev. 6:64–72.
  • Haffter P, et al. 1996. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123:1–36.
  • Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT. 2010. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. Antioxid. Redox. Signal. 13:1713–1748.
  • Higgins LG, et al. 2009. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicol. Appl. Pharmacol. 237:267–280.
  • Ho YS, et al. 1998. Reduced fertility in female mice lacking copper-zinc superoxide dismutase. J. Biol. Chem. 273:7765–7769.
  • Ilizarov AM, et al. 2001. Overexpression of manganese superoxide dismutase protects lung epithelial cells against oxidant injury. Am. J. Respir. Cell Mol. Biol. 24:436–441.
  • Itoh K, Igarashi K, Hayashi N, Nishizawa M, Yamamoto M. 1995. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol. Cell. Biol. 15:4184–4193.
  • Itoh K, et al. 1997. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236:313–322.
  • Itoh K, Mimura J, Yamamoto M. 2010. Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid. Redox. Signal. 13:1665–1678.
  • Jung KA, Kwak MK. 2010. The Nrf2 system as a potential target for the development of indirect antioxidants. Molecules 15:7266–7291.
  • Kensler TW, Wakabayashi N, Biswal S. 2007. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47:89–116.
  • Kishi S, et al. 2008. The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet. 4:e1000152. https://doi.org/10.1371/journal.pgen.1000152.
  • Kishi S, Slack BE, Uchiyama J, Zhdanova IV. 2009. Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates—a mini-review. Gerontology 55:430–441.
  • Kobayashi M, Nishikawa K, Suzuki T, Yamamoto M. 2001. The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. Dev. Biol. 232:315–326.
  • Kobayashi M, et al. 2002. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 7:807–820.
  • Kobayashi M, Yamamoto M. 2005. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid. Redox. Signal. 7:385–394.
  • Kobayashi M, Yamamoto M. 2006. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzyme Regul. 46:113–140.
  • Kobayashi M, et al. 2009. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol. Cell. Biol. 29:493–502.
  • Li L, et al. 2008. Molecular evolution of Keap1: two Keap1 molecules with distinctive intervening region structures are conserved among fish. J. Biol. Chem. 283:3248–3255.
  • Mizuno K, et al. 2011. Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)–antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. J. Pharmacol. Sci. 115:320–328.
  • Moens CB, Donn TM, Wolf-Saxon ER, Ma TP. 2008. Reverse genetics in zebrafish by TILLING. Brief Funct. Genomic Proteomics 7:454–459.
  • Mohler J, Mahaffey JW, Deutsch E, Vani K. 1995. Control of Drosophila head segment identity by the bZIP homeotic gene cnc. Development 121:237–247.
  • Nakajima H, et al. 2011. Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One 6:e26884. https://doi.org/10.1371/journal.pone.0026884.
  • Neumann CA, et al. 2003. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424:561–565.
  • Pearson KJ, et al. 2008. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc. Natl. Acad. Sci. U. S. A. 105:2325–2330.
  • Roberts RA, et al. 2009. Nitrative and oxidative stress in toxicology and disease. Toxicol. Sci. 112:4–16.
  • Scholz S, et al. 2008. The zebrafish embryo model in environmental risk assessment—applications beyond acute toxicity testing. Environ. Sci. Pollut. Res. Int. 15:394–404.
  • Shi S, et al. 2007. Over expression of glutamate cysteine ligase increases cellular resistance to H2O2-induced DNA single-strand breaks. Cytometry A 71:686–692.
  • Shi X, Zhou B. 2010. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol. Sci. 115:391–400.
  • Suzuki T, et al. 2005. Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved regulatory element in zebrafish. Biochem. J. 388:65–73.
  • Suzuki T, et al. 2008. Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2. J. Biol. Chem. 283:2021–2030.
  • Sykiotis GP, Bohmann D. 2008. Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev. Cell 14:76–85.
  • Takagi Y, et al. 2004. MafT, a new member of the small Maf protein family in zebrafish. Biochem. Biophys. Res. Commun. 320:62–69.
  • Timme-Laragy AR, et al. 2012. Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). J. Biol. Chem. 287:4609–4627.
  • Toyama T, et al. 2011. Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury. Environ. Health Perspect. 119:1117–1122.
  • Tsujita T, et al. 2011. Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish. Genes Cells 16:46–57.
  • Tsutsui T, et al. 2003. Adenoviral transfection of hepatocytes with the thioredoxin gene confers protection against apoptosis and necrosis. Biochem. Biophys. Res. Commun. 307:765–770.
  • Vijayavel K, Gopalakrishnan S, Thilagam H, Balasubramanian MP. 2006. Dietary ascorbic acid and α-tocopherol mitigates oxidative stress induced by copper in the thornfish Terapon jarbua. Sci. Total Environ. 372:157–163.
  • Villeneuve NF, Lau A, Zhang DD. 2010. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid. Redox. Signal. 13:1699–1712.
  • Waagbø R, et al. 2003. Cataract formation in Atlantic salmon, Salmo salar L., smolt relative to dietary pro- and antioxidants and lipid level. J. Fish Dis. 26:213–229.
  • Welker TL, Congleton JL. 2009. Effect of dietary α-tocopherol + ascorbic acid, selenium, and iron on oxidative stress in sub-yearling Chinook salmon (Oncorhynchus tshawytscha Walbaum). J. Anim. Physiol. Anim. Nutr. 93:15–25.
  • Wienholds E, et al. 2003. Efficient target-selected mutagenesis in zebrafish. Genome Res. 13:2700–2707.
  • Xu C, et al. 2006. Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. Cancer Res. 66:8293–8296.
  • Yanaka A, et al. 2009. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev. Res. 2:353–360.

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