Fission Yeast Pot1 and RecQ Helicase Are Required for Efficient Chromosome Segregation

REFERENCES

• Arnoult, N., C. Saintome, I. Ourliac-Garnier, J. F. Riou, and A. Londono-Vallejo. 2009. Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev. 23:2915–2924.
   PubMed Web of Science ®Google Scholar
• Bachrati, C. Z., and I. D. Hickson. 2003. RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem. J. 374:577–606.
   PubMed Web of Science ®Google Scholar
• Baumann, P. 2006. Are mouse telomeres going to pot? Cell 126:33–36.
   PubMedGoogle Scholar
• Baumann, P., and T. R. Cech. 2001. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292:1171–1175.
   PubMed Web of Science ®Google Scholar
• Baumann, P., and T. R. Cech. 2000. Protection of telomeres by the Ku protein in fission yeast. Mol. Biol. Cell 11:3265–3275.
   PubMedGoogle Scholar
• Bonetti, D., M. Martina, M. Clerici, G. Lucchini, and M. P. Longhese. 2009. Multiple pathways regulate 3′ overhang generation at S. cerevisiae telomeres. Mol. Cell 35:70–81.
   PubMed Web of Science ®Google Scholar
• Carneiro, T., et al. 2010. Telomeres avoid end detection by severing the checkpoint signal transduction pathway. Nature 467:228–232.
   PubMedGoogle Scholar
• Churikov, D., C. Wei, and C. M. Price. 2006. Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Mol. Cell. Biol. 26:6971–6982.
   PubMed Web of Science ®Google Scholar
• Cobb, J. A., and L. Bjergbaek. 2006. RecQ helicases: lessons from model organisms. Nucleic Acids Res. 34:4106–4114.
   PubMedGoogle Scholar
• Cooper, J. P., E. R. Nimmo, R. C. Allshire, and T. R. Cech. 1997. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385:744–747.
   PubMed Web of Science ®Google Scholar
• Crabbe, L., R. E. Verdun, C. I. Haggblom, and J. Karlseder. 2004. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306:1951–1953.
   PubMed Web of Science ®Google Scholar
• Doe, C. L., J. Dixon, F. Osman, and M. C. Whitby. 2000. Partial suppression of the fission yeast rqh1− phenotype by expression of a bacterial Holliday junction resolvase. EMBO J. 19:2751–2762.
   PubMedGoogle Scholar
• Ekwall, K., et al. 1996. Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J. Cell Sci. 109 (11):2637–2648.
   PubMed Web of Science ®Google Scholar
• Gray, J. T., D. W. Celander, C. M. Price, and T. R. Cech. 1991. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell 67:807–814.
   PubMedGoogle Scholar
• Hockemeyer, D., J. P. Daniels, H. Takai, and T. de Lange. 2006. Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126:63–77.
   PubMed Web of Science ®Google Scholar
• Hockemeyer, D., A. J. Sfeir, J. W. Shay, W. E. Wright, and T. de Lange. 2005. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24:2667–2678.
   PubMed Web of Science ®Google Scholar
• Hope, J. C., S. M. Mense, M. Jalakas, J. Mitsumoto, and G. A. Freyer. 2006. Rqh1 blocks recombination between sister chromatids during double strand break repair, independent of its helicase activity. Proc. Natl. Acad. Sci. U. S. A. 103:5875–5880.
   PubMedGoogle Scholar
• Jain, D., A. K. Hebden, T. M. Nakamura, K. M. Miller, and J. P. Cooper. 2010. HAATI survivors replace canonical telomeres with blocks of generic heterochromatin. Nature 467:223–227.
   PubMed Web of Science ®Google Scholar
• Kibe, T., Y. Ono, K. Sato, and M. Ueno. 2007. Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss. Mol. Biol. Cell 18:2378–2387.
   PubMedGoogle Scholar
• Laud, P. R., et al. 2005. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 19:2560–2570.
   PubMed Web of Science ®Google Scholar
• Laursen, L. V., E. Ampatzidou, A. H. Andersen, and J. M. Murray. 2003. Role for the fission yeast RecQ helicase in DNA repair in G2. Mol. Cell. Biol. 23:3692–3705.
   PubMed Web of Science ®Google Scholar
• Lundblad, V., and E. H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues est1− senescence. Cell 73:347–360.
   PubMed Web of Science ®Google Scholar
• Miller, K. M., and J. P. Cooper. 2003. The telomere protein Taz1 is required to prevent and repair genomic DNA breaks. Mol. Cell 11:303–313.
   PubMedGoogle Scholar
• Miller, K. M., O. Rog, and J. P. Cooper. 2006. Semi-conservative DNA replication through telomeres requires Taz1. Nature 440:824–828.
   PubMed Web of Science ®Google Scholar
• Mimitou, E. P., and L. S. Symington. 2008. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455:770–774.
   PubMed Web of Science ®Google Scholar
• Miyoshi, T., J. Kanoh, M. Saito, and F. Ishikawa. 2008. Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science 320:1341–1344.
   PubMed Web of Science ®Google Scholar
• Muramatsu, Y., H. Tahara, T. Ono, T. Tsuruo, and H. Seimiya. 2008. Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation. Exp. Cell Res. 314:1115–1124.
   PubMedGoogle Scholar
• Muris, D. F., et al. 1993. Cloning the RAD51 homologue of Schizosaccharomyces pombe. Nucleic Acids Res. 21:4586–4591.
   PubMedGoogle Scholar
• Murray, J. M., H. D. Lindsay, C. A. Munday, and A. M. Carr. 1997. Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance. Mol. Cell. Biol. 17:6868–6875.
   PubMed Web of Science ®Google Scholar
• Nakamura, K., et al. 2008. Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe. EMBO J. 27:3036–3046.
   PubMed Web of Science ®Google Scholar
• Nakamura, T. M., J. P. Cooper, and T. R. Cech. 1998. Two modes of survival of fission yeast without telomerase. Science 282:493–496.
   PubMed Web of Science ®Google Scholar
• Ono, Y., et al. 2003. A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation. Nucleic Acids Res. 31:7141–7149.
   PubMed Web of Science ®Google Scholar
• Opresko, P. L., et al. 2005. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J. Biol. Chem. 280:32069–32080.
   PubMed Web of Science ®Google Scholar
• Rog, O., K. M. Miller, M. G. Ferreira, and J. P. Cooper. 2009. Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres. Mol. Cell 33:559–569.
   PubMed Web of Science ®Google Scholar
• Sato, M., S. Dhut, and T. Toda. 2005. New drug-resistant cassettes for gene disruption and epitope tagging in Schizosaccharomyces pombe. Yeast 22:583–591.
   PubMed Web of Science ®Google Scholar
• Seimiya, H., Y. Muramatsu, S. Smith, and T. Tsuruo. 2004. Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation. Mol. Cell. Biol. 24:1944–1955.
   PubMed Web of Science ®Google Scholar
• Stewart, E., C. R. Chapman, F. Al-Khodairy, A. M. Carr, and T. Enoch. 1997. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J. 16:2682–2692.
   PubMed Web of Science ®Google Scholar
• Sugawara, N. 1988. DNA sequences at the telomeres of the fission yeast S. pombe. Ph.D. thesis. Harvard University, Cambridge, MA.
   Google Scholar
• Tanaka, K., et al. 1999. Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation. Mol. Cell. Biol. 19:8660–8672.
   PubMed Web of Science ®Google Scholar
• Tatebayashi, K., J. Kato, and H. Ikeda. 1998. Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis. Genetics 148: 49–57.
   PubMedGoogle Scholar
• Tomita, K., and J. P. Cooper. 2008. Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller. Genes Dev. 22:3461–3474.
   PubMedGoogle Scholar
• van den Bosch, M., et al. 2001. Characterization of RAD52 homologs in the fission yeast Schizosaccharomyces pombe. Mutat. Res. 461:311–323.
   PubMedGoogle Scholar
• Veldman, T., K. T. Etheridge, and C. M. Counter. 2004. Loss of hPot1 function leads to telomere instability and a cut-like phenotype. Curr. Biol. 14:2264–2270.
   PubMed Web of Science ®Google Scholar
• Wang, X., and P. Baumann. 2008. Chromosome fusions following telomere loss are mediated by single-strand annealing. Mol. Cell 31:463–473.
   PubMed Web of Science ®Google Scholar
• Win, T. Z., H. W. Mankouri, I. D. Hickson, and S. W. Wang. 2005. A role for the fission yeast Rqh1 helicase in chromosome segregation. J. Cell Sci. 118:5777–5784.
   PubMedGoogle Scholar
• Wu, L., et al. 2006. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126: 49–62.
   PubMed Web of Science ®Google Scholar
• Xhemalce, B., J. S. Seeler, G. Thon, A. Dejean, and B. Arcangioli. 2004. Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. EMBO J. 23:3844–3853.
   PubMedGoogle Scholar
• Yang, Q., Y. L. Zheng, and C. C. Harris. 2005. POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol. 25:1070–1080.
   PubMedGoogle Scholar
• Zhu, Z., W. H. Chung, E. Y. Shim, S. E. Lee, and G. Ira. 2008. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134:981–994.
   PubMed Web of Science ®Google Scholar