An Inducible Enhancer Required for Il12b Promoter Activity in an Insulated Chromatin Environment

REFERENCES

• Agalioti, T., S. Lomvardas, B. Parekh, J. Yie, T. Maniatis, and D. Thanos. 2000. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell 103:667–678.
   PubMed Web of Science ®Google Scholar
• Agarwal, S., and A. Rao. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9:765–775.
   PubMed Web of Science ®Google Scholar
• Agarwal, S., O. Avni, and A. Rao. 2000. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12:643–652.
   PubMedGoogle Scholar
• Berkowitz, L. A., K. T. Riabowol, and M. Z. Gilman. 1989. Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol. Cell. Biol. 9:4272–4281.
   PubMed Web of Science ®Google Scholar
• Bertolino, E., and H. Singh. 2002. POU/TBP cooperativity: a mechanism for enhancer action from a distance. Mol. Cell 10:397–407.
   PubMedGoogle Scholar
• Bradley, M. N., L. Zhou, and S. T. Smale. 2003. C/EBPβ regulation in lipopolysaccharide-stimulated macrophages. Mol. Cell. Biol. 23:4841–4858.
   PubMedGoogle Scholar
• Brightbill, H. D., S. E. Plevy, R. L. Modlin, and S. T. Smale. 2000. A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. J. Immunol. 164:1940–1951.
   PubMed Web of Science ®Google Scholar
• Carey, M., and S. T. Smale. 2000. Transcriptional regulation in eukaryotes. Concepts, strategies, and techniques. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
   Google Scholar
• Corcoran, L. M., M. Karvelas, G. J. V. Nossal, Z. S. Ye, T. Jacks, and D. Baltimore. 1993. Oct-2, although not required for early B cell development, is critical for later B cell maturation and for postnatal survival. Genes Dev. 7:570–582.
   PubMed Web of Science ®Google Scholar
• Dunn, T. L., I. L. Ross, and D. A. Hume. 1996. Transcription factor Oct-2 is expressed in primary murine macrophages. Blood 88:4072.
   PubMed Web of Science ®Google Scholar
• Gstaiger, M., L. Knoepfel, O. Georgiev, W. Schaffner, and C. M. Hovens. 1995. A B-cell coactivator of octamer-binding transcription factors. Nature 373:360–362.
   PubMed Web of Science ®Google Scholar
• Hatzis, P., and I. Talianidis. 2002. Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol. Cell 10:1467–1477.
   PubMed Web of Science ®Google Scholar
• Hunter, C. A. 2005. New IL-12 family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5:521–531.
   PubMed Web of Science ®Google Scholar
• Jankovic, D., M. C. Kullberg, S. Hieny, P. Caspar, C. M. Collazo, and A. Sher. 2002. In the absence of IL-12, CD4+ T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10−/− setting. Immunity 16:429–439.
   PubMed Web of Science ®Google Scholar
• Kim, H. P., and W. J. Leonard. 2002. The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. EMBO J. 21:3051–3059.
   PubMedGoogle Scholar
• Kim, H. P., J. Kelly, and W. J. Leonard. 2001. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity 15:159–172.
   PubMed Web of Science ®Google Scholar
• Kim, Y. M., C. B. Ko, Y. P. Park, Y. J. Kim, and S. G. Paik. 1999. Octamer motif is required for the NF-kappaB-mediated induction of the inducible nitric oxide synthase gene expression in RAW 264.7 macrophages. Mol. Cells 9:99–109.
   PubMedGoogle Scholar
• Konig, H., P. Pfisterer, L. M. Corcoran, and T. Wirth. 1995. Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Genes Dev. 9:1598–1607.
   PubMed Web of Science ®Google Scholar
• Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965–1977.
   PubMed Web of Science ®Google Scholar
• Lécine, P., M. Algarté, P. Rameil, C. Beadling, P. Bucher, M. Nabholz, and J. Imbert. 1996. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene. Mol. Cell. Biol. 16:6829–6840.
   PubMed Web of Science ®Google Scholar
• Lin, B. B., S. L. Cross, N. F. Halden, D. G. Roman, M. B. Toledano, and W. J. Leonard. 1990. Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene. Mol. Cell. Biol. 10:850–853.
   PubMedGoogle Scholar
• Luo, Y., H. Fujii, T. Gerster, and R. G. Roeder. 1992. A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell 71:231–241.
   PubMed Web of Science ®Google Scholar
• Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183:147–157.
   PubMed Web of Science ®Google Scholar
• Ma, X., and G. Trinchieri. 2001. Regulation of interleukin-12 production in antigen-presenting cells. Adv. Immunol. 79:55–92.
   PubMed Web of Science ®Google Scholar
• Maniatis, T., J. V. Falvo, T. H. Kim, T. K. Kim, C. H. Lin, B. S. Parekh, and M. G. Wathelet. 1998. Structure and function of the interferon-beta enhanceosome. Cold Spring Harbor Symp. Quant. Biol. 63:609–620.
   PubMedGoogle Scholar
• Matthias, P. 1998. Lymphoid-specific transcription mediated by the conserved octamer site: who is doing what? Semin. Immunol. 10:155–163.
   PubMedGoogle Scholar
• Merika, M., A. J. Williams, G. Chen, T. Collins, and D. Thanos. 1998. Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol. Cell 1:277–287.
   PubMed Web of Science ®Google Scholar
• Muljo, S. A., and M. S. Schlissel. 2002. The variable, C(H)1, C(H)2, and C(H)3 domains of Ig heavy chain are dispensable for pre-BCR function in transgenic mice. Int. Immunol. 14:577–584.
   PubMedGoogle Scholar
• Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao, S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292:1907–1910.
   PubMed Web of Science ®Google Scholar
• Munshi, N., Y. Yie, M. Merika, K. Senger, S. Lomvardas, T. Agalioti, and D. Thanos. 1999. The IFN-beta enhancer: a paradigm for understanding activation and repression of inducible gene expression. Cold Spring Harbor Symp. Quant. Biol. 64:149–159.
   PubMedGoogle Scholar
• Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258–5267.
   PubMed Web of Science ®Google Scholar
• Neumann, M., H. Fries, C. Scheicher, P. Keikavoussi, A. Kolb-Maurer, E. Brocker, E. Serfling, and E. Kampgen. 2000. Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells. Blood 95:277–285.
   PubMed Web of Science ®Google Scholar
• Plevy, S. E., J. H. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572–4588.
   PubMed Web of Science ®Google Scholar
• Ramirez-Carrozzi, V. R., A. A. Nazarian, C. C. Li, S. L Gore, R. Sridharan, A. N. Imbalzano, and S. T. Smale. 2006. Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response. Genes Dev. 20:282–296.
   PubMed Web of Science ®Google Scholar
• Sanjabi, S., A. Hoffmann, H. C. Liou, D. Baltimore, and S. T. Smale. 2000. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc. Natl. Acad. Sci. USA 97:12705–12710.
   PubMed Web of Science ®Google Scholar
• Sanjabi, S., K. J. Williams, S. Saccani, L. Zhou, A. Hoffmann, G. Ghosh, S. Gerondakis, G. Natoli, and S. T. Smale. 2005. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 19:2138–2151.
   PubMedGoogle Scholar
• Schubart, D. B., A. Rolink, M. H. Kosco-Vilbois, F. Botteri, and P. Matthias. 1996. B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature 383:538–542.
   PubMed Web of Science ®Google Scholar
• Smale, S. T., and A. G. Fisher. 2002. Chromatin structure and gene regulation in the immune system. Annu. Rev. Immunol. 20:427–462.
   PubMedGoogle Scholar
• Spilianakis, C. G., and R. A. Flavell. 2004. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat. Immunol. 5:1017–1027.
   PubMed Web of Science ®Google Scholar
• Strubin, M., J. W. Newell, and P. Matthias. 1995. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497–506.
   PubMed Web of Science ®Google Scholar
• Takemoto, N., N. Koyano-Nakagawa, T. Yokota, N. Arai, S. Miyatake, and K. Arai. 1998. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Int. Immunol. 10:1981–1985.
   PubMedGoogle Scholar
• Tone, Y., S. A. Thompson, J. M. Babik, K. F. Nolan, M. Tone, C. Raven, and H. Waldmann. 1996. Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur. J. Immunol. 26:1222–1227.
   PubMed Web of Science ®Google Scholar
• Treisman, R. 1992. The serum response element. Trends Biochem. Sci. 17:423–426.
   PubMed Web of Science ®Google Scholar
• Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133–146.
   PubMed Web of Science ®Google Scholar
• Verrijzer, C. P., and P. C. Van der Vliet. 1993. POU domain transcription factors. Biochim. Biophys. Acta 1173:1–21.
   PubMedGoogle Scholar
• Wang, V. E., T. Schmidt, J. Chen, P. A. Sharp, and D. Tantin. 2004. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol. Cell. Biol. 24:1022–1032.
   PubMedGoogle Scholar
• Wegner, M., D. W. Drolet, and M. G. Rosenfeld. 1993. POU-domain proteins: structure and function of developmental regulators. Curr. Opin. Cell Biol. 5:488–498.
   PubMedGoogle Scholar
• Weinmann, A. S., D. M. Mitchell, S. Sanjabi, M. N. Bradley, A. Hoffmann, H. C. Liou, and S. T. Smale. 2001. Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nat. Immunol. 2:51–57.
   PubMedGoogle Scholar
• Weinmann, A. S., S. E. Plevy, and S. T. Smale. 1999. Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription. Immunity 11:665–675.
   PubMed Web of Science ®Google Scholar
• Yeh, J. H., P. Lecine, J. A. Nunes, S. Spicuglia, P. Ferrier, D. Olive, and J. Imbert. 2001. Novel CD28-responsive enhancer activated by CREB/ATF and AP-1 families in the human interleukin-2 receptor alpha-chain locus. Mol. Cell. Biol. 21:4515–4527.
   PubMed Web of Science ®Google Scholar
• Yui, M. A., G. Hernandez-Hoyos, and E. V. Rothenberg. 2001. A new regulatory region of the IL-2 locus that confers position-independent transgene expression. J. Immunol. 166:1730–1739.
   PubMedGoogle Scholar
• Zhou, L., A. A. Nazarian, and S. T. Smale. 2004. Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway. Mol. Cell. Biol. 24:2385–2396.
   PubMed Web of Science ®Google Scholar
• Zhu, C., K. Gagnidze, J. H. Gemberling, and S. E. Plevy. 2001. Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approach. J. Biol. Chem. 276:18519–18528.
   PubMedGoogle Scholar
• Zhu, C., K. Rao, H. Xiong, K. Gagnidze, F. Li, C. Horvath, and S. Plevy. 2003. Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. J. Biol. Chem. 278:39372–39382.
   PubMedGoogle Scholar