MBD2 and Multiple Domains of CHD4 Are Required for Transcriptional Repression by Mi-2/NuRD Complexes

REFERENCES

• Agalioti T, et al. 2000. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter. Cell 103:667–678.
   PubMed Web of Science ®Google Scholar
• Aguilera C, et al. 2011. c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. Nature 469:231–235.
   PubMedGoogle Scholar
• Bouazoune K, et al. 2002. The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J. 21:2430–2440.
   PubMed Web of Science ®Google Scholar
• Durr H, Korner C, Muller M, Hickmann V, Hopfner KP. 2005. X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA. Cell 121:363–373.
   PubMedGoogle Scholar
• Fujita N, et al. 2004. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 119:75–86.
   PubMedGoogle Scholar
• Gao H, et al. 2009. Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc. Natl. Acad. Sci. U. S. A. 106:11258–11263.
   PubMedGoogle Scholar
• Gnanapragasam MN, et al. 2011. p66α-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex. Proc. Natl. Acad. Sci. U. S. A. 108:7487–7492.
   PubMed Web of Science ®Google Scholar
• Gregory GD, et al. 2010. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood 115:2156–2166.
   PubMed Web of Science ®Google Scholar
• Harju-Baker S, Costa FC, Fedosyuk H, Neades R, Peterson KR. 2008. Silencing of Aγ-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the −566 GATA site. Mol. Cell Biol. 28:3101–3113.
   PubMed Web of Science ®Google Scholar
• Harker N, et al. 2011. Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development. J. Immunol. 186:6368–6377.
   PubMedGoogle Scholar
• Hauk G, McKnight JN, Nodelman IM, Bowman GD. 2010. The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor. Mol. Cell 39:711–723.
   PubMedGoogle Scholar
• Hendrich B, Tweedie S. 2003. The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends Genet. 19:269–277.
   PubMed Web of Science ®Google Scholar
• Hombach J, Tsubata T, Leclerq L, Stappert H, Reth M. 1990. Molecular components of the B-cell antigen receptor complex of the IgM class. Nature 343:760–762.
   PubMed Web of Science ®Google Scholar
• Hu G, Wade PA. 2012. NuRD and pluripotency: a complex balancing act. Cell Stem Cell 10:497–503.
   PubMedGoogle Scholar
• Hutchins AS, et al. 2002. Gene silencing quantitatively controls the function of a developmental trans-activator. Mol. Cell 10:81–91.
   PubMed Web of Science ®Google Scholar
• Kaji K, et al. 2006. The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat. Cell Biol. 8:285–292.
   PubMed Web of Science ®Google Scholar
• Kaji K, Nichols J, Hendrich B. 2007. Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Development 134:1123–1132.
   PubMedGoogle Scholar
• Kim J, et al. 1999. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10:345–355.
   PubMed Web of Science ®Google Scholar
• Kransdorf EP, et al. 2006. MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells. Blood 108:2836–2845.
   PubMedGoogle Scholar
• Lai AY, Wade PA. 2011. Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat. Rev. Cancer 11:588–596.
   PubMedGoogle Scholar
• Le Guezennec X, et al. 2006. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol. Cell Biol. 26:843–851.
   PubMed Web of Science ®Google Scholar
• Lejon S, et al. 2011. Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48.FOG-1 complex. J. Biol. Chem. 286:1196–1203.
   PubMed Web of Science ®Google Scholar
• Lin YC, et al. 2010. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat. Immunol. 11:635–643.
   PubMed Web of Science ®Google Scholar
• Lukin K, et al. 2010. Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc. Natl. Acad. Sci. U. S. A. 107:7869–7874.
   PubMedGoogle Scholar
• Magdinier F, Wolffe AP. 2001. Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. Proc. Natl. Acad. Sci. U. S. A. 98:4990–4995.
   PubMedGoogle Scholar
• Maier H, Colbert J, Fitzsimmons D, Clark DR, Hagman J. 2003. Activation of the early B-cell-specific mb-1 (Ig-α) gene by Pax-5 is dependent on an unmethylated Ets binding site. Mol. Cell Biol. 23:1946–1960.
   PubMed Web of Science ®Google Scholar
• Maier H, et al. 2004. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat. Immunol. 5:1069–1077.
   PubMedGoogle Scholar
• Mansfield RE, et al. 2011. Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J. Biol. Chem. 286:11779–11791.
   PubMed Web of Science ®Google Scholar
• Mian OY, et al. 2011. Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells. Mol. Cancer Res. 9:1152–1162.
   PubMedGoogle Scholar
• Miccio A, Blobel GA. 2010. Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol. Cell Biol. 30:3460–3470.
   PubMedGoogle Scholar
• Miccio A, et al. 2010. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J. 29:442–456.
   PubMedGoogle Scholar
• Morra R, Lee BM, Shaw H, Tuma R, Mancini EJ. 2012. Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4. FEBS Lett. 586:2513–2521.
   PubMedGoogle Scholar
• Musselman CA, et al. 2009. Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem. J. 423:179–187.
   PubMed Web of Science ®Google Scholar
• Musselman CA, et al. 2012. Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proc. Natl. Acad. Sci. U. S. A. 109:787–792.
   PubMedGoogle Scholar
• Naito T, Gómez-Del Arco P, Williams CJ, Georgopoulos K. 2007. Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2β determine silencer activity and Cd4 gene expression. Immunity 27:723–734.
   PubMed Web of Science ®Google Scholar
• Ramirez-Carrozzi VR, et al. 2006. Selective and antagonistic properties of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response. Genes Dev. 20:282–296.
   PubMed Web of Science ®Google Scholar
• Reynolds N, et al. 2012. NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell 10:583–594.
   PubMedGoogle Scholar
• Reynolds N, et al. 2012. NuRD-mediated deacetylation of H3K27 facilitates recruitment of polycomb repressive complex 2 to direct gene repression. EMBO J. 31:593–605.
   PubMed Web of Science ®Google Scholar
• Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD. 2006. Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 103:6617–6622.
   PubMedGoogle Scholar
• Rupon JW, Wang SZ, Gnanapragasam M, Labropoulos S, Ginder GD. 2011. MBD2 contributes to developmental silencing of the human epsilon-globin gene. Blood Cells Mol. Dis. 46:212–219.
   PubMedGoogle Scholar
• Saito M, Ishikawa F. 2002. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J. Biol. Chem. 277:35434–35439.
   PubMedGoogle Scholar
• Sillibourne JE, Delaval B, Redick S, Sinha M, Doxsey SJ. 2007. Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. Mol. Biol. Cell 18:3667–3680.
   PubMedGoogle Scholar
• Sridharan R, Smale ST. 2007. Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J. Biol. Chem. 282:30227–30238.
   PubMedGoogle Scholar
• Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM. 2003. CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system. Oncogene 22:1002–1011.
   PubMed Web of Science ®Google Scholar
• Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. 1998. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 395:917–921.
   PubMed Web of Science ®Google Scholar
• Treiber T, et al. 2010. Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription-independent poising of chromatin. Immunity 32:714–725.
   PubMedGoogle Scholar
• Wang Y, et al. 2009. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 138:660–672.
   PubMed Web of Science ®Google Scholar
• Wang Z, et al. 2009. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138:1019–1031.
   PubMed Web of Science ®Google Scholar
• Watson AA, et al. 2012. The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J. Mol. Biol. 422:3–17.
   PubMed Web of Science ®Google Scholar
• Xie W, et al. 2012. The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions. Proc. Natl. Acad. Sci. U. S. A. 109:8161–8166.
   PubMed Web of Science ®Google Scholar
• Xue Y, et al. 1998. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol. Cell 2:851–861.
   PubMed Web of Science ®Google Scholar
• Yildirim O, et al. 2011. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell 147:1498–1510.
   PubMed Web of Science ®Google Scholar
• Zhang J, et al. 2012. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nat. Immunol. 13:86–94.
   PubMedGoogle Scholar
• Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D. 1998. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell 95:279–289.
   PubMed Web of Science ®Google Scholar
• Zhang Y, et al. 1999. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13:1924–1935.
   PubMed Web of Science ®Google Scholar
• Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T. 2003. Inhibition of p300/CBP by early B-cell factor. Mol. Cell. Biol. 23:3837–3846.
   PubMedGoogle Scholar