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Article

Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover

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Pages 1272-1286 | Received 02 Oct 2015, Accepted 01 Feb 2016, Published online: 18 Mar 2023

REFERENCES

  • Kass DJ. 2011. Cytokine-like factor 1 (CLF1): life after development? Cytokine 55:325–329. http://dx.doi.org/10.1016/j.cyto.2011.05.021.
  • Fischer P, Hilfiker-Kleiner D. 2007. Survival pathways in hypertrophy and heart failure: the gp130-STAT axis. Basic Res Cardiol 102:393–411. http://dx.doi.org/10.1007/s00395-007-0674-z.
  • Elson GC, Graber P, Losberger C, Herren S, Gretener D, Menoud LN, Wells TN, Kosco-Vilbois MH, Gauchat JF. 1998. Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol 161:1371–1379.
  • Elson GC, Lelievre E, Guillet C, Chevalier S, Plun-Favreau H, Froger J, Suard I, de Coignac AB, Delneste Y, Bonnefoy JY, Gauchat JF, Gascan H. 2000. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat Neurosci 3:867–872. http://dx.doi.org/10.1038/78765.
  • Senaldi G, Varnum BC, Sarmiento U, Starnes C, Lile J, Scully S, Guo J, Elliott G, McNinch J, Shaklee CL, Freeman D, Manu F, Simonet WS, Boone T, Chang MS. 1999. Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc Natl Acad Sci U S A 96:11458–11463. http://dx.doi.org/10.1073/pnas.96.20.11458.
  • Lelievre E, Plun-Favreau H, Chevalier S, Froger J, Guillet C, Elson GC, Gauchat JF, Gascan H. 2001. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. J Biol Chem 276:22476–22484. http://dx.doi.org/10.1074/jbc.M101681200.
  • Alexander WS, Rakar S, Robb L, Farley A, Willson TA, Zhang JG, Hartley L, Kikuchi Y, Kojima T, Nomura H, Hasegawa M, Maeda M, Fabri L, Jachno K, Nash A, Metcalf D, Nicola NA, Hilton DJ. 1999. Suckling defect in mice lacking the soluble haemopoietin receptor NR6. Curr Biol 9:605–608. http://dx.doi.org/10.1016/S0960-9822(99)80266-8.
  • Piras R, Chiappe F, Torraca IL, Buers I, Usala G, Angius A, Akin MA, Basel-Vanagaite L, Benedicenti F, Chiodin E, El Assy O, Feingold-Zadok M, Guibert J, Kamien B, Kasapkara CS, Kilic E, Boduroglu K, Kurtoglu S, Manzur AY, Onal EE, Paderi E, Roche CH, Tumer L, Unal S, Utine GE, Zanda G, Zankl A, Zampino G, Crisponi G, Crisponi L, Rutsch F. 2014. Expanding the mutational spectrum of CRLF1 in Crisponi/CISS1 syndrome. Hum Mutat 35:424–433. http://dx.doi.org/10.1002/humu.22522.
  • Zou X, Bolon B, Pretorius J, Kurahara C, McCabe J, Christensen K, Sun N, Duryea D, Foreman O, Senaldi G, Itano A, Siu G. 2008. Neonatal death in mice lacking cardiotrophin-like cytokine (CLC) is associated with multifocal neuronal hypoplasia. Vet Pathol 46:514–519. http://dx.doi.org/10.1354/vp.08-VP-0239-B-BC.
  • DeChiara TM, Vejsada R, Poueymirou WT, Acheson A, Suri C, Conover JC, Friedman B, McClain J, Pan L, Stahl N, Ip NY, Yancopoulos GD. 1995. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83:313–322. http://dx.doi.org/10.1016/0092-8674(95)90172-8.
  • Forger NG, Prevette D, deLapeyriere O, de Bovis B, Wang S, Bartlett P, Oppenheim RW. 2003. Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. J Neurosci 23:8854–8858.
  • Rousseau F, Gauchat JF, McLeod JG, Chevalier S, Guillet C, Guilhot F, Cognet I, Froger J, Hahn AF, Knappskog PM, Gascan H, Boman H. 2006. Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. Proc Natl Acad Sci U S A 103:10068–10073. http://dx.doi.org/10.1073/pnas.0509598103.
  • Knappskog PM, Majewski J, Livneh A, Nilsen PT, Bringsli JS, Ott J, Boman H. 2003. Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. Am J Hum Genet 72:375–383. http://dx.doi.org/10.1086/346120.
  • Sohar E, Shoenfeld Y, Udassin R, Magazanik A, Revach M. 1978. Cold-induced profuse sweating on back and chest. A new genetic entity? Lancet ii:1073–1074.
  • Crisponi G. 1996. Autosomal recessive disorder with muscle contractions resembling neonatal tetanus, characteristic face, camptodactyly, hyperthermia, and sudden death: a new syndrome? Am J Med Genet 62:365–371. http://dx.doi.org/10.1002/(SICI)1096-8628(19960424)62:4<365::AID-AJMG8>3.0.CO;2-Q.
  • Crisponi L, Crisponi G, Meloni A, Toliat MR, Nurnberg G, Usala G, Uda M, Masala M, Hohne W, Becker C, Marongiu M, Chiappe F, Kleta R, Rauch A, Wollnik B, Strasser F, Reese T, Jakobs C, Kurlemann G, Cao A, Nurnberg P, Rutsch F. 2007. Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1. Am J Hum Genet 80:971–981. http://dx.doi.org/10.1086/516843.
  • Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, Hara T, Ishibashi H, Koshihara Y, Yamada K, Yoneda Y. 2010. Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta. Calcif Tissue Int 86:47–57. http://dx.doi.org/10.1007/s00223-009-9311-1.
  • Kass DJ, Yu G, Loh KS, Savir A, Borczuk A, Kahloon R, Juan-Guardela B, Deiuliis G, Tedrow J, Choi J, Richards T, Kaminski N, Greenberg SM. 2012. Cytokine-like factor 1 gene expression is enriched in idiopathic pulmonary fibrosis and drives the accumulation of CD4+ T cells in murine lungs: evidence for an antifibrotic role in bleomycin injury. Am J Pathol 180:1963–1978. http://dx.doi.org/10.1016/j.ajpath.2012.01.010.
  • Crabe S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, Guilhot F, Mavoungou-Bigouagou U, Lefouili F, Cognet I, Ferlin W, Elson G, Jeannin P, Gauchat JF. 2009. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J Immunol 183:7692–7702. http://dx.doi.org/10.4049/jimmunol.0901464.
  • Larsen JV, Hansen M, Moller B, Madsen P, Scheller J, Nielsen M, Petersen CM. 2010. Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol Cell Biol 30:4175–4187. http://dx.doi.org/10.1128/MCB.00274-10.
  • Willnow TE, Petersen CM, Nykjaer A. 2008. VPS10P-domain receptors—regulators of neuronal viability and function. Nat Rev Neurosci 9:899–909. http://dx.doi.org/10.1038/nrg2454.
  • Quistgaard EM, Madsen P, Groftehauge MK, Nissen P, Petersen CM, Thirup SS. 2009. Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat Struct Mol Biol 16:96–98. http://dx.doi.org/10.1038/nsmb.1543.
  • Jacobsen L, Madsen P, Moestrup SK, Lund AH, Tommerup N, Nykjaer A, Sottrup-Jensen L, Gliemann J, Petersen CM. 1996. Molecular characterization of a novel human hybrid-type receptor that binds the α2-macroglobulin receptor-associated protein. J Biol Chem 271:31379–31383. http://dx.doi.org/10.1074/jbc.271.49.31379.
  • Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, Roigaard H, Gliemann J, Madsen P, Moestrup SK. 1997. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem 272:3599–3605. http://dx.doi.org/10.1074/jbc.272.6.3599.
  • Gliemann J, Hermey G, Nykjaer A, Petersen CM, Jacobsen C, Andreasen PA. 2004. The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand. Biochem J 381:203–212. http://dx.doi.org/10.1042/BJ20040149.
  • Jacobsen L, Madsen P, Jacobsen C, Nielsen MS, Gliemann J, Petersen CM. 2001. Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem 276:22788–22796. http://dx.doi.org/10.1074/jbc.M100857200.
  • Nielsen MS, Gustafsen C, Madsen P, Nyengaard JR, Hermey G, Bakke O, Mari M, Schu P, Pohlmann R, Dennes A, Petersen CM. 2007. Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol 27:6842–6851. http://dx.doi.org/10.1128/MCB.00815-07.
  • Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, Militz D, Schmidt V, Madsen P, Nyengaard JR, Willnow TE, Christensen EI, Mobley WB, Nykjaer A, Andersen OM. 2012. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci 32:1467–1480. http://dx.doi.org/10.1523/JNEUROSCI.2272-11.2012.
  • Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM. 2002. The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. FEBS Lett 511:155–158. http://dx.doi.org/10.1016/S0014-5793(01)03299-9.
  • Klinger SC, Glerup S, Raarup MK, Mari MC, Nyegaard M, Koster G, Prabakaran T, Nilsson SK, Kjaergaard MM, Bakke O, Nykjaer A, Olivecrona G, Petersen CM, Nielsen MS. 2011. SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. J Cell Sci 124:1095–1105. http://dx.doi.org/10.1242/jcs.072538.
  • Glerup S, Lume M, Olsen D, Nyengaard JR, Vaegter CB, Gustafsen C, Christensen EI, Kjolby M, Hay-Schmidt A, Bender D, Madsen P, Saarma M, Nykjaer A, Petersen CM. 2013. SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. Cell Rep 3:186–199. http://dx.doi.org/10.1016/j.celrep.2012.12.011.
  • Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE. 2005. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 102:13461–13466. http://dx.doi.org/10.1073/pnas.0503689102.
  • Petersen CM, Ellgaard L, Nykjær A, Vilhardt F, Vorum H, Thøgersen HC, Nielsen MS, Jacobsen C, Moestrup SK, Gliemann J. 1996. The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II. EMBO J 15:4165–4173.
  • Gearing DP, Ziegler SF, Comeau MR, Friend D, Thoma B, Cosman D, Park L, Mosley B. 1994. Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc Natl Acad Sci U S A 91:1119–1123. http://dx.doi.org/10.1073/pnas.91.3.1119.
  • Munck Petersen C, Nielsen MS, Jacobsen C, Tauris J, Jacobsen L, Gliemann J, Moestrup SK, Madsen P. 1999. Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. EMBO J 18:595–604. http://dx.doi.org/10.1093/emboj/18.3.595.
  • Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. 1998. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 334:297–314. http://dx.doi.org/10.1042/bj3340297.
  • Taga T, Narazaki M, Yasukawa K, Saito T, Miki D, Hamaguchi M, Davis S, Shoyab M, Yancopoulos GD, Kishimoto T. 1992. Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130. Proc Natl Acad Sci U S A 89:10998–11001. http://dx.doi.org/10.1073/pnas.89.22.10998.
  • Nicola NA, Babon JJ. 2015. Leukemia inhibitory factor (LIF). Cytokine Growth Factor Rev 26:533–544. http://dx.doi.org/10.1016/j.cytogfr.2015.07.001.
  • de Bovis B, Derouet D, Gauchat JF, Elson G, Gascan H, Delapeyriere O. 2005. CLC is co-expressed with CLF or CNTFR in developing mouse muscles. Cell Commun Signal 3:1. http://dx.doi.org/10.1186/1478-811X-3-1.
  • Uemura A, Takizawa T, Ochiai W, Yanagisawa M, Nakashima K, Taga T. 2002. Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine 18:1–7. http://dx.doi.org/10.1006/cyto.2002.1006.
  • Herholz J, Meloni A, Marongiu M, Chiappe F, Deiana M, Herrero CR, Zampino G, Hamamy H, Zalloum Y, Waaler PE, Crisponi G, Crisponi L, Rutsch F. 2011. Differential secretion of the mutated protein is a major component affecting phenotypic severity in CRLF1-associated disorders. Eur J Hum Genet 19:525–533. http://dx.doi.org/10.1038/ejhg.2010.253.
  • Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H. 1993. Disruption of the CNTF gene results in motor neuron degeneration. Nature 365:27–32. http://dx.doi.org/10.1038/365027a0.
  • Takahashi R, Yokoji H, Misawa H, Hayashi M, Hu J, Deguchi T. 1994. A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet 7:79–84. http://dx.doi.org/10.1038/ng0594-79.
  • Dagoneau N, Bellais S, Blanchet P, Sarda P, Al-Gazali LI, Di Rocco M, Huber C, Djouadi F, Le Goff C, Munnich A, Cormier-Daire V. 2007. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. Am J Hum Genet 80:966–970. http://dx.doi.org/10.1086/513608.
  • Perret D, Guillet C, Elson G, Froger J, Plun-Favreau H, Rousseau F, Chabbert M, Gauchat JF, Gascan H. 2004. Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRα composite cytokines. J Biol Chem 279:43961–43970. http://dx.doi.org/10.1074/jbc.M407686200.
  • Plun-Favreau H, Elson G, Chabbert M, Froger J, deLapeyriere O, Lelievre E, Guillet C, Hermann J, Gauchat JF, Gascan H, Chevalier S. 2001. The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J 20:1692–1703. http://dx.doi.org/10.1093/emboj/20.7.1692.
  • Guillet C, Lelievre E, Plun-Favreau H, Froger J, Chabbert M, Hermann J, Benoit de Coignac A, Bonnefoy JY, Gascan H, Gauchat JF, Elson G. 2002. Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor. Eur J Biochem 269:1932–1941. http://dx.doi.org/10.1046/j.1432-1033.2002.02850.x.
  • Cramer JF, Gustafsen C, Behrens MA, Oliveira CL, Pedersen JS, Madsen P, Petersen CM, Thirup SS. 2010. GGA autoinhibition revisited. Traffic 11:259–273. http://dx.doi.org/10.1111/j.1600-0854.2009.01017.x.

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