The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

REFERENCES

• Akoulitchev, S., S. Chuikov, and D. Reinberg. 2000. TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature 407:102–106.
   PubMed Web of Science ®Google Scholar
• Andrau, J., L. van de Pasch, P. Lijnzaad, T. Bijma, M. G. Koerkamp, J. van de Peppel, M. Werner, and F. C. P. Holstege. 2006. Genome-wide location of the coactivator Mediator: binding without activation and transient cdk8 interaction on DNA. Mol. Cell 22:179–192.
   PubMed Web of Science ®Google Scholar
• Anest, V., J. L. Hanson, P. C. Cogswell, K. A. Steinbrecher, B. D. Strahl, and A. S. Baldwin. 2003. A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression. Nature 423:659–663.
   PubMed Web of Science ®Google Scholar
• Behrends, C., C. A. Langer, R. Boteva, U. M. Bottcher, M. J. Stemp, G. Schaffar, B. V. Rao, A. Giese, H. Kretzschmar, K. Siegers, and F. U. Hartl. 2006. Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol. Cell 23:887–897.
   PubMed Web of Science ®Google Scholar
• Borggrefe, T., R. Davis, H. Erdjument-Bromage, P. Tempst, and R. D. Kornberg. 2002. A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. J. Biol. Chem. 277:44202–44207.
   PubMed Web of Science ®Google Scholar
• Boube, M., C. Faucher, L. Joulia, D. L. Cribbs, and H. Bourbon. 2000. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev. 14:2906–2917.
   PubMed Web of Science ®Google Scholar
• Carlson, M. 1997. Genetics of transcriptional regulation in yeast: connections with the RNA polymerase II CTD. Annu. Rev. Cell Dev. Biol. 13:1–23.
   PubMed Web of Science ®Google Scholar
• Chi, Y., M. J. Huddleston, X. Zhang, R. A. Young, R. S. Annan, S. A. Carr, and R. A. Deshaies. 2001. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 15:1078–1092.
   PubMed Web of Science ®Google Scholar
• Donner, A. J., S. Szostek, J. M. Hoover, and J. M. Espinosa. 2007. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol. Cell 27:121–133.
   PubMed Web of Science ®Google Scholar
• Dull, T., R. Zufferey, M. Kelly, R. J. Mandel, M. Nguyen, D. Trono, and L. Naldini. 1998. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 72:8463–8471.
   PubMed Web of Science ®Google Scholar
• Feldman, D. E., V. Thulasiraman, R. G. Ferreyra, and J. Frydman. 1999. Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC. Mol. Cell 4:1051–1061.
   PubMed Web of Science ®Google Scholar
• Firestein, R., A. J. Bass, S. Y. Kim, I. F. Dunn, S. J. Silver, I. Guney, E. Freed, A. H. Ligon, N. Vena, S. Ogino, M. G. Chheda, P. Tamayo, S. Finn, Y. Shrestha, J. S. Boehm, S. Jain, E. Bojarski, C. Mermel, J. Barretina, J. A. Chan, J. Baselga, J. Tabernero, D. E. Root, C. S. Fuchs, M. Loda, R. A. Shivdasani, M. Meyerson, and W. C. Hahn. 2008. CDK8 is a colorectal cancer oncogene that regulates b-catenin activity. Nature 455:547–551.
   PubMed Web of Science ®Google Scholar
• Fischle, W., B. S. Tseng, H. L. Dormann, B. M. Ueberheide, B. A. Garcia, J. Shabanowitz, D. F. Hunt, H. Funabiki, and C. D. Allis. 2005. Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature 438:1116–1122.
   PubMed Web of Science ®Google Scholar
• Fryer, C. J., J. B. White, and K. A. Jones. 2004. Mastermind recruits CycC:Cdk8 to phosphorylate the notch ICD and coordinate activation with turnover. Mol. Cell 16:509–520.
   PubMed Web of Science ®Google Scholar
• Garcia-Barrio, M., J. Dong, S. Ufano, and A. G. Hinnebusch. 2000. Association of GCN1-GCN20 regulatory complex with the N terminus of eIF2α kinase GCN2 is required for GCN2 activation. EMBO J. 19:1887–1899.
   PubMedGoogle Scholar
• Guenther, M. G., J. Yu, G. D. Kao, T. J. Yen, and M. A. Lazar. 2002. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev. 16:3130–3135.
   PubMed Web of Science ®Google Scholar
• Gwack, Y., H. J. Baek, H. Nakamura, S. H. Lee, M. Meisterernst, R. G. Roeder, and J. U. Jung. 2003. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol. Cell. Biol. 23:2055–2067.
   PubMed Web of Science ®Google Scholar
• Hengartner, C. J., V. E. Myer, S. Liao, C. J. Wilson, S. S. Koh, and R. A. Young. 1998. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol. Cell 2:43–53.
   PubMed Web of Science ®Google Scholar
• Hirota, T., J. J. Lipp, B. Toh, and J. Peters. 2005. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 438:1176–1180.
   PubMed Web of Science ®Google Scholar
• Holstege, F. C., E. G. Jennings, J. J. Wyrick, T. I. Lee, C. J. Hengartner, M. R. Green, T. R. Golub, E. S. Lander, and R. A. Young. 1998. Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95:717–728.
   PubMed Web of Science ®Google Scholar
• Hong, S., C. E. Haldin, N. D. Lawson, B. M. Weinstein, I. B. Dawid, and N. A. Hukriede. 2005. The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc. Natl. Acad. Sci. USA 102:18473–18478.
   PubMed Web of Science ®Google Scholar
• Ikeda, K., D. J. Steger, A. Eberharter, and J. L. Workman. 1999. Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes. Mol. Cell. Biol. 19:855–863.
   PubMedGoogle Scholar
• Janody, F., Z. Martirosyan, A. Benlali, and J. E. Treisman. 2003. Two subunits of the Drosophila mediator complex act together to control cell affinity. Development 130:3691–3701.
   PubMed Web of Science ®Google Scholar
• Kim, S., X. Xu, A. Hecht, and T. G. Boyer. 2006. Mediator is a transducer of Wnt/beta-catenin signaling. J. Biol. Chem. 281:14066–14075.
   PubMed Web of Science ®Google Scholar
• Knuesel, M., Y. Wan, Z. Xiao, E. Holinger, N. Lowe, W. Wang, and X. Liu. 2003. Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol. Cell Proteomics 2:1225–1233.
   PubMed Web of Science ®Google Scholar
• Kubota, H., K. Ota, Y. Sakaki, and T. Ito. 2001. Budding yeast GCN1 binds the GI domain to activate the eIF2α kinase GCN2. J. Biol. Chem. 276:17591–17596.
   PubMedGoogle Scholar
• Laybourn, P. J., and J. T. Kadonaga. 1991. Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II. Science 254:238–245.
   PubMedGoogle Scholar
• Lefebvre, B., K. Ozato, and P. Lefebvre. 2002. Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation. EMBO Rep. 3:335–340.
   PubMed Web of Science ®Google Scholar
• Lehner, B., C. Crombie, J. Tischler, A. Fortunato, and A. G. Fraser. 2006. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat. Genet. 38:896–903.
   PubMed Web of Science ®Google Scholar
• Levine, M., and R. Tjian. 2003. Transcription regulation and animal diversity. Nature 424:147–151.
   PubMed Web of Science ®Google Scholar
• Liao, S., J. Zhang, D. A. Jeffery, A. J. Koleske, C. M. Thompson, D. M. Chao, M. Viljoen, H. J. J. van Vuuren, and R. A. Young. 1995. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374:193–196.
   PubMed Web of Science ®Google Scholar
• Liu, Y., C. Kung, J. Fishburn, A. Z. Ansari, K. M. Shokat, and S. Hahn. 2004. Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol. Cell. Biol. 24:1721–1735.
   PubMed Web of Science ®Google Scholar
• Loncle, N., M. Boube, L. Joulia, C. Boschiero, M. Werner, D. L. Cribbs, and H. Bourbon. 2007. Distinct roles for Mediator cdk8 module subunits in Drosophila development. EMBO J. 26:1045–1054.
   PubMed Web of Science ®Google Scholar
• Luger, K., T. J. Rechsteiner, and T. J. Richmond. 1999. Expression and purification of recombinant histones and nucleosome reconstitution. Methods Mol. Biol. 119:1–16.
   PubMedGoogle Scholar
• Malik, S., and R. G. Roeder. 2005. Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem. Sci. 30:256–263.
   PubMed Web of Science ®Google Scholar
• Meyer, K. D., A. J. Donner, M. Knuesel, A. G. York, J. M. Espinosa, and D. J. Taatjes. 2008. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J. 27:1447–1457.
   PubMed Web of Science ®Google Scholar
• Mo, X., E. Kowenz-Leutz, H. Xu, and A. Leutz. 2004. Ras induces mediator complex exchange on C/EBPβ. Mol. Cell 13:241–250.
   PubMed Web of Science ®Google Scholar
• Morris, E. J., J. Ji, F. Yang, L. Di Stefano, A. Herr, N. Moon, E. Kwon, K. M. Haigis, A. M. Naar, and N. J. Dyson. 2008. E2F1 represses b-catenin transcription and is antagonized by both pRB and CDK8. Nature 455:552–556.
   PubMed Web of Science ®Google Scholar
• Muncke, N., C. Jung, H. Rudiger, H. Ulmer, R. Roeth, A. Hubert, E. Goldmuntz, D. Driscoll, J. Goodship, K. Schon, and G. Rappold. 2003. Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries). Circulation 108:2843–2850.
   PubMed Web of Science ®Google Scholar
• Myer, V. E., and R. A. Young. 1998. RNA polymerase II holoenzymes and subcomplexes. J. Biol. Chem. 273:27757–27760.
   PubMed Web of Science ®Google Scholar
• Naldini, L., U. Blomer, P. Gallay, D. Ory, R. Mulligan, F. H. Gage, I. M. Verma, and D. Trono. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263–267.
   PubMed Web of Science ®Google Scholar
• Nelson, C., S. Goto, K. Lund, W. Hung, and I. Sadowski. 2003. Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12. Nature 421:187–190.
   PubMed Web of Science ®Google Scholar
• Nowak, S. J., and V. G. Corces. 2000. Phosphorylation of histone H3 correlates with transcriptionally active loci. Genes Dev. 14:3003–3013.
   PubMed Web of Science ®Google Scholar
• Nowak, S. J., and V. G. Corces. 2004. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet. 20:214–220.
   PubMed Web of Science ®Google Scholar
• Pavri, R., B. Lewis, T. K. Kim, F. J. Dilworth, H. Erdjument-Bromage, P. Tempst, G. de Murcia, R. Evans, P. Chambon, and D. Reinberg. 2005. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol. Cell 18:83–96.
   PubMed Web of Science ®Google Scholar
• Philibert, R. A., B. H. King, S. Winfield, E. H. Cook, Y. H. Lee, B. Stubblefield, P. Damschroder-Williams, C. Dea, A. Palotie, C. Tengstrom, B. M. Martin, and E. I. Ginns. 1998. Association of an X-chromosome dodecamer insertional variant allele with mental retardation. Mol. Psychiatry 3:303–309.
   PubMedGoogle Scholar
• Rau, M. J., S. Fischer, and C. J. Neumann. 2006. Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage, and ear development. Dev. Biol. 296:83–93.
   PubMed Web of Science ®Google Scholar
• Risheg, H., J. M. Graham, R. D. Clark, R. C. Rogers, J. M. Opitz, J. B. Moeschler, A. P. Peiffer, M. May, S. M. Joseph, J. R. Jones, R. E. Stevenson, C. E. Schwartz, and M. J. Friez. 2007. A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome. Nat. Genet. 39:451–453.
   PubMed Web of Science ®Google Scholar
• Smith, G. C. M., and S. P. Jackson. 1999. The DNA-dependent protein kinase. Genes Dev. 13:916–934.
   PubMed Web of Science ®Google Scholar
• Taatjes, D. J., A. M. Naar, F. Andel, E. Nogales, and R. Tjian. 2002. Structure, function, and activator-induced conformations of the CRSP coactivator. Science 295:1058–1062.
   PubMed Web of Science ®Google Scholar
• Tam, S., R. Geller, C. Spiess, and J. Frydman. 2006. The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat. Cell Biol. 8:1155–1162.
   PubMed Web of Science ®Google Scholar
• Treisman, J. E. 2001. Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development 128:603–615.
   PubMed Web of Science ®Google Scholar
• van de Peppel, J., N. Kettelarij, H. van Bakel, T. T. J. P. Kockelkorn, D. van Leenen, and F. C. P. Holstege. 2005. Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. Mol. Cell 19:511–522.
   PubMed Web of Science ®Google Scholar
• Vincent, O., S. Kuchin, S. P. Hong, R. Townley, V. K. Vyas, and M. Carlson. 2001. Interaction of the srb10 kinase with sip4, a transcriptional activator of gluconeogenic genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 21:5790–5796.
   PubMed Web of Science ®Google Scholar
• Wang, J., A. Walker, T. K. Blackwell, and K. R. Yamamoto. 2004. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J. Biol. Chem. 279:29270–29277.
   PubMed Web of Science ®Google Scholar
• Wang, X., N. Yang, E. Uno, R. G. Roeder, and S. Guo. 2006. A subunit of the mediator complex regulates vertebrate neuronal development. Proc. Natl. Acad. Sci. USA 103:17284–17289.
   PubMed Web of Science ®Google Scholar
• Westerling, T., E. Kuuluvainen, and T. P. Makela. 2007. Cdk8 is essential for preimplantation mouse development. Mol. Cell. Biol. 27:6177–6182.
   PubMed Web of Science ®Google Scholar
• Won, K., R. J. Schumacher, G. W. Farr, A. L. Horwich, and S. I. Reed. 1998. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Mol. Cell. Biol. 18:7584–7589.
   PubMedGoogle Scholar
• Yamamoto, Y., U. N. Verma, S. Pajapati, Y. Kwak, and R. B. Gaynor. 2003. Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression. Nature 423:655–659.
   PubMed Web of Science ®Google Scholar
• Yoda, A., H. Kouike, H. Okano, and H. Sawa. 2005. Components of the transcriptional Mediator complex are required for asymmetric cell division in Caenorhabditis elegans. Development 132:1885–1893.
   PubMed Web of Science ®Google Scholar
• Zhang, H., and S. W. Emmons. 2000. A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene. Genes Dev. 14:2161–2172.
   PubMedGoogle Scholar
• Zhou, R., N. Bonneaud, C. X. Yuan, P. de Santa Barbara, B. Boizet, T. Schomber, G. Scherer, R. G. Roeder, F. Poulat, P. Berta, and S. Tibor. 2002. SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res. 30:3245–3452.
   PubMed Web of Science ®Google Scholar
• Zhu, X., M. Wiren, I. Sinha, N. N. Rasmussen, T. Linder, S. Holmberg, K. Ekwall, and C. M. Gustafsson. 2006. Genome-wide occupancy profile of Mediator and the srb8-11 submodule reveals interactions with coding regions. Mol. Cell 22:169–178.
   PubMed Web of Science ®Google Scholar
• Zippo, A., A. De Robertis, R. Serafini, and S. Oliviero. 2007. PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. Nat. Cell Biol. 9:932–944.
   PubMed Web of Science ®Google Scholar