Distinct Functions of Dispersed GATA Factor Complexes at an Endogenous Gene Locus

REFERENCES

• Anguita, E., J. Hughes, C. Heyworth, G. A. Blobel, W. G. Wood, and D. R. Higgs. 2004. Globin gene activation during hematopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 23:2841–2852.
   PubMedGoogle Scholar
• Blobel, G. A., T. Nakajima, R. Eckner, M. Montminy, and S. H. Orkin. 1998. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc. Natl. Acad. Sci. USA 95:2061–2066.
   PubMedGoogle Scholar
• Bresnick, E. H., K. D. Johnson, S.-I. Kim, and H. Im. 2006. Establishment and regulation of chromatin domains: mechanistic insights from studies of hemoglobin synthesis. Prog. Nucleic Acids Res. Mol. Biol. 81:435–471.
   PubMedGoogle Scholar
• Bresnick, E. H., M. L. Martowicz, S. Pal, and K. D. Johnson. 2005. Developmental control via GATA factor interplay at chromatin domains. J. Cell. Physiol. 205:1–9.
   PubMed Web of Science ®Google Scholar
• Cantor, A. B., S. G. Katz, and S. H. Orkin. 2002. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol. Cell. Biol. 22:4268–4279.
   PubMed Web of Science ®Google Scholar
• Cantor, A. B., and S. H. Orkin. 2002. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21:3368–3376.
   PubMed Web of Science ®Google Scholar
• Carter, D., L. Chakalova, C. S. Osborne, Y. F. Dai, and P. Fraser. 2002. Long-range chromatin regulatory interactions in vivo. Nat. Genet. 32:623–626.
   PubMed Web of Science ®Google Scholar
• Crispino, J. D., M. B. Lodish, J. P. MacKay, and S. H. Orkin. 1999. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol. Cell 3:219–228.
   PubMedGoogle Scholar
• Cullen, K. E., M. P. Kladde, and M. A. Seyfred. 1993. Interaction between transcriptional regulatory elements of prolactin chromatin. Science 261:203–206.
   PubMed Web of Science ®Google Scholar
• Dekker, J. 2006. The three ‘c’s of chromosome conformation capture: controls, controls, controls. Nat. Methods 3:17–21.
   PubMedGoogle Scholar
• Dekker, J., K. Rippe, M. Dekker, and N. Kleckner. 2002. Capturing chromosome conformation. Science 295:1306–1311.
   PubMed Web of Science ®Google Scholar
• Dorfman, D. M., D. B. Wilson, G. A. Bruns, and S. H. Orkin. 1992. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J. Biol. Chem. 267:1279–1285.
   PubMed Web of Science ®Google Scholar
• Drissen, R., R. J. Palstra, N. Gillemans, E. Splinter, F. Grosveld, S. Philipsen, and W. de Laat. 2004. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev. 18:2485–2490.
   PubMed Web of Science ®Google Scholar
• Eivazova, E. R., and T. M. Aune. 2004. Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation. Proc. Natl. Acad. Sci. USA 101:251–256.
   PubMedGoogle Scholar
• Evans, T., and G. Felsenfeld. 1989. The erythroid-specific transcription factor Eryf1: a new finger protein. Cell 58:877–885.
   PubMed Web of Science ®Google Scholar
• Fujiwara, Y., A. N. Chang, A. M. Williams, and S. H. Orkin. 2004. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood 103:583–585.
   PubMed Web of Science ®Google Scholar
• Garriga-Canut, M., and S. H. Orkin. 2004. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J. Biol. Chem. 279:23597–23605.
   PubMedGoogle Scholar
• Ghirlando, R., and C. D. Trainor. 2003. Determinants of GATA-1 binding to DNA: the role of non-finger residues. J. Biol. Chem. 278:45620–45628.
   PubMedGoogle Scholar
• Grass, J. A., M. E. Boyer, S. Paul, J. Wu, M. J. Weiss, and E. H. Bresnick. 2003. GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc. Natl. Acad. Sci. USA 100:8811–8816.
   PubMed Web of Science ®Google Scholar
• Gregory, T., C. Yu, A. Ma, S. H. Orkin, G. A. Blobel, and M. J. Weiss. 1999. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xl expression. Blood 94:87–96.
   PubMed Web of Science ®Google Scholar
• Hong, W., M. Nakazawa, Y. Y. Chen, R. Kori, C. R. Vakoc, C. Rakowski, and G. A. Blobel. 2005. FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J. 24:67–78.
   Google Scholar
• Im, H., J. A. Grass, K. D. Johnson, M. E. Boyer, J. Wu, and E. H. Bresnick. 2004. Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation. Methods Mol. Biol. 284:129–146.
   PubMedGoogle Scholar
• Im, H., J. A. Grass, K. D. Johnson, S.-I. Kim, M. E. Boyer, A. N. Imbalzano, J. J. Bieker, and E. H. Bresnick. 2005. Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc. Natl. Acad. Sci. USA 102:17065–17070.
   PubMedGoogle Scholar
• Johnson, K. D., J. D. Grass, M. E. Boyer, C. M. Kiekhaefer, G. A. Blobel, M. J. Weiss, and E. H. Bresnick. 2002. Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain. Proc. Natl. Acad. Sci. USA 99:11760–11765.
   PubMedGoogle Scholar
• Kirmizis, A., S. M. Bartley, A. Kuzmichev, R. Margueron, D. Reinberg, R. Green, and P. J. Farnham. 2004. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev. 18:1592–1605.
   PubMed Web of Science ®Google Scholar
• Ko, L. J., and J. D. Engel. 1993. DNA-binding specificities of the GATA transcription factor family. Mol. Cell. Biol. 13:4011–4022.
   PubMed Web of Science ®Google Scholar
• Kobayashi-Osaki, M., O. Ohneda, N. Suzuki, N. Minegishi, T. Yokomizo, S. Takahashi, K.-C. Lim, J. D. Engel, and M. Yamamoto. 2005. GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene. Mol. Cell. Biol. 25:7005–7020.
   PubMedGoogle Scholar
• Lee, M. E., D. H. Temizer, J. A. Clifford, and T. Quertermous. 1991. Cloning of the GATA binding protein that regulates endothelin-1 gene expression in endothelial cells. J. Biol. Chem. 266:16188–16192.
   PubMedGoogle Scholar
• Leonard, M., M. Brice, J. D. Engel, and T. Papayannopoulou. 1993. Dynamics of GATA transcription factor expression during erythroid differentiation. Blood 82:1071–1079.
   PubMed Web of Science ®Google Scholar
• Letting, D. L., Y. Y. Chen, C. Rakowski, S. Reedy, and G. A. Blobel. 2004. Context-dependent regulation of GATA-1 by friend of GATA-1. Proc. Natl. Acad. Sci. USA 101:476–481.
   PubMed Web of Science ®Google Scholar
• Letting, D. L., C. Rakowski, M. J. Weiss, and G. A. Blobel. 2003. Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1. Mol. Cell. Biol. 23:1334–1340.
   PubMedGoogle Scholar
• Ling, K. W., K. Ottersbach, J. P. van Hamburg, A. Oziemlak, F. Y. Tsai, S. H. Orkin, R. Ploemacher, R. W. Hendriks, and E. Dzierzak. 2004. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J. Exp. Med. 200:871–882.
   PubMed Web of Science ®Google Scholar
• Lu, Q., L. L. Wallrath, and S. C. Elgin. 1995. The role of a positioned nucleosome at the Drosophila melanogaster hsp26 promoter. EMBO J. 14:4738–4746.
   PubMedGoogle Scholar
• Martin, D. I., and S. H. Orkin. 1990. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev. 4:1886–1898.
   PubMed Web of Science ®Google Scholar
• Martowicz, M. L., J. A. Grass, M. E. Boyer, H. Guend, and E. H. Bresnick. 2005. Dynamic GATA factor interplay at a multi-component regulatory region of the GATA-2 locus. J. Biol. Chem. 280:1724–1732.
   PubMedGoogle Scholar
• Merika, M., and S. H. Orkin. 1993. DNA-binding specificity of GATA family transcription factors. Mol. Cell. Biol. 13:3999–4010.
   PubMed Web of Science ®Google Scholar
• Minegishi, N., J. Ohta, H. Yamagiwa, N. Suzuki, S. Kawauchi, Y. Zhou, S. Takahashi, N. Hayashi, J. D. Engel, and M. Yamamoto. 1999. The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region. Blood 93:4196–4207.
   PubMedGoogle Scholar
• Mouthon, M. A., O. Bernard, M. T. Mitjavila, P. H. Romeo, W. Vainchenker, and D. Mathieu-Mahul. 1993. Expression of Tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81:647–655.
   PubMed Web of Science ®Google Scholar
• Nardelli, J., D. Thiesson, Y. Fujiwara, F.-Y. Tsai, and S. H. Orkin. 1999. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev. Biol. 210:305–321.
   PubMedGoogle Scholar
• Newton, A., J. P. MacKay, and M. Crossley. 2001. The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA. J. Biol. Chem. 276:35794–35801.
   PubMed Web of Science ®Google Scholar
• Nichols, K. E., J. D. Crispino, M. Poncz, J. G. White, S. H. Orkin, J. M. Maris, and M. J. Weiss. 2000. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA-1. Nat. Genet. 24:266–270.
   PubMed Web of Science ®Google Scholar
• Orlic, D., S. Anderson, L. G. Biesecker, B. P. Sorrentino, and D. M. Bodine. 1995. Pluripotent hematopoietic stem cells contain high levels of mRNA for c Kit, GATA-2, p45 NF-E2, and myb and low levels or no RNA for c-fms and the receptors for granulocyte macrophage colony stimulating factor and interleukins 5 and 7. Proc. Natl. Acad. Sci. USA 92:4601.
   PubMed Web of Science ®Google Scholar
• Pal, S., A. B. Cantor, K. D. Johnson, T. Moran, M. E. Boyer, S. H. Orkin, and E. H. Bresnick. 2004. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc. Natl. Acad. Sci. USA 101:980–985.
   PubMed Web of Science ®Google Scholar
• Pal, S., M. J. Nemeth, D. M. Bodine, J. L. Miller, J. Svaren, S. L. Thein, P. J. Lowry, and E. H. Bresnick. 2004. Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1. J. Biol. Chem. 279:31348–31356.
   PubMedGoogle Scholar
• Pedone, P. V., J. G. Omichinski, P. Nony, C. Trainor, A. M. Gronenborn, G. M. Clore, and G. Felsenfeld. 1997. The N-terminal fingers of chicken GATA-2 and GATA-3 are independent sequence-specific DNA binding domains. EMBO J. 16:2874–2882.
   PubMedGoogle Scholar
• Pevny, L., M. C. Simon, E. Robertson, W. H. Klein, S. F. Tsai, V. D'Agati, S. H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:257–260.
   PubMed Web of Science ®Google Scholar
• Ren, B., F. Robert, J. J. Wyrick, O. Aparicio, E. G. Jennings, I. Simon, J. Zeitlinger, J. Schreiber, N. Hannett, E. Kanin, T. L. Volkert, C. J. Wilson, S. P. Bell, and R. A. Young. 2000. Genome-wide location and function of DNA binding proteins. Science 290:2306–2309.
   PubMed Web of Science ®Google Scholar
• Reznikoff, C. A., D. W. Brankow, and C. Heidelberger. 1973. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res. 33:3231–3238.
   PubMed Web of Science ®Google Scholar
• Rodriquez, P., E. Bonte, J. Krijgsveld, K. E. Kolodziej, B. Guyot, A. J. Heck, P. Vyas, E. de Boer, F. Grosveld, and J. Strouboulis. 2005. GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 24:2354–2366.
   PubMedGoogle Scholar
• Schleif, R. 1992. DNA looping. Annu. Rev. Biochem. 61:199–223.
   PubMed Web of Science ®Google Scholar
• Simon, M. C., L. Pevny, M. V. Wiles, G. Keller, F. Costantini, and S. H. Orkin. 1992. Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat. Genet. 1:92–98.
   PubMed Web of Science ®Google Scholar
• Simpson, R. J., S. H. Yi Lee, N. Bartle, E. Y. Sum, J. E. Visvader, J. M. Matthews, J. P. MacKay, and M. Crossley. 2004. A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3. J. Biol. Chem. 279:39789–39797.
   PubMed Web of Science ®Google Scholar
• Spilianakis, C. G., and R. A. Flavell. 2004. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat. Immunol. 5:1017–1027.
   PubMed Web of Science ®Google Scholar
• Thomas, G. H., and S. C. Elgin. 1988. Protein/DNA architecture of the DNaseI hypersensitive region of the Drosophila hsp26 promoter. EMBO J. 7:2191–2201.
   PubMedGoogle Scholar
• Tolhuis, B., R. J. Palstra, E. Splinter, F. Grosveld, and W. de Laat. 2002. Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol. Cell 10:1453–1475.
   PubMed Web of Science ®Google Scholar
• Tsai, F.-Y., and S. H. Orkin. 1997. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89:3636–3643.
   PubMed Web of Science ®Google Scholar
• Tsai, F. Y., G. Keller, F. C. Kuo, M. Weiss, J. Chen, M. Rosenblatt, F. W. Alt, and S. H. Orkin. 1994. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371:221–226.
   PubMed Web of Science ®Google Scholar
• Tsai, S. F., D. I. Martin, L. I. Zon, A. D. D'Andrea, G. G. Wong, and S. H. Orkin. 1989. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature 339:446–451.
   PubMed Web of Science ®Google Scholar
• Tsang, A. P., Y. Fujiwara, D. B. Hom, and S. H. Orkin. 1998. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 12:1176–1188.
   PubMedGoogle Scholar
• Tsang, A. P., J. E. Visvader, C. A. Turner, Y. Fujuwara, C. Yu, M. J. Weiss, M. Crossley, and S. H. Orkin. 1997. FOG, a multitype zinc finger protein as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 90:109–119.
   PubMed Web of Science ®Google Scholar
• Vakoc, C. R., D. L. Letting, N. Gheldof, T. Sawado, M. A. Bender, M. Groudine, M. J. Weiss, J. Dekker, and G. A. Blobel. 2005. Proximity among distant regulatory elements at the beta globin locus requires GATA-1 and FOG-1. Mol. Cell 17:453–462.
   PubMed Web of Science ®Google Scholar
• Weiss, M. J., G. Keller, and S. H. Orkin. 1994. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 8:1184–1197.
   PubMed Web of Science ®Google Scholar
• Weiss, M. J., C. Yu, and S. H. Orkin. 1997. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol. Cell. Biol. 17:1642–1651.
   PubMed Web of Science ®Google Scholar
• Welch, J. J., J. A. Watts, C. R. Vakoc, Y. Yao, H. Wang, R. C. Hardison, G. A. Blobel, L. A. Chodosh, and M. J. Weiss. 2004. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 104:3136–3147.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., H. H. Ng, H. Erdjument-Bromage, P. Tempst, A. Bird, and D. Reinberg. 1999. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13:1924–1935.
   PubMed Web of Science ®Google Scholar
• Zhou, Y., K. C. Lim, K. Onodera, S. Takahashi, J. Ohta, N. Minegishi, F. Y. Tsai, S. H. Orkin, M. Yamamoto, and J. D. Engel. 1998. Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J. 17:6689–6700.
   PubMedGoogle Scholar
• Zon, L. I., M. F. Gurish, R. L. Stevens, C. Mather, D. S. Reynolds, K. F. Austen, and S. H. Orkin. 1991. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J. Biol. Chem. 266:22948–22953.
   PubMedGoogle Scholar
• Zon, L. I., Y. Yamaguchi, K. Yee, E. A. Albee, A. Kimura, J. C. Bennett, S. H. Orkin, and S. J. Ackerman. 1993. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood 81:3234–3241.
   PubMedGoogle Scholar