Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic Response to DNA Damage

REFERENCES

• Baker, S. J., S. Markowitz, E. R. Fearon, J. K. Willson, and B. Vogelstein. 1990. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249:912–915.
   PubMed Web of Science ®Google Scholar
• Bose, R., M. Verheij, A. Haimovitz-Friedman, K. Scotto, Z. Fuks, and R. Kolesnick. 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82:405–414.
   PubMed Web of Science ®Google Scholar
• Cillo, C., A. Faiella, M. Cantile, and E. Boncinelli. 1999. Homeobox genes and cancer. Exp. Cell Res. 248:1–9.
   PubMed Web of Science ®Google Scholar
• Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Emoto, Y., H. Kisaki, Y. Manome, S. Kharbanda, and D. Kufe. 1996. Activation of protein kinase Cδ in human myeloid leukemia cells treated with 1-beta-D-arabinofuranosylcytosine. Blood 87:1990–1996.
   PubMed Web of Science ®Google Scholar
• Emoto, Y., Y. Manome, G. Meinhardt, H. Kisaki, S. Kharbanda, M. Robertson, T. Ghayur, W. W. Wong, R. Kamen, R. Weichselbaum, and D. Kufe. 1995. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J. 14:6148–6156.
   PubMed Web of Science ®Google Scholar
• Evan, G. I., and K. H. Vousden. 2001. Proliferation, cell cycle and apoptosis in cancer. Nature 411:342–348.
   PubMed Web of Science ®Google Scholar
• Finlay, C. A., P. W. Hinds, and A. J. Levine. 1989. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083–1093.
   PubMed Web of Science ®Google Scholar
• Ghayur, T., M. Hugunin, R. V. Talanian, S. Ratnofsky, C. Quinlan, Y. Emoto, P. Pandey, R. Datta, Y. Huang, S. Kharbanda, H. Allen, R. Kamen, W. Wong, and D. Kufe. 1996. Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis. J. Exp. Med. 184:2399–2404.
   PubMed Web of Science ®Google Scholar
• Haraguchi, T., J. M. Holaska, M. Yamane, T. Koujin, N. Hashiguchi, C. Mori, K. L. Wilson, and Y. Hiraoka. 2004. Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy. Eur. J. Biochem. 271:1035–1045.
   PubMedGoogle Scholar
• Hellin, A. C., P. Calmant, J. Gielen, V. Bours, and M. P. Merville. 1998. Nuclear factor-κB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug. Oncogene 16:1187–1195.
   PubMed Web of Science ®Google Scholar
• Jain, N., T. Zhang, W. H. Kee, W. Li, and X. Cao. 1999. Protein kinase C δ associates with and phosphorylates Stat3 in an interleukin-6-dependent manner. J. Biol. Chem. 274:24392–24400.
   PubMed Web of Science ®Google Scholar
• Kasof, G. M., L. Goyal, and E. White. 1999. Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. Mol. Cell. Biol. 19:4390–4404.
   PubMedGoogle Scholar
• Kharbanda, S., A. Bharti, D. Pei, J. Wang, P. Pandey, R. Ren, R. Weichselbaum, C. T. Walsh, and D. Kufe. 1996. The stress response to ionizing radiation involves c-Abl-dependent phosphorylation of SHPTP1. Proc. Natl. Acad. Sci. USA 93:6898–6901.
   PubMed Web of Science ®Google Scholar
• Li, C., T. E. Ahlborn, K. Tokita, L. M. Boxer, A. Noda, and J. Liu. 2001. The critical role of the PE21 element in oncostatin M-mediated transcriptional repression of the p53 tumor suppressor gene in breast cancer cells. Oncogene 20:8193–8202.
   PubMedGoogle Scholar
• Lowe, S. W., and A. W. Lin. 2000. Apoptosis in cancer. Carcinogenesis 21:485–495.
   PubMed Web of Science ®Google Scholar
• Majumder, P. K., N. C. Mishra, X. Sun, A. Bharti, S. Kharbanda, S. Saxena, and D. Kufe. 2001. Targeting of protein kinase C δ to mitochondria in the oxidative stress response. Cell Growth Differ. 12:465–470.
   PubMedGoogle Scholar
• Majumder, P. K., P. Pandey, X. Sun, K. Cheng, R. Datta, S. Saxena, S. Kharbanda, and D. Kufe. 2000. Mitochondrial translocation of protein kinase C δ in phorbol ester-induced cytochrome c release and apoptosis. J. Biol. Chem. 275:21793–21796.
   PubMed Web of Science ®Google Scholar
• Nishizuka, Y. 1988. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334:661–665.
   PubMed Web of Science ®Google Scholar
• Noda, A., Y. Toma-Aiba, and Y. Fujiwara. 2000. A unique, short sequence determines p53 gene basal and UV-inducible expression in normal human cells. Oncogene 19:21–31.
   PubMedGoogle Scholar
• Phan, R. T., and R. Dalla-Favera. 2004. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432:635–639.
   PubMed Web of Science ®Google Scholar
• Raman, V., S. A. Martensen, D. Reisman, E. Evron, W. F. Odenwald, E. Jaffee, J. Marks, and S. Sukumar. 2000. Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature 405:974–978.
   PubMed Web of Science ®Google Scholar
• Reisman, D., and W. T. Loging. 1998. Transcriptional regulation of the p53 tumor suppressor gene. Semin. Cancer Biol. 8:317–324.
   PubMed Web of Science ®Google Scholar
• Rowland, B. D., R. Bernards, and D. S. Peeper. 2005. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat. Cell Biol. 7:1074–1082.
   PubMedGoogle Scholar
• Sherr, C. J. 2004. Principles of tumor suppression. Cell 116:235–246.
   PubMed Web of Science ®Google Scholar
• Strausberg, R. L., E. A. Feingold, L. H. Grouse, J. G. Derge, R. D. Klausner, F. S. Collins, L. Wagner, C. M. Shenmen, G. D. Schuler, S. F. Altschul, B. Zeeberg, K. H. Buetow, C. F. Schaefer, N. K. Bhat, R. F. Hopkins, H. Jordan, T. Moore, S. I. Max, J. Wang, F. Hsieh, L. Diatchenko, K. Marusina, A. A. Farmer, G. M. Rubin, L. Hong, M. Stapleton, M. B. Soares, M. F. Bonaldo, T. L. Casavant, T. E. Scheetz, M. J. Brownstein, T. B. Usdin, S. Toshiyuki, P. Carninci, C. Prange, S. S. Raha, N. A. Loquellano, G. J. Peters, R. D. Abramson, S. J. Mullahy, S. A. Bosak, P. J. McEwan, K. J. McKernan, J. A. Malek, P. H. Gunaratne, S. Richards, K. C. Worley, S. Hale, A. M. Garcia, L. J. Gay, S. W. Hulyk, D. K. Villalon, D. M. Muzny, E. J. Sodergren, X. Lu, R. A. Gibbs, J. Fahey, E. Helton, M. Ketteman, A. Madan, S. Rodrigues, A. Sanchez, M. Whiting, A. Madan, A. C. Young, Y. Shevchenko, G. G. Bouffard, R. W. Blakesley, J. W. Touchman, E. D. Green, M. C. Dickson, A. C. Rodriguez, J. Grimwood, J. Schmutz, R. M. Myers, Y. S. Butterfield, M. I. Krzywinski, U. Skalska, D. E. Smailus, A. Schnerch, J. E. Schein, S. J. Jones, and M. A. Marra. 2002. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. USA 99:16899–16903.
   PubMed Web of Science ®Google Scholar
• Sun, X., H. Shimizu, and K. Yamamoto. 1995. Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression. Mol. Cell. Biol. 15:4489–4496.
   PubMed Web of Science ®Google Scholar
• Sun, X., F. Wu, R. Datta, S. Kharbanda, and D. Kufe. 2000. Interaction between protein kinase C δ and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J. Biol. Chem. 275:7470–7473.
   PubMedGoogle Scholar
• Taira, N., K. Nihira, T. Yamaguchi, Y. Miki, and K. Yoshida. 2007. DYRK2 Is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol. Cell 25:725–738.
   PubMed Web of Science ®Google Scholar
• Tuck, S. P., and L. Crawford. 1989. Characterization of the human p53 gene promoter. Mol. Cell. Biol. 9:2163–2172.
   PubMed Web of Science ®Google Scholar
• Uddin, S., A. Sassano, D. K. Deb, A. Verma, B. Majchrzak, A. Rahman, A. B. Malik, E. N. Fish, and L. C. Platanias. 2002. Protein kinase C-δ (PKC-δ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J. Biol. Chem. 277:14408–14416.
   PubMed Web of Science ®Google Scholar
• Vogelstein, B., and K. W. Kinzler. 2004. Cancer genes and the pathways they control. Nat. Med. 10:789–799.
   PubMed Web of Science ®Google Scholar
• Vogelstein, B., D. Lane, and A. J. Levine. 2000. Surfing the p53 network. Nature 408:307–310.
   PubMed Web of Science ®Google Scholar
• Vousden, K. H., and X. Lu. 2002. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2:594–604.
   PubMed Web of Science ®Google Scholar
• Wang, S., and W. S. El-Deiry. 2006. p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints. Cancer Res. 66:6982–6989.
   PubMed Web of Science ®Google Scholar
• Wei, X., H. Xu, and D. Kufe. 2007. Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene. Cancer Res. 67:1853–1858.
   PubMed Web of Science ®Google Scholar
• Yoshida, K. 2007. PKCδ signaling: mechanisms of DNA damage response and apoptosis. Cell. Signal. 19:892–901.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., S. Kharbanda, and D. Kufe. 1999. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. J. Biol. Chem. 274:34663–34668.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., K. Komatsu, H. G. Wang, and D. Kufe. 2002. c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol. Cell. Biol. 22:3292–3300.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., and D. Kufe. 2001. Negative regulation of the SHPTP1 protein tyrosine phosphatase by protein kinase C δ in response to DNA damage. Mol. Pharmacol. 60:1431–1438.
   PubMedGoogle Scholar
• Yoshida, K., H. Liu, and Y. Miki. 2006. Protein kinase C δ regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J. Biol. Chem. 281:5734–5740.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., and Y. Miki. 2005. Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage. Cell Cycle 4:777–779.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., Y. Miki, and D. Kufe. 2002. Activation of SAPK/JNK signaling by protein kinase Cδ in response to DNA damage. J. Biol. Chem. 277:48372–48378.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., H. G. Wang, Y. Miki, and D. Kufe. 2003. Protein kinase Cδ is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J. 22:1431–1441.
   PubMedGoogle Scholar
• Yoshida, K., R. Weichselbaum, S. Kharbanda, and D. Kufe. 2000. Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. Mol. Cell. Biol. 20:5370–5380.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., T. Yamaguchi, T. Natsume, D. Kufe, and Y. Miki. 2005. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat. Cell Biol. 7:278–285.
   PubMed Web of Science ®Google Scholar
• Yoshida, K., T. Yamaguchi, H. Shinagawa, N. Taira, K. I. Nakayama, and Y. Miki. 2006. Protein kinase C δ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage. Mol. Cell. Biol. 26:3414–3431.
   PubMedGoogle Scholar
• Yuan, L. W., J. W. Soh, and I. B. Weinstein. 2002. Inhibition of histone acetyltransferase function of p300 by PKCδ. Biochim. Biophys. Acta 1592:205–211.
   PubMed Web of Science ®Google Scholar
• Yuan, Z. M., Y. Huang, T. Ishiko, S. Kharbanda, R. Weichselbaum, and D. Kufe. 1997. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. USA 94:1437–1440.
   PubMed Web of Science ®Google Scholar
• Yuan, Z. M., T. Utsugisawa, T. Ishiko, S. Nakada, Y. Huang, S. Kharbanda, R. Weichselbaum, and D. Kufe. 1998. Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene 16:1643–1648.
   PubMed Web of Science ®Google Scholar