Neoplasia Driven by Mutant c-KIT Is Mediated by Intracellular, Not Plasma Membrane, Receptor Signaling

REFERENCES

• Beghini, A., L. Larizza, R. Cairoli, and E. Morra. 1998. c-kit activating mutations and mast cell proliferation in human leukemia. Blood 92:701–702.
   PubMed Web of Science ®Google Scholar
• Beghini, A., P. Peterlongo, C. B. Ripamonti, L. Larizza, R. Cairoli, E. Morra, and C. Mecucci. 2000. c-kit mutations in core binding factor leukemias. Blood 95:726–727.
   PubMed Web of Science ®Google Scholar
• Beghini, A., C. B. Ripamonti, R. Cairoli, G. Cazzaniga, P. Colapietro, F. Elice, G. Nadali, G. Grillo, O. A. Haas, A. Biondi, E. Morra, and L. Larizza. 2004. KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication. Haematologica 89:920–925.
   PubMed Web of Science ®Google Scholar
• Bejcek, B. E., D. Y. Li, and T. F. Deuel. 1989. Transformation by v-sis occurs by an internal autoactivation mechanism. Science 245:1496–1499.
   PubMed Web of Science ®Google Scholar
• Besmer, P., J. E. Murphy, P. C. George, F. H. Qiu, P. J. Bergold, L. Lederman, H. W. Snyder, Jr., D. Brodeur, E. E. Zuckerman, and W. D. Hardy. 1986. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 320:415–421.
   PubMed Web of Science ®Google Scholar
• Blom, N., S. Gammeltoft, and S. Brunak. 1999. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol. 294:1351–1362.
   PubMed Web of Science ®Google Scholar
• Broudy, V. C. 1997. Stem cell factor and hematopoiesis. Blood 90:1345–1364.
   PubMed Web of Science ®Google Scholar
• Charest, A., V. Kheifets, J. Park, K. Lane, K. McMahon, C. L. Nutt, and D. Housman. 2003. Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma. Proc. Natl. Acad. Sci. USA 100:916–921.
   PubMed Web of Science ®Google Scholar
• Corbin, A. S., I. J. Griswold, P. La Rosee, K. W. Yee, M. C. Heinrich, C. L. Reimer, B. J. Druker, and M. W. Deininger. 2004. Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970. Blood 104:3754–3757.
   PubMed Web of Science ®Google Scholar
• Ferrao, P., T. J. Gonda, and L. K. Ashman. 1997. Expression of constitutively activated human c-Kit in Myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity. Blood 90:4539–4552.
   PubMed Web of Science ®Google Scholar
• Furitsu, T., T. Tsujimura, T. Tono, H. Ikeda, H. Kitayama, U. Koshimizu, H. Sugahara, J. H. Butterfield, L. K. Ashman, Y. Kanayama, et al. 1993. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J. Clin. Investig. 92:1736–1744.
   PubMed Web of Science ®Google Scholar
• Geissler, E. N., M. A. Ryan, and D. E. Housman. 1988. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55:185–192.
   PubMed Web of Science ®Google Scholar
• Grisolano, J. L., J. O'Neal, J. Cain, and M. H. Tomasson. 2003. An activated receptor tyrosine kinase, TEL/PDGFβR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. Proc. Natl. Acad. Sci. USA 100:9506–9511.
   PubMed Web of Science ®Google Scholar
• Hart, K. C., Y. F. Xu, A. N. Meyer, B. A. Lee, and D. J. Donoghue. 1994. The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex. J. Cell Biol. 127:1843–1857.
   PubMedGoogle Scholar
• Kanakura, Y., T. Furitsu, T. Tsujimura, J. H. Butterfield, L. K. Ashman, H. Ikeda, H. Kitayama, Y. Kanayama, Y. Matsuzawa, and Y. Kitamura. 1994. Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. Leukemia 8(Suppl. 1):S18–S22.
   PubMedGoogle Scholar
• Keating, M. T., and L. T. Williams. 1988. Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science 239:914–916.
   PubMed Web of Science ®Google Scholar
• Kitayama, H., Y. Kanakura, T. Furitsu, T. Tsujimura, K. Oritani, H. Ikeda, H. Sugahara, H. Mitsui, Y. Kanayama, Y. Kitamura, et al. 1995. Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 85:790–798.
   PubMed Web of Science ®Google Scholar
• Kitayama, H., T. Tsujimura, I. Matsumura, K. Oritani, H. Ikeda, J. Ishikawa, M. Okabe, M. Suzuki, K. Yamamura, Y. Matsuzawa, Y. Kitamura, and Y. Kanakura. 1996. Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase. Blood 88:995–1004.
   PubMed Web of Science ®Google Scholar
• Kosmider, O., N. Denis, C. Lacout, W. Vainchenker, P. Dubreuil, and F. Moreau-Gachelin. 2005. Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice. Cancer Cell 8:467–478.
   PubMed Web of Science ®Google Scholar
• Lev, S., J. Blechman, S. Nishikawa, D. Givol, and Y. Yarden. 1993. Interspecies molecular chimeras of kit help define the binding site of the stem cell factor. Mol. Cell. Biol. 13:2224–2234.
   PubMed Web of Science ®Google Scholar
• Lev, S., Y. Yarden, and D. Givol. 1992. Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor. J. Biol. Chem. 267:15970–15977.
   PubMed Web of Science ®Google Scholar
• Linnekin, D. 1999. Early signaling pathways activated by c-Kit in hematopoietic cells. Int. J. Biochem. Cell Biol. 31:1053–1074.
   PubMed Web of Science ®Google Scholar
• Lippincott-Schwartz, J., L. C. Yuan, J. S. Bonifacino, and R. D. Klausner. 1989. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell 56:801–813.
   PubMed Web of Science ®Google Scholar
• Longley, B. J., L. Tyrrell, S. Z. Lu, Y. S. Ma, K. Langley, T. G. Ding, T. Duffy, P. Jacobs, L. H. Tang, and I. Modlin. 1996. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat. Genet. 12:312–314.
   PubMed Web of Science ®Google Scholar
• Luo, H., Q. Li, J. O'Neal, F. Kreisel, M. M. Le Beau, and M. H. Tomasson. 2005. c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Blood 106:2452–2461.
   PubMed Web of Science ®Google Scholar
• Majumder, S., K. Brown, F. H. Qiu, and P. Besmer. 1988. c-kit protein, a transmembrane kinase: identification in tissues and characterization. Mol. Cell. Biol. 8:4896–4903.
   PubMed Web of Science ®Google Scholar
• Mollenhauer, H. H., D. J. Morre, and L. D. Rowe. 1990. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim. Biophys. Acta 1031:225–246.
   PubMed Web of Science ®Google Scholar
• Moriyama, Y., T. Tsujimura, K. Hashimoto, M. Morimoto, H. Kitayama, Matsuzawa, Y. Kitamura, and Y. Kanakura. 1996. Role of aspartic acid 814 in the function and expression of c-kit receptor tyrosine kinase. J. Biol. Chem. 271:3347–3350.
   PubMed Web of Science ®Google Scholar
• Nakai, Y., N. Nonomura, D. Oka, M. Shiba, Y. Arai, M. Nakayama, H. Inoue, K. Nishimura, K. Aozasa, Y. Mizutani, T. Miki, and A. Okuyama. 2005. KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors. Biochem. Biophys. Res. Commun. 337:289–296.
   PubMedGoogle Scholar
• Philips, M. R. 2005. Compartmentalized signalling of Ras. Biochem. Soc. Trans. 33:657–661.
   PubMedGoogle Scholar
• Qiu, F. H., P. Ray, K. Brown, P. E. Barker, S. Jhanwar, F. H. Ruddle, and P. Besmer. 1988. Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family—oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J. 7:1003–1011.
   PubMed Web of Science ®Google Scholar
• Reilly, J. T. 2002. Class III receptor tyrosine kinases: role in leukaemogenesis. Br. J. Haematol. 116:744–757.
   PubMed Web of Science ®Google Scholar
• Rubin, B. P., S. Singer, C. Tsao, A. Duensing, M. L. Lux, R. Ruiz, M. K. Hibbard, C. J. Chen, S. Xiao, D. A. Tuveson, G. D. Demetri, C. D. Fletcher, and J. A. Fletcher. 2001. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res. 61:8118–8121.
   PubMed Web of Science ®Google Scholar
• Schmidt-Arras, D. E., A. Bohmer, B. Markova, C. Choudhary, H. Serve, and F. D. Bohmer. 2005. Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. Mol. Cell. Biol. 25:3690–3703.
   PubMed Web of Science ®Google Scholar
• Tomasson, M. H., D. W. Sternberg, I. R. Williams, M. Carroll, D. Cain, J. C. Aster, R. L. Ilaria, Jr., R. A. Van Etten, and D. G. Gilliland. 2000. Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFβR tyrosines 579/581. J. Clin. Investig. 105:423–432.
   PubMed Web of Science ®Google Scholar
• Tsujimura, T., T. Furitsu, M. Morimoto, K. Isozaki, S. Nomura, Y. Matsuzawa, Y. Kitamura, and Y. Kanakura. 1994. Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation. Blood 83:2619–2626.
   PubMed Web of Science ®Google Scholar
• Tsujimura, T., T. Furitsu, M. Morimoto, Y. Kanayama, S. Nomura, Y. Matsuzawa, Y. Kitamura, and Y. Kanakura. 1995. Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3. Int. Arch. Allergy Immunol. 106:377–385.
   PubMed Web of Science ®Google Scholar
• Wang, Y. Y., G. B. Zhou, T. Yin, B. Chen, J. Y. Shi, W. X. Liang, X. L. Jin, J. H. You, G. Yang, Z. X. Shen, J. Chen, S. M. Xiong, G. Q. Chen, F. Xu, Y. W. Liu, Z. Chen, and S. J. Chen. 2005. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc. Natl. Acad. Sci. USA 102:1104–1109.
   PubMed Web of Science ®Google Scholar
• Wu, H., U. Klingmuller, P. Besmer, and H. F. Lodish. 1995. Interaction of the erythropoietin and stem-cell-factor receptors. Nature 377:242–246.
   PubMed Web of Science ®Google Scholar
• Yeh, H. J., G. F. Pierce, and T. F. Deuel. 1987. Ultrastructural localization of a platelet-derived growth factor/v-sis-related protein(s) in cytoplasm and nucleus of simian sarcoma virus-transformed cells. Proc. Natl. Acad. Sci. USA 84:2317–2321.
   PubMed Web of Science ®Google Scholar
• Zuber, M. X., S. M. Strittmatter, and M. C. Fishman. 1989. A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43. Nature 341:345–348.
   PubMed Web of Science ®Google Scholar