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Article

Prep1 Directly Regulates the Intrinsic Apoptotic Pathway by Controlling Bcl-XL Levels

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Pages 1143-1151 | Received 11 Aug 2008, Accepted 14 Dec 2008, Published online: 21 Mar 2023

REFERENCES

  • Berthelsen, J., C. Kilstrup-Nielsen, F. Blasi, F. Mavilio, and V. Zappavigna. 1999. The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev. 13:946–953.
  • Berthelsen, J., L. Viggiano, H. Schulz, E. Ferretti, G. G. Consalez, M. Rocchi, and F. Blasi. 1998. PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C. Genomics 47:323–324.
  • Berthelsen, J., V. Zappavigna, E. Ferretti, F. Mavilio, and F. Blasi. 1998. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J. 17:1434–1445.
  • Berthelsen, J., V. Zappavigna, F. Mavilio, and F. Blasi. 1998. Prep1, a novel functional partner of Pbx proteins. EMBO J. 17:1423–1433.
  • Borner, C. 2003. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol. Immunol. 39:615–647.
  • Brendolan, A., E. Ferretti, V. Salsi, K. Moses, S. Quaggin, F. Blasi, M. L. Cleary, and L. Selleri. 2005. A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development 132:3113–3126.
  • Capellini, T. D., G. Di Giacomo, V. Salsi, A. Brendolan, E. Ferretti, D. Srivastava, V. Zappavigna, and L. Selleri. 2006. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development 133:2263–2273.
  • Chang, C. P., Y. Jacobs, T. Nakamura, N. A. Jenkins, N. G. Copeland, and M. L. Cleary. 1997. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol. 17:5679–5687.
  • Chipuk, J. E., L. Bouchier-Hayes, T. Kuwana, D. D. Newmeyer, and D. R. Green. 2005. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309:1732–1735.
  • Coluccia, A. M., S. Perego, L. Cleris, R. H. Gunby, L. Passoni, E. Marchesi, F. Formelli, and C. Gambacorti-Passerini. 2004. Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo. Blood 103:2787–2794.
  • Deflorian, G., N. Tiso, E. Ferretti, D. Meyer, F. Blasi, M. Bortolussi, and F. Argenton. 2004. Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development 131:613–627.
  • Desagher, S., and J. C. Martinou. 2000. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10:369–377.
  • Di Rosa, P., J. C. Villaescusa, E. Longobardi, G. Iotti, E. Ferretti, V. M. Diaz, A. Miccio, G. Ferrari, and F. Blasi. 2007. The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev. Biol. 311:324–334.
  • Ferrai, C., D. Munari, P. Luraghi, L. Pecciarini, M. G. Cangi, C. Doglioni, F. Blasi, and M. P. Crippa. 2007. A transcription-dependent micrococcal nuclease-resistant fragment of the urokinase-type plasminogen activator promoter interacts with the enhancer. J. Biol. Chem. 282:12537–12546.
  • Ferretti, E., J. C. Villaescusa, P. Di Rosa, L. C. Fernandez-Diaz, E. Longobardi, R. Mazzieri, A. Miccio, N. Micali, L. Selleri, G. Ferrari, and F. Blasi. 2006. Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol. Cell. Biol. 26:5650–5662.
  • Fridman, J. S., and S. W. Lowe. 2003. Control of apoptosis by p53. Oncogene 22:9030–9040.
  • Fulda, S., and K. M. Debatin. 2006. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25:4798–4811.
  • Gross, A., J. M. McDonnell, and S. J. Korsmeyer. 1999. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1899–1911.
  • Hemann, M. T., and S. W. Lowe. 2006. The p53-Bcl-2 connection. Cell Death Differ. 13:1256–1259.
  • Igney, F. H., and P. H. Krammer. 2002. Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer. 2:277–288.
  • Kasai, S., S. Chuma, N. Motoyama, and N. Nakatsuji. 2003. Haploinsufficiency of Bcl-x leads to male-specific defects in fetal germ cells: differential regulation of germ cell apoptosis between the sexes. Dev. Biol. 264:202–216.
  • Knoepfler, P. S., and M. P. Kamps. 1997. The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins—evidence for selective targeting of E2a-Pbx1 to a subset of Pbx-recognition elements. Oncogene 14:2521–2531.
  • Kroemer, G., N. Zamzami, and S. A. Susin. 1997. Mitochondrial control of apoptosis. Immunol. Today 18:44–51.
  • Lakin, N. D., and S. P. Jackson. 1999. Regulation of p53 in response to DNA damage. Oncogene 18:7644–7655.
  • Longobardi, E., and F. Blasi. 2003. Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. J. Biol. Chem. 278:39235–39241.
  • Meek, D. W. 1998. Multisite phosphorylation and the integration of stress signals at p53. Cell Signal. 10:159–166.
  • Nicholson, D. W. 1999. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 6:1028–1042.
  • Pecci, A., L. R. Viegas, J. L. Baranao, and M. Beato. 2001. Promoter choice influences alternative splicing and determines the balance of isoforms expressed from the mouse bcl-X gene. J. Biol. Chem. 276:21062–21069.
  • Penkov, D., P. Di Rosa, L. Fernandez Diaz, V. Basso, E. Ferretti, F. Grassi, A. Mondino, and F. Blasi. 2005. Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol. Cell. Biol. 25:10768–10781.
  • Reers, M., S. T. Smiley, C. Mottola-Hartshorn, A. Chen, M. Lin, and L. B. Chen. 1995. Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol. 260:406–417.
  • Resnati, M., I. Pallavicini, R. Daverio, N. Sidenius, P. Bonini, and F. Blasi. 2006. Specific immunofluorimetric assay detecting the chemotactic epitope of the urokinase receptor (uPAR). J. Immunol. Methods 308:192–202.
  • Sakaguchi, K., J. E. Herrera, S. Saito, T. Miki, M. Bustin, A. Vassilev, C. W. Anderson, and E. Appella. 1998. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12:2831–2841.
  • Selleri, L., J. DiMartino, J. van Deursen, A. Brendolan, M. Sanyal, E. Boon, T. Capellini, K. S. Smith, J. Rhee, H. Popperl, G. Grosveld, and M. L. Cleary. 2004. The TALE homeodomain protein Pbx2 is not essential for development and long-term survival. Mol. Cell. Biol. 24:5324–5331.
  • Tian, C., P. Gregoli, and M. Bondurant. 2003. The function of the bcl-x promoter in erythroid progenitor cells. Blood 101:2235–2242.
  • Vander Heiden, M. G., N. S. Chandel, E. K. Williamson, P. T. Schumacker, and C. B. Thompson. 1997. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91:627–637.
  • Wang, D., H. Masutani, S. Oka, T. Tanaka, Y. Yamaguchi-Iwai, H. Nakamura, and J. Yodoi. 2006. Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells. J. Biol. Chem. 281:7384–7391.

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