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Article

Thio Modification of Yeast Cytosolic tRNA Is an Iron-Sulfur Protein-Dependent Pathway

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Pages 2841-2847 | Received 18 Jul 2006, Accepted 22 Jan 2007, Published online: 27 Mar 2023

REFERENCES

  • Adam, A. C., C. Bornhovd, H. Prokisch, W. Neupert, and K. Hell. 2006. The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. EMBO J. 25:174–183.
  • Balk, J., D. J. Aguilar Netz, K. Tepper, A. J. Pierik, and R. Lill. 2005. The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Mol. Cell. Biol. 25:10833–10841.
  • Balk, J., A. J. Pierik, D. J. Netz, U. Mühlenhoff, and R. Lill. 2004. The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins. EMBO J. 23:2105–2115.
  • Biederbick, A., O. Stehling, R. Rösser, B. Niggemeyer, Y. Nakai, H. P. Elsässer, and R. Lill. 2006. Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. Mol. Cell. Biol. 26:5675–5687.
  • Dong, J., R. Lai, K. Nielsen, C. A. Fekete, H. Qiu, and A. G. Hinnebusch. 2004. The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J. Biol. Chem. 279:42157–42168.
  • Fosset, C., M.-J. Chauveau, B. Guillon, F. Canal, J.-C. Drapier, and C. Bouton. 2006. RNA silencing of mitochondrial m-Nfs1 reduces Fe-S enzyme activity both in mitochondria and cytosol of mammalian cells. J. Biol. Chem. 281:25398–25406.
  • Gerber, J., K. Neuman, C. Prohl, U. Mühlenhoff, and R. Lill. 2004. The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins. Mol. Cell. Biol. 24:4848–4857.
  • Hausmann, A., D. J. Aguilar Netz, J. Balk, A. J. Pierik, U. Mühlenhoff, and R. Lill. 2005. The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery. Proc. Natl. Acad. Sci. USA 102:3266–3271.
  • Huang, B., M. J. Johansson, and A. S. Byström. 2005. An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 11:424–436.
  • Ikeuchi, Y., N. Shigi, J. Kato, A. Nishimura, and T. Suzuki. 2006. Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions. Mol. Cell 21:97–108.
  • Jäger, G., R. Leipuviene, M. G. Pollard, Q. Qian, and G. R. Björk. 2004. The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium. J. Bacteriol. 186:750–757.
  • Johnson, D. C., D. R. Dean, A. D. Smith, and M. K. Johnson. 2005. Structure, function, and formation of biological iron-sulfur clusters. Annu. Rev. Biochem. 74:247–281.
  • Kambampati, R., and C. T. Lauhon. 1999. IscS is a sulfurtransferase for the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. Biochemistry 38:16561–16568.
  • Kambampati, R. and C. T. Lauhon. 2003. MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli. Biochemistry 42:1109–1117.
  • Kispal, G., P. Csere, C. Prohl, and R. Lill. 1999. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 18:3981–3989.
  • Kispal, G., K. Sipos, H. Lange, Z. Fekete, T. Bedekovics, T. Janaky, J. Bassler, D. J. Aguilar Netz, J. Balk, C. Rotte, and R. Lill. 2005. Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J. 24:589–598.
  • Kolman, C. and D. Söll. 1993. SPL1-1, a Saccharomyces cerevisiae mutation affecting tRNA splicing. J. Bacteriol. 175:1433–1442.
  • Lauhon, C. T. 2002. Requirement for IscS in biosynthesis of all thionucleosides in Escherichia coli. J. Bacteriol. 184:6820–6829.
  • Lauhon, C. T., and R. Kambampati. 2000. The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD. J. Biol. Chem. 275:20096–20103.
  • Leipuviene, R., Q. Qian, and G. R. Björk. 2004. Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways. J. Bacteriol. 186:758–766.
  • Li, J., M. Kogan, S. A. Knight, D. Pain, and A. Dancis. 1999. Yeast mitochondrial protein, Nfs1p, coordinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron distribution. J. Biol. Chem. 274:33025–33034.
  • Lill, R. and U. Mühlenhoff. 2005. Iron-sulfur-protein biogenesis in eukaryotes. Trends Biochem. Sci. 30:133–141.
  • Lill, R. and U. Mühlenhoff. 2006. Iron-sulfur protein biogenesis in eukaryotes: components and mechanisms. Annu. Rev. Cell Dev. Biol. 22:457–486.
  • Lundgren, H. K., and G. R. Björk. 2006. Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation. J. Bacteriol. 188:3052–3062.
  • Mueller, E. G., P. M. Palenchar, and C. J. Buck. 2001. The role of the cysteine residues of ThiI in the generation of 4-thiouridine in tRNA. J. Biol. Chem. 276:33588–33595.
  • Mühlenhoff, U., J. Balk, N. Richhardt, J. T. Kaiser, K. Sipos, G. Kispal, and R. Lill. 2004. Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae. J. Biol. Chem. 279:36906–36915.
  • Mühlenhoff, U., J. Gerber, N. Richhardt, and R. Lill. 2003. Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p. EMBO J. 22:4815–4825.
  • Nakai, Y., M. Nakai, H. Hayashi, and H. Kagamiyama. 2001. Nuclear localization of yeast Nfs1p is required for cell survival. J. Biol. Chem. 276:8314–8320.
  • Nakai, Y., Y. Yoshihara, H. Hayashi, and H. Kagamiyama. 1998. cDNA cloning and characterization of mouse nifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins. FEBS Lett. 433:143–148.
  • Nakai, Y., N. Umeda, T. Suzuki, M. Nakai, H. Hayashi, K. Watanabe, and H. Kagamiyama. 2004. Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J. Biol. Chem. 279:12363–12368.
  • Nilsson, K., H. K. Lundgren, T. G. Hagervall, and G. R. Björk. 2002. The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium. J. Bacteriol. 184:6830–6835.
  • Paraskevopoulou, C., S. A. Fairhurst, D. J. Lowe, P. Brick, and S. Onesti. 2006. The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine. Mol. Microbiol. 59:795–806.
  • Pierrel, F., G. R. Björk, M. Fontecave, and M. Atta. 2002. Enzymatic modification of tRNAs: MiaB is an iron-sulfur protein. J. Biol. Chem. 277:13367–13370.
  • Schwartz, C. J., O. Djaman, J. A. Imlay, and P. J. Kiley. 2000. The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli. Proc. Natl. Acad. Sci. USA 97:9009–9014.
  • Takano, A., T. Endo, and T. Yoshihisa. 2005. tRNA actively shuttles between the nucleus and cytosol in yeast. Science 309:140–142.
  • Umeda, N., T. Suzuki, M. Yukawa, Y. Ohya, H. Shindo, K. Watanabe, and T. Suzuki. 2005. Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J. Biol. Chem. 280:1613–1624.
  • Urbina, H. D., J. J. Silberg, K. G. Hoff, and L. E. Vickery. 2001. Transfer of sulfur from IscS to IscU during Fe/S cluster assembly. J. Biol. Chem. 276:44521–44526.
  • Wiedemann, N., E. Urzica, B. Guiard, H. Muller, C. Lohaus, H. E. Meyer, M. T. Ryan, C. Meisinger, U. Mühlenhoff, R. Lill, and N. Pfanner. 2006. Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J. 25:184–195.
  • Yarunin, A., V. G. Panse, E. Petfalski, C. Dez, D. Tollervey, and E. C. Hurt. 2005. Functional link between ribosome formation and biogenesis of iron-sulfur proteins. EMBO J. 24:580–588.
  • Yuvaniyama, P., J. N. Agar, V. L. Cash, M. K. Johnson, and D. R. Dean. 2000. NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein. Proc. Natl. Acad. Sci. USA 97:599–604.
  • Zheng, L., V. L. Cash, D. H. Flint, and D. R. Dean. 1998. Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii. J. Biol. Chem. 273:13264–13272.
  • Zheng, L., R. H. White, V. L. Cash, and D. R. Dean. 1994. Mechanism for the desulfurization of l-cysteine catalyzed by the nifS gene product. Biochemistry 33:4714–4720.

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