Early-Onset Aging and Defective DNA Damage Response in Cdc14b-Deficient Mice

REFERENCES

• Adams, P. D. 2009. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol. Cell 36:2–14.
   PubMed Web of Science ®Google Scholar
• Bassermann, F., et al. 2008. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 134:256–267.
   PubMed Web of Science ®Google Scholar
• Bembenek, J., and H. Yu. 2003. Regulation of CDC14: pathways and checkpoints of mitotic exit. Front. Biosci. 8:d1275–d1287.
   PubMedGoogle Scholar
• Berdougo, E., M. V. Nachury, P. K. Jackson, and P. V. Jallepalli. 2008. The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Cell Cycle 7:1184–1190.
   PubMed Web of Science ®Google Scholar
• Cho, H. P., et al. 2005. The Dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. Mol. Cell. Biol. 25:4541–4551.
   PubMed Web of Science ®Google Scholar
• Dimri, G. P., et al. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 92:9363–9367.
   PubMed Web of Science ®Google Scholar
• García-Higuera, I., et al. 2008. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat. Cell Biol. 10:802–811.
   PubMed Web of Science ®Google Scholar
• Hoeijmakers, J. H. J. 2009. DNA damage, aging, and cancer. N. Engl. J. Med. 361:1475–1485.
   PubMed Web of Science ®Google Scholar
• Jackson, S. P., and J. Bartek. 2009. The DNA-damage response in human biology and disease. Nature 461:1071–1078.
   PubMed Web of Science ®Google Scholar
• Kaiser, B. K., Z. A. Zimmerman, H. Charbonneau, and P. K. Jackson. 2002. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. Mol. Biol. Cell 13:2289–2300.
   PubMed Web of Science ®Google Scholar
• Li, L., B. R. Ernsting, M. J. Wishart, D. L. Lohse, and J. E. Dixon. 1997. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J. Biol. Chem. 272:29403–29406.
   PubMed Web of Science ®Google Scholar
• Li, M., et al. 2008. The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat. Cell Biol. 10:1083–1089.
   PubMed Web of Science ®Google Scholar
• Lindahl, T. 1993. Instability and decay of the primary structure of DNA. Nature 362:709–715.
   PubMed Web of Science ®Google Scholar
• Mailand, N., et al. 2002. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat. Cell Biol. 4:317–322.
   PubMed Web of Science ®Google Scholar
• Mocciaro, A., et al. 2010. Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J. Cell Biol. 189:631–639.
   PubMed Web of Science ®Google Scholar
• Rodier, G., P. Coulombe, P.-L. Tanguay, C. Boutonnet, and S. Meloche. 2008. Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC-Cdh1 in G1 phase. EMBO J. 27:679–691.
   PubMed Web of Science ®Google Scholar
• Schindler, K., and R. M. Schultz. 2009. The CDC14A phosphatase regulates oocyte maturation in mouse. Cell Cycle 8:1090–1098.
   PubMed Web of Science ®Google Scholar
• Schindler, K., and R. M. Schultz. 2009. CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes. Biol. Reprod. 80:795–803.
   PubMedGoogle Scholar
• Schmitz, M. H. A., et al. 2010. Live-cell imaging RNAi screen identifies PP2A –B55α and importin-β1 as key mitotic exit regulators in human cells. Nat. Cell Biol. 12:886–893.
   PubMed Web of Science ®Google Scholar
• Stegmeier, F., and A. Amon. 2004. Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu. Rev. Genet. 38:203–232.
   PubMed Web of Science ®Google Scholar
• Tallquist, M., and P. Soriano. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26:113–115.
   PubMedGoogle Scholar
• Todaro, G. J., and H. Green. 1963. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17:299–313.
   PubMed Web of Science ®Google Scholar
• Wu, J., et al. 2008. Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. J. Cell Biol. 181:475–483.
   PubMed Web of Science ®Google Scholar
• Wu, J., et al. 2009. PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat. Cell Biol. 11:644–651.
   PubMedGoogle Scholar
• Zhang, L., et al. 2010. Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. EMBO J. 29:1726–1737.
   PubMed Web of Science ®Google Scholar