29
Views
17
CrossRef citations to date
0
Altmetric
Article

Fyn Regulates Adipogenesis by Promoting PIKE-A/STAT5a Interaction

, , , &
Pages 1797-1808 | Received 17 Oct 2012, Accepted 15 Feb 2013, Published online: 20 Mar 2023

REFERENCES

  • Gesta S, Tseng YH, Kahn CR. 2007. Developmental origin of fat: tracking obesity to its source. Cell 131:242–256.
  • Nanbu-Wakao R, Fujitani Y, Masuho Y, Muramatu M, Wakao H. 2000. Prolactin enhances CCAAT enhancer-binding protein-beta (C/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells. Mol. Endocrinol. 14:307–316.
  • White UA, Stephens JM. 2010. Transcriptional factors that promote formation of white adipose tissue. Mol. Cell. Endocrinol. 318:10–14.
  • Hennighausen L, Robinson GW. 2008. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev. 22:711–721.
  • Shang CA, Waters MJ. 2003. Constitutively active signal transducer and activator of transcription 5 can replace the requirement for growth hormone in adipogenesis of 3T3-F442A preadipocytes. Mol. Endocrinol. 17:2494–2508.
  • Floyd ZE, Stephens JM. 2003. STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes 52:308–314.
  • Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, Hennighausen L. 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 11:179–186.
  • Stewart WC, Pearcy LA, Floyd ZE, Stephens JM. 2011. STAT5A expression in Swiss 3T3 cells promotes adipogenesis in vivo in an athymic mice model system. Obesity (Silver Spring) 19:1731–1734.
  • Kefalas P, Brown TR, Brickell PM. 1995. Signalling by the p60c-src family of protein-tyrosine kinases. Int. J. Biochem. Cell Biol. 27:551–563.
  • Fresno Vara JA, Caceres MA, Silva A, Martin-Perez J. 2001. Src family kinases are required for prolactin induction of cell proliferation. Mol. Biol. Cell 12:2171–2183.
  • Van Coppenolle F, Skryma R, Ouadid-Ahidouch H, Slomianny C, Roudbaraki M, Delcourt P, Dewailly E, Humez S, Crepin A, Gourdou I, Djiane J, Bonnal JL, Mauroy B, Prevarskaya N. 2004. Prolactin stimulates cell proliferation through a long form of prolactin receptor and K+ channel activation. Biochem. J. 377:569–578.
  • Bastie CC, Zong H, Xu J, Busa B, Judex S, Kurland IJ, Pessin JE. 2007. Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Cell Metab. 5:371–381.
  • Yamada E, Pessin JE, Kurland IJ, Schwartz GJ, Bastie CC. 2010. Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab. 11:113–124.
  • Long H, Bock HH, Lei T, Chai X, Yuan J, Herz J, Frotscher M, Yang Z. 2011. Identification of alternatively spliced Dab1 and Fyn isoforms in pig. BMC Neurosci. 12:17.
  • Li S, Zhang HY, Hu CC, Lawrence F, Gallagher KE, Surapaneni A, Estrem ST, Calley JN, Varga G, Dow ER, Chen Y. 2008. Assessment of diet-induced obese rats as an obesity model by comparative functional genomics. Obesity (Silver Spring) 16:811–818.
  • Ahn JY, Hu Y, Kroll TG, Allard P, Ye K. 2004. PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc. Natl. Acad. Sci. U. S. A. 101:6993–6998.
  • Cai Y, Wang J, Li R, Ayala G, Ittmann M, Liu M. 2009. GGAP2/PIKE-a directly activates both the Akt and nuclear factor-κB pathways and promotes prostate cancer progression. Cancer Res. 69:819–827.
  • Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS. 1997. Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. Genomics 42:295–301.
  • Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N. 1996. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 3:17–24.
  • Nie Z, Fei J, Premont RT, Randazzo PA. 2005. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. J. Cell Sci. 118:3555–3566.
  • Chan CB, Liu X, Jung DY, Jun JY, Luo HR, Kim JK, Ye K. 2010. Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes 59:883–893.
  • Chan CB, Liu X, Ensslin MA, Dillehay DL, Ormandy CJ, Sohn P, Serra R, Ye K. 2010. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J. 29:956–968.
  • Chan CB, Liu X, He K, Qi Q, Jung DY, Kim JK, Ye K. 2011. The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep. 12:847–854.
  • Osterhout DJ, Wolven A, Wolf RM, Resh MD, Chao MV. 1999. Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase. J. Cell Biol. 145:1209–1218.
  • Kline JB, Roehrs H, Clevenger CV. 1999. Functional characterization of the intermediate isoform of the human prolactin receptor. J. Biol. Chem. 274:35461–35468.
  • Abella A, Dubus P, Malumbres M, Rane SG, Kiyokawa H, Sicard A, Vignon F, Langin D, Barbacid M, Fajas L. 2005. Cdk4 promotes adipogenesis through PPARγ activation. Cell Metab. 2:239–249.
  • Kim WK, Jung H, Kim DH, Kim EY, Chung JW, Cho YS, Park SG, Park BC, Ko Y, Bae KH, Lee SC. 2009. Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3T3-L1 preadipocytes. J. Cell Sci. 122:4160–4167.
  • Wang J, Lazar MA. 2008. Bifunctional role of Rev.-erbα in adipocyte differentiation. Mol. Cell. Biol. 28:2213–2220.
  • Kang NJ, Lee KW, Shin BJ, Jung SK, Hwang MK, Bode AM, Heo YS, Lee HJ, Dong Z. 2009. Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis 30:321–330.
  • Stewart WC, Baugh JEJr, Floyd ZE, Stephens JM. 2004. STAT 5 activators can replace the requirement of FBS in the adipogenesis of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 324:355–359.
  • Tang X, Feng Y, Ye K. 2007. Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Cell Death Differ. 14:368–377.
  • Fleenor D, Arumugam R, Freemark M. 2006. Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. Horm. Res. 66:101–110.
  • Sun Y, Ma YC, Huang J, Chen KY, McGarrigle DK, Huang XY. 2005. Requirement of SRC-family tyrosine kinases in fat accumulation. Biochemistry 44:14455–14462.
  • Cooke MP, Abraham KM, Forbush KA, Perlmutter RM. 1991. Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell 65:281–291.
  • Morse WR, Whitesides JGIII, LaMantia AS, Maness PF. 1998. p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway. J. Neurobiol. 36:53–63.
  • Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER. 1992. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258:1903–1910.
  • Yadav V, Denning MF. 2011. Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Mol. Carcinog. 50:346–352.
  • Wu W, Kinsey WH. 2000. Fertilization triggers activation of Fyn kinase in the zebrafish egg. Int. J. Dev. Biol. 44:837–841.
  • Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Naslund E, Britton T, Concha H, Hassan M, Ryden M, Frisen J, Arner P. 2008. Dynamics of fat cell turnover in humans. Nature 453:783–787.
  • Stephens JM, Morrison RF, Pilch PF. 1996. The expression and regulation of STATs during 3T3-L1 adipocyte differentiation. J. Biol. Chem. 271:10441–10444.
  • Stephens JM, Morrison RF, Wu Z, Farmer SR. 1999. PPARγ ligand-dependent induction of STAT1, STAT5A, and STAT5B during adipogenesis. Biochem. Biophys. Res. Commun. 262:216–222.
  • Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW. 1997. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. U. S. A. 94:7239–7244.
  • Gregoire FM, Smas CM, Sul HS. 1998. Understanding adipocyte differentiation. Physiol. Rev. 78:783–809.
  • Freemark M, Fleenor D, Driscoll P, Binart N, Kelly P. 2001. Body weight and fat deposition in prolactin receptor-deficient mice. Endocrinology 142:532–537.
  • LaPensee CR, Horseman ND, Tso P, Brandebourg TD, Hugo ER, Ben-Jonathan N. 2006. The prolactin-deficient mouse has an unaltered metabolic phenotype. Endocrinology 147:4638–4645.
  • McAveney KM, Gimble JM, Yu-Lee L. 1996. Prolactin receptor expression during adipocyte differentiation of bone marrow stroma. Endocrinology 137:5723–5726.
  • Harp JB, Franklin D, Vanderpuije AA, Gimble JM. 2001. Differential expression of signal transducers and activators of transcription during human adipogenesis. Biochem. Biophys. Res. Commun. 281:907–912.
  • Doknic M, Pekic S, Zarkovic M, Medic-Stojanoska M, Dieguez C, Casanueva F, Popovic V. 2002. Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptine. Eur. J. Endocrinol. 147:77–84.
  • Greenman Y, Tordjman K, Stern N. 1998. Increased body weight associated with prolactin secreting pituitary adenomas: weight loss with normalization of prolactin levels. Clin. Endocrinol. (Oxf.) 48:547–553.
  • Clevenger CV, Medaglia MV. 1994. The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes. Mol. Endocrinol. 8:674–681.
  • Agarwal AK, Garg A. 2006. Genetic disorders of adipose tissue development, differentiation, and death. Annu. Rev. Genomics Hum. Genet. 7:175–199.
  • Camp HS, Ren D, Leff T. 2002. Adipogenesis and fat-cell function in obesity and diabetes. Trends Mol. Med. 8:442–447.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.