Extracellular Signal-Regulated Protein Kinase 2 Is Required for Efficient Generation of B Cells Bearing Antigen-Specific Immunoglobulin G

REFERENCES

• Allan, L. A., N. Morrice, S. Brady, G. Magee, S. Pathak, and P. R. Clarke. 2003. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat. Cell. Biol. 5:647–654.
   PubMed Web of Science ®Google Scholar
• Bain, G., C. B. Cravatt, C. Loomans, J. Alberola-Ila, S. M. Hedrick, and C. Murre. 2001. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat. Immunol. 2:165–171.
   PubMed Web of Science ®Google Scholar
• Chu, C. C., W. E. Paul, and E. E. Max. 1992. Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. Proc. Natl. Acad. Sci. USA 89:6978–6982.
   PubMed Web of Science ®Google Scholar
• Cory, S., and J. M. Adams. 2002. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2:647–656.
   PubMed Web of Science ®Google Scholar
• Enders, A., P. Bouillet, H. Puthalakath, Y. Xu, D. M. Tarlinton, and A. Strasser. 2003. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J. Exp. Med. 198:1119–1126.
   PubMed Web of Science ®Google Scholar
• Fischer, A. M., C. D. Katayama, G. Pages, J. Pouyssegur, and S. M. Hedrick. 2005. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23:431–443.
   PubMed Web of Science ®Google Scholar
• Fleming, H. E., and C. J. Paige. 2001. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity 15:521–531.
   PubMedGoogle Scholar
• Genot, E., and D. A. Cantrell. 2000. Ras regulation and function in lymphocytes. Curr. Opin. Immunol. 12:289–294.
   PubMedGoogle Scholar
• Glynne, R., S. Akkaraju, J. I. Healy, J. Rayner, C. C. Goodnow, and D. H. Mack. 2000. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature 403:672–676.
   PubMedGoogle Scholar
• Hasbold, J., L. M. Corcoran, D. M. Tarlinton, S. G. Tangye, and P. D. Hodgkin. 2004. Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation. Nat. Immunol. 5:55–63.
   PubMedGoogle Scholar
• Hatano, N., Y. Mori, M. Oh-hora, A. Kosugi, T. Fujikawa, N. Nakai, H. Niwa, J. Miyazaki, T. Hamaoka, and M. Ogata. 2003. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8:847–856.
   PubMed Web of Science ®Google Scholar
• Healy, J. I., R. E. Dolmetsch, L. A. Timmerman, J. G. Cyster, M. L. Thomas, G. R. Crabtree, R. S. Lewis, and C. C. Goodnow. 1997. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 6:419–428.
   PubMed Web of Science ®Google Scholar
• Hikida, M., S. Johmura, A. Hashimoto, M. Takezaki, and T. Kurosaki. 2003. Coupling between B cell receptor and phospholipase C-gamma2 is essential for mature B cell development. J. Exp. Med. 198:581–589.
   PubMed Web of Science ®Google Scholar
• Honjo, T., K. Kinoshita, and M. Muramatsu. 2002. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 20:165–196.
   PubMed Web of Science ®Google Scholar
• Huntington, N. D., Y. Xu, H. Puthalakath, A. Light, S. N. Willis, A. Strasser, and D. M. Tarlinton. 2006. CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat. Immunol. 7:190–198.
   PubMed Web of Science ®Google Scholar
• Ikeda, M., O. Ishida, T. Hinoi, S. Kishida, and A. Kikuchi. 1998. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. J. Biol. Chem. 273:814–821.
   PubMed Web of Science ®Google Scholar
• Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165–1175.
   PubMed Web of Science ®Google Scholar
• Jacob, J., and G. Kelsoe. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679–687.
   PubMed Web of Science ®Google Scholar
• Katz, M. E., and F. McCormick. 1997. Signal transduction from multiple Ras effectors. Curr. Opin. Genet. Dev. 7:75–79.
   PubMed Web of Science ®Google Scholar
• Kolch, W. 2005. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat. Rev. Mol. Cell. Biol. 6:827–837.
   PubMed Web of Science ®Google Scholar
• Ley, R., K. Balmanno, K. Hadfield, C. Weston, and S. J. Cook. 2003. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 278:18811–18816.
   PubMed Web of Science ®Google Scholar
• Liu, Y. J., J. Zhang, P. J. Lane, E. Y. Chan, and I. C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951–2962.
   PubMed Web of Science ®Google Scholar
• Luciano, F., A. Jacquel, P. Colosetti, M. Herrant, S. Cagnol, G. Pages, and P. Auberger. 2003. Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 22:6785–6793.
   PubMed Web of Science ®Google Scholar
• MacLennan, I. C., A. Gulbranson-Judge, K. M. Toellner, M. Casamayor-Palleja, E. Chan, D. M. Sze, S. A. Luther, and H. A. Orbea. 1997. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol. Rev. 156:53–66.
   PubMed Web of Science ®Google Scholar
• MacLennan, I. C., K. M. Toellner, A. F. Cunningham, K. Serre, D. M. Sze, E. Zuniga, M. C. Cook, and C. G. Vinuesa. 2003. Extrafollicular antibody responses. Immunol. Rev. 194:8–18.
   PubMed Web of Science ®Google Scholar
• Martin, S. W., and C. C. Goodnow. 2002. Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory. Nat. Immunol. 3:182–188.
   PubMed Web of Science ®Google Scholar
• McHeyzer-Williams, L. J., and M. G. McHeyzer-Williams. 2005. Antigen-specific memory B cell development. Annu. Rev. Immunol. 23:487–513.
   PubMed Web of Science ®Google Scholar
• Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553–563.
   PubMed Web of Science ®Google Scholar
• Nagaoka, H., Y. Takahashi, R. Hayashi, T. Nakamura, K. Ishii, J. Matsuda, A. Ogura, Y. Shirakata, H. Karasuyama, T. Sudo, S. Nishikawa, T. Tsubata, T. Mizuochi, T. Asano, H. Sakano, and T. Takemori. 2000. Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J. Exp. Med. 192:171–182.
   PubMedGoogle Scholar
• O'Connor, B. P., V. S. Raman, L. D. Erickson, W. J. Cook, L. K. Weaver, C. Ahonen, L. L. Lin, G. T. Mantchev, R. J. Bram, and R. J. Noelle. 2004. BCMA is essential for the survival of long-lived bone marrow plasma cells. J. Exp. Med. 199:91–98.
   PubMed Web of Science ®Google Scholar
• Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751–758.
   PubMed Web of Science ®Google Scholar
• Richards, J. D., S. H. Dave, C. H. Chou, A. A. Mamchak, and A. L. DeFranco. 2001. Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J. Immunol. 166:3855–3864.
   PubMed Web of Science ®Google Scholar
• Rickert, R. C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25:1317–1318.
   PubMed Web of Science ®Google Scholar
• Rui, L., C. G. Vinuesa, J. Blasioli, and C. C. Goodnow. 2003. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat. Immunol. 4:594–600.
   PubMed Web of Science ®Google Scholar
• Saba-El-Leil, M. K., F. D. Vella, B. Vernay, L. Voisin, L. Chen, N. Labrecque, S. L. Ang, and S. Meloche. 2003. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4:964–968.
   PubMed Web of Science ®Google Scholar
• Shapiro-Shelef, M., and K. Calame. 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5:230–242.
   PubMed Web of Science ®Google Scholar
• Shaw, A. C., W. Swat, R. Ferrini, L. Davidson, and F. W. Alt. 1999. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. J. Exp. Med. 189:123–129.
   PubMedGoogle Scholar
• Strasser, A., S. Whittingham, D. L. Vaux, M. L. Bath, J. M. Adams, S. Cory, and A. W. Harris. 1991. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA 88:8661–8665.
   PubMed Web of Science ®Google Scholar
• Sze, D. M. Y., K.-M. Toellner, C. G. de Vinuesa, D. R. Taylor, and I. C. M. MacLennan. 2000. Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival. J. Exp. Med. 192:813–822.
   PubMed Web of Science ®Google Scholar
• Takahashi, Y., A. Inamine, S. Hashimoto, S. Haraguchi, E. Yoshioka, N. Kojima, R. Abe, and T. Takemori. 2005. Novel role of the Ras cascade in memory B cell response. Immunity 23:127–138.
   PubMedGoogle Scholar
• Vinuesa, C. G., S. G. Tangye, B. Moser, and C. R. Mackay. 2005. Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol. 5:853–865.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, C., T. Adachi, J. Wienands, and T. Tsubata. 2002. A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science 298:2392–2395.
   PubMed Web of Science ®Google Scholar
• Wolthuis, R. M., F. Zwartkruis, T. C. Moen, and J. L. Bos. 1998. Ras-dependent activation of the small GTPase Ral. Curr. Biol. 8:471–474.
   PubMed Web of Science ®Google Scholar
• Yamaguchi, A., T. Urano, T. Goi, and L. A. Feig. 1997. An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1. J. Biol. Chem. 272:31230–31234.
   PubMed Web of Science ®Google Scholar