Thioesterase Superfamily Member 2 (Them2) and Phosphatidylcholine Transfer Protein (PC-TP) Interact To Promote Fatty Acid Oxidation and Control Glucose Utilization

REFERENCES

• Wei J, Kang HW, Cohen DE. 2009. Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs. Biochem. J. 421:311–322. http://dx.doi.org/10.1042/BJ20090039.
   PubMedGoogle Scholar
• Cao J, Xu H, Zhao H, Gong W, Dunaway-Mariano D. 2009. The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry 48:1293–1304. http://dx.doi.org/10.1021/bi801879z.
   PubMedGoogle Scholar
• Kanno K, Wu MK, Agate DS, Fanelli BJ, Wagle N, Scapa EF, Ukomadu C, Cohen DE. 2007. Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2. J. Biol. Chem. 282:30728–30736. http://dx.doi.org/10.1074/jbc.M703745200.
   PubMedGoogle Scholar
• Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE. 2009. Mice lacking Pctp/StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J. Lipid Res. 50:2212–2221. http://dx.doi.org/10.1194/jlr.M900013-JLR200.
   PubMedGoogle Scholar
• Cheng Z, Bao S, Shan X, Xu H, Gong W. 2006. Human thioesterase superfamily member 2 (hTHEM2) is co-localized with beta-tubulin onto the microtubule. Biochem. Biophys. Res. Commun. 350:850–853. http://dx.doi.org/10.1016/j.bbrc.2006.09.105.
   PubMedGoogle Scholar
• Kang HW, Niepel MW, Han S, Kawano Y, Cohen DE. 2012. Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism. FASEB J. 26:2209–2221. http://dx.doi.org/10.1096/fj.11-202853.
   PubMed Web of Science ®Google Scholar
• Kang HW, Ozdemir C, Kawano Y, LeClair KB, Vernochet C, Kahn CR, Hagen SJ, Cohen DE. 2013. Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. J. Biol. Chem. 288:33376–33386. http://dx.doi.org/10.1074/jbc.M113.481408.
   PubMedGoogle Scholar
• Roderick SL, Chan WW, Agate DS, Olsen LR, Vetting MW, Rajashankar KR, Cohen DE. 2002. Structure of human phosphatidylcholine transfer protein in complex with its ligand. Nat. Struct. Biol. 9:507–511. http://dx.doi.org/10.1038/nsb812.
   PubMedGoogle Scholar
• Scapa EF, Pocai A, Wu MK, Gutierrez-Juarez R, Glenz L, Kanno K, Li H, Biddinger S, Jelicks LA, Rossetti L, Cohen DE. 2008. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. FASEB J. 22:2579–2590. http://dx.doi.org/10.1096/fj.07-105395.
   PubMedGoogle Scholar
• Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. 2013. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci. Signal. 6:ra64. http://dx.doi.org/10.1126/scisignal.2004111.
   PubMed Web of Science ®Google Scholar
• Kang HW, Kanno K, Scapa EF, Cohen DE. 2010. Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα). Biochim. Biophys. Acta 1801:496–502. http://dx.doi.org/10.1016/j.bbalip.2009.12.013.
   PubMedGoogle Scholar
• Kang HW, Wei J, Cohen DE. 2010. PC-TP/StARD2: of membranes and metabolism. Trends Endocrinol. Metab. 21:449–456. http://dx.doi.org/10.1016/j.tem.2010.02.001.
   PubMedGoogle Scholar
• Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. 1999. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103:1489–1498. http://dx.doi.org/10.1172/JCI6223.
   PubMed Web of Science ®Google Scholar
• Lee P, Peng H, Gelbart T, Beutler E. 2004. The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and β2-microglobulin-deficient hepatocytes. Proc. Natl. Acad. Sci. U. S. A. 101:9263–9265. http://dx.doi.org/10.1073/pnas.0403108101.
   PubMed Web of Science ®Google Scholar
• Ellis JM, Li LO, Wu PC, Koves TR, Ilkayeva O, Stevens RD, Watkins SM, Muoio DM, Coleman RA. 2010. Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab. 12:53–64. http://dx.doi.org/10.1016/j.cmet.2010.05.012.
   PubMed Web of Science ®Google Scholar
• Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K, Inoue H, Hosooka T, Takazawa K, Kido Y, Yasuda K, Hiramatsu R, Matsuki Y, Kasuga M. 2012. CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis. Nat. Med. 18:612–617. http://dx.doi.org/10.1038/nm.2691.
   PubMedGoogle Scholar
• Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman MA, Gutierrez-Juarez R, Cuny GD, Cohen DE. 2011. Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54:664–674. http://dx.doi.org/10.1002/hep.24393.
   PubMed Web of Science ®Google Scholar
• Lee AH, Scapa EF, Cohen DE, Glimcher LH. 2008. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320:1492–1496. http://dx.doi.org/10.1126/science.1158042.
   PubMed Web of Science ®Google Scholar
• Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA. 2007. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab. 5:313–320. http://dx.doi.org/10.1016/j.cmet.2007.03.004.
   PubMed Web of Science ®Google Scholar
• Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, Finck BN. 2006. Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α)-deficient mice. J. Biol. Chem. 281:19000–19008. http://dx.doi.org/10.1074/jbc.M600050200.
   PubMedGoogle Scholar
• Chutkow WA, Patwari P, Yoshioka J, Lee RT. 2008. Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. J. Biol. Chem. 283:2397–2406. http://dx.doi.org/10.1074/jbc.M708169200.
   PubMed Web of Science ®Google Scholar
• Foster DW. 2012. Malonyl-CoA: the regulator of fatty acid synthesis and oxidation. J. Clin. Invest. 122:1958–1959. http://dx.doi.org/10.1172/JCI63967.
   PubMed Web of Science ®Google Scholar
• Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. 2007. Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5:426–437. http://dx.doi.org/10.1016/j.cmet.2007.05.002.
   PubMed Web of Science ®Google Scholar
• Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC. 2009. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc. Natl. Acad. Sci. U. S. A. 106:10853–10858. http://dx.doi.org/10.1073/pnas.0904187106.
   PubMed Web of Science ®Google Scholar
• Hondares E, Rosell M, Diaz-Delfin J, Olmos Y, Monsalve M, Iglesias R, Villarroya F, Giralt M. 2011. Peroxisome proliferator-activated receptor alpha (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J. Biol. Chem. 286:43112–43122. http://dx.doi.org/10.1074/jbc.M111.252775.
   PubMed Web of Science ®Google Scholar
• Kawano Y, Cohen DE. 2013. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J. Gastroenterol. 48:434–441. http://dx.doi.org/10.1007/s00535-013-0758-5.
   PubMed Web of Science ®Google Scholar
• Wagle N, Xian J, Shishova EY, Wei J, Glicksman MA, Cuny GD, Stein RL, Cohen DE. 2008. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal. Biochem. 383:85–92. http://dx.doi.org/10.1016/j.ab.2008.07.039.
   PubMedGoogle Scholar
• Lee K, Kerner J, Hoppel CL. 2011. Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex. J. Biol. Chem. 286:25655–25662. http://dx.doi.org/10.1074/jbc.M111.228692.
   PubMed Web of Science ®Google Scholar
• Kerner J, Hoppel C. 2000. Fatty acid import into mitochondria. Biochim. Biophys. Acta 1486:1–17. http://dx.doi.org/10.1016/S1388-1981(00)00044-5.
   PubMed Web of Science ®Google Scholar
• Rinaldo P, Matern D, Bennett MJ. 2002. Fatty acid oxidation disorders. Annu. Rev. Physiol. 64:477–502. http://dx.doi.org/10.1146/annurev.physiol.64.082201.154705.
   PubMed Web of Science ®Google Scholar
• Longuet C, Sinclair EM, Maida A, Baggio LL, Maziarz M, Charron MJ, Drucker DJ. 2008. The glucagon receptor is required for the adaptive metabolic response to fasting. Cell Metab. 8:359–371. http://dx.doi.org/10.1016/j.cmet.2008.09.008.
   PubMed Web of Science ®Google Scholar
• Owen OE, Kalhan SC, Hanson RW. 2002. The key role of anaplerosis and cataplerosis for citric acid cycle function. J. Biol. Chem. 277:30409–30412. http://dx.doi.org/10.1074/jbc.R200006200.
   PubMed Web of Science ®Google Scholar
• Jenkins CM, Yang J, Sims HF, Gross RW. 2011. Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism. J. Biol. Chem. 286:11937–11950. http://dx.doi.org/10.1074/jbc.M110.203661.
   PubMed Web of Science ®Google Scholar
• Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. 1999. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115–124. http://dx.doi.org/10.1016/S0092-8674(00)80611-X.
   PubMed Web of Science ®Google Scholar
• Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB. 2006. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 55:2562–2570. http://dx.doi.org/10.2337/db05-1322.
   PubMed Web of Science ®Google Scholar
• Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B. 2005. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54:1331–1339. http://dx.doi.org/10.2337/diabetes.54.5.1331.
   PubMed Web of Science ®Google Scholar
• Taylor EB, Ellingson WJ, Lamb JD, Chesser DG, Winder WW. 2005. Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25. Am. J. Physiol. Endocrinol. Metab. 288:E1055–E1061. http://dx.doi.org/10.1152/ajpendo.00516.2004.
   PubMedGoogle Scholar
• Guillou H, Martin P, Jan S, D'Andrea S, Roulet A, Catheline D, Rioux V, Pineau T, Legrand P. 2002. Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor alpha-deficient mice. Lipids 37:981–989. http://dx.doi.org/10.1007/s11745-006-0990-3.
   PubMedGoogle Scholar
• Tang C, Cho HP, Nakamura MT, Clarke SD. 2003. Regulation of human Δ-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J. Lipid Res. 44:686–695. http://dx.doi.org/10.1194/jlr.M200195-JLR200.
   PubMed Web of Science ®Google Scholar
• Wheelock CE, Goto S, Hammock BD, Newman JW. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics 3:137–145. http://dx.doi.org/10.1007/s11306-007-0052-8.
   PubMedGoogle Scholar