Regulation of p27 Degradation and S-Phase Progression by Ro52 RING Finger Protein

REFERENCES

• Bashir, T., N. V. Dorrello, V. Amador, D. Guardavaccaro, and M. Pagano. 2004. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428:190–193.
   PubMed Web of Science ®Google Scholar
• Bloom, J., and M. Pagano. 2003. Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin. Cancer Biol. 13:41–47.
   PubMed Web of Science ®Google Scholar
• Carrano, A., E. Eytan, A. Hershko, and M. Pagano. 1999. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1:193–199.
   PubMed Web of Science ®Google Scholar
• Chan, E. K., F. Di Donato, J. C. Hamel, C. E. Tseng, and J. P. Buyon. 1995. 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. J. Exp. Med. 182:983–992.
   PubMed Web of Science ®Google Scholar
• Chan, E. K., J. C. Hamel, J. P. Buyon, and E. M. Tan. 1991. Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. J. Clin. Investig. 87:68–76.
   PubMed Web of Science ®Google Scholar
• Freemont, P. S. 2000. RING for destruction? Curr. Biol. 10:R84–R87.
   PubMed Web of Science ®Google Scholar
• Fukuda-Kamitani, T., and T. Kamitani. 2002. Ubiquitination of Ro52 autoantigen. Biochem. Biophys. Res. Commun. 295:774–778.
   PubMedGoogle Scholar
• Ganoth, D., G. Bornstein, T. K. Ko, B. Larsen, M. Tyers, M. Pagano, and A. Hershko. 2001. The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat. Cell Biol. 3:321–324.
   PubMed Web of Science ®Google Scholar
• Gstaiger, M., R. Jordan, M. Lim, C. Catzavelos, J. Mestan, J. Slingerland, and W. Krek. 2001. Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl. Acad. Sci. USA 98:5043–5048.
   PubMed Web of Science ®Google Scholar
• Gstaiger, M., B. Luke, D. Hess, E. J. Oakeley, C. Wirbelauer, M. Blondel, M. Vigneron, M. Peter, and W. Krek. 2003. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 302:1208–1212.
   PubMedGoogle Scholar
• Hengstermann, A., L. K. Linares, A. Ciechanover, N. J. Whitaker, and M. Scheffner. 2001. Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proc. Natl. Acad. Sci. USA 98:1218–1223.
   PubMedGoogle Scholar
• Ishii, T., K. Ohnuma, A. Murakami, N. Takasawa, T. Yamochi, S. Iwata, M. Uchiyama, N. H. Dang, H. Tanaka, and C. Morimoto. 2003. SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production. J. Immunol. 170:3653–3661.
   PubMedGoogle Scholar
• Koepp, D. M., L. K. Schaefer, X. Ye, K. Keyomarsi, C. Chu, J. W. Harper, and S. J. Elledge. 2001. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294:173–177.
   PubMed Web of Science ®Google Scholar
• Kossatz, U., N. Dietrich, L. Zender, J. Buer, M. P. Manns, and N. P. Malek. 2004. Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev. 18:2602–2607.
   PubMed Web of Science ®Google Scholar
• Latres, E., R. Chiarle, B. A. Schulman, N. P. Pavletich, A. Pellicer, G. Inghirami, and M. Pagano. 2001. Role of the F-box protein Skp2 in lymphomagenesis. Proc. Natl. Acad. Sci. USA 98:2515–2520.
   PubMed Web of Science ®Google Scholar
• Liao, E. H., W. Hung, B. Abrams, and M. Zhen. 2004. An SCF-like ubiquitin ligase complex that controls presynaptic differentiation. Nature 430:345–350.
   PubMedGoogle Scholar
• Lisztwan, J., G. Imbert, C. Wirbelauer, M. Gstaiger, and W. Krek. 1999. The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev. 13:1822–1833.
   PubMed Web of Science ®Google Scholar
• Lisztwan, J., A. Marti, H. Sutterluty, M. Gstaiger, C. Wirbelauer, and W. Krek. 1998. Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 17:368–383.
   PubMedGoogle Scholar
• Lorick, K. L., J. P. Jensen, S. Fang, A. M. Ong, S. Hatakeyama, and A. M. Weissman. 1999. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl. Acad. Sci. USA 96:11364–11369.
   PubMed Web of Science ®Google Scholar
• Marti, A., C. Wirbelauer, M. Scheffner, and W. Krek. 1999. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat. Cell Biol. 1:14–19.
   PubMed Web of Science ®Google Scholar
• Massague, J. 2004. G1 cell-cycle control and cancer. Nature 432:298–306.
   PubMed Web of Science ®Google Scholar
• Moberg, K. H., D. W. Bell, D. C. Wahrer, D. A. Haber, and I. K. Hariharan. 2001. Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413:311–316.
   PubMed Web of Science ®Google Scholar
• Montagnoli, A., F. Fiore, E. Eytan, A. C. Carrano, G. F. Draetta, A. Hershko, and M. Pagano. 1999. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13:1181–1189.
   PubMed Web of Science ®Google Scholar
• Nakayama, K., H. Nagahama, Y. A. Minamishima, M. Matsumoto, I. Nakamichi, K. Kitagawa, M. Shirane, R. Tsunematsu, T. Tsukiyama, N. Ishida, M. Kitagawa, K. Nakayama, and S. Hatakeyama. 2000. Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication. EMBO J. 19:2069–2081.
   PubMed Web of Science ®Google Scholar
• Nakayama, K., H. Nagahama, Y. A. Minamishima, S. Miyake, N. Ishida, S. Hatakeyama, M. Kitagawa, S. Iemura, T. Natsume, and K. I. Nakayama. 2004. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell 6:661–672.
   PubMed Web of Science ®Google Scholar
• Noureddine, M. A., T. D. Donaldson, S. A. Thacker, and R. J. Duronio. 2002. Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Dev. Cell 2:757–770.
   PubMedGoogle Scholar
• Reymond, A., G. Meroni, A. Fantozzi, G. Merla, S. Cairo, L. Luzi, D. Riganelli, E. Zanaria, S. Messali, S. Cainarca, A. Guffanti, S. Minucci, P. G. Pelicci, and A. Ballabio. 2001. The tripartite motif family identifies cell compartments. EMBO J. 20:2140–2151.
   PubMed Web of Science ®Google Scholar
• Rhodes, D. A., G. Ihrke, A. T. Reinicke, G. Malcherek, M. Towey, D. A. Isenberg, and J. Trowsdale. 2002. The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon-gamma inducible tripartite motif protein associated with membrane proximal structures. Immunology 106:246–256.
   PubMed Web of Science ®Google Scholar
• Scheffner, M., J. M. Huibregtse, and P. M. Howley. 1994. Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc. Natl. Acad. Sci. USA 91:8797–8801.
   PubMedGoogle Scholar
• Sherr, C. J., and J. M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512.
   PubMed Web of Science ®Google Scholar
• Spruck, C., H. Strohmaier, M. Watson, A. P. Smith, A. Ryan, T. W. Krek, and S. I. Reed. 2001. A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol. Cell 7:639–650.
   PubMed Web of Science ®Google Scholar
• Strohmaier, H., C. H. Spruck, P. Kaiser, K. A. Won, O. Sangfelt, and S. I. Reed. 2001. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413:316–322.
   PubMed Web of Science ®Google Scholar
• Sutterluty, H., E. Chatelain, A. Marti, C. Wirbelauer, M. Senften, U. Muller, and W. Krek. 1999. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat. Cell Biol. 1:207–214.
   PubMed Web of Science ®Google Scholar
• Tsvetkov, L. M., K. H. Yeh, S. H. Lee, H. Sun, and H. Zhang. 1999. p27 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated thr 187 in p27. Curr. Biol. 9:661–664.
   PubMed Web of Science ®Google Scholar
• Wei, W., N. G. Ayad, Y. Wan, G. J. Zhang, M. W. Kirschner, and W. G. Kaelin, Jr. 2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428:194–198.
   PubMed Web of Science ®Google Scholar
• Willems, A. R., M. Schwab, and M. Tyers. 2004. A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim. Biophys. Acta 1695:133–170.
   PubMed Web of Science ®Google Scholar
• Wirbelauer, C., H. Sutterluty, M. Blondel, M. Gstaiger, M. Peter, F. Reymond, and W. Krek. 2000. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J. 19:5362–5375.
   PubMedGoogle Scholar