Erythropoiesis in the Absence of Adult Hemoglobin

REFERENCES

• Boria I, Garelli E, Gazda HT, Aspesi A, Quarello P, Pavesi E, Ferrante D, Meerpohl JJ, Kartal M, Da Costa L, Proust A, Leblanc T, Simansour M, Dahl N, Frojmark AS, Pospisilova D, Cmejla R, Beggs AH, Sheen MR, Landowski M, Buros CM, Clinton CM, Dobson LJ, Vlachos A, Atsidaftos E, Lipton JM, Ellis SR, Ramenghi U, Dianzani I. 2010. The ribosomal basis of Diamond-Blackfan Anemia: mutation and database update. Hum. Mutat. 31:1269–1279.
   PubMed Web of Science ®Google Scholar
• Carotta S, Pilat S, Mairhofer A, Schmidt U, Dolznig H, Steinlein P, Beug H. 2004. Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells. Blood 104:1873–1880.
   PubMedGoogle Scholar
• Chen K, Liu J, Heck S, Chasis JA, An X, Mohandas N. 2009. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proc. Natl. Acad. Sci. U. S. A. 106:17413–17418.
   PubMed Web of Science ®Google Scholar
• Ciavatta DJ, Ryan TM, Farmer SC, Townes TM. 1995. Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 92:9259–9263.
   PubMedGoogle Scholar
• Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WMIII, Yanagimachi R, Jaenisch R. 2001. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc. Natl. Acad. Sci. U. S. A. 98:6209–6214.
   PubMed Web of Science ®Google Scholar
• Evans MJ, Kaufman MH. 1981. Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154–156.
   PubMed Web of Science ®Google Scholar
• Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. 1996. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc. Natl. Acad. Sci. U. S. A. 93:12355–12358.
   PubMed Web of Science ®Google Scholar
• Hentze MW, Muckenthaler MU, Galy B, Camaschella C. 2010. Two to tango: regulation of mammalian iron metabolism. Cell 142:24–38.
   PubMed Web of Science ®Google Scholar
• Hunefeld FL. 1836. Ueber das Verhalten des Blutroths zum Aether, und die Reindarstellung desselben. J. Prakt. Chem. 8:547–549.
   Google Scholar
• Huo Y, McConnell SC, Liu SR, Yang R, Zhang TT, Sun CW, Wu LC, Ryan TM. 2009. Humanized mouse model of Cooley's anemia. J. Biol. Chem. 284:4889–4896.
   PubMedGoogle Scholar
• Huo Y, McConnell SC, Ryan TM. 2009. Preclinical transfusion-dependent humanized mouse model of beta thalassemia major. Blood 113:4763–4770.
   PubMed Web of Science ®Google Scholar
• Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL. 2008. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319:825–828.
   PubMed Web of Science ®Google Scholar
• Kent G, Minick OT, Volini FI, Orfei E. 1966. Autophagic vacuoles in human red cells. Am. J. Pathol. 48:831–857.
   PubMed Web of Science ®Google Scholar
• Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J. 2006. “Maturational” globin switching in primary primitive erythroid cells. Blood 107:1665–1672.
   PubMedGoogle Scholar
• Kingsley PD, Malik J, Fantauzzo KA, Palis J. 2004. Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis. Blood 104:19–25.
   PubMed Web of Science ®Google Scholar
• Koller BH, Kim HS, Latour AM, Brigman K, Boucher RCJr, Scambler P, Wainwright B, Smithies O. 1991. Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 88:10730–10734.
   PubMed Web of Science ®Google Scholar
• Koury MJ, Koury ST, Kopsombut P, Bondurant MC. 2005. In vitro maturation of nascent reticulocytes to erythrocytes. Blood 105:2168–2174.
   PubMed Web of Science ®Google Scholar
• Libani IV, Guy EC, Melchiori L, Schiro R, Ramos P, Breda L, Scholzen T, Chadburn A, Liu Y, Kernbach M, Baron-Luhr B, Porotto M, de Sousa M, Rachmilewitz EA, Hood JD, Cappellini MD, Giardina PJ, Grady RW, Gerdes J, Rivella S. 2008. Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. Blood 112:875–885.
   PubMed Web of Science ®Google Scholar
• Lichtman MA, Santillo P. 1986. Red cell egress from the marrow? Vis-a-tergo. Blood Cells 12:11–23.
   PubMedGoogle Scholar
• McGrath K, Palis J. 2008. Ontogeny of erythropoiesis in the mammalian embryo. Curr. Top. Dev. Biol. 82:1–22.
   PubMedGoogle Scholar
• Miller IJ, Bieker JJ. 1993. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol. Cell. Biol. 13:2776–2786.
   PubMed Web of Science ®Google Scholar
• Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott WJJr, Potter SS. 1991. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677–689.
   PubMed Web of Science ®Google Scholar
• Na Nakorn T, Traver D, Weissman IL, Akashi K. 2002. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J. Clin. Investig. 109:1579–1585.
   PubMed Web of Science ®Google Scholar
• Nagy A, Gertsenstein M, Vintersten K, Behringer R. 2002. Manipulating the mouse embryo: a laboratory manual, 3rd ed, p 388–389. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
   Google Scholar
• Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. 1993. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 90:8424–8428.
   PubMed Web of Science ®Google Scholar
• Narla A, Ebert BL. 2010. Ribosomopathies: human disorders of ribosome dysfunction. Blood 115:3196–3205.
   PubMed Web of Science ®Google Scholar
• Neildez-Nguyen TM, Wajcman H, Marden MC, Bensidhoum M, Moncollin V, Giarratana MC, Kobari L, Thierry D, Douay L. 2002. Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo. Nat. Biotechnol. 20:467–472.
   PubMedGoogle Scholar
• Neuwirt J, Ponka P, Borova J. 1972. Evidence for the presence of free and protein-bound nonhemoglobin heme in rabbit reticulocytes. Biochim. Biophys. Acta 264:235–244.
   PubMedGoogle Scholar
• Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321–330.
   PubMed Web of Science ®Google Scholar
• Paszty C, Mohandas N, Stevens ME, Loring JF, Liebhaber SA, Brion CM, Rubin EM. 1995. Lethal alpha-thalassaemia created by gene targeting in mice and its genetic rescue. Nat. Genet. 11:33–39.
   PubMedGoogle Scholar
• Ponka P. 1997. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood 89:1–25.
   PubMed Web of Science ®Google Scholar
• Ponka P, Borova J, Neuwirt J. 1973. Accumulation of heme in mitochondria from rabbit reticulocytes with inhibited globin synthesis. Biochim. Biophys. Acta 304:715–718.
   PubMedGoogle Scholar
• Poueymirou WT, Auerbach W, Frendewey D, Hickey JF, Escaravage JM, Esau L, Dore AT, Stevens S, Adams NC, Dominguez MG, Gale NW, Yancopoulos GD, DeChiara TM, Valenzuela DM. 2007. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat. Biotechnol. 25:91–99.
   PubMedGoogle Scholar
• Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL. 2004. Identification of a human heme exporter that is essential for erythropoiesis. Cell 118:757–766.
   PubMed Web of Science ®Google Scholar
• Rivella S, May C, Chadburn A, Riviere I, Sadelain M. 2003. A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. Blood 101:2932–2939.
   PubMed Web of Science ®Google Scholar
• Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D, Begley CG. 1995. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc. Natl. Acad. Sci. U. S. A. 92:7075–7079.
   PubMedGoogle Scholar
• Rund D, Rachmilewitz E. 2005. Beta-thalassemia. N. Engl. J. Med. 353:1135–1146.
   PubMed Web of Science ®Google Scholar
• Ryan TM, Ciavatta DJ, Townes TM. 1997. Knockout-transgenic mouse model of sickle cell disease. Science 278:873–876.
   PubMed Web of Science ®Google Scholar
• Sassa S. 1976. Sequential induction of heme pathway enzymes during erythroid differentiation of mouse Friend leukemia virus-infected cells. J. Exp. Med. 143:305–315.
   PubMed Web of Science ®Google Scholar
• Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY. 2004. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22:1567–1572.
   PubMed Web of Science ®Google Scholar
• Shaner NC, Steinbach PA, Tsien RY. 2005. A guide to choosing fluorescent proteins. Nat. Methods 2:905–909.
   PubMed Web of Science ®Google Scholar
• Shinar E, Rachmilewitz EA. 1990. Differences in the pathophysiology of hemolysis of alpha- and beta-thalassemic red blood cells. Ann. N. Y. Acad. Sci. 612:118–126.
   PubMedGoogle Scholar
• Shivdasani RA, Mayer EL, Orkin SH. 1995. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373:432–434.
   PubMed Web of Science ®Google Scholar
• Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. 2001. Ineffective erythropoiesis in Stat5a(−/−)5b(−/−) mice due to decreased survival of early erythroblasts. Blood 98:3261–3273.
   PubMed Web of Science ®Google Scholar
• Tavassoli M. 1978. Red cell delivery and the function of the marrow-blood barrier: a review. Exp. Hematol. 6:257–269.
   PubMedGoogle Scholar
• Tavassoli M, Crosby WH. 1973. Fate of the nucleus of the marrow erythroblast. Science 179:912–913.
   PubMedGoogle Scholar
• Zhang J, Socolovsky M, Gross AW, Lodish HF. 2003. Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood 102:3938–3946.
   PubMed Web of Science ®Google Scholar