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Article

Structural and Mechanistic Features of Protein O Glycosylation Linked to CD8+ T-Cell Apoptosis

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Pages 1096-1111 | Received 15 Sep 2006, Accepted 04 Nov 2006, Published online: 27 Mar 2023

REFERENCES

  • Amado, M., Q. Yan, E. M. Comelli, B. E. Collins, and J. C. Paulson. 2004. Peanut agglutinin high phenotype of activated CD8+ T cells results from de novo synthesis of CD45 glycans. J. Biol. Chem. 279:36689–36697.
  • Badovinac, V. P., A. R. Tvinnereim, and J. T. Harty. 2000. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-γ. Science 290:1354–1357.
  • Badovinac, V. P., B. B. Porter, and J. T. Harty. 2004. CD8+ T cell contraction is controlled by early inflammation. Nat. Immunol. 5:809–817.
  • Bartholdy, C., J. P. Christensen, D. Wodarz, and A. R. Thomsen. 2000. Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus. J. Virol. 74:10304–10311.
  • Bouillet, P., D. Metcalf, D. C. S. Huang, D. M. Tarlington, T. W. H. Kay, F. Köntgen, J. M. Adams, and A. Strasser. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286:1735–1738.
  • Brown, T. J., W. W. Shuford, W.-C. Wang, S. G. Nadler, T. S. Bailey, H. Marquhardt, and R. S. Mittler. 1996. Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells. J. Biol. Chem. 271:27686–27695.
  • Carlow, D. A., S. Y. Corbel, and H. J. Ziltener. 2001. Absence of CD43 fails to alter T cell development and responsiveness. J. Immunol. 166:256–261.
  • Casabo, L. G., C. Mamalaki, D. Kioussis, and R. Zamoyska. 1994. T cell activation results in the physical modification of the mouse CD8b chain. J. Immunol. 152:397–404.
  • Chui, D., G. Sellakumar, R. S. Green, M. Sutton-Smith, T. McQuistan, K. W. Marek, H. R. Morris, A. Dell, and J. D. Marth. 2001. Genetic remodeling of protein glycosylation in vivo induces autoimmune disease. Proc. Natl. Acad. Sci. USA 98:1142–1147.
  • Dell, A., and H. R. Morris. 2001. Glycoprotein structure determination by mass spectrometry. Science 291:2351–2356.
  • Devadas, S., J. Das, C. Liu, L. Zhang, A. I. Roberts, Z. Pan, P. A. Moore, G. Das, and Y. Shi. 2006. Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells. Immunity 25:237–247.
  • Ellies, L. G., S. Tsuboi, B. Petryniak, J. B. Lowe, M. Fukuda, and J. D. Marth. 1998. Core 2 oligosaccharide biosythesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity 9:881–890.
  • Fukumori, T., Y. Takenaka, T. Yoshii, H. R. Kim, V. Hogan, H. Inohara, S. Kagawa, and A. Raz. 2003. CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis. Cancer Res. 63:8302–8311.
  • Galvan, M., K. Murali-Krishna, L. L. Ming, L. Baum, and R. Ahmed. 1998. Alterations in cell surface carbohydrates on T cells from virally infected mice can distinguish effector / memory CD8+ T cells from naive cells. J. Immunol. 161:641–648.
  • Goldrath, A. W., and M. J. Bevan. 1999. Selecting and maintaining a diverse T-cell repertoire. Nature 402:255–262.
  • Grebe, K. M., R. L. Clarke, and T. A. Potter. 2004. Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection. Proc. Natl. Acad. Sci. USA 101:10410–10415.
  • Green, D. R. 2005. Apoptotic pathways: ten minutes to dead. Cell 121:671–674.
  • Han, S., B. E. Collins, P. Bengston, and J. C. Paulson. 2005. Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking. Nat. Chem. Biol. 1:93–97.
  • Haring, J. S., V. P. Badovinac, and J. T. Harty. 2006. Inflaming the CD8+ T cell response. Immunity 25:19–29.
  • Hildeman, D. A., T. Mitchell, T. K. Teague, P. Henson, B. J. Day, J. Kappler, and P. C. Marrack. 1999. Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity 10:735–744.
  • Hildeman, D. A., Y. Zhu, T. C. Mitchell, P. Bouillet, A. Strasser, J. Kappler, and P. Marrack. 2002. Activated T cell death in vivo mediated by pro-apoptotic Bcl-2 family member Bim. Immunity 16:759–767.
  • Kao, C., M. M. Sandau, M. A. Daniels, and S. C. Jameson. 2006. The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development. J. Immunol. 176:7421–7430.
  • Kashio, Y., K. Nakamura, M. J. Abedin, M. Seki, N. Nishi, N. Yoshida, T. Nakamura, and M. Hirashima. 2003. Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J. Immunol. 170:3631–3636.
  • Kitagawa, H., and J. C. Paulson. 1994. Differential expression of five sialyltransferase genes in human tissues. J. Biol. Chem. 269:17872–17878.
  • Kuwabara, I., Y. Kuwabara, R. Y. Yang, M. Schuler, D. R. Green, B. L. Zuraw, D. K. Hsu, and F. T. Liu. 2002. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J. Biol. Chem. 277:3487–3497.
  • Landolfi, N. F., J. Leone, J. E. Womack, and R. G. Cook. 1985. Activation of T lymphocytes results in an increase in H-2-encoded neuraminidase. Immunogenetics 22:159–167.
  • Lau, L. L., B. D. Jamieson, T. Somasundaram, and R. Ahmed. 1994. Cytotoxic T-cell memory without antigen. Nature 369:648–652.
  • Lenardo, M., K. M. Chan, F. Hornung, H. McFarland, R. Siegel, J. Wang, and L. Zheng. 1999. Mature T lymphocyte apoptosis—immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17:221–253.
  • Liu, Y., R. Wada, H. Kawai, K. Sango, C. Deng, T. Tai, M. P. McDonald, K. Araujo, J. N. Crawley, U. Bierfreund, K. Sandhoff, K. Suzuki, and R. L. Proia. 1999. A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J. Clin. Investig. 103:497–505.
  • Lohman, B. L., E. S. Razvi, and R. M. Welsh. 1996. T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions. J. Virol. 70:8199–8203.
  • Lohman, B. L., and R. M. Welsh. 1998. Apoptotic regulation of T cells and absence of immune deficiency in virus-infected IFN-gamma receptor knock-out mice. J. Virol. 72:7815–7821.
  • Manjunath, N., M. Correa, M. Ardman, and B. Ardman. 1995. Negative regulation of T-cell adhesion and activation by CD43. Nature 377:535–538.
  • Marrack, P., and J. Kappler. 2004. Control of T cell viability. Annu. Rev. Immunol. 22:765–787.
  • Matloubian, M., M. Suresh, A. Glass, M. Galvan, K. Chow, J. K. Whitmire, C. M. Walsh, W. R. Clark, and R. Ahmed. 1999. A role for perforin in downregulating T-cell responses during chronic viral infection. J. Virol. 73:2527–2536.
  • Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869–877.
  • Moody, A. M., D. Chui, P. A. Reche, J. J. Priatel, J. D. Marth, and E. L. Reinherz. 2001. Developmentally regulated glycosylation of the CD8αβ coreceptor stalk modulates ligand binding. Cell 107:501–512.
  • Moody, A. M., S. J. North, B. Reinhold, S. J. Van Dyken, M. E. Rogers, M. Panico, A. Dell, H. R. Morris, J. D. Marth, and E. L. Reinherz. 2003. Sialic capping of CD8β core-1-O glycans controls thymocyte-major histocompatibility complex class I interaction. J. Biol. Chem. 278:7240–7246.
  • Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevalulation of bystander activation during viral infection. Immunity 8:177–187.
  • Nguyen, L. T., K. McKall-Faienza, A. Zakarian, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 2000. TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions. Eur. J. Immunol. 30:683–688.
  • Ohtsubo, K., S. Takamatsu, M. T. Minowa, A. Yoshida, M. Takeuchi, and J. D. Marth. 2005. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 123:1307–1321.
  • Ohtsubo, K., and J. D. Marth. 2006. Glycosylation in cellular mechanisms of health and disease. Cell 126:855–867.
  • Onami, T. M., L. E. Harrington, M. A. Williams, M. Galvan, C. P. Larsen, T. C. Pearson, N. Manjunath, L. G. Baum, B. D. Pearce, and R. Ahmed. 2002. Dynamic regulation of T cell immunity by CD43. J. Immunol. 168:6022–6031.
  • Ong, C. J., D. Chui, H. S. Teh, and J. D. Marth. 1994. Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection. J. Immunol. 152:3793–3805.
  • Ou, R., S. Zhou, L. Huang, and D. Moskophidis. 2001. Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J. Virol. 75:8407–8423.
  • Pellegrini, M., G. Belz, P. Bouillet, and A. Strasser. 2003. Shutdown of an acute T cell immune response to viral infection is mediated by the pro-apoptotic Bcl-2 homology 3-only protein Bim. Proc. Natl. Acad. Sci. USA 100:14175–14180.
  • Perillo, N. L., K. E. Pace, J. J. Seilhamer, and L. G. Baum. 1995. Apoptosis of T cells mediated by galectin-1. Nature 378:736–739.
  • Piller, F., V. Piller, R. I. Fox, and M. Fukuda. 1988. Human T-lymphcyte activation is associated with changes in O-glycan biosynthesis. J. Biol. Chem. 263:15146–15150.
  • Priatel, J. J., D. Chui, N. Hiraoka, C. J. Simmons, K. B. Richardson, D. M. Page, M. Fukuda, N. M. Varki, and J. D. Marth. 2000. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity 12:273–283.
  • Razvi, E. S., Z. Jiang, B. A. Woda, and R. M. Welsh. 1995. Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice. Am. J. Pathol. 147:79–91.
  • Reich, A., H. Körner, J. D. Sedgwick, and H. Pircher. 2000. Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1). Eur. J. Immunol. 30:678–682.
  • Schachter, H., and I. Brockhausen. 1989. The biosythesis of branched O-glycans. Symp. Soc. Exp. Biol. 43:1–26.
  • Seder, R. A., and R. Ahmed. 2003. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat. Immunol. 4:835–842.
  • Sharma, V., M. Delgado, and D. Ganea. 2006. Granzyme B, a new player in activation-induced cell death, is down-regulated by vasoactive intestinal peptide in Th2 but not Th1 effectors. J. Immunol. 176:97–110.
  • Siegel, R. M., F. K. Chan, H. J. Chun, and M. J. Lenardo. 2000. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat. Immunol. 1:469–474.
  • Snapp, K. R., C. E. Heitzig, L. G. Ellies, J. D. Marth, and G. S. Kansas. 2001. Differential requirements for the O-linked branching enzyme core 2 β 1-6-N-glycosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin. Blood 97:3806–3811.
  • Strasser, A., A. W. Harris, and S. Cory. 1991. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889–899.
  • Strasser, A. 2005. The role of BH3-only proteins in the immune system. Nat. Rev. Immunol. 5:189–200.
  • Sturm, A., M. Lensch, S. Andre, H. Kaltner, B. Wiedenmann, S. Rosewicz, A. U. Dignass, and H. J. Gabius. 2004. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. J. Immunol. 173:3825–3837.
  • Taira, S., and H. Nariuchi. 1988. Possible role of neuraminidase in activated T cells in the recognition of allogeneic Ia. J. Immunol. 141:440–446.
  • Wang, X. Z., S. E. Stepp, M. A. Brehm, H. D. Chen, L. K. Selin, and R. M. Welsh. 2003. Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs. Immunity 18:631–642.
  • Wu, W., P. H. Harley, J. A. Punt, S. O. Sharrow, and K. P. Kearse. 1996. Identification of CD8 as a peanut agglutinin (PNA) receptor molecule on immature thymocytes. J. Exp. Med. 184:759–764.
  • Zhang, M., S. M. Park, Y. Wang, R. Shah, N. Liu, A. E. Murmann, C. R. Wang, M. E. Peter, and P. G. Ashton-Rickardt. 2006. Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Immunity 24:451–461.
  • Zhou, S., R. Ou, L. Huang, and D. Moskophidis. 2002. Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection. J. Virol. 76:829–840.
  • Zhumabekov, T., P. Corbella, M. Tolaini, and D. Kioussis. 1995. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods 185:133–140.

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