Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis

REFERENCES

• Balasubramanian, P., L.-J. Zhao, and G. Chinnadurai. 2003. Nicotinamide adenine dinucleotide stimulates oligomerization, interaction with adenovirus E1A and an intrinsic dehydrogenase activity of CtBP. FEBS Lett. 537:157–160.
   PubMed Web of Science ®Google Scholar
• Banerjee, S. S., M. W. Feinberg, M. Watanabe, S. Gray, R. L. Haspel, D. J. Denkinger, R. Kawahara, H. Hauner, and M. K. Jain. 2003. The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J. Biol. Chem. 278:2581–2584.
   PubMed Web of Science ®Google Scholar
• Bartz, R., J. Seemann, J. K. Zehmer, G. Serrero, K. D. Chapman, R. G. Anderson, and P. Liu. 2007. Evidence that mono-ADP-ribosylation of CtBP1/BARS regulates lipid storage. Mol. Biol. Cell 18:3015–3025.
   PubMedGoogle Scholar
• Bieker, J. J. 1996. Isolation, genomic structure, and expression of human erythroid Kruppel-like factor (EKLF). DNA Cell Biol. 15:347–352.
   PubMedGoogle Scholar
• Bieker, J. J. 2001. Kruppel-like factors: three fingers in many pies. J. Biol. Chem. 276:34355–34358.
   PubMed Web of Science ®Google Scholar
• Cao, S., M. E. Fernandez-Zapico, D. Jin, V. Puri, T. A. Cook, L. O. Lerman, X.-Y. Zhu, R. Urrutia, and V. Shah. 2005. KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling. J. Biol. Chem. 280:1901-1910. doi:10.1074/jbc.M407941200.
   PubMedGoogle Scholar
• Christian, M., E. Kiskinis, D. Debevec, G. Leonardsson, R. White, and M. G. Parker. 2005. RIP140-targeted repression of gene expression in adipocytes. Mol. Cell. Biol. 25:9383–9391.
   PubMed Web of Science ®Google Scholar
• Coghill, E., S. Eccleston, V. Fox, L. Cerruti, C. Brown, J. Cunningham, S. Jane, and A. Perkins. 2001. Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice. Blood 97:1861–1868.
   PubMed Web of Science ®Google Scholar
• Crossley, M., E. Whitelaw, A. Perkins, G. Williams, Y. Fujiwara, and S. H. Orkin. 1996. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol. Cell. Biol. 16:1695–1705.
   PubMed Web of Science ®Google Scholar
• Funnell, A. P., C. A. Maloney, L. J. Thompson, J. Keys, M. Tallack, A. C. Perkins, and M. Crossley. 2007. Erythroid Kruppel-like factor directly activates the basic Kruppel-like factor gene in erythroid cells. Mol. Cell. Biol. 27:2777–2790.
   PubMed Web of Science ®Google Scholar
• Grooteclaes, M., Q. Deveraux, J. Hildebrand, Q. Zhang, R. H. Goodman, and S. M. Frisch. 2003. C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc. Natl. Acad. Sci. USA 100:4568–4573.
   PubMed Web of Science ®Google Scholar
• Jiang, M. S., and M. D. Lane. 2000. Sequential repression and activation of the CCAAT enhancer-binding protein-alpha (C/EBPalpha) gene during adipogenesis. Proc. Natl. Acad. Sci. USA 97:12519–12523.
   PubMed Web of Science ®Google Scholar
• Kaczynski, J., T. Cook, and R. Urrutia. 2003. Sp1- and Kruppel-like transcription factors. Genome Biol. 4:206.
   PubMed Web of Science ®Google Scholar
• Kanazawa, A., Y. Kawamura, A. Sekine, A. Iida, T. Tsunoda, A. Kashiwagi, Y. Tanaka, T. Babazono, M. Matsuda, K. Kawai, T. Iiizumi, T. Fujioka, M. Imanishi, K. Kaku, Y. Iwamoto, R. Kawamori, R. Kikkawa, Y. Nakamura, and S. Maeda. 2005. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. Diabetologia 48:1315–1322.
   PubMed Web of Science ®Google Scholar
• Kumar, V., J. E. Carlson, K. A. Ohgi, T. A. Edwards, D. W. Rose, C. R. Escalante, M. G. Rosenfeld, and A. K. Aggarwal. 2002. Transcription corepressor CtBP is an NAD+-regulated dehydrogenase. Mol. Cell 10:857–869.
   PubMed Web of Science ®Google Scholar
• Leonardsson, G., J. H. Steel, M. Christian, V. Pocock, S. Milligan, J. Bell, P. W. So, G. Medina-Gomez, A. Vidal-Puig, R. White, and M. G. Parker. 2004. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. USA 101:8437–8442.
   PubMed Web of Science ®Google Scholar
• Li, D., S. Yea, S. Li, Z. Chen, G. Narla, M. Banck, J. Laborda, S. Tan, J. M. Friedman, S. L. Friedman, and M. J. Walsh. 2005. Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J. Biol. Chem. 280:26941–26952.
   PubMed Web of Science ®Google Scholar
• Linhart, H. G., K. Ishimura-Oka, F. DeMayo, T. Kibe, D. Repka, B. Poindexter, R. J. Bick, and G. J. Darlington. 2001. C/EBPα is required for differentiation of white, but not brown, adipose tissue. Proc. Natl. Acad. Sci. USA 98:12532–12537.
   PubMed Web of Science ®Google Scholar
• Mori, T., H. Sakaue, H. Iguchi, H. Gomi, Y. Okada, Y. Takashima, K. Nakamura, T. Nakamura, T. Yamauchi, N. Kubota, T. Kadowaki, Y. Matsuki, W. Ogawa, R. Hiramatsu, and M. Kasuga. 2005. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J. Biol. Chem. 280:12867–12875.
   PubMed Web of Science ®Google Scholar
• Nuez, B., D. Michalovich, A. Bygrave, R. Ploemacher, and F. Grosveld. 1995. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316–318.
   PubMed Web of Science ®Google Scholar
• Oishi, Y., I. Manabe, K. Tobe, K. Tsushima, T. Shindo, K. Fujiu, G. Nishimura, K. Maemura, T. Yamauchi, N. Kubota, R. Suzuki, T. Kitamura, S. Akira, T. Kadowaki, and R. Nagai. 2005. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1:27–39.
   PubMed Web of Science ®Google Scholar
• Otto, T. C., and M. D. Lane. 2005. Adipose development: from stem cell to adipocyte. Crit. Rev. Biochem. Mol. Biol. 40:229–242.
   PubMed Web of Science ®Google Scholar
• Patel, S., Z. F. Xi, E. Y. Seo, D. McGaughey, and J. A. Segre. 2006. Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc. Natl. Acad. Sci. U S A 103:18668–18673.
   PubMed Web of Science ®Google Scholar
• Perdomo, J., A. Verger, J. Turner, and M. Crossley. 2005. Role for SUMO modification in facilitating transcriptional repression by BKLF. Mol. Cell. Biol. 25:1549–1559.
   PubMedGoogle Scholar
• Perkins, A. C., A. H. Sharpe, and S. H. Orkin. 1995. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375:318–322.
   PubMed Web of Science ®Google Scholar
• Picard, F., M. Kurtev, N. Chung, A. Topark-Ngarm, T. Senawong, R. Machado De Oliveira, M. Leid, M. W. McBurney, and L. Guarente. 2004. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429:771–776.
   PubMed Web of Science ®Google Scholar
• Rodbell, M. 1964. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J. Biol. Chem. 239:375–380.
   PubMed Web of Science ®Google Scholar
• Rosen, E. D., and O. A. MacDougald. 2006. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7:885–896.
   PubMed Web of Science ®Google Scholar
• Suske, G., E. Bruford, and S. Philipsen. 2005. Mammalian SP/KLF transcription factors: bring in the family. Genomics 85:551–556.
   PubMed Web of Science ®Google Scholar
• Tang, Q.-Q., M.-S. Jiang, and M. D. Lane. 1999. Repressive effect of Sp1 on the C/EBPα gene promoter: role in adipocyte differentiation. Mol. Cell. Biol. 19:4855–4865.
   PubMed Web of Science ®Google Scholar
• Thio, S. S. C., J. V. Bonventre, and S. I.-H. Hsu. 2004. The CtBP2 co-repressor is regulated by NADH-dependent dimerization and possesses a novel N-terminal repression domain 10.1093/nar/gkh344. Nucleic Acids Res. 32:1836–1847.
   PubMed Web of Science ®Google Scholar
• Turner, J., and M. Crossley. 1998. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. EMBO J. 17:5129–5140.
   PubMed Web of Science ®Google Scholar
• Umek, R. M., A. D. Friedman, and S. L. McKnight. 1991. CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251:288–292.
   PubMedGoogle Scholar
• Vo, N., C. Fjeld, and R. H. Goodman. 2001. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. Mol. Cell. Biol. 21:6181–6188.
   PubMedGoogle Scholar
• Wu, J., S. V. Srinivasan, J. C. Neumann, and J. B. Lingrel. 2005. The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes. Biochemistry 44:11098–11105.
   PubMed Web of Science ®Google Scholar
• Zhang, Q., C. C. Fjeld, A. C. Nottke, and R. H. Goodman. 2006. CtBP as a redox sensor in transcriptional repression, p. 68-76. In G. Chinnadurai (ed.), CtBP family proteins. Landes Bioscience, Austin, TX.
   Google Scholar
• Zhang, Q., D. W. Piston, and R. H. Goodman. 2002. Regulation of corepressor function by nuclear NADH. Science 295:1895–1897.
   PubMed Web of Science ®Google Scholar