Aberrant Regulation of Hematopoiesis by T Cells in BAZF-Deficient Mice

REFERENCES

• Asari, S., A. Sakamoto, S. Okada, Y. Ohkubo, M. Arima, M. Hatano, Y. Kuroda, and T. Tokuhisa. 2005. Abnormal erythroid differentiation in neonatal bcl-6-deficient mice. Exp. Hematol. 33:26–34.
   PubMedGoogle Scholar
• Boring, L., J. Gosling, S. W. Chensue, S. L. Kunkel, R. V. Farese, Jr., H. E. Broxmeyer, and I. F. Charo. 1997. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Investig. 100:2552–2561.
   PubMed Web of Science ®Google Scholar
• Broxmeyer, H. E., H. A. Bruns, S. Zhang, S. Cooper, G. Hangoc, A. N. McKenzie, A. L. Dent, U. Schindler, L. K. Naeger, T. Hoey, and M. H. Kaplan. 2002. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity 16:815–825.
   PubMed Web of Science ®Google Scholar
• Broxmeyer, H. E., S. Cooper, G. Cacalano, N. L. Hague, E. Bailish, and M. W. Moore. 1996. Involvement of interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue. J. Exp. Med. 184:1825–1832.
   PubMed Web of Science ®Google Scholar
• Broxmeyer, H. E., S. Cooper, G. Hangoc, J. L. Gao, and P. M. Murphy. 1999. Dominant myelopoietic effector functions mediated by chemokine receptor CCR1. J. Exp. Med. 189:1987–1992.
   PubMed Web of Science ®Google Scholar
• Broxmeyer, H. E., S. Cooper, G. Hangoc, C. Mantel, and D. S. Franklin. 2000. Modulation of myeloid progenitor cell proliferation by cyclin-dependent kinase inhibitors as determined in p21cip1/waf1 p21cip1/waf1 p21cip1/waf1 p21cip1/waf1 gene knockout mice. Blood 96:539a.
   Google Scholar
• Broxmeyer, H. E., S. Cooper, L. A. Lasky, and F. De Sauvage. 2005. Identification of a massive reserve of hematopoietic progenitors in mice. Stem Cells Dev. 14:105–110.
   PubMedGoogle Scholar
• Broxmeyer, H. E., and C. H. Kim. 1999. Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. Exp. Hematol. 27:1113–1123.
   PubMed Web of Science ®Google Scholar
• Broxmeyer, H. E., D. E. Williams, S. Cooper, R. K. Shadduck, S. Gillis, A. Waheed, D. L. Urdal, and D. C. Bicknell. 1987. Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony-stimulating factor-1, and recombinant murine granulocyte-macrophage colony-stimulating factor on myelopoiesis in mice. J. Clin. Investig. 79:721–730.
   PubMed Web of Science ®Google Scholar
• Carver-Moore, K., H. E. Broxmeyer, S. M. Luoh, S. Cooper, J. Peng, S. A. Burstein, M. W. Moore, and F. J. de Sauvage. 1996. Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice. Blood 88:803–808.
   PubMed Web of Science ®Google Scholar
• Cheng, J., S. Baumhueter, G. Cacalano, K. Carver-Moore, H. Thibodeaux, R. Thomas, H. E. Broxmeyer, S. Cooper, N. Hague, M. Moore, and L. A. Lasky. 1996. Hematopoietic defects in mice lacking the sialomucin CD34. Blood 87:479–490.
   PubMed Web of Science ®Google Scholar
• Christopherson, K. W., S. Cooper, G. Hangoc, and H. E. Broxmeyer. 2003. CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26−/− mice. Exp. Hematol. 31:1126–1134.
   PubMed Web of Science ®Google Scholar
• Christopherson, K. W., II, S. Cooper, and H. E. Broxmeyer. 2003. Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells. Blood 101:4680–4686.
   PubMed Web of Science ®Google Scholar
• Cooper, S., and H. E. Broxmeyer. 1991. Clonogenic methods in vitro for the enumeration of granuloctye-macrophage progenitor cell (CFU-GM) in human bone marrow and mouse bone marrow and spleen. J. Tissue Cult. Methods 13:77–82.
   Google Scholar
• Dalla-Favera, R., A. Migliazza, C. C. Chang, H. Niu, L. Pasqualucci, M. Butler, Q. Shen, and G. Cattoretti. 1999. Molecular pathogenesis of B cell malignancy: the role of BCL-6. Curr. Top. Microbiol. Immunol. 246:257–263.
   PubMed Web of Science ®Google Scholar
• Deconinck, A. E., P. E. Mead, S. G. Tevosian, J. D. Crispino, S. G. Katz, L. I. Zon, and S. H. Orkin. 2000. FOG acts as a repressor of red blood cell development in Xenopus. Development 127:2031–2040.
   PubMedGoogle Scholar
• Dent, A. L., J. Hu-Li, W. E. Paul, and L. S. Staudt. 1998. T helper type 2 inflammatory disease in the absence of IL-4 and STAT6. Proc. Natl. Acad. Sci. USA 95:13823–13828.
   PubMed Web of Science ®Google Scholar
• Dent, A. L., A. L. Shaffer, X. Yu, D. Allman, and L. M. Staudt. 1997. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276:589–592.
   PubMed Web of Science ®Google Scholar
• Dent, A. L., F. H. Vasanwala, and L. M. Toney. 2002. Regulation of gene expression by the proto-oncogene BCL-6. Crit. Rev. Oncol. Hematol. 41:1–9.
   PubMedGoogle Scholar
• Fukuda, T., T. Yoshida, S. Okada, M. Hatano, T. Miki, K. Ishibashi, S. Okabe, H. Koseki, S. Hirosawa, M. Taniguchi, N. Miyasaka, and T. Tokuhisa. 1997. Disruption of the Bcl6 gene results in an impaired germinal center formation. J. Exp. Med. 186:439–448.
   PubMed Web of Science ®Google Scholar
• Gao, J. L., T. A. Wynn, Y. Chang, E. J. Lee, H. E. Broxmeyer, S. Cooper, H. L. Tiffany, H. Westphal, J. Kwon-Chung, and P. M. Murphy. 1997. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185:1959–1968.
   PubMed Web of Science ®Google Scholar
• Haneline, L. S., H. E. Broxmeyer, S. Cooper, G. Hangoc, M. Carreau, M. Buchwald, and D. W. Clapp. 1998. Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac−/− mice. Blood 91:4092–4098.
   PubMed Web of Science ®Google Scholar
• Hartatik, T., S. Okada, S. Okabe, M. Arima, M. Hatano, and T. Tokuhisa. 2001. Binding of BAZF and Bc16 to STAT6-binding DNA sequences. Biochem. Biophys. Res. Commun. 284:26–32.
   PubMedGoogle Scholar
• Hirai, H., I. M. Samokhvalov, T. Fujimoto, S. Nishikawa, and J. Imanishi. 2005. Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells. Blood 106:1948–1955.
   PubMedGoogle Scholar
• Ichii, H., A. Sakamoto, Y. Kuroda, and T. Tokuhisa. 2004. Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. J. Immunol. 173:883–891.
   PubMedGoogle Scholar
• Kaplan, M. H., H. C. Chang, S. Cooper, Y. Lee, and H. E. Broxmeyer. 2003. Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines. J. Hematother. Stem Cell Res. 12:401–408.
   PubMedGoogle Scholar
• Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174–177.
   PubMed Web of Science ®Google Scholar
• Kim, C. H., G. Hangoc, S. Cooper, C. D. Helgason, S. Yew, R. K. Humphries, G. Krystal, and H. E. Broxmeyer. 1999. Altered responsiveness to chemokines due to targeted disruption of SHIP. J. Clin. Investig. 104:1751–1759.
   PubMed Web of Science ®Google Scholar
• Kim, C. H., C. K. Qu, G. Hangoc, S. Cooper, N. Anzai, G. S. Feng, and H. E. Broxmeyer. 1999. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. J. Exp. Med. 190:681–690.
   PubMedGoogle Scholar
• Kusam, S., L. M. Toney, H. Sato, and A. L. Dent. 2003. Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J. Immunol. 170:2435–2441.
   PubMed Web of Science ®Google Scholar
• Lessard, J., A. Schumacher, U. Thorsteinsdottir, M. van Lohuizen, T. Magnuson, and G. Sauvageau. 1999. Functional antagonism of the Polycomb-group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev. 13:2691–2703.
   PubMed Web of Science ®Google Scholar
• Liu, C., M. Levenstein, J. Chen, E. Tsifrina, R. Yonescu, C. Griffin, C. I. Civin, and D. Small. 1999. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. Exp. Hematol. 27:313–325.
   PubMed Web of Science ®Google Scholar
• Manders, P. M., P. J. Hunter, A. I. Telaranta, J. M. Carr, J. L. Marshall, M. Carrasco, Y. Murakami, M. J. Palmowski, V. Cerundolo, S. M. Kaech, R. Ahmed, and D. T. Fearon. 2005. BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proc. Natl. Acad. Sci. USA 102:7418–7425.
   PubMed Web of Science ®Google Scholar
• Mantel, C., Y. J. Kim, S. Cooper, B. Kwon, and H. E. Broxmeyer. 1993. Polymerization of murine macrophage inflammatory protein 1 alpha inactivates its myelosuppressive effects in vitro: the active form is a monomer. Proc. Natl. Acad. Sci. USA 90:2232–2236.
   PubMed Web of Science ®Google Scholar
• Oatley, J. M., M. R. Avarbock, A. I. Telaranta, D. T. Fearon, and R. L. Brinster. 2006. Identifying genes important for spermatogonial stem cell self-renewal and survival. Proc. Natl. Acad. Sci. USA 103:9524–9529.
   PubMed Web of Science ®Google Scholar
• Okabe, S., T. Fukuda, K. Ishibashi, S. Kojima, S. Okada, M. Hatano, M. Ebara, H. Saisho, and T. Tokuhisa. 1998. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol. Cell. Biol. 18:4235–4244.
   PubMedGoogle Scholar
• Perez-Losada, J., M. Sanchez-Martin, A. Rodriguez-Garcia, M. L. Sanchez, A. Orfao, T. Flores, and I. Sanchez-Garcia. 2002. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood 100:1274–1286.
   PubMed Web of Science ®Google Scholar
• Qu, C. K., W. M. Yu, B. Azzarelli, S. Cooper, H. E. Broxmeyer, and G. S. Feng. 1998. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol. Cell. Biol. 18:6075–6082.
   PubMedGoogle Scholar
• Reid, S., A. Ritchie, L. Boring, J. Gosling, S. Cooper, G. Hangoc, I. F. Charo, and H. E. Broxmeyer. 1999. Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2. Blood 93:1524–1533.
   PubMedGoogle Scholar
• Schwartzberg, P. L., A. M. Stall, J. D. Hardin, K. S. Bowdish, T. Humaran, S. Boast, M. L. Harbison, E. J. Robertson, and S. P. Goff. 1991. Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations. Cell 65:1165–1175.
   PubMed Web of Science ®Google Scholar
• Shaffer, A. L., X. Yu, Y. He, J. Boldrick, E. P. Chan, and L. M. Staudt. 2000. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13:199–212.
   PubMed Web of Science ®Google Scholar
• Shaheen, M., and H. E. Broxmeyer. 2005. The humoral regulation of hematopoiesis, p. 223–265. In R. Hoffman, E. Benz, S. Shattil, B. Furie, H. Cohen, L. Silberstein, and P. MacGlave (ed.), Hematology: basic principles and practice, 4th ed. U.K. Elsevier Inc., Churchill Livingston, London, United Kingdom.
   Google Scholar
• Staudt, L. M., A. L. Dent, A. L. Shaffer, and X. Yu. 1999. Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6. Intern. Rev. Immunol. 18:381.
   PubMedGoogle Scholar
• Takamori, M., M. Hatano, M. Arima, A. Sakamoto, L. Fujimura, T. Hartatik, T. Kuriyama, and T. Tokuhisa. 2004. BAZF is required for activation of naive CD4 T cells by TCR triggering. Int. Immunol. 16:1439–1449.
   PubMedGoogle Scholar
• Takenaga, M., M. Hatano, M. Takamori, Y. Yamashita, S. Okada, Y. Kuroda, and T. Tokuhisa. 2003. Bcl6-dependent transcriptional repression by BAZF. Biochem. Biophys. Res. Commun. 303:600–608.
   PubMedGoogle Scholar
• Taylor, G. A., E. Carballo, D. M. Lee, W. S. Lai, M. J. Thompson, D. D. Patel, D. I. Schenkman, G. S. Gilkeson, H. E. Broxmeyer, B. F. Haynes, and P. J. Blackshear. 1996. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 4:445–454.
   PubMed Web of Science ®Google Scholar
• Tian, M., H. E. Broxmeyer, Y. Fan, Z. Lai, S. Zhang, S. Aronica, S. Cooper, R. M. Bigsby, R. Steinmetz, S. J. Engle, A. Mestek, J. D. Pollock, M. N. Lehman, H. T. Jansen, M. Ying, P. J. Stambrook, J. A. Tischfield, and L. Yu. 1997. Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice. J. Exp. Med. 185:1517–1522.
   PubMed Web of Science ®Google Scholar
• Toney, L. M., G. Cattorretti, J. A. Graf, T. Merghoub, P. P. Pandolfi, R. Dalla-Favera, B. H. Ye, and A. L. Dent. 2000. BCL-6 regulates chemokine gene transcription in macrophages. Nat. Immunol. 1:214–220.
   PubMedGoogle Scholar
• Ye, B. H., G. Cattoretti, Q. Shen, J. Zhang, N. Hawe, R. de Waard, C. Leung, M. Nouri-Shirazi, A. Orazi, R. S. Chaganti, P. Rothman, A. M. Stall, P. P. Pandolfi, and R. Dalla-Favera. 1997. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16:161–170.
   PubMed Web of Science ®Google Scholar
• Yu, R. Y., X. Wang, F. J. Pixley, J. J. Yu, A. L. Dent, H. E. Broxmeyer, E. R. Stanley, and B. H. Ye. 2005. BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 105:1777–1784.
   PubMedGoogle Scholar
• Zhang, S., S. Fukuda, Y. Lee, G. Hangoc, S. Cooper, R. Spolski, W. J. Leonard, and H. E. Broxmeyer. 2000. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J. Exp. Med. 192:719–728.
   PubMed Web of Science ®Google Scholar