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Article

Ectodomain Shedding of Preadipocyte Factor 1 (Pref-1) by Tumor Necrosis Factor Alpha Converting Enzyme (TACE) and Inhibition of Adipocyte Differentiation

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Pages 5421-5435 | Received 21 Dec 2005, Accepted 20 Apr 2006, Published online: 27 Mar 2023

REFERENCES

  • Abbondanzo, S. J., I. Gadi, and C. L. Stewart. 1993. Derivation of embryonic stem cell lines. Methods Enzymol. 225:803–823.
  • Abdallah, B. M., C. H. Jensen, G. Gutierrez, R. G. Leslie, T. G. Jensen, and M. Kassem. 2004. Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1. J. Bone Miner. Res. 19:841–852.
  • Amour, A., P. M. Slocombe, A. Webster, M. Butler, C. G. Knight, B. J. Smith, P. E. Stephens, C. Shelley, M. Hutton, V. Knauper, A. J. Docherty, and G. Murphy. 1998. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett. 435:39–44.
  • Arribas, J., L. Coodly, P. Vollmer, T. K. Kishimoto, S. Rose-John, and J. Massague. 1996. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J. Biol. Chem. 271:11376–11382.
  • Arribas, J., and J. Massague. 1995. Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism. J. Cell Biol. 128:433–441.
  • Artemenko, Y., A. Gagnon, D. Aubin, and A. Sorisky. 2005. Anti-adipogenic effect of PDGF is reversed by PKC inhibition. J. Cell Physiol. 204:646–653.
  • Aubert, J., S. Dessolin, N. Belmonte, M. Li, F. R. McKenzie, L. Staccini, P. Villageois, B. Barhanin, A. Vernallis, A. G. Smith, G. Ailhaud, and C. Dani. 1999. Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade. J. Biol. Chem. 274:24965–24972.
  • Baker, A. H., D. R. Edwards, and G. Murphy. 2002. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J. Cell Sci. 115:3719–3727.
  • Belmonte, N., B. W. Phillips, F. Massiera, P. Villageois, B. Wdziekonski, P. Saint-Marc, J. Nichols, J. Aubert, K. Saeki, A. Yuo, S. Narumiya, G. Ailhaud, and C. Dani. 2001. Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes. Mol. Endocrinol. 15:2037–2049.
  • Black, R. A. 2002. Tumor necrosis factor-alpha converting enzyme. Int. J. Biochem. Cell. Biol. 34:1–5.
  • Black, R. A., C. T. Rauch, C. J. Kozlosky, J. J. Peschon, J. L. Slack, M. F. Wolfson, B. J. Castner, K. L. Stocking, P. Reddy, S. Srinivasan, N. Nelson, N. Boiani, K. A. Schooley, M. Gerhart, R. Davis, J. N. Fitzner, R. S. Johnson, R. J. Paxton, C. J. March, and D. P. Cerretti. 1997. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 385:729–733.
  • Black, R. A., and J. M. White. 1998. ADAMs: focus on the protease domain. Curr. Opin. Cell Biol. 10:654–659.
  • Blobel, C. P. 2005. ADAMs: key components in EGFR signalling and development. Nat. Rev. Mol. Cell. Biol. 6:32–43.
  • Blobel, C. P. 2000. Remarkable roles of proteolysis on and beyond the cell surface. Curr. Opin. Cell Biol. 12:606–612.
  • Borland, G., G. Murphy, and A. Ager. 1999. Tissue inhibitor of metalloproteinases-3 inhibits shedding of L-selectin from leukocytes. J. Biol. Chem. 274:2810–2815.
  • Borroto, A., S. Ruiz-Paz, T. V. de la Torre, M. Borrell-Pages, A. Merlos-Suarez, A. Pandiella, C. P. Blobel, J. Baselga, and J. Arribas. 2003. Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding. J. Biol. Chem. 278:25933–25939.
  • Bost, F., M. Aouadi, L. Caron, P. Even, N. Belmonte, M. Prot, C. Dani, P. Hofman, G. Pages, J. Pouyssegur, Y. Le Marchand-Brustel, and B. Binetruy. 2005. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54:402–411.
  • Brou, C., F. Logeat, N. Gupta, C. Bessia, O. LeBail, J. R. Doedens, A. Cumano, P. Roux, R. A. Black, and A. Israel. 2000. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell 5:207–216.
  • Brown, C. L., K. S. Meise, G. D. Plowman, R. J. Coffey, and P. J. Dempsey. 1998. Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor: release of a predominant N-glycosylated 43-kDa soluble form. J. Biol. Chem. 273:17258–17268.
  • Buxbaum, J. D., K. N. Liu, Y. Luo, J. L. Slack, K. L. Stocking, J. J. Peschon, R. S. Johnson, B. J. Castner, D. P. Cerretti, and R. A. Black. 1998. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273:27765–27767.
  • Carlsson, C., D. Tornehave, K. Lindberg, P. Galante, N. Billestrup, B. Michelsen, L. I. Larsson, and J. H. Nielsen. 1997. Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas. Endocrinology 138:3940–3948.
  • Dang, Z. C., and C. W. Lowik. 2005. Removal of serum factors by charcoal treatment promotes adipogenesis via a MAPK-dependent pathway. Mol. Cell Biochem. 268:159–167.
  • Diaz-Rodriguez, E., J. C. Montero, A. Esparis-Ogando, L. Yuste, and A. Pandiella. 2002. Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol. Biol. Cell 13:2031–2044.
  • Doedens, J. R., R. M. Mahimkar, and R. A. Black. 2003. TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation. Biochem. Biophys. Res. Commun. 308:331–338.
  • Ehlers, M. R., and J. F. Riordan. 1991. Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins. Biochemistry 30:10065–10074.
  • Fan, H., and R. Derynck. 1999. Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J. 18:6962–6972.
  • Fleming, I., S. J. MacKenzie, R. G. Vernon, N. G. Anderson, M. D. Houslay, and E. Kilgour. 1998. Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation. Biochem. J. 333(Pt. 3):719–727.
  • Floridon, C., C. H. Jensen, P. Thorsen, O. Nielsen, L. Sunde, J. G. Westergaard, S. G. Thomsen, and B. Teisner. 2000. Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation. Differentiation 66:49–59.
  • Font de Mora, J., A. Porras, N. Ahn, and E. Santos. 1997. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol. Cell. Biol. 17:6068–6075.
  • Garces, C., M. J. Ruiz-Hidalgo, E. Bonvini, J. Goldstein, and J. Laborda. 1999. Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk. Differentiation 64:103–114.
  • Garton, K. J., P. J. Gough, C. P. Blobel, G. Murphy, D. R. Greaves, P. J. Dempsey, and E. W. Raines. 2001. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J. Biol. Chem. 276:37993–38001.
  • Garton, K. J., P. J. Gough, J. Philalay, P. T. Wille, C. P. Blobel, R. H. Whitehead, P. J. Dempsey, and E. W. Raines. 2003. Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). J. Biol. Chem. 278:37459–37464.
  • Gregoire, F. M., C. M. Smas, and H. S. Sul. 1998. Understanding adipocyte differentiation. Physiol. Rev. 78:783–809.
  • Hansen, J. B., R. K. Petersen, C. Jorgensen, and K. Kristiansen. 2002. Deregulated MAPK activity prevents adipocyte differentiation of fibroblasts lacking the retinoblastoma protein. J. Biol. Chem. 277:26335–26339.
  • Hansen, L. H., B. Madsen, B. Teisner, J. H. Nielsen, and N. Billestrup. 1998. Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation. Mol. Endocrinol. 12:1140–1149.
  • Hooper, N. M., E. H. Karran, and A. J. Turner. 1997. Membrane protein secretases. Biochem. J. 321(Pt. 2):265–279.
  • Hu, E., J. B. Kim, P. Sarraf, and B. M. Spiegelman. 1996. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274:2100–2103.
  • Huovila, A. P., A. J. Turner, M. Pelto-Huikko, I. Karkkainen, and R. M. Ortiz. 2005. Shedding light on ADAM metalloproteinases. Trends Biochem. Sci. 30:413–422.
  • Izumi, Y., M. Hirata, H. Hasuwa, R. Iwamoto, T. Umata, K. Miyado, Y. Tamai, T. Kurisaki, A. Sehara-Fujisawa, S. Ohno, and E. Mekada. 1998. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J. 17:7260–7272.
  • Jensen, C. H., T. N. Krogh, P. Hojrup, P. P. Clausen, K. Skjodt, L. I. Larsson, J. J. Enghild, and B. Teisner. 1994. Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. Eur. J. Biochem. 225:83–92.
  • Jensen, C. H., T. N. Krogh, R. K. Stoving, U. Holmskov, and B. Teisner. 1997. Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily: ELISA development, physiology and metabolism in relation to renal function. Clin. Chim. Acta 268:1–20.
  • Kaneta, M., M. Osawa, K. Sudo, H. Nakauchi, A. G. Farr, and Y. Takahama. 2000. A role for pref-1 and HES-1 in thymocyte development. J. Immunol. 164:256–264.
  • Lambert, E., E. Dasse, B. Haye, and E. Petitfrere. 2004. TIMPs as multifacial proteins. Crit. Rev. Oncol. Hematol. 49:187–198.
  • Lee, K., J. A. Villena, Y. S. Moon, K. H. Kim, S. Lee, C. Kang, and H. S. Sul. 2003. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J. Clin. Investig. 111:453–461.
  • Le Gall, S. M., R. Auger, C. Dreux, and P. Mauduit. 2003. Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. J. Biol. Chem. 278:45255–45268.
  • Li, X., and H. Fan. 2004. Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE). J. Biol. Chem. 279:27365–27375.
  • Mandrup, S., and M. D. Lane. 1997. Regulating adipogenesis. J. Biol. Chem. 272:5367–5370.
  • Massague, J., and A. Pandiella. 1993. Membrane-anchored growth factors. Annu. Rev. Biochem. 62:515–541.
  • McGowan, K., J. DeVente, J. O. Carey, D. K. Ways, and P. H. Pekala. 1996. Protein kinase C isoform expression during the differentiation of 3T3-L1 preadipocytes: loss of protein kinase C-alpha isoform correlates with loss of phorbol 12-myristate 13-acetate activation of nuclear factor κB and acquisition of the adipocyte phenotype. J. Cell Physiol. 167:113–120.
  • Mei, B., L. Zhao, L. Chen, and H. S. Sul. 2002. Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing. Biochem. J. 364:137–144.
  • Merlos-Suarez, A., J. Fernandez-Larrea, P. Reddy, J. Baselga, and J. Arribas. 1998. Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing. J. Biol. Chem. 273:24955–24962.
  • Mezyk, R., M. Bzowska, and J. Bereta. 2003. Structure and functions of tumor necrosis factor-alpha converting enzyme. Acta Biochim. Pol. 50:625–645.
  • Moon, Y. S., C. M. Smas, K. Lee, J. A. Villena, K. H. Kim, E. J. Yun, and H. S. Sul. 2002. Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol. Cell. Biol. 22:5585–5592.
  • Moss, M. L., S. L. Jin, M. E. Milla, D. M. Bickett, W. Burkhart, H. L. Carter, W. J. Chen, W. C. Clay, J. R. Didsbury, D. Hassler, C. R. Hoffman, T. A. Kost, M. H. Lambert, M. A. Leesnitzer, P. McCauley, G. McGeehan, J. Mitchell, M. Moyer, G. Pahel, W. Rocque, L. K. Overton, F. Schoenen, T. Seaton, J. L. Su, J. D. Becherer, et al. 1997. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature 385:733–736.
  • Ohno, N., A. Izawa, M. Hattori, R. Kageyama, and T. Sudo. 2001. dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect. Stem. Cells 19:71–79.
  • Pandiella, A., and J. Massague. 1991. Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor. J. Biol. Chem. 266:5769–5773.
  • Peschon, J. J., J. L. Slack, P. Reddy, K. L. Stocking, S. W. Sunnarborg, D. C. Lee, W. E. Russell, B. J. Castner, R. S. Johnson, J. N. Fitzner, R. W. Boyce, N. Nelson, C. J. Kozlosky, M. F. Wolfson, C. T. Rauch, D. P. Cerretti, R. J. Paxton, C. J. March, and R. A. Black. 1998. An essential role for ectodomain shedding in mammalian development. Science 282:1281–1284.
  • Prusty, D., B. H. Park, K. E. Davis, and S. R. Farmer. 2002. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARγ) and C/EBPα gene expression during the differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 277:46226–46232.
  • Qi, H., M. D. Rand, X. Wu, N. Sestan, W. Wang, P. Rakic, T. Xu, and S. Artavanis-Tsakonas. 1999. Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science 283:91–94.
  • Reginato, M. J., S. L. Krakow, S. T. Bailey, and M. A. Lazar. 1998. Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 273:1855–1858.
  • Rosen, E. D., C. J. Walkey, P. Puigserver, and B. M. Spiegelman. 2000. Transcriptional regulation of adipogenesis. Genes Dev. 14:1293–1307.
  • Sale, E. M., P. G. Atkinson, and G. J. Sale. 1995. Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis. EMBO J. 14:674–684.
  • Schmidt, J. V., P. G. Matteson, B. K. Jones, X. J. Guan, and S. M. Tilghman. 2000. The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev. 14:1997–2002.
  • Singh, R. J., J. C. Mason, E. A. Lidington, D. R. Edwards, R. K. Nuttall, R. Khokha, V. Knauper, G. Murphy, and J. Gavrilovic. 2005. Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovasc. Res. 67:39–49.
  • Smas, C. M., L. Chen, and H. S. Sul. 1997. Cleavage of membrane-associated pref-1 generates a soluble inhibitor of adipocyte differentiation. Mol. Cell. Biol. 17:977–988.
  • Smas, C. M., L. Chen, L. Zhao, M. J. Latasa, and H. S. Sul. 1999. Transcriptional repression of pref-1 by glucocorticoids promotes 3T3-L1 adipocyte differentiation. J. Biol. Chem. 274:12632–12641.
  • Smas, C. M., D. Green, and H. S. Sul. 1994. Structural characterization and alternate splicing of the gene encoding the preadipocyte EGF-like protein pref-1. Biochemistry 33:9257–9265.
  • Smas, C. M., D. Kachinskas, C. M. Liu, X. Xie, L. K. Dircks, and H. S. Sul. 1998. Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation. Sequence requirement for differentiation-dependent suppression. J. Biol. Chem. 273:31751–31758.
  • Smas, C. M., and H. S. Sul. 1995. Control of adipocyte differentiation. Biochem. J. 309(Pt. 3):697–710.
  • Smas, C. M., and H. S. Sul. 1993. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73:725–734.
  • Sunnarborg, S. W., C. L. Hinkle, M. Stevenson, W. E. Russell, C. S. Raska, J. J. Peschon, B. J. Castner, M. J. Gerhart, R. J. Paxton, R. A. Black, and D. C. Lee. 2002. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J. Biol. Chem. 277:12838–12845.
  • Takada, S., M. Tevendale, J. Baker, P. Georgiades, E. Campbell, T. Freeman, M. H. Johnson, M. Paulsen, and A. C. Ferguson-Smith. 2000. Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Curr. Biol. 10:1135–1138.
  • Tang, Q. Q., T. C. Otto, and M. D. Lane. 2003. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. USA 100:44–49.
  • Tanimizu, N., M. Nishikawa, H. Saito, T. Tsujimura, and A. Miyajima. 2003. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J. Cell Sci. 116:1775–1786.
  • Thabard, W., M. Collette, R. Bataille, and M. Amiot. 2001. Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells. Biochem. J. 358:193–200.
  • Werb, Z., and Y. Yan. 1998. A cellular striptease act. Science 282:1279–1280.
  • Wylie, A. A., S. K. Murphy, T. C. Orton, and R. L. Jirtle. 2000. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 10:1711–1718.
  • Zhang, H., J. Noohr, C. H. Jensen, R. K. Petersen, E. Bachmann, B. Teisner, L. K. Larsen, S. Mandrup, and K. Kristiansen. 2003. Insulin-like growth factor-1/insulin bypasses Pref-1/FA1-mediated inhibition of adipocyte differentiation. J. Biol. Chem. 278:20906–20914.

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