Cytohesin Binder and Regulator (Cybr) Is Not Essential for T- and Dendritic-Cell Activation and Differentiation

REFERENCES

• Boehm, T., S. Hofer, P. Winklehner, B. Kellersch, C. Geiger, A. Trockenbacher, S. Neyer, H. Fiegl, S. Ebner, L. Ivarsson, R. Schneider, E. Kremmer, C. Heufler, and W. Kolanus. 2003. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. EMBO J. 22:1014–1024.
   PubMedGoogle Scholar
• Cogliati, T., D. J. Good, M. Haigney, P. Delgado-Romero, M. A. Eckhaus, W. J. Koch, and I. R. Kirsch. 2002. Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice. Mol. Cell. Biol. 22:4977–4983.
   PubMed Web of Science ®Google Scholar
• Downey, J. S., and J. Han. 1998. Cellular activation mechanisms in septic shock. Front. Biosci. 3:d468–d476.
   PubMedGoogle Scholar
• Geiger, C., W. Nagel, T. Boehm, Y. van Kooyk, C. G. Figdor, E. Kremmer, N. Hogg, L. Zeitlmann, H. Dierks, K. S. Weber, and W. Kolanus. 2000. Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1. EMBO J. 19:2525–2536.
   PubMedGoogle Scholar
• Hofer, S., K. Pfeil, H. Niederegger, S. Ebner, V. A. Nguyen, E. Kremmer, M. Auffinger, S. Neyer, C. Furhapter, and C. Heufler. 2005. Dendritic cells regulate T-cell deattachment through the integrin-interacting protein CYTIP. Blood 7:1003–1009.
   Google Scholar
• Huang, Y. H., D. Li, A. Winoto, and E. A. Robey. 2004. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc. Natl. Acad. Sci. USA 101:4936–4941.
   PubMedGoogle Scholar
• Jackson, T. R., B. G. Kearns, and A. B. Theibert. 2000. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. Trends Biochem. Sci. 25:489–495.
   PubMed Web of Science ®Google Scholar
• Kitano, J., K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, and S. Nakanishi. 2002. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J. Neurosci. 22:1280–1289.
   PubMedGoogle Scholar
• Kitano, J., Y. Yamazaki, K. Kimura, T. Masukado, Y. Nakajima, and S. Nakanishi. 2003. Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. J. Biol. Chem. 278:14762–14768.
   PubMedGoogle Scholar
• Lazarini, F., T. N. Tham, P. Casanova, F. Arenzana-Seisdedos, and M. Dubois-Dalcq. 2003. Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia 42:139–148.
   PubMed Web of Science ®Google Scholar
• Ma, Q., D. Jones, and T. A. Springer. 1999. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 10:463–471.
   PubMed Web of Science ®Google Scholar
• Mansour, M., S. Y. Lee, and B. Pohajdak. 2002. The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP. J. Biol. Chem. 277:32302–32309.
   PubMed Web of Science ®Google Scholar
• Mick, V. E., T. K. Starr, T. M. McCaughtry, L. K. McNeil, and K. A. Hogquist. 2004. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J. Immunol. 173:5434–5444.
   PubMedGoogle Scholar
• Moriguchi, M., B. D. Hissong, M. Gadina, K. Yamaoka, H. L. Tiffany, P. M. Murphy, F. Candotti, and J. J. O'Shea. 2005. CXCL12 signaling is independent of Jak2 and Jak3. J. Biol. Chem. 280:17408–17414.
   PubMed Web of Science ®Google Scholar
• Morinobu, A., M. Gadina, W. Strober, R. Visconti, A. Fornace, C. Montagna, G. M. Feldman, R. Nishikomori, and J. J. O'Shea. 2002. STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation. Proc. Natl. Acad. Sci. USA 99:12281–12286.
   PubMed Web of Science ®Google Scholar
• Nevrivy, D. J., V. J. Peterson, D. Avram, J. E. Ishmael, S. G. Hansen, P. Dowell, D. E. Hruby, M. I. Dawson, and M. Leid. 2000. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. J. Biol. Chem. 275:16827–16836.
   PubMedGoogle Scholar
• Randazzo, P. A., Z. Nie, K. Miura, and V. W. Hsu. 2000. Molecular aspects of the cellular activities of ADP-ribosylation factors. Sci. STKE 2000:RE1.
   PubMedGoogle Scholar
• Rogge, L., E. Bianchi, M. Biffi, E. Bono, S. Y. Chang, H. Alexander, C. Santini, G. Ferrari, L. Sinigaglia, M. Seiler, M. Neeb, J. Mous, F. Sinigaglia, and U. Certa. 2000. Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat. Genet. 25:96–101.
   PubMedGoogle Scholar
• Tang, P., T. P. Cheng, D. Agnello, C. Y. Wu, B. D. Hissong, W. T. Watford, H. J. Ahn, J. Galon, J. Moss, M. Vaughan, J. J. O'Shea, and M. Gadina. 2002. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. Proc. Natl. Acad. Sci. USA 99:2625–2629.
   PubMedGoogle Scholar
• Yamaoka, K., B. Min, Y. J. Zhou, W. E. Paul, and J. O'Shea, J. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106:3227–3233.
   PubMed Web of Science ®Google Scholar