REFERENCES
- Anderson, A. C. et al. 2007. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 318:1141–1143.
- Angelosanto, J. M., and E. J. Wherry. 2010. Transcription factor regulation of CD8+ T-cell memory and exhaustion. Immunol. Rev. 236:167–175.
- Apetoh, L. et al. 2010. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat. Immunol. 11:854–861.
- Barber, D. L. et al. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682–687.
- Binne, L. L., M. L. Scott, and P. D. Rennert. 2007. Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals. J. Immunol. 178:4342–4350.
- Blackburn, S. D., H. Shin, G. J. Freeman, and E. J. Wherry. 2008. Selective expansion of a subset of exhausted CD8 T cells by anti-PD-L1 blockade. Proc. Natl. Acad. Sci. U. S. A. 105:15016–15021.
- Blackburn, S. D. et al. 2009. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10:29–37.
- Cao, E. et al. 2007. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity 26:311–321.
- Dardalhon, V. et al. 2010. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J. Immunol. 185:1383–1392.
- Day, C. L. et al. 2006. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443:350–354.
- DeKruyff, R. H. et al. 2010. T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells. J. Immunol. 184:1918–1930.
- de Souza, A. J., and L. P. Kane. 2006. Immune regulation by the TIM gene family. Immunol. Res. 36:147–155.
- de Souza, A. J. et al. 2008. T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase. J. Immunol. 180:6518–6526.
- de Souza, A. J., T. B. Oriss, K. O'Malley, A. Ray, and L. P. Kane. 2005. TIM-1 is expressed on in vivo-activated T cells and provides a co-stimulatory signal for T cell activation. Proc. Natl. Acad. Sci. U. S. A. 102:17113–17118.
- Fourcade, J. et al. 2010. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J. Exp. Med. 207:2175–2186.
- Jin, H. T. et al. 2010. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. U. S. A. 107:14733–14738.
- Jones, R. B. et al. 2008. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J. Exp. Med. 205:2763–2779.
- Kane, L. P., V. S. S. Shapiro, D. Stokoe, and A. Weiss. 1999. Induction of NF-κB by the Akt/PKB kinase. Curr. Biol. 9:601–604.
- Knickelbein, J. E., A. J. de Souza, R. Tosti, P. Narayan, and L. P. Kane. 2006. Cutting edge: inhibition of T cell activation by TIM-2. J. Immunol. 177:4966–4970.
- Kuchroo, V. K., J. H. Meyers, D. T. Umetsu, and R. H. DeKruyff. 2006. TIM family of genes in immunity and tolerance. Adv. Immunol. 91:227–249.
- Nakayama, M. et al. 2009. Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood 113:3821–3830.
- Narayan, P., B. Holt, R. Tosti, and L. P. Kane. 2006. CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. Mol. Cell. Biol. 26:2327–2336.
- Obenauer, J. C., L. C. Cantley, and M. B. Yaffe. 2003. Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 31:3635–3641.
- Obenauer, J. C., and M. B. Yaffe. 2004. Computational prediction of protein-protein interactions. Methods Mol. Biol. 261:445–468.
- Okazaki, T., and T. Honjo. 2007. PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 19:813–824.
- Riley, J. L. 2009. PD-1 signaling in primary T cells. Immunol. Rev. 229:114–125.
- Sakuishi, K. et al. 2010. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207:2187–2194.
- Shin, H. et al. 2009. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity 31:309–320.
- Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585–593.
- Su, E. W., J. Y. Lin, and L. P. Kane. 2008. TIM-1 and TIM-3 proteins in immune regulation. Cytokine 44:9–13.
- Trible, R. P., L. Emert-Sedlak, and T. E. Smithgall. 2006. HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction. J. Biol. Chem. 281:27029–27038.
- van de Weyer, P. S. et al. 2006. A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem. Biophys. Res. Commun. 351:571–576.
- Virgin, H. W., E. J. Wherry, and R. Ahmed. 2009. Redefining chronic viral infection. Cell 138:30–50.
- Wherry, E. J. et al. 2007. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27:670–684.
- Williams, B. L. et al. 1998. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol. Cell. Biol. 18:1388–1399.
- Xiao, S. et al. 2007. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J. Exp. Med. 204:1691–1702.
- Yablonski, D., M. R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science 281:413–416.
- Zhu, C. et al. 2005. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6:1245–1252.