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Article

Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin

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Pages 4789-4800 | Received 04 May 2011, Accepted 24 Sep 2011, Published online: 20 Mar 2023

REFERENCES

  • Abe, K., et al. 2000. Vav2 is an activator of Cdc42, Rac1, and RhoA. J. Biol. Chem. 275:10141–10149.
  • Abramoff, M. D., P. J. Magelhaes, and S. J. Ram. 2004. Image processing with Image J. Biophotonics Int. 11:36–42.
  • Aitsebaomo, J., et al. 2004. p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation. J. Biol. Chem. 279:17963–17972.
  • Arrieumerlou, C., and T. Meyer. 2005. A local coupling model and compass parameter for eukaryotic chemotaxis. Dev. Cell 8:215–227.
  • Azim, A. C., K. Barkalow, J. Chou, and J. H. Hartwig. 2000. Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor. Blood 95:959–964.
  • Bae, S. S., H. Cho, J. Mu, and M. J. Birnbaum. 2003. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J. Biol. Chem. 278:49530–49536.
  • Brummer, T., et al. 2008. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J. 27:2305–2316.
  • Carpenter, A. E., et al. 2006. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7:R100.
  • Cheresh, D. A., J. Leng, and R. L. Klemke. 1999. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J. Cell Biol. 146:1107–1116.
  • Chung, C. Y., G. Potikyan, and R. A. Firtel. 2001. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7:937–947.
  • Enomoto, A., et al. 2005. Akt/PKB regulates actin organization and cell motility via girdin/APE. Dev. Cell 9:389–402.
  • Gail, M. 1973. Locomotion of tissue cells. Elsevier, Amsterdam, The Netherlands.
  • Genot, E. M., et al. 2000. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol. Cell Biol. 20:5469–5478.
  • Han, J., et al. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558–560.
  • Higuchi, M., N. Masuyama, Y. Fukui, A. Suzuki, and Y. Gotoh. 2001. Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr. Biol. 11:1958–1962.
  • Kolsch, V., P. G. Charest, and R. A. Firtel. 2008. The regulation of cell motility and chemotaxis by phospholipid signaling. J. Cell Sci. 121:551–559.
  • Larance, M., et al. 2010. Global phosphoproteomics identifies a major role for Akt and 14-3-3 in regulating EDC3. Mol. Cell. Proteomics 9:682–694.
  • Letunic, I., T. Doerks, and P. Bork. 2009. SMART 6: recent updates and new developments. Nucleic Acids Res. 37:D229–232.
  • Linding, R., R. B. Russell, V. Neduva, and T. J. Gibson. 2003. GlobPlot: exploring protein sequences for globularity and disorder. Nucleic Acids Res. 31:3701–3708.
  • Morita, S., T. Kojima, and T. Kitamura. 2000. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7:1063–1069.
  • Obata, T., et al. 2000. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J. Biol. Chem. 275:36108–36115.
  • Obenauer, J. C., L. C. Cantley, and M. B. Yaffe. 2003. Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 31:3635–3641.
  • Primo, L., et al. 2007. Essential role of PDK1 in regulating endothelial cell migration. J. Cell Biol. 176:1035–1047.
  • Puntervoll, P., et al. 2003. ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res. 31:3625–3630.
  • Ramm, G., M. Larance, M. Guilhaus, and D. E. James. 2006. A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its Interaction with the RabGAP AS160. J. Biol. Chem. 281:29174–29180.
  • Sander, E. E., J. P. ten Klooster, S. van Delft, R. A. van der Kammen, and J. G. Collard. 1999. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 147:1009–1022.
  • Sanz-Moreno, V., et al. 2008. Rac activation and inactivation control plasticity of tumor cell movement. Cell 135:510–523.
  • Scholz, R.-P., et al. 2009. DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. J. Cell Sci. 122:92–102.
  • Wolf, K., et al. 2003. Compensation mechanism in tumor cell migration. J. Cell Biol. 160:267–277.
  • Yoeli-Lerner, M., et al. 2005. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 20:539–550.

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