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Article

Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via β-Catenin

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Pages 2966-2978 | Received 23 May 2011, Accepted 03 May 2012, Published online: 20 Mar 2023

REFERENCES

  • Altafaj X, et al. 2001. Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum. Mol. Genet. 10:1915–1923.
  • Anderson CT, Sheets PL, Kiritani T, Shepherd GM. 2010. Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex. Nat. Neurosci. 13:739–744.
  • Anderson P. 2005. Pin1: a proline isomerase that makes you wheeze? Nat. Immunol. 6:1211–1212.
  • Angevine JBJr, Sidman RL. 1961. Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature 192:766–768.
  • Arlotta P, et al. 2005. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 45:207–221.
  • Arnold SJ, et al. 2008. The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 22:2479–2484.
  • Becker EB, Bonni A. 2006. Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery. Neuron 49:655–662.
  • Blume-Jensen P, Hunter T. 2001. Oncogenic kinase signalling. Nature 411:355–365.
  • Butterfield DA, et al. 2006. Pin1 in Alzheimer's disease. J. Neurochem. 98:1697–1706.
  • Caviness VSJr, Takahashi T. 1995. Proliferative events in the cerebral ventricular zone. Brain Dev. 17:159–163.
  • Chen SY, et al. 2006. Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor–beta-catenin interaction. Mol. Cell. Biol. 26:929–939.
  • Chenn A, Walsh CA. 2002. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297:365–369.
  • Clevers H. 2006. Wnt/beta-catenin signaling in development and disease. Cell 127:469–480.
  • Englund C, et al. 2005. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J. Neurosci. 25:247–251.
  • Fotaki V, Martinez De Lagran M, Estivill X, Arbones M, Dierssen M. 2004. Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity. Behav. Neurosci. 118:815–821.
  • Gage FH. 2010. Molecular and cellular mechanisms contributing to the regulation, proliferation and differentiation of neural stem cells in the adult dentate gyrus. Keio J. Med. 59:79–83.
  • Goutagny N, Severa M, Fitzgerald KA. 2006. Pin-ning down immune responses to RNA viruses. Nat. Immunol. 7:555–557.
  • Grigoryan T, Wend P, Klaus A, Birchmeier W. 2008. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev. 22:2308–2341.
  • Hajnoczky G, Hoek JB. 2007. Cell signaling. Mitochondrial longevity pathways. Science 315:607–609.
  • Hamdane M, et al. 2006. Pin1 allows for differential Tau dephosphorylation in neuronal cells. Mol. Cell. Neurosci. 32:155–160.
  • He TC, et al. 1998. Identification of c-MYC as a target of the APC pathway. Science 281:1509–1512.
  • Hirabayashi Y, Gotoh Y. 2005. Stage-dependent fate determination of neural precursor cells in mouse forebrain. Neurosci. Res. 51:331–336.
  • Hirabayashi Y, et al. 2004. The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 131:2791–2801.
  • Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51–59.
  • Israsena N, Hu M, Fu W, Kan L, Kessler JA. 2004. The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells. Dev. Biol. 268:220–231.
  • Kalani MY, et al. 2008. Wnt-mediated self-renewal of neural stem/progenitor cells. Proc. Natl. Acad. Sci. U. S. A. 105:16970–16975.
  • Kesavapany S, et al. 2007. Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol. Biol. Cell 18:3645–3655.
  • Kim CJ, et al. 2005. Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression. World J. Gastroenterol. 11:5006–5009.
  • Korinek V, et al. 1997. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC−/− colon carcinoma. Science 275:1784–1787.
  • Kuwabara T, et al. 2009. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat. Neurosci. 12:1097–1105.
  • Lai T, et al. 2008. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron 57:232–247.
  • Lee TH, et al. 2009. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat. Cell Biol. 11:97–105.
  • Lie DC, et al. 2005. Wnt signalling regulates adult hippocampal neurogenesis. Nature 437:1370–1375.
  • Lim J, et al. 2008. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J. Clin. Invest. 118:1877–1889.
  • Liou Y-C, et al. 2003. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424:556–561.
  • Liu C, et al. 1999. Beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc. Natl. Acad. Sci. U. S. A. 96:6273–6278.
  • Lopez-Toledano MA, Shelanski ML. 2004. Neurogenic effect of beta-amyloid peptide in the development of neural stem cells. J. Neurosci. 24:5439–5444.
  • Lu KP, Finn G, Lee TH, Nicholson LK. 2007. Prolyl cis-trans isomerization as a molecular timer. Nat. Chem. Biol. 3:619–629.
  • Lu KP, Hanes SD, Hunter T. 1996. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380:544–547.
  • Lu KP, Zhou XZ. 2007. The prolyl isomerase Pin1: a pivotal new twist in phosphorylation signalling and human disease. Nat. Rev. Mol. Cell. Biol. 8:904–916.
  • Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP. 1999. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399:784–788.
  • Lu PJ, Zhou XZ, Shen M, Lu KP. 1999. A function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283:1325–1328.
  • Lyu J, Yamamoto V, Lu W. 2008. Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev. Cell 15:773–780.
  • Ma SL, et al. 2012. A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease. Neurobiol. Aging 33:804–813.
  • Ma SL, Pastorino L, Zhou XZ, Lu KP. 2012. Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease. J. Biol. Chem. 287:6969–6973.
  • MacDonald BT, Tamai K, He X. 2009. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17:9–26.
  • Machon O, et al. 2007. A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev. Biol. 311:223–237.
  • Machon O, van den Bout CJ, Backman M, Kemler R, Krauss S. 2003. Role of beta-catenin in the developing cortical and hippocampal neuroepithelium. Neuroscience 122:129–143.
  • Maudsley S, Mattson MP. 2006. Protein twists and turns in Alzheimer disease. Nat. Med. 12:392–393.
  • McEvilly RJ, de Diaz MO, Schonemann MD, Hooshmand F, Rosenfeld MG. 2002. Transcriptional regulation of cortical neuron migration by POU domain factors. Science 295:1528–1532.
  • Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD. 2007. Neuronal subtype specification in the cerebral cortex. Nat. Rev. Neurosci. 8:427–437.
  • Moretto Zita M, et al. 2007. Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function. EMBO J. 26:1761–1771.
  • Moretto-Zita M, et al. 2010. Phosphorylation stabilizes Nanog by promoting its interaction with Pin1. Proc. Natl. Acad. Sci. U. S. A. 107:13312–13317.
  • Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ. 2011. Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. J. Neurosci. 31:1676–1687.
  • Nakamura K, et al. 2012. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell 149:232–244.
  • Nakamura K, et al. 2007. CD3 and immunoglobulin G Fc receptor regulate cerebellar functions. Mol. Cell. Biol. 27:5128–5134.
  • Nakamura K, et al. 2006. Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating. J. Mol. Biol. 363:345–354.
  • Nakamura K, et al. 2001. Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur. J. Neurosci. 13:179–189.
  • Nakamura K, Sato T, Ohashi A, Tsurui H, Hasegawa H. 2008. Role of a serotonin precursor in development of gut microvilli. Am. J. Pathol. 172:333–344.
  • Nakashima M, et al. 2004. Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression. J. Pathol. 202:446–455.
  • Nigg EA. 2001. Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell. Biol. 2:21–32.
  • Nusse R, et al. 2008. Wnt signaling and stem cell control. Cold Spring Harb. Symp. Quant. Biol. 73:59–66.
  • Pang R, et al. 2004. PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma. Oncogene 23:4182–4186.
  • Pastorino L, et al. 2006. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature 440:528–534.
  • Pastorino L, et al. 2012. Alzheimer's disease-related loss of Pin1 function influences the intracellular localization and the processing of AβPP. J. Alzheimers Dis. 30:277–297.
  • Pawson T, Scott JD. 2005. Protein phosphorylation in signaling—50 years and counting. Trends Biochem. Sci. 30:286–290.
  • Rakic P. 1974. Neurons in rhesus monkey visual cortex: systematic relation between time of origin and eventual disposition. Science 183:425–427.
  • Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. 2009. Decision by division: making cortical maps. Trends Neurosci. 32:291–301.
  • Ranganathan R, Lu KP, Hunter T, Noel JP. 1997. Structural and functional analysis of the mitotic peptidyl-prolyl isomerase Pin1 suggests that substrate recognition is phosphorylation dependent. Cell 89:875–886.
  • Rudrabhatla P, Albers W, Pant HC. 2009. Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins. J. Neurosci. 29:14869–14880.
  • Rudrabhatla P, et al. 2008. Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J. Biol. Chem. 283:26737–26747.
  • Rustighi A, et al. 2009. The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. Nat. Cell Biol. 11:133–142.
  • Ryo A, et al. 2002. Pin1 is an E2F target gene essential for the Neu/Ras-induced transformation of mammary epithelial cells. Mol. Cell. Biol. 22:5281–5295.
  • Ryo A, Nakamura N, Wulf G, Liou YC, Lu KP. 2001. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3:793–801.
  • Ryo A, et al. 2003. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell 12:1413–1426.
  • Ryo A, et al. 2006. Prolyl-isomerase Pin1 accumulates in Lewy bodies of Parkinson disease and facilitates formation of alpha-synuclein inclusions. J. Biol. Chem. 281:4117–4125.
  • Segat L, et al. 2007. Pin1 promoter polymorphisms are associated with Alzheimer's disease. Neurobiol. Aging 28:69–74.
  • Shaw PE. 2007. Peptidyl-prolyl cis/trans isomerases and transcription: is there a twist in the tail? EMBO Rep. 8:40–45.
  • Solberg N, Machon O, Krauss S. 2008. Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev. Dyn. 237:1799–1811.
  • Sugitani Y, et al. 2002. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev. 16:1760–1765.
  • Sultana R, et al. 2006. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: a redox proteomics analysis. Neurobiol. Aging 27:918–925.
  • Svenningsson P, et al. 2007. Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine. Eur. J. Neurosci. 26:3509–3517.
  • Thullier F, Lalonde R, Cousin X, Lestienne F. 1997. Neurobehavioral evaluation of lurcher mutant mice during ontogeny. Brain Res. Dev. Brain Res. 100:22–28.
  • Wang S, et al. 2007. The significance of Pin1 in the development of Alzheimer's disease. J. Alzheimers Dis. 11:13–23.
  • Wrobel CN, Mutch CA, Swaminathan S, Taketo MM, Chenn A. 2007. Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. Dev. Biol. 309:285–297.
  • Wu SX, et al. 2005. Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone. Proc. Natl. Acad. Sci. U. S. A. 102:17172–17177.
  • Yaffe MB, et al. 1997. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science 278:1957–1960.
  • Yeh ES, Means AR. 2007. PIN1, the cell cycle and cancer. Nat. Rev. Cancer 7:381–388.
  • Zacchi P, et al. 2002. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 419:853–857.
  • Zechner D, et al. 2003. Beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev. Biol. 258:406–418.
  • Zhang CL, Zou Y, He W, Gage FH, Evans RM. 2008. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451:1004–1007.
  • Zheng H, et al. 2002. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 419:849–853.
  • Zhou CX, Gao Y. 2006. Aberrant expression of beta-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: relation to tumor proliferation and metastasis. Oncol. Rep. 16:505–511.
  • Zhou XZ, et al. 2000. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol. Cell 6:873–883.

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