Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2

REFERENCES

• Camps, C., et al. 2008. hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin. Cancer Res. 14:1340–1348.
   PubMed Web of Science ®Google Scholar
• Caruso, P., et al. 2010. Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arterioscler. Thromb. Vasc. Biol. 30:716–723.
   PubMed Web of Science ®Google Scholar
• Chan, M. C., et al. 2010. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 29:559–573.
   PubMed Web of Science ®Google Scholar
• Cheloufi, S., C. O. Dos Santos, M. M. Chong, and G. J. Hannon. 2010. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465:584–589.
   PubMed Web of Science ®Google Scholar
• Cheng, Y., and C. Zhang. 2010. MicroRNA-21 in cardiovascular disease. J. Cardiovasc. Transl. Res. 3:251–255.
   PubMed Web of Science ®Google Scholar
• Cowland, J. B., C. Hother, and K. Gronbaek. 2007. MicroRNAs and cancer. APMIS 115:1090–1106.
   PubMed Web of Science ®Google Scholar
• Croce, C. M., and G. A. Calin. 2005. miRNAs, cancer, and stem cell division. Cell 122:6–7.
   PubMed Web of Science ®Google Scholar
• Cullen, B. R. 2006. Viruses and microRNAs. Nat. Genet. 38(Suppl.):S25–S30.
   PubMed Web of Science ®Google Scholar
• Davis, B. N., A. C. Hilyard, G. Lagna, and A. Hata. 2008. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454:56–61.
   PubMed Web of Science ®Google Scholar
• Davis, B. N., A. C. Hilyard, P. H. Nguyen, G. Lagna, and A. Hata. 2009. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J. Biol. Chem. 284:3728–3738.
   PubMed Web of Science ®Google Scholar
• Eisenberg, I., M. S. Alexander, and L. M. Kunkel. 2009. miRNAS in normal and diseased skeletal muscle. J. Cell Mol. Med. 13:2–11.
   PubMedGoogle Scholar
• Ender, C., and G. Meister. 2010. Argonaute proteins at a glance. J. Cell Sci. 123:1819–1823.
   PubMedGoogle Scholar
• Fahling, M., et al. 2006. Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability. J. Biol. Chem. 281:9279–9286.
   PubMed Web of Science ®Google Scholar
• Fahling, M., et al. 2006. Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia. J. Biol. Chem. 281:26089–26101.
   PubMed Web of Science ®Google Scholar
• Gardner, L. B. 2008. Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response. Mol. Cell. Biol. 28:3729–3741.
   PubMed Web of Science ®Google Scholar
• Gorres, K. L., and R. T. Raines. 2010. Prolyl 4-hydroxylase. Crit. Rev. Biochem. Mol. Biol. 45:106–124.
   PubMed Web of Science ®Google Scholar
• Harris, A. L. 2002. Hypoxia—a key regulatory factor in tumour growth. Nat. Rev. Cancer 2:38–47.
   PubMed Web of Science ®Google Scholar
• Hirsila, M., P. Koivunen, V. Gunzler, K. I. Kivirikko, and J. Myllyharju. 2003. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278:30772–30780.
   PubMed Web of Science ®Google Scholar
• Hofbauer, K. H., et al. 2003. Oxygen tension regulates the expression of a group of procollagen hydroxylases. Eur. J. Biochem. 270:4515–4522.
   PubMedGoogle Scholar
• Inchley, C. S., T. Sonerud, H. O. Fjaerli, and B. Nakstad. 2011. Reduced Dicer expression in the cord blood of infants admitted with severe respiratory syncytial virus disease. BMC Infect. Dis. 11:59.
   PubMed Web of Science ®Google Scholar
• Iwasaki, S., et al. 2010. Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes. Mol. Cell 39:292–299.
   PubMed Web of Science ®Google Scholar
• Kedersha, N., and P. Anderson. 2007. Mammalian stress granules and processing bodies. Methods Enzymol. 431:61–81.
   PubMed Web of Science ®Google Scholar
• Kedersha, N. L., M. Gupta, W. Li, I. Miller, and P. Anderson. 1999. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. J. Cell Biol. 147:1431–1442.
   PubMed Web of Science ®Google Scholar
• Kim, V. N. 2005. MicroRNA biogenesis: coordinated cropping and dicing. Nat. Rev. Mol. Cell Biol. 6:376–385.
   PubMed Web of Science ®Google Scholar
• Kulshreshtha, R., et al. 2007. A microRNA signature of hypoxia. Mol. Cell. Biol. 27:1859–1867.
   PubMed Web of Science ®Google Scholar
• Kumar, M. S., J. Lu, K. L. Mercer, T. R. Golub, and T. Jacks. 2007. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat. Genet. 39:673–677.
   PubMed Web of Science ®Google Scholar
• Kumar, M. S., et al. 2009. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 23:2700–2704.
   PubMed Web of Science ®Google Scholar
• Leung, A. K., J. M. Calabrese, and P. A. Sharp. 2006. Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc. Natl. Acad. Sci. U. S. A. 103:18125–18130.
   PubMed Web of Science ®Google Scholar
• Leung, A. K., et al. 2011. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol. Cell 42:489–499.
   PubMed Web of Science ®Google Scholar
• Levene, C. I., and C. J. Bates. 1976. The effect of hypoxia on collagen synthesis in cultured 3T6 fibroblasts and its relationship to the mode of action of ascorbate. Biochim. Biophys. Acta 444:446–452.
   PubMedGoogle Scholar
• Liu, C. J. 2009. MicroRNAs in skeletogenesis. Front. Biosci. 14:2757–2764.
   Google Scholar
• McEwen, E., et al. 2005. Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J. Biol. Chem. 280:16925–16933.
   PubMed Web of Science ®Google Scholar
• Minet, E., et al. 1999. Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Lett. 460:251–256.
   PubMed Web of Science ®Google Scholar
• Myllyharju, J. 2008. Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets. Ann. Med. 40:402–417.
   PubMed Web of Science ®Google Scholar
• Myllyharju, J., and K. I. Kivirikko. 2004. Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet. 20:33–43.
   PubMed Web of Science ®Google Scholar
• Naeije, R., and B. Rondelet. 2004. Pathobiology of pulmonary arterial hypertension. Bull. Mem. Acad. R. Med. Belg. 159:219–226.
   PubMedGoogle Scholar
• Owens, G. K., M. S. Kumar, and B. R. Wamhoff. 2004. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol. Rev. 84:767–801.
   PubMed Web of Science ®Google Scholar
• Pare, J. M., et al. 2009. Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies. Mol. Biol. Cell 20:3273–3284.
   PubMedGoogle Scholar
• Perhonen, M., X. Han, W. Wang, J. Karpakka, and T. E. Takala. 1996. Skeletal muscle collagen type I and III mRNA, [corrected] prolyl 4-hydroxylase, and collagen in hypobaric trained rats. J. Appl. Physiol. 80:2226–2233.
   PubMedGoogle Scholar
• Pothof, J., N. S. Verkaik, and I. W. van IJcken, et al. 2009. MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J. 28:2090–2099.
   PubMed Web of Science ®Google Scholar
• Preston, I. R., N. S. Hill, R. R. Warburton, and B. L. Fanburg. 2006. Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. Am. J. Physiol. Lung Cell. Mol. Physiol. 290:L367–L374.
   PubMedGoogle Scholar
• Qi, H. H., et al. 2008. Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature 455:421–424.
   PubMed Web of Science ®Google Scholar
• Rich, S., et al. 1987. Primary pulmonary hypertension. A national prospective study. Ann. Intern. Med. 107:216–223.
   PubMed Web of Science ®Google Scholar
• Semenza, G. L. 2009. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 24:97–106.
   PubMed Web of Science ®Google Scholar
• Shu, C. W., N. L. Cheng, W. M. Chang, T. L. Tseng, and Y. K. Lai. 2005. Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C. J. Cell. Biochem. 94:1199–1209.
   PubMedGoogle Scholar
• Siomi, H., and M. C. Siomi. 2010. Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell 38:323–332.
   PubMed Web of Science ®Google Scholar
• Stenmark, K. R., B. Meyrick, N. Galie, W. J. Mooi, and I. F. McMurtry. 2009. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am. J. Physiol. Lung Cell. Mol. Physiol. 297:L1013–L1032.
   PubMed Web of Science ®Google Scholar
• Tahbaz, N., J. B. Carmichael, and T. C. Hobman. 2001. GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization. J. Biol. Chem. 276:43294–43299.
   PubMedGoogle Scholar
• Takahashi, Y., S. Takahashi, Y. Shiga, T. Yoshimi, and T. Miura. 2000. Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. J. Biol. Chem. 275:14139–14146.
   PubMed Web of Science ®Google Scholar
• Tsuji-Naito, K., S. Ishikura, M. Akagawa, and H. Saeki. 2010. α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts. Connect. Tissue Res. 51:378–387.
   PubMed Web of Science ®Google Scholar
• Yang, J. S., et al. 2010. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc. Natl. Acad. Sci. U. S. A. 107:15163–15168.
   PubMed Web of Science ®Google Scholar