Androgen-Induced Activation of Gonadotropin-Regulated Testicular RNA Helicase (GRTH/Ddx25) Transcription: Essential Role of a Nonclassical Androgen Response Element Half-Site

REFERENCES

• Belakavadi M, Fondell JD. 2006. Role of the mediator complex in nuclear hormone receptor signaling. Rev. Physiol. Biochem. Pharmacol. 156:23–43.
   PubMedGoogle Scholar
• Bennett NC, Gardiner RA, Hooper JD, Johnson DW, Gobe GC. 2010. Molecular cell biology of androgen receptor signalling. Int. J. Biochem. Cell Biol. 42:813–827.
   PubMed Web of Science ®Google Scholar
• Briegel K, et al. 1993. Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Genes Dev. 7:1097–1109.
   PubMedGoogle Scholar
• Collins LL, et al. 2003. The androgen receptor in spermatogenesis. Cytogenet. Genome Res. 103:299–301.
   PubMed Web of Science ®Google Scholar
• Dekker J, Rippe K, Dekker M, Kleckner N. 2002. Capturing chromosome conformation. Science 295:1306–1311.
   PubMed Web of Science ®Google Scholar
• Dong J, Tsai-Morris CH, Dufau ML. 2006. A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. J. Biol. Chem. 281:18825–18836.
   PubMed Web of Science ®Google Scholar
• Dufau ML, Tsai-Morris CH. 2007. Gonadotropin-regulated testicular helicase (GRTH/DDX25): an essential regulator of spermatogenesis. Trends Endocrinol. Metab. 18:314–320.
   PubMedGoogle Scholar
• Fujimoto N, et al. 1999. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. J. Biol. Chem. 274:8316–8321.
   PubMed Web of Science ®Google Scholar
• Fukushima M, Villar J, Tsai-Morris C-H, Dufau ML. 2011. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells. Central role of steroidogenic acute regulatory protein (StAR). J. Biol. Chem. 286:29932–29940.
   PubMedGoogle Scholar
• Gao N, et al. 2003. The role of hepatocyte nuclear factor-3 alpha (Forkhead box A1) and androgen receptor in transcriptional regulation of prostatic genes. Mol. Endocrinol. 17:1484–1507.
   PubMedGoogle Scholar
• Haelens A, et al. 1999. The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element. Mol. Cell. Endocrinol. 153:91–102.
   PubMedGoogle Scholar
• Holdcraft RW, Braun RE. 2004. Hormonal regulation of spermatogenesis. Int. J. Androl. 27:335–342.
   PubMed Web of Science ®Google Scholar
• Kang HY, Yeh S, Fujimoto N, Chang C. 1999. Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. J. Biol. Chem. 274:8570–8576.
   PubMed Web of Science ®Google Scholar
• Kasper S, et al. 1994. Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene. J. Biol. Chem. 269:31763–31769.
   PubMedGoogle Scholar
• Kutoh E, Stromstedt PE, Poellinger L. 1992. Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1. Mol. Cell. Biol. 12:4960–4969.
   PubMedGoogle Scholar
• Li X, Wong J, Tsai SY, Tsai MJ, O'Malley BW. 2003. Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol. Cell. Biol. 23:3763–3773.
   PubMedGoogle Scholar
• Liao M, Zhang Y, Dufau ML. 2008. Protein kinase Calpha-induced derepression of the human luteinizing hormone receptor gene transcription through ERK-mediated release of HDAC1/Sin3A repressor complex from Sp1 sites. Mol. Endocrinol. 22:1449–1463.
   PubMedGoogle Scholar
• Lin B, et al. 2009. Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One 4:e6589.
   PubMedGoogle Scholar
• Malinowska K, et al. 2009. Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. Endocr. Relat. Cancer 16:155–169.
   PubMed Web of Science ®Google Scholar
• Mellon PL, et al. 1990. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1–10.
   PubMed Web of Science ®Google Scholar
• Pan YF, et al. 2008. Regulation of estrogen receptor-mediated long range transcription via evolutionarily conserved distal response elements. J. Biol. Chem. 283:32977–32988.
   PubMed Web of Science ®Google Scholar
• Peng Y, et al. 2008. Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Am. J. Pathol. 172:225–235.
   PubMedGoogle Scholar
• Shaffer PL, Jivan A, Dollins DE, Claessens F, Gewirth DT. 2004. Structural basis of androgen receptor binding to selective androgen response elements. Proc. Natl. Acad. Sci. U. S. A. 101:4758–4763.
   PubMed Web of Science ®Google Scholar
• Sheng Y, Tsai-Morris CH, Dufau ML. 2003. Cell-specific and hormone-regulated expression of gonadotropin-regulated testicular RNA helicase gene (GRTH/Ddx25) resulting from alternative utilization of translation initiation codons in the rat testis. J. Biol. Chem. 278:27796–27803.
   PubMedGoogle Scholar
• Sheng Y, Tsai-Morris CH, Gutti R, Maeda Y, Dufau ML. 2006. Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis. J. Biol. Chem. 281:35048–35056.
   PubMedGoogle Scholar
• Tang PZ, Tsai-Morris CH, Dufau ML. 1999. A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. J. Biol. Chem. 274:37932–37940.
   PubMedGoogle Scholar
• Tsai-Morris CH, Lei S, Jiang Q, Sheng Y, Dufau ML. 2004. Genomic organization and transcriptional analysis of gonadotropin-regulated testicular RNA helicase-GRTH/DDX25 gene. Gene 331:83–94.
   PubMedGoogle Scholar
• Tsai-Morris CH, et al. 2010. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis. J. Cell. Biochem. 109:1142–1147.
   PubMedGoogle Scholar
• Tsai-Morris CH, Sheng Y, Gutti RK, Tang PZ, Dufau ML. 2010. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25): a multifunctional protein essential for spermatogenesis. J. Androl. 31:45–52.
   PubMedGoogle Scholar
• Tsai-Morris CH, Sheng Y, Lee E, Lei KJ, Dufau ML. 2004. Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis. Proc. Natl. Acad. Sci. U. S. A. 101:6373–6378.
   PubMed Web of Science ®Google Scholar
• Verhoeven G, Willems A, Denolet E, Swinnen JV, De Gendt K. 2010. Androgens and spermatogenesis: lessons from transgenic mouse models. Philos. Trans. R. Soc. Lond. B Biol. Sci. 365:1537–1556.
   PubMed Web of Science ®Google Scholar
• Verrijdt G, et al. 1999. Androgen specificity of a response unit upstream of the human secretory component gene is mediated by differential receptor binding to an essential androgen response element. Mol. Endocrinol. 13:1558–1570.
   PubMedGoogle Scholar
• Wang Q, Carroll JS, Brown M. 2005. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol. Cell 19:631–642.
   PubMed Web of Science ®Google Scholar
• Wang Q, et al. 2007. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol. Cell 27:380–392.
   PubMed Web of Science ®Google Scholar
• Wei GH, et al. 2010. Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 29:2147–2160.
   PubMed Web of Science ®Google Scholar
• York B, O'Malley BW. 2010. Steroid receptor coactivator (SRC) family: masters of systems biology. J. Biol. Chem. 285:38743–38750.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liao M, Dufau ML. 2006. Phosphatidylinositol 3-kinase/protein kinase Cζ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Mol. Cell. Biol. 26:6748–6761.
   PubMed Web of Science ®Google Scholar