115
Views
402
CrossRef citations to date
0
Altmetric
Research Article

Expression and Regulation by Interferon of a Double-Stranded-RNA-Specific Adenosine Deaminase from Human Cells: Evidence for Two Forms of the Deaminase

&
Pages 5376-5388 | Received 12 Apr 1995, Accepted 05 Jul 1995, Published online: 30 Mar 2023

REFERENCES

  • Aebi, M., J. Fah, N. Hurt, C. E. Samuel, D. Thomis, L. Bazzigher, J. Pavlovic, O. Haller, and P. Staeheli. 1989. cDNA structures and regulation of two interferon-induced human Mx proteins. Mol. Cell. Biol. 9:5062–5072.
  • Ahn, B.-Y., P. D. Gershon, E. V. Jones, and B. Moss. 1990. Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor. Mol. Cell. Biol. 10:5433–5441.
  • Alberts, B., D. Bray, J. Lewis, M. Raff, K. Roberts, and J. D. Watson. 1994. Molecular biology of the cell, 3rd ed. Garland Publishing Co., New York.
  • Arnason, B. G. W., and A. T. Reder. 1994. Interferons and multiple sclerosis. Clin. Neuropharmacol. 17:495–547.
  • Atwater, J. A., S. M. Munemitsu, and C. E. Samuel. 1987. Efficiency of expression of cDNAs of the reovirus S1 and S4 genes in transfected animal cells differs at the level of translation. Virology 159:350–357.
  • Baczko, K., J. Lampe, U. G. Liebert, U. Brinckmann, V. ter Meulen, I. Pardowitz, H. Budka, S. L. Cosby, S. Isserte, and B. K. Rima. 1993. Clonal expansion of hypermutated measles virus in SSPE brain. Virology 197:188–195.
  • Bass, B. L. 1991. The dsRNA unwinding/modifying activity: fact and fiction. Semin. Dev. Biol. 3:425–432.
  • Bass, B. L., and H. Weintraub. 1987. A developmentally regulated activity that unwinds RNA duplexes. Cell 48:607–613.
  • Bass, B. L., and H. Weintraub. 1988. An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell 55:1089–1098.
  • Bass, B. L., H. Weintraub, R. Cattaneo, and M. A. Billeter. 1989. Biased hypermutation of viral RNA genomes could be due to unwinding/modification of double-stranded RNA. Cell 56:331.
  • Belli, B. A., and C. E. Samuel. 1991. Expression of reovirus S1-encoded σ1NS protein in transfected and infected cells as measured with serotype specific polyclonal antibody. Virology 185:698–709.
  • Biedler, J. L., S. Roffler-Tarlov, M. Schachner, and L. S. Freedman. 1978. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38:3751–3757.
  • Billeter, M. A., R. Cattaneo, P. Spielhofer, K. Kaelin, M. Huber, and A. Schmid. 1994. Generation and properties of measles virus mutations typically associated with subacute sclerosing panencephalitis. Ann. N. Y. Acad. Sci. 724:367–377.
  • Brawerman, G. 1989. mRNA decay: finding right targets. Cell 57:9–10.
  • Cattaneo, R., and M. A. Billeter. 1992. Mutations and A/I hypermutations in measles virus persistent infections. Curr. Top. Microbiol. Immunol. 176:63–74.
  • Cattaneo, R., A. Schmid, D. Eschle, K. Baczko, V. ter Meulen, and M. A. Billeter. 1988. Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell 55:255–265.
  • Cattaneo, R., A. Schmid, P. Spielhofer, K. Kaelin, K. Baczko, V. ter Meulen, J. Pardowitz, S. Flanagan, B. K. Rima, S. A. Udem, and M. A. Billeter. 1989. Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Virology 173:415–425.
  • Chang, H.-W., and B. L. Jacobs. 1993. Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA. Virology 194:537–547.
  • Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299.
  • Fields, B. N., and D. M. Knipe. 1990. Virology, 2nd ed. Raven Press, New York.
  • Gluzman, Y. 1981. SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23:175–182.
  • Green, S. R., and M. B. Mathews. 1992. Two RNA binding motifs in the double-stranded RNA activated protein kinase, DAI. Genes Dev. 6:2478–2490.
  • Green, S. R., L. Manche, and M. B. Mathews. 1995. Two functionally distinct RNA-binding motifs in the regulatory domain of the protein kinase DAI. Mol. Cell. Biol. 15:358–364.
  • Guan, K. L., and J. E. Dixon. 1991. Eukaryotic proteins expressed in Esch-erichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192:262–267.
  • Hanks, S. K., A. M. Quinn, and T. Hunter. 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42–52.
  • Higuchi, M., F. N. Single, M. Kohler, B. Sommer, R. Sprengel, and P. H. Seeburg. 1993. RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell 75: 1361–1370.
  • Hough, R. F., and B. L. Bass. 1994. Purification of the Xenopus laevis double-stranded RNA adenosine deaminase. J. Biol. Chem. 269:9933–9939.
  • Jacobs, L., A. M. Salazar, and J. A. O'Malley. 1987. The use of interferon in the treatment of certain diseases of the central nervous system, p. 527–535. In S. Baron et al. (ed.), The interferon system. University of Texas Press, Austin.
  • Jimenez-Garcia, L. F., S. R. Green, M. B. Mathews, and D. L. Spector. 1993. Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNA in adenovirus-2-infected HeLa cells. J. Cell Sci. 106:11–22.
  • Jordan, M. A., D. Thrower, and L. Wilson. 1991. Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res. 51:2212–2222.
  • Kim, U., and K. Nishikura. 1993. Double-stranded RNA adenosine deami-nase as a potential mammalian RNA editing factor. Semin. Cell Biol. 4:285–293.
  • Kim, U., T. L. Garner, T. Sanford, D. Speicher, J. M. Murray, and K. Nishikura. 1994. Purification and characterization of double-stranded RNA adenosine deaminase from bovine nuclear extracts. J. Biol. Chem. 269: 13480–13489.
  • Kim, U., Y. Wang, T. Sanford, Y. Zeng, and K. Nishikura. 1994. Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. Proc. Natl. Acad. Sci. USA 91:11457–11461.
  • Kohler, M., N. Burnashev, B. Sakmann, and P. H. Seeburg. 1993. Determination of Ca12 permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron 10:491–500.
  • Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229–241.
  • Lasky, S. R., B. L. Jacobs, and C. E. Samuel. 1982. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1. J. Biol. Chem. 257:11087–11093.
  • Lengyel, P. 1993. Tumor suppressor genes: news about the interferon connection. Proc. Natl. Acad. Sci. USA 90:5893–5895.
  • Lomeli, H., J. Mosbacher, T. Melcher, T. Hoger, J. R. P. Geiger, T. Kuner, H. Monyer, M. Higuchi, A. Bach, and P. H. Seeburg. 1994. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science 266:1709–1712.
  • Luthman, H., and G. Magnusson. 1983. High efficiency polyoma DNA trans-fection of chloroquine-treated cells. Nucleic Acids Res. 11:1295–1308.
  • Mathews, M. B. 1993. Viral evasion of cellular defense mechanisms: regulation of the protein kinase DAI by RNA effectors. Semin. Virol. 4:247–257.
  • McCormack, S. J., D. C. Thomis, and C. E. Samuel. 1992. Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2α protein kinase. Virology 188:47–56.
  • McCormack, S. J., L. G. Ortega, J. P. Doohan, and C. E. Samuel. 1994. Mechanism of interferon action: motif I of the interferon-induced RNA-dependent protein kinase PKR is sufficient to mediate RNA-binding activity. Virology 198:92–99.
  • McMillan, N. A. J., B. W. Carpick, B. Hollis, W. M. Toone, M. Zamanian-Daryoush, and B. R. G. Williams. 1995. Mutational analysis of the double-stranded RNA binding domain of the dsRNA-activated protein kinase, PKR. J. Biol. Chem. 270:2601–2606.
  • Messing, J., and J. Vieira. 1992. A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. Gene 19:269–276.
  • Munemitsu, S. M., and C. E. Samuel. 1988. Biosynthesis of reovirus-specified polypeptides: effect of point mutation of the sequences flanking the 59-proximal AUG initiator codons of the reovirus s1 and s4 genes on the efficiency of mRNA translation. Virology 163:643–646.
  • Murphy, D. G., K. Dimock, and C. Y. Kang. 1991. Numerous transitions in human parainfluenza virus 3 RNA recovered from persistently infected cells. Virology 181:760–763.
  • O'Connell, M. A., and W. Keller. 1994. Purification and properties of double-stranded RNA-specific adenosine deaminase from calf thymus. Proc. Natl. Acad. Sci. USA 91:10596–10600.
  • O'Connell, M. A., S. Krause, M. Higuchi, J. J. Hsuan, N. F. Totty, A. Jenny, and W. Keller. 1995. Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase. Mol. Cell. Biol. 15:1389–1397.
  • O'Hara, P. J., S. T. Nichol, F. M. Horodyski, and J. J. Holland. 1984. Vesicular stomatitis virus defective interfering particles can contain excessive genomic sequence rearrangements and base substitutions. Cell 36:915–924.
  • Pestka, S., J. A. Langer, K. C. Zoon, and C. E. Samuel. 1987. Interferons and their actions. Annu. Rev. Biochem. 56:727–777.
  • Rebagliati, M. R., and D. A. Melton. 1987. Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity. Cell 48:599–605.
  • Saiki, R. K., S. Scharf, F. Faloona, K. B. Mullis, G. T. Horn, H. A. Erlich, and N. Arnheim. 1985. Enzymatic amplification of b-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350–1354.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Samuel, C. E. 1979. Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated protein kinase possessing site-specificity similar to hemin-regulated rabbit reticulocyte kinase. Proc. Natl. Acad. Sci. USA 76: 600–604.
  • Samuel, C. E. 1991. Antiviral actions of interferon: interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1–11.
  • Samuel, C. E. 1993. The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268:7603–7606.
  • Samuel, C. E., and D. A. Farris. 1977. Species specificity of interferon and of the interferon-mediated inhibitor of translation from mouse, monkey and human cells. Virology 77:556–565.
  • Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
  • Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res. 17:6419.
  • Schumacher, J. M., K. Lee, S. Edelhoff, and R. E. Braun. 1995. Tenr, an RNA-binding protein that is distributed in a lattice-like network within the spermatid nucleus. Biol. Reprod. 52:1274–1283.
  • Sekellick, M. J., and P. I. Marcus. 1980. The interferon system as a regulator of persistent infection. Ann. N. Y. Acad. Sci. 350:545–557.
  • Sen, G. C., and P. Lengyel. 1992. The interferon system: a bird's eye view of its biochemistry. J. Biol. Chem. 267:5017–5020.
  • Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–517.
  • St. Johnston, D., N. H. Brown, J. G. Gall, and M. Jantsch. 1992. A conserved double-stranded RNA-binding domain. Proc. Natl. Acad. Sci. USA 89:10979–10983.
  • Thomis, D. C., G. Floyd-Smith, and C. E. Samuel. 1992. Mechanism of interferon action: cDNA structure and regulation of a novel splice-site variant of the catalytic subunit of human protein kinase A from interferon treated human cells. J. Biol. Chem. 267:10723–10728.
  • Thomis, D. C., J. P. Doohan, and C. E. Samuel. 1992. Mechanism of interferon action: cDNA structure, expression and regulation of the interferon-induced, RNA-dependent P1/eIF-2α protein kinase from human cells. Virology 188:33–46.
  • Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350–4354.
  • Ulker, N., X. Zhang, and C. E. Samuel. 1987. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskel-etal component. J. Biol. Chem. 262:16798–16803.
  • Wagner, R. W., J. E. Smith, B. S. Cooperman, and K. Nishikura. 1989. A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs. Proc. Natl. Acad. Sci. USA 86:2647–2651.
  • Wagner, R. W., C. Yoo, L. Wrabetz, J. Kamholz, J. Buchhalter, N. F. Hassan, K. Khalili, S. U. Kim, B. Perussia, F. A. McMorris, and K. Nishikura. 1990. Double-stranded RNA unwinding and modifying activity is detected ubiquitously in primary tissues and cell lines. Mol. Cell. Biol. 10:5586–5590.
  • Wickens, M. 1990. How the messenger got its tail: addition of poly(A) in the nucleus. Trends Biochem. Sci. 15:277–281.
  • Wilson, R., R. Alnscough, K. Anderson, C. Baynes, M. Berks, J. Bonfield, J. Burton, M. Connell, T. Copsey, J. Cooper, A. Coulson, M. Craxton, S. Dear, Z. Du, R. Durbin, A. Favello, A. Fraser, L. Fulton, A. Gardner, P. Green, T. Hawkins, L. Hillier, M. Jier, L. Johnston, M. Jones, J. Kershaw, J. Kirsten, N. Laisster, P. Latrelille, J. Lightning, C. Lloyds, B. Mortimore, M. O'Callaghan, J. Parson, C. Percy, L. Rifken, A. Roopra, D. Saunders, R. Shownkeen, M. Sims, N. Smaldron, A. Smith, M. Smith, E. Sonnhammer, R. Staden, J. Suston, J. Thierry-Mieg, K. Thomas, M. Vaudin, K. Vaughan, R. Waterston, A. Watson, L. Weinstock, J. Wilkinson-Sproat, and P. Wohldman. 1994. 2.2Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature (London) 368:32–38.
  • Yang, J.-H., P. Sklar, R. Axel, and T. Maniatis. 1995. Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of aden-osine. Nature (London) 374:77–81.
  • Yuwen, H., J. H. Cox, J. W. Yewdell, J. R. Bennink, and B. Moss. 1993. Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene. Virology 195:732–744.
  • Zhang, X. T., D. C. Thomis, and C. E. Samuel. 1989. Isolation and charac-terization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin. Biochem. Biophys. Res. Commun. 164:176–184.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.