2
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Adenovirus Type 12-Induced Fragility of the Human RNU2 Locus Requires U2 Small Nuclear RNA Transcriptional Regulatory Elements

, , &
Pages 6246-6255 | Received 03 May 1995, Accepted 26 Jul 1995, Published online: 30 Mar 2023

REFERENCES

  • Ach, R. A., and A. M. Weiner. 1987. The highly conserved U small nuclear RNA 39-end formation signal is quite tolerant to mutation. Mol. Cell. Biol. 7:2070–2079.
  • Ares, M. Jr., J.-S. Chung, L. Giglio, and A. M. Weiner. 1987. Distinct factors with Sp1 and NF-A specificities bind to adjacent functional elements of the human U2 snRNA gene enhancer. Genes Dev. 1:808–817.
  • Ares, M. Jr., M. Mangin, and A. M. Weiner. 1985. Orientation-dependent transcriptional activator upstream of a human U2 snRNA gene. Mol. Cell. Biol. 5:1560–1570.
  • Bailey, A. D. Unpublished data.
  • Ballard, S. G., and D. C. Ward. 1993. Fluorescence in situ hybridization using digital imaging microscopy. J. Histochem. Cytochem. 41:1755–1759.
  • Bloomfield, V. A. 1991. Condensation of DNA by multivalent cations: considerations on mechanism. Biopolymers 31:1471–1481.
  • Caporossi, D., S. Bacchetti, and B. Nicoletti. 1991. Synergism between aphidicolin and adenoviruses in the induction of breaks at fragile sites on human chromosomes. Cancer Genet. Cytogenet. 54:39–53.
  • Card, C. O., G. G. Morris, D. T. Brown, and W. F. Marzluff. 1982. Sea urchin small nuclear RNA genes are organized in distinct tandemly repeated units. Nucleic Acids Res. 10:7677–7688.
  • Chung, J. H., M. Whiteley, and G. Felsenfeld. 1993. A 59 element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74:505–514.
  • Dahlberg, J. E., and E. Lund. 1988. The genes and transcription of the major small nuclear RNAs, p. 38–70. In M. Birnstiel (ed.), Structure and function of major and minor small nuclear ribonucleoprotein particles. Springer-Verlag, Heidelberg, Germany.
  • Drapkin, R., J. T. Reardon, A. Ansari, J. C. Huang, L. Zawel, K. Ahn, A. Sancar, and D. Reinberg. 1994. Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Nature (London) 368:769–772.
  • Durnam, D. M., J. C. Menninger, S. H. Chandler, P. P. Smith, and J. K. McDougall. 1988. A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection. Mol. Cell. Biol. 8:1863–1867.
  • Durnam, D. M., P. P. Smith, J. C. Menninger, and J. K. McDougall. 1986. The E1 region of human adenovirus type 12 determines the sites of virally induced chromosomal damage. Cancer cells 4:349–354.
  • Favre, D. 1992. Improved phenol-based method for the isolation of DNA fragments from low melting temperature agarose gels. BioTechniques 13: 24–26.
  • Gargano, S., P. Wang, E. Rusanganwa, and S. Bacchetti. 1995. The tran-scriptionally competent U2 gene is necessary and sufficient for adenovirus type 12 induction of the fragile site at 17q21-22. Mol. Cell. Biol. 15:6256–6261.
  • Hammarstrom, K., B. Santesson, G. Westin, and U. Pettersson. 1985. The gene cluster for human U2 RNA is located on chromosome 17q21. Exp. Cell Res. 159:473–478.
  • Hanawalt, P. C. 1994. Transcription-coupled repair and human disease. Science 266:1957–1958.
  • Hansen, R. S., T. K. Canfield, M. M. Lamb, S. M. Gartler, and C. D. Laird. 1993. Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell 73:1403–1409.
  • Harnden, D. G., and H. P. Klinger (ed.). 1985. An international system for human cytogenetic nomenclature. S. Karger, Basel.
  • Knight, S. J. L., et al. 1993. Trinucleotide repeat amplification and hyper-methylation of a CpG island in FRAXE mental retardation. Cell 74:127–134.
  • Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488–492.
  • Leung, H., and N. Maizels. 1994. Regulation and targeting of recombination in extrachromosomal substrates carrying immunoglobulin switch region sequences. Mol. Cell. Biol. 14:1450–1458.
  • Li, Y.-P., R. Tomanin, J. R. Smiley, and S. Bacchetti. 1993. Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome. Mol. Cell. Biol. 13:6064–6070.
  • Li, Z. Unpublished results.
  • Lindgren, V., M. Ares, Jr., A. M. Weiner, and U. Francke. 1985. Human genes for U2 small nuclear RNA map to a major adenovirus 12 modification site on chromosome 17. Nature (London) 314:115–116.
  • Lindgren, V., L. B. Bernstein, A. M. Weiner, and U. Francke. 1985. Human U1 small nuclear RNA pseudogenes do not map to the site of the U1 genes in 1p36 but are clustered in 1q12-22. Mol. Cell. Biol. 5:2172–2180.
  • Lund, E. 1988. Heterogeneity of human U1 snRNAs. Nucleic Acids Res. 16:5813–5826.
  • Lund, E., and J. E. Dahlberg. 1992. Control of 4-8S RNA transcription at the midblastula transition in Xenopus laevis embryos. Genes Dev. 6:1097–1106.
  • Mangin, M., M. Ares, Jr., and A. M. Weiner. 1985. U1 small nuclear RNA genes are subject to dosage compensation in mouse cells. Science 229:272–275.
  • Mangin, M., M. Ares, Jr., and A. M. Weiner. 1986. Human U2 small nuclear RNA genes contain an upstream enhancer. EMBO J. 5:987–995.
  • Mather, M. W. 1988. Base composition-independent hybridization in dried agarose gels: screening and recovery for cloning of genomic DNA fragments. BioTechniques 6:444–447.
  • Mattaj, I. W., and R. Zeller. 1983. Xenopus laevis snRNA genes: tandemly repeated transcription units showing 59 and 39 flanking homology with other RNA polymerase II transcribed genes. EMBO J. 2:1883–1891.
  • McDougall, J. K. 1970. Effects of adenoviruses on the chromosomes of normal human cells and cells trisomic for an E group chromosome. Nature (London) 225:456–458.
  • McDougall, J. K. 1971. Spontaneous and adenovirus type 12 induced chromosome aberrations in Fanconi's anemia fibroblasts. Int. J. Cancer 7:526–534.
  • McDougall, J. K., A. R. Dunn, and K. W. Jones. 1972. In situ hybridization of adenovirus RNA and DNA. Nature (London) 236:346–348.
  • Miro, R., I. C. Clemente, C. Fuster, and J. Egozcue. 1987. Fragile sites, chromosome evolution and human neoplasia. Hum. Genet. 75:345–349.
  • Nancarrow, J. K., E. Kremer, K. Holman, H. Eyre, N. A. Doggett, D. Le Paslier, D. F. Callen, G. R. Sutherland, and R. I. Richards. 1994. Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis. Science 264:1938–1941.
  • Naylor, S. L., B. U. Zabel, T. Manser, R. Gesteland, and A. Y. Sakaguchi. 1984. Localization of human U1 small nuclear RNA genes to band p36.3 of chromosome 1 by in situ hybridization. Somatic Cell Mol. Genet. 10:307–313.
  • Paranjape, S. M., R. T. Kamakaka, and J. T. Kadonaga. 1994. Role of chromatin structure in the regulation of transcription by RNA polymerase II. Annu. Rev. Biochem. 63:265–297.
  • Pavelitz, T., L. Rusché, A. G. Matera, J. M. Scharf, and A. M. Weiner. 1995. Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus. EMBO J. 14:169–177.
  • Pirrotta, V., and L. Rastelli. 1994. White gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila. Bioessays 16: 549–556.
  • Romani, M., A. Baldini, E. V. Volpi, I. Casciano, C. Nobile, R. Muresu, and M. Siniscalco. 1994. Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRNA cluster (RNU1) within 400 kb of the chromosome region 1p36.1. Cytogenet. Cell Genet. 67:37–40.
  • Sadowski, C. L., R. W. Henry, S. M. Lobo, and N. Hernandez. 1993. Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE. Genes Dev. 7:1535–1548.
  • Schramayr, S., D. Caporossi, I. Mak, T. Jelinek, and S. Bacchetti. 1990. Chromosomal damage induced by human adenovirus type 12 requires expression of the E1B 55-kilodalton viral protein. J. Virol. 64:2090–2095.
  • Segil, N., S. B. Roberts, and N. Heintz. 1991. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science 254:1814–1816.
  • Simonsen, C. C., and A. D. Levinson. 1983. Isolation and expression of an altered mouse dihydrofolate reductase cDNA. Proc. Natl. Acad. Sci. USA 80:2495–2499.
  • Skuzeski, J. M., E. Lund, J. T. Murphy, T. H. Steinberg, R. R. Burgess, and J. E. Dahlberg. 1984. Synthesis of human U1 RNA. II. Identification of two regions of the promoter essential for transcription initiation at position 11. J. Biol. Chem. 259:8345–8352.
  • Smeets, D. F. C. M., and F. A. J. M. van de Klundert. 1990. Common fragile sites in man and three closely related primate species. Cytogenet. Cell Genet. 53:8–14.
  • Smith, P. P., C. L. Friedman, E. M. Bryant, and J. K. McDougall. 1992. Viral integration and fragile sites in human papillomavirus-immortalized human keratinocyte cell lines. Genes Chromosomes Cancer 5:150–157.
  • Sorensen, P. D., B. Lomholt, S. Frederiksen, and N. Tommerup. 1991. Fine mapping of human 5S rRNA genes to chromosome 1q42.11-q42.13. Cyto-genet. Cell Genet. 57:26–29.
  • Steffensen, D. M., P. Szabo, and J. K. McDougall. 1976. Adenovirus 12 uncoiler regions of human chromosome 1 in relation to 5S rRNA genes. Exp. Cell Res. 100:436–439.
  • Sutherland, G., and F. Hecht. 1985. Oxford monographs on medical genetics, vol. 13. Fragile sites on human chromosomes. Oxford University Press, Oxford.
  • van Arsdell, S. W., and A. M. Weiner. 1984. Human genes for U2 small nuclear RNA are tandemly repeated. Mol. Cell. Biol. 4:492–499.
  • Van Arsdell, S. W., and A. M. Weiner. 1984. Pseudogenes for human U2 do not have a fixed site of 39 truncation. Nucleic Acids Res. 12:1463–1471.
  • van der Drift, P., A. Chan, N. van Roy, G. Laureys, A. Westerveld, F. Speleman, and R. Versteeg. 1994. A multimegabase cluster of snRNA and tRNA genes on chromosome 1p36 harbours an adenovirus/SV40 hybrid virus integration site. Hum. Mol. Genet. 3:2131–2136.
  • Vazquez, J., and P. Schedl. 1994. Sequences required for enhancer blocking activity of scs are located within two nuclease-hypersensitive regions. EMBO J. 13:5984–5993.
  • von Knebel Doeberitz, M., T. Bauknecht, D. Bartsch, and H. zur Hausen. 1991. Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells. Proc. Natl. Acad. Sci. USA 88:1411–1415.
  • Westin, G., J. Zabielski, J. Hammarstrøm, H.-J. Monstein, C. Bark, and U. Pettersson. 1984. Clustered genes for human U2 RNA. Proc. Natl. Acad. Sci. USA 81:3811–3815.
  • White, R. J., T. M. Gottlieb, C. S. Downes, and S. P. Jackson. 1995. Mitotic regulation of a TATA-binding-protein-containing complex. Mol. Cell. Biol. 15:1983–1992.
  • Withers-Ward, E. S., Y. Kitamura, J. P. Barnes, and J. M. Coffin. 1994. Distribution of targets for avian retrovirus DNA integration in vivo. Genes Dev. 8:1473–1487.
  • Wu, T.-C., and M. Lichten. 1993. Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science 263:515–518.
  • Yunis, J. J., and W. R. Hoffman. 1990. Nuclear enzymes, fragile sites, and cancer. J. Gerontol. 44:37–44.
  • Yunis, J. J., and A. L. Soreng. 1984. Constitutive fragile sites and cancer. Science 226:1199–1204.
  • Zavanelli, M. I., J. S. Britton, A. H. Igel, and M. Ares, Jr. 1994. Mutations in an essential U2 small nuclear RNA structure cause cold-sensitive U2 small nuclear ribonucleoprotein function by favoring competing alternative U2 RNA structures. Mol. Cell. Biol. 14:1689–1697.
  • Zhuang, Y., and A. M. Weiner. 1989. A compensatory base change in human U2 snRNA can suppress a branch site mutation. Genes Dev. 3:1545–1552.
  • zur Hausen, H. 1967. Induction of specific chromosomal aberrations by adenovirus type 12 in human embryonic kidney cells. J. Virol. 1:1174–1185.
  • Zwerschke, W., H. W. Rottjakob, and H. Kuntzel. 1994. The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes an ATP/ GTPase controlling S phase initiation. J. Biol. Chem. 269:23351–23356.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.