Ubiquitous and Neuronal DNA-Binding Proteins Interact with a Negative Regulatory Element of the Human Hypoxanthine Phosphoribosyltransferase Gene

REFERENCES

• Adams, A. D., D. M. Choate, and M. A. Thompson. 1995. NF1-L is the DNA-binding component of the protein complex at the peripherin negative regulatory element. J. Biol. Chem. 270:6975–6983.
   PubMedGoogle Scholar
• Akerblom, I. E., E. P. Slater, M. Beato, J. D. Baxter, and P. L. Mellon. 1988. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science 241:350–353.
   PubMedGoogle Scholar
• Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
   PubMed Web of Science ®Google Scholar
• Andrews, P. W. 1984. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 103:285–293.
   PubMed Web of Science ®Google Scholar
• Baumhueter, S., G. Courtois, and G. R. Crabtree. 1988. A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the β-fibrinogen gene promoter as HNF-1. EMBO J. 7:2485–2493.
   PubMedGoogle Scholar
• Boulikas, T. 1994. A compilation and classification of DNA binding sites for protein transcription factors from vertebrates. Crit. Rev. Eukaryot. Gene Express. 4:117–321.
   PubMedGoogle Scholar
• Chinault, A. C., and C. T. Caskey. 1984. The hypoxanthine phosphoribosyl-transferase gene: a model for the study of mutation in mammalian cells. Prog. Nucleic Acid Res. Mol. Biol. 31:295–313.
   PubMedGoogle Scholar
• Chodosh, L. A. 1990. Methylation interference assay for analysis of DNA-protein interactions, p. 12.3.1. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. Wiley Interscience, New York.
   Google Scholar
• Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156–159.
   PubMed Web of Science ®Google Scholar
• Edwards, A., H. Voss, P. Rice, A. Civitello, J. Stegemann, C. Schwager, J. Zimmermann, H. Erfle, C. T. Caskey, and W. Ansorge. 1990. Automated DNA sequencing of the human HPRT locus. Genomics 6:593–608.
   PubMed Web of Science ®Google Scholar
• Faisst, S., and S. Meyer. 1992. Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res. 20:3–26.
   PubMed Web of Science ®Google Scholar
• Fuscoe, J. C., R. G. Fenwick, Jr., D. H. Ledbetter, and C. T. Caskey. 1983. Deletion and amplification of the HGPRT locus in Chinese hamster cells. Mol. Cell. Biol. 3:1086–1096.
   PubMed Web of Science ®Google Scholar
• Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
   PubMed Web of Science ®Google Scholar
• Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467.
   PubMed Web of Science ®Google Scholar
• Gray, T. A., D. L. Gumucio, and F. S. Collins. 1990. A two-dimensional electrophoresis system for DNA-binding proteins. Technique J. Methods Cell Mol. Biol. 2:147–154.
   Google Scholar
• Herschbach, B. M., and A. D. Johnson. 1993. Transcriptional repression in eukaryotes. Annu. Rev. Cell Biol. 9:479–509.
   PubMedGoogle Scholar
• Hornstra, I. K., and T. P. Yang. 1992. Multiple in vivo footprints are specific to the active allele of the X-linked human hypoxanthine phosphoribosyl-transferase gene 59 region: Implications for X chromosome inactivation. Mol. Cell. Biol. 12:5345–5354.
   PubMedGoogle Scholar
• Hornstra, I. K., and T. P. Yang. 1993. In vivo footprinting and genomic sequencing by ligation-mediated PCR. Anal. Biochem. 213:179–193.
   PubMedGoogle Scholar
• Hornstra, I. K., and T. P. Yang. 1994. High-resolution methylation analysis of the human hypoxanthine phosphoribosyltransferase gene 59 region on the active and inactive X chromosomes: correlation with binding sites for transcription factors. Mol. Cell. Biol. 14:1419–1430.
   PubMedGoogle Scholar
• Ingolia, D. E., M. R. Al-Ubaidi, C. Y. Yeung, H. A. Bigo, D. A. Wright, and R. E. Kellems. 1986. Molecular cloning of the murine adenosine deaminase gene from a genetically enriched source: identification and characterization of the promoter region. Mol. Cell. Biol. 6:4458–4466.
   PubMedGoogle Scholar
• Johnson, P., and T. Friedmann. 1990. Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene 88:207–213.
   PubMedGoogle Scholar
• Kadonaga, J. T., K. A. Jones, and R. Tjian. 1986. Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends Biochem. Sci. 11:20–23.
   Web of Science ®Google Scholar
• Kamachi, Y., and H. Kondoh. 1993. Overlapping positive and negative regulatory elements determine lens-specific activity of the d-1 crystallin enhancer. Mol. Cell. Biol. 13:5206–5215.
   PubMedGoogle Scholar
• Kato, H., M. Horikoshi, and R. Roeder. 1991. Repression of HIV-1 transcription by a cellular protein. Science 251:1476–1479.
   PubMed Web of Science ®Google Scholar
• Kelley, W. N., F. M. Rosenbloom, J. F. Henderson, and J. E. Seegmiller. 1967. A specific enzyme defect in gout associated with overproduction of uric acid. Proc. Natl. Acad. Sci. USA 57:1735–1739.
   PubMed Web of Science ®Google Scholar
• Kim, S. H., J. C. Moores, D. David, J. G. Respess, D. J. Jolly, and T. Friedmann. 1986. The organization of the human HPRT gene. Nucleic Acids Res. 14:3103–3118.
   PubMedGoogle Scholar
• Kraner, S. D., J. A. Chong, H.-J. Tsay, and G. Mandel. 1992. Silencing the type II sodium channel gene: a model for neural-specific gene regulation. Neuron 9:37–44.
   PubMed Web of Science ®Google Scholar
• Krenitsky, T. A. 1969. Tissue distribution of purine ribosyl- and phosphori-bosyl-transferases in the Rhesus monkey. Biochim. Biophys. Acta 179:506–509.
   PubMedGoogle Scholar
• Lesch, M., and W. L. Nyhan. 1964. A familial disorder of uric acid metabolism and central nervous system function. Am. J. Med. 36:561–570.
   PubMed Web of Science ®Google Scholar
• Levine, M., and J. L. Manley. 1989. Transcriptional repression of eukaryotic promoters. Cell 59:405–408.
   PubMedGoogle Scholar
• Li, L., T. Suzuki, N. Mori, and P. Greengard. 1993. Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proc. Natl. Acad. Sci. USA 90:1460–1464.
   PubMedGoogle Scholar
• Linton, J. P., J. J. Yen, E. Selby, Z. Chen, J. M. Chinsky, K. Liu, R. E. Kellems, and G. F. Crouse. 1989. Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the diver-gently transcribed Rep-1 gene. Mol. Cell. Biol. 9:3058–3072.
   PubMedGoogle Scholar
• Lo, Y. F. V., and R. M. Palmour. 1979. Developmental expression of murine HPRT. I. Activities, heat stabilities and electrophoretic mobilities in adult tissues. Biochem. Genet. 17:737–746.
   PubMedGoogle Scholar
• Mandel, G., and D. McKinnon. 1993. Molecular basis of neural-specific gene expression. Annu. Rev. Neurosci. 16:323–345.
   PubMedGoogle Scholar
• Melton, D. W., D. S. Konecki, J. Brennand, and C. T. Caskey. 1984. Structure, expression, and mutation of the hypoxanthine phosphoribosyltrans-ferase gene. Proc. Natl. Acad. Sci. USA 81:2147–2151.
   PubMed Web of Science ®Google Scholar
• Melton, D. W., D. S. Konecki, D. H. Ledbetter, J. F. Hejtmancik, and C. T. Caskey. 1981. In vitro translation of hypoxanthine/guanine phosphoribosyl-transferase mRNA: characterization of a mouse neuroblastoma cell line that has elevated levels of hypoxanthine/guanine phosphoribosyltransferase protein. Proc. Natl. Acad. Sci. USA 78:6977–6980.
   PubMed Web of Science ®Google Scholar
• Melton, D. W., C. McEwan, A. B. McKie, and A. M. Reid. 1986. Expression of the mouse HPRT gene: deletional analysis of the promoter region of an X-chromosome linked housekeeping gene. Cell 44:319–328.
   PubMedGoogle Scholar
• Mori, N., C. Schoenherr, D. J. Vanderbergh, and D. J. Anderson. 1992. A common silencer element in the SCG10 and type II Na1 channel genes binds a factor present in nonneuronal cells but not in neuronal cells. Neuron 9:45–54.
   PubMedGoogle Scholar
• Ohkuma, Y., M. Horikoshi, R. G. Roeder, and C. Desplan. 1990. Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding protein transcription factor IID. Proc. Natl. Acad. Sci. USA 87:2289–2293.
   PubMedGoogle Scholar
• Parker, B. A., and G. R. Stark. 1979. Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA. J. Virol. 31:360–369.
   PubMed Web of Science ®Google Scholar
• Patel, P. I., P. E. Framson, C. T. Caskey, and A. C. Chinault. 1986. Fine structure of the human hypoxanthine phosphoribosyltransferase gene. Mol. Cell. Biol. 6:393–403.
   PubMed Web of Science ®Google Scholar
• Pathak, B. G., J. C. Neumann, M. L. Croyle, and J. B. Lingrel. 1994. The presence of both negative and positive elements in the 59-flanking sequence of the rat Na,K-ATPase α3 subunit gene are required for brain expression in transgenic mice. Nucleic Acids Res. 22:4748–4755.
   PubMedGoogle Scholar
• Pleasure, S. J., and V. M.-Y. Lee. 1993. NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. J. Neurosci. Res. 35:585–602.
   PubMed Web of Science ®Google Scholar
• Pleasure, S. J., C. Page, and V. M.-Y. Lee. 1992. Pure, postmitotic, polarized human neurons derived from NTera2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J. Neurosci. 12: 1802–1815.
   PubMed Web of Science ®Google Scholar
• Rahuel, C., M. A. Vinit, V. Lemarchandel, J. P. Cartron, and P. H. Romeo. 1992. Erythroid-specific activity of the glycophorin B promoter requires GATA-1 mediated displacement of a repressor. EMBO J. 11:4095–4102.
   PubMedGoogle Scholar
• Renkawitz, R. 1990. Transcriptional repression in eukaryotes. Trends Genet. 6:192–197.
   PubMedGoogle Scholar
• Rincón-Limas, D. E., R. S. Geske, J.-J. Xue, C. Y. Hsu, P. A. Overbeek, and P. I. Patel. 1994. 59-flanking sequences of the human HPRT gene direct neuronal expression in the brain of transgenic mice. J. Neurosci. Res. 38: 259–267.
   PubMedGoogle Scholar
• Rincón-Limas, D. E., D. A. Krueger, and P. I. Patel. 1991. Functional char-acterization of the human hypoxanthine phosphoribosyltransferase gene promoter: evidence for a negative regulatory element. Mol. Cell. Biol. 11: 4157–4164.
   PubMed Web of Science ®Google Scholar
• Rosenbloom, F. M., W. N. Kelley, J. Miller, J. F. Henderson, and J. E. Seegmiller. 1967. Inherited disorder of purine metabolism: correlation between central nervous system dysfunction and biochemical defects. JAMA 202:103–105.
   Google Scholar
• Rossiter, B. J. F., J. C. Fuscoe, D. M. Muzny, M. Fox, and C. T. Caskey. 1991. The chinese hamster HPRT gene: restriction map, sequence analysis, and multiplex PCR deletion screen. Genomics 9:247–256.
   PubMedGoogle Scholar
• Ruezinsky, D., H. Beckmann, and T. Kadesch. 1991. Modulation of the IgH enhancer's cell type specificity through a genetic switch. Genes Dev. 5:29–37.
   PubMedGoogle Scholar
• Saiki, R. K., D. H. Gelfand, S. Stoffel, S. J. Scharf, R. Higuchi, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
   PubMed Web of Science ®Google Scholar
• Schoenherr, C. J., and D. J. Anderson. 1995. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267:1360–1363.
   PubMed Web of Science ®Google Scholar
• Seegmiller, J. E., F. M. Rosenbloom, and W. N. Kelley. 1967. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science 155:1682–1684.
   PubMed Web of Science ®Google Scholar
• Shrivastava, A., and K. Calame. 1994. An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1. Nucleic Acids Res. 22:5151–5155.
   PubMed Web of Science ®Google Scholar
• Stout, J. T., and C. T. Caskey. 1989. Hypoxanthine phosphoribosyltrans-ferase deficiency: the Lesch-Nyhan syndrome and gouty arthritis, p. 1007–1028. In C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle (ed.), The metabolic basis of inherited disease, 6th ed. McGraw-Hill Book Co., New York.
   Google Scholar
• Strömstedt, P.-E., L. Poellinger, J.-Å. Gustafsson, and J. Carlstedt-Duke. 1991. The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation. Mol. Cell. Biol. 11:3379–3383.
   PubMed Web of Science ®Google Scholar
• Takimoto, M., J. P. Quinn, A. R. Farina, L. M. Staudt, and D. Levens. 1989. Fos/jun and octamer-binding protein interact with a common site in a negative element of the human c-myc gene. J. Biol. Chem. 264:8992–8999.
   PubMedGoogle Scholar
• Tamura, T.-A., Y. Ohya, M. Miura, A. Aoyama, T. Inoue, and K. Mikoshiba. 1989. Preparation of large amounts of transcription-competent nuclear extracts from mouse brain. Technique 1:33–36.
   Google Scholar
• Thompson, M. A., E. Lee, D. Lawe, E. Gizang-Ginsberg, and E. B. Ziff. 1992. Nerve growth factor-induced derepression of peripherin gene expression is associated with alteration in proteins binding to a negative regulatory element. Mol. Cell. Biol. 12:2501–2513.
   PubMedGoogle Scholar
• Watts, R. W. E., E. Spellacy, D. A. Gibbs, J. Allsop, R. O. McKeran, and G. E. Slavin. 1982. Clinical, post-mortem, biochemical and therapeutic observations on the Lesch-Nyhan syndrome with particular reference to the neurological manifestations. Q. J. Med. 201:43–78.
   Google Scholar