11
Views
149
CrossRef citations to date
0
Altmetric
Research Article

Characterization of a Mammalian Homolog of the Escherichia coli MutY Mismatch Repair Protein

, , , &
Pages 989-996 | Received 04 May 1994, Accepted 10 Nov 1994, Published online: 30 Mar 2023

REFERENCES

  • Aaltonen, L. A., P. Peltomäki, F. S. Leach, P. Sistonen, L. Rylkkänen, J. P. Mecklin, H. Järvinen, S. M. Powell, J. Jen, S. R. Hamilton, G. M. Petersen, K. W. Kinzler, B. Vogelstein, and A. de la Chapelle. 1993. Clues to the pathogenesis of familial colorectal cancer. Science 260:812–816.
  • Ames, B. N., and L. S. Gold. 1991. Endogenous mutagens and the causes of aging and cancer. Mutat. Res. 250:3–16.
  • Au, K. G., M. Cabrera, J. H. Miller, and P. Modrich. 1988. Escherichia coli mutY gene product is required for specific A-G to C z G mismatch correction. Proc. Natl. Acad. Sci. USA 85:9163–9166.
  • Au, K. G., S. Clark, J. H. Miller, and P. Modrich. 1989. Escherichia coli mutY gene encodes an adenine glycosylase active on G/A mispairs. Proc. Natl. Acad. Sci. USA 86:8877–8881.
  • Beinert, H., and A. J. Thomson. 1983. Three iron clusters in iron-sulfur proteins. Arch. Biochem. Biophys. 222:333–361.
  • Bessho, T., K. Tano, H. Kasai, E. Ohtsuka, and S. Nishimura. 1993. Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells. J. Biol. Chem. 268:19416–19421.
  • Bishop, D. K., M. S. Williamson, S. Fogel, and R. D. Kolodner. 1987. The role of heteroduplex correction in gene conversion in Saccharomyces cerevi-siae. Nature (London) 238:362–364.
  • Bodepudi, V., S. Shibutani, and F. Johnson. 1992. Synthesis of 29-deoxy-7,8-dihydro-8-oxoguanosine and their incorporation into oligomeric DNA. Chem. Res. Toxicol. 5:608–617.
  • Bradford, M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
  • Bronner, C. E., S. M. Baker, P. T. Morrison, G. Warren, L. G. Smith, M. K. Lescoe, M. Kane, C. Earabino, J. Lipford, A. Lindblom, P. Tannergard, R. J. Bollag, A. R. Godwin, D. C. Ward, M. Nordenskjøld, R. Fishel, R. Kolodner, and R. M. Liskay. 1994. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (London) 368:258–261.
  • Brown, T. C., and J. Jiricny. 1987. A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine. Cell 50:945–950.
  • Cheng, K. C., D. S. Cahill, H. Kasai, S. Nishimura, and L. A. Loeb. 1991. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem. 267:166–172.
  • Chetsanga, C. J., and T. Lindahl. 1979. Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichia coli. Nucleic Acids Res. 6:3673–3683.
  • Claverys, J.-P., and S. A. Lacks. 1986. Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria. Microbiol. Rev. 50:133–165.
  • Cunningham, R. P., H. Asahara, J. F. Bank, C. P. Scholes, H. C. Salerno, K. Surerus, E. Münck, J. McCracken, J. Peisach, and M. H. Emptage. 1989. Endonuclease III is an iron-sulfur protein. Biochemistry 28:4450–4455.
  • Desiraju, V., W. G. Shanabruch, and A.-L. Lu. 1993. Nucleotide sequence of the Salmonella typhimurium mutB gene, the homolog of Escherichia coli mutY. J. Bacteriol. 175:541–543.
  • Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription inhibition by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
  • Fishel, R., M. K. Lescoe, M. R. S. Rao, N. G. Copeland, N. A. Jenkins, J. Garber, M. Kane, and R. Kolodner. 1993. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75:1027–1038.
  • Friedberg, E. C. 1985. DNA repair. W. H. Freeman, New York.
  • Fujii, H., and T. Shimada. 1989. Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene. J. Biol. Chem. 264:10057–10064.
  • Hollstein, M., D. Sidransky, B. Vogelstein, and C. C. Harris. 1991. p53 mutations in human cancers. Science 253:49–53.
  • Holmes, J., Jr., S. Clark, and P. Modrich. 1990. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc. Natl. Acad. Sci. USA 87:5837–5841.
  • Jiricny, J., M. Hughes, N. Corman, and B. B. Rudkin. 1988. A human 200-kDa protein binds selectively to DNA fragments containing G/T mismatches. Proc. Natl. Acad. Sci. USA 85:8860–8864.
  • Jones, M., R. Wagner, and M. Radman. 1987. Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence. Genetics 115:605–610.
  • Kasai, H., and S. Nishimura. 1991. Formation of 8-hydroxydeoxyguanosine in DNA by oxygen radicals and its biological significance, p. 99–116. In H. Sies (ed.), Oxidative stress: oxidants and antioxidants. Academic Press, London.
  • Kramer, W., B. Kramer, M. S. Williamson, and S. Fogel. 1989. Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB. J. Bacteriol. 171:5339–5346.
  • Laemmli, U. K. 1970. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
  • Leach, F. S., N. C. Nicolaides, N. Papadopoulos, B. Liu, H. Hen, R. Parsons, P. Peltomaki, P. Sistonen, L. A. Aaltonen, M. Nystrom-Lahti, X.-Y. Guan, J. Zhang, P. S. Meltzer, J.-W. Yu, F.-T. Kao, D. J. Chen, K. M. Cerosaletti, R. E. K. Fournier, S. Todd, T. Lewis, R. J. Leach, S. L. Naylor, J. Weisen-bach, J.-P. Mecklin, H. Jarvinen, G. M. Petersen, S. R. Hamilton, J. Green, J. Jas, P. Watson, H. T. Lynch, J. M. Trent, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein. 1993. Mutations of a mutS homolog in hereditary non-polyposis colorectal cancer. Cell 75:1215–1225.
  • Lerner, R. A., N. Green, H. Alexander, F. T. Liu, J. G. Sutcliffe, and T. M. Shinnick. 1981. Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc. Natl. Acad. Sci. USA 78:3403–3407.
  • Lieb, M. 1983. Specific mismatch correction in bacteriophage lambda crosses by very short patch repair. Mol. Gen. Genet. 181:118–125.
  • Lieb, M., E. Allen, and D. Read. 1986. Very short patch mismatch repair in phage lambda: repair sites and length of repair tracts. Genetics 114:1041–1060.
  • Linton, J. P., J.-Y. J. Yen, E. Selby, Z. Chen, J. M. Chinsky, K. Liu, R. E. Kellems, and G. F. Crouse. 1989. Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene. Mol. Cell. Biol. 9:3058–3072.
  • Lu, A.-L., and D.-Y. Chang. 1988. Repair of single base-pair transversion mismatches of Escherichia coli in vitro: correction of certain A/G mismatches is independent of dam methylation and host mutHLS gene functions. Genetics 118:593–600.
  • Lu, A.-L., and D.-Y. Chang. 1988. A novel nucleotide excision repair for the conversion of an A/G mismatch to C/G base pair in E. coli. Cell 54:805–812.
  • Lu, A.-L., H.-F. Liu, C. P. Scholes, K. K. Surerus, and E. Münck. 1994. Unpublished data.
  • Maki, H., and M. Sekiguchi. 1992. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature (London) 355:273–275.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Marginson, G. P., and A. E. Pegg. 1981. Enzymatic release of 7-methylgua-nine from methylated DNA by rodent liver extracts. Proc. Natl. Acad. Sci. USA 78:861–865.
  • Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labelled DNA with base-specific chemical cleavage. Methods Enzymol. 65:499–560.
  • Michaels, M. L., C. Cruz, A. P. Grollman, and J. H. Miller. 1992. Evidence that MutM and MutY combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc. Natl. Acad. Sci. USA 89:7022–7025.
  • Michaels, M. L., and J. H. Miller. 1992. The GO repair system protects organisms from the mutagenesis effect of 8-hydroxyguanine (7,8-dihydro-8-oxo-guanine). J. Bacteriol. 174:6321–6325.
  • Michaels, M. L., L. Pham, Y. Ngheim, C. Cruz, and J. H. Miller. 1990. MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III. Nucleic Acids Res. 18:3841–3845.
  • Michaels, M. L., J. Tchou, A. P. Grollman, and J. H. Miller. 1992. A repair system for 8-oxo-7,8-dihydrodeoxyguanine (8-hydroxyguanine). Biochemistry 31:10964–10968.
  • Mo, J.-Y., H. Maki, and M. Sekiguchi. 1992. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. Proc. Natl. Acad. Sci. USA 89:11021–11025.
  • Modrich, P. 1991. Mechanisms and biological effects of mismatch repair. Annu. Rev. Genet. 25:229–253.
  • Moriya, M. 1993. Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G z C 3 T z A transversions in simian kidney cells. Proc. Natl. Acad. Sci. USA 90:1122–1126.
  • Moriya, M., C. Ou, V. Bodepudi, F. Johnson, M. Takeshita, and A. P. Grollman. 1991. Site-specific mutagenesis using a gapped duplex vector: a study of translesion synthesis past 8-oxodeoxyguanosine in Escherichia coli. Mutat. Res. 254:281–288.
  • New, L., K. Liu, and G. F. Crouse. 1993. The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. Mol. Gen. Genet. 239:97–108.
  • Papadopoulos, N., N. C. Nicolaides, Y.-F. Wei, S. M. Ruben, K. C. Carter, C. A. Rosen, W. A. Haseltine, R. K. Fleischmann, C. M. Graser, M. D. Adams, J. C. Venter, S. R. Hamilton, G. M. Petersen, P. Watson, H. T. Lynch, P. Peltomaki, J.-P. Mecklin, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein. 1994. Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625–1629.
  • Parsons, R., G.-M. Li, M. J. Longley, W. Fang, N. Papadopoulos, J. Jen, A. de la Chapelle, K. W. Kinzler, B. Vogelstein, and P. Modrich. 1993. Hypermutability and mismatch repair deficiency in RER1 tumor cells. Cell 75: 1227–1236.
  • Prolla, T. A., D.-M. Christie, and R. M. Liskay. 1994. Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. Mol. Cell. Biol. 14:407–415.
  • Radicella, J. P., E. A. Clark, S. Chen, and M. S. Fox. 1993. Patch length of localized repair event: role of DNA polymerase I in mutY-dependent mismatch repair. J. Bacteriol. 175:7732–7736.
  • Radicella, J. P., E. A. Clark, and M. S. Fox. 1988. Some mismatch repair activities in Escherichia coli. Proc. Natl. Acad. Sci. USA 85:9674–9678.
  • Radman, M., and R. Wagner. 1986. Mismatch repair in Escherichia coli. Annu. Rev. Genet. 20:523–528.
  • Raposa, S., and M. S. Fox. 1987. Some features of base pair mismatch and heterology repair in Escherichia coli. Genetics 117:381–390.
  • Reenan, R. A., and R. D. Kolodner. 1992. Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics 132:963–973.
  • Reenan, R. A., and R. D. Kolodner. 1992. Characterization of insertion mutations in Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics 132:975–985.
  • Roelen, H. C. P. F., C. P. Saris, H. F. Brugghe, H. van den Elst, J. G. Westra, G. A. van der Marel, and J. H. van Boom. 1991. Solid-phase synthesis of DNA fragments containing the modified base 7-hydro-8-oxo-29-deoxy-guanosine. Nucleic Acids Res. 19:4361–4369.
  • Sakumi, K., M. Furuichi, T. Tsuzuki, T. Kakuma, S.-I. Kawabata, H. Maki, and M. Sekiguchi. 1993. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 268:23524–23530.
  • Shibutani, S., M. Takeshita, and A. P. Grollman. 1991. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature (London) 349:431–434.
  • Strand, M., T. A. Prolla, R. M. Liskay, and T. Petes. 1993. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature (London) 365:274–276.
  • Su, S.-S., R. S. Lahue, K. G. Au, and P. Modrich. 1988. Mispair specificity of methyl-directed DNA mismatch correction in vitro. J. Biol. Chem. 263:6829–6835.
  • Tchou, J., and A. P. Grollman. 1993. Repair of DNA containing the oxidatively-damaged base 8-hydroxyguanine. Mutat. Res. 299:277–287.
  • Tchou, J., H. Kasai, S. Shibutani, M.-H. Chung, A. P. Grollman, and S. Nishimura. 1991. 8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc. Natl. Acad. Sci. USA 88:4690–4694.
  • Thomas, D. C., J. D. Roberts, and T. A. Kunkel. 1991. Heteroduplex repair in extracts of human HeLa cells. J. Biol. Chem. 266:3744–3751.
  • Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350–4354.
  • Tsai-Wu, J.-J., H.-F. Liu, and A.-L. Lu. 1992. Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A z C and A z G mispairs. Proc. Natl. Acad. Sci. USA 89:8779–8783.
  • Tsai-Wu, J.-J., and A.-L. Lu. 1994. Escherichia coli mutY-dependent mismatch repair involves DNA polymerase I and a short repair tract. Mol. Gen. Genet. 244:444–450.
  • Tsai-Wu, J.-J., J. P. Radicella, and A.-L. Lu. 1991. Nucleotide sequence of the Escherichia coli micA gene required for A/G-specific mismatch repair: identity of MicA and MutY. J. Bacteriol. 173:1902–1910.
  • Varlet, I., M. Radman, and B. Brooks. 1990. DNA mismatch repair in Xenopus egg extracts: repair efficiency and DNA repair synthesis for all single base-pair mismatches. Proc. Natl. Acad. Sci. USA 87:7883–7887.
  • Wiebauer, K., and J. Jiricny. 1989. In vitro correction of G z T mispairs to G z C pairs in nuclear extracts from human cells. Nature (London) 339:234–236.
  • Wiebauer, K., and J. Jiricny. 1990. Mismatch-specific thymine DNA glyco-sylase and DNA polymerase β mediate the correction of G z T mispairs in nuclear extracts from human cells. Proc. Natl. Acad. Sci. USA 87:5842–5845.
  • Williamson, M., J. Game, and S. Fogel. 1985. Meiotic gene conversion mutants in Saccharomyces cerevisiae. I. Isolation and characterization of pms1-1 and pms1-2. Genetics 110:609–646.
  • Wood, M. L., M. Dizdaroglu, E. Gajewski, and J. M. Essigmann. 1990. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of single 8-hydroxylguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 29:7024–7032.
  • Yeh, Y.-C., D.-Y. Chang, J. Masin, and A.-L. Lu. 1991. Two nicking enzyme systems specific for mismatch-containing DNA in nuclear extracts from human cells. J. Biol. Chem. 266:6480–6484.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.