Multiple Changes in E2F Function and Regulation Occur upon Muscle Differentiation

REFERENCES

• Bagchi, S., R. Weinmann, and P. Raychaudhuri. 1991. The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F. Cell 65:1063–1072.
   PubMed Web of Science ®Google Scholar
• Bandara, L., V. Buck, M. Zamanian, L. Johnston, and N. LaThangue. 1993. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J. 12:4314–4324.
   Google Scholar
• Bandara, L. R., J. P. Adamczewski, T. Hunt, and N. LaThangue. 1991. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature (London) 352:249–251.
   PubMed Web of Science ®Google Scholar
• Beijersbergen, R. L., R. M. Kerkhoven, L. Zhu, L. Carlee, P. M. Voorhoeve, and R. Bernards. 1994. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 8:2680–2690.
   PubMed Web of Science ®Google Scholar
• Blau, H. 1992. Differentiation requires continuous active control. Annu. Rev. Biochem. 61:1213–1230.
   PubMedGoogle Scholar
• Cao, L., B. Faha, M. Dembski, L. H. Tsai, and E. Harlow. 1992. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature (London) 355:176–179.
   PubMedGoogle Scholar
• Caruso, M., F. Martelli, A. Giordano, and A. Felsani. 1993. Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein. Oncogene 8:267–278.
   PubMedGoogle Scholar
• Chellapan, S., S. Hiebert, M. Mudryj, J. Horowitz, and J. R. Nevins. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053–1061.
   PubMedGoogle Scholar
• Chittenden, T., D. Livingston, and W. G. Kaelin. 1991. The T/E1A binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA binding protein. Cell 65:1073–1082.
   PubMed Web of Science ®Google Scholar
• Chittenden, T., D. M. Livingston, and J. A. DeCaprio. 1993. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol. Cell. Biol. 13:3975–3983.
   PubMedGoogle Scholar
• Cobrinik, D., P. Whyte, D. Peeper, T. Jacks, and R. Weinberg. 1993. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 7:2392–2404.
   PubMed Web of Science ®Google Scholar
• Cohen, B., Y. Liu, B. Druker, T. M. Roberts, and B. S. Schaffhausen. 1990. Characterization of pp85, a target of oncogenes and growth factor receptors. Mol. Cell. Biol. 10:2909–2915.
   PubMedGoogle Scholar
• Cress, W. D., D. G. Johnson, and J. R. Nevins. 1993. A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol. Cell. Biol. 13:6314–6325.
   PubMedGoogle Scholar
• Dalton, S. 1992. Cell cycle regulation of the human cdc2 gene. EMBO J. 11:1797–1804.
   PubMed Web of Science ®Google Scholar
• Davis, R. L., H. Weintraub, and A. Lassar. 1987. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51:987–1000.
   PubMed Web of Science ®Google Scholar
• Devoto, S. H., M. Mudryj, J. Pines, T. Hunter, and J. R. Nevins. 1992. A cyclin A-specific protein kinase complex possesses sequence-specific DNA binding activity: p33 cdk2 is a component of the E2F-cyclin A complex. Cell 68:167–176.
   PubMed Web of Science ®Google Scholar
• Dynlacht, B., O. Flores, J. A. Lees, and E. Harlow. 1994. Differential regulation of E2F trans-activation by cyclin/cdk2 complexes. Genes Dev. 8:1772–1786.
   PubMed Web of Science ®Google Scholar
• Dyson, N., M. Dembski, A. Fattaey, C. Nguw, M. Ewen, and K. Helin. 1993. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol. 67:7641–7647.
   PubMedGoogle Scholar
• Ewen, M. E., Y. Xing, J. Lawrence, and D. M. Livingston. 1991. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66:1155–1164.
   PubMed Web of Science ®Google Scholar
• Fagan, R., K. Flint, and N. Jones. 1994. Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19kDa protein. Cell 78:799–811.
   PubMedGoogle Scholar
• Flemington, E. K., S. H. Speck, and W. G. Kaelin. 1993. E2F-1 mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc. Natl. Acad. Sci. USA 90:6914–6918.
   PubMed Web of Science ®Google Scholar
• Ginsberg, D., G. Vairo, T. Chittenden, Z. H. Xiao, G. Xu, K. L. Wydner, J. DeCaprio, J. Lawrence, and D. M. Livingston. 1994. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 8:2665–2679.
   PubMed Web of Science ®Google Scholar
• Girling, R., J. Partridge, L. R. Bandara, N. Burden, N. F. Totty, J. J. Hsuan, and N. B. LaThangue. 1993. A new component of the transcription factor DRTF1/E2F. Nature (London) 362:83–87.
   PubMed Web of Science ®Google Scholar
• Gu, W., J. W. Schneider, G. Condorelli, S. Kaushal, V. Mahdavi, and B. Nadal-Ginard. 1993. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72:309–324.
   PubMed Web of Science ®Google Scholar
• Hamel, P. A., R. M. Gill, R. A. Phillips, and B. L. Gallie. 1992. Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol. Cell. Biol. 12:3431–3438.
   PubMed Web of Science ®Google Scholar
• Hannon, G. J., D. Demetrick, and D. Beach. 1993. Isolation of the Rb-related p130 through its interaction with cdk2 and cyclins. Genes Dev. 7:2378–2391.
   PubMed Web of Science ®Google Scholar
• Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Helin, K., and E. Harlow. 1993. The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol. 3:43–46.
   PubMedGoogle Scholar
• Helin, K., E. Harlow, and A. Fattaey. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13: 6501–6508.
   PubMed Web of Science ®Google Scholar
• Helin, K., J. A. Lees, M. Vidal, N. Dyson, E. Harlow, and A. Fattaey. 1992. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70:337–350.
   PubMed Web of Science ®Google Scholar
• Helin, K., C. L. Wu, A. Fattaey, J. Lees, B. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7:1850–1861.
   PubMed Web of Science ®Google Scholar
• Hiebert, S., S. P. Chellapan, J. Horowitz, and J. R. Nevins. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6:177–185.
   PubMed Web of Science ®Google Scholar
• Hiebert, S., M. Lipp, and J. R. Nevins. 1989. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA 86:3594–3598.
   PubMed Web of Science ®Google Scholar
• Hsiao, K. M., S. McMahon, and P. J. Farnham. 1994. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev. 8:1526–1537.
   PubMed Web of Science ®Google Scholar
• Huang, S., E. Shin, K. A. Sheppard, L. Chokoroverty, B. Shan, Y. W. Qian, E. Y. H. P. Lee, and A. S. Yee. 1992. The retinoblastoma protein region required for interaction with the E2F transcription factor includes the T/E1A binding and carboxy-terminal sequences. DNA Cell Biol. 11:539–548.
   PubMedGoogle Scholar
• Huang, S., N. P. Wang, B. Tseng, W. H. Lee, and E. Y. H.-P. Lee. 1990. Two distinct and frequently mutated regions of the retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9:1815–1822.
   PubMed Web of Science ®Google Scholar
• Ivey-Hoyle, M., R. Conroy, H. E. Huber, P. J. Goodhart, A. Oliff, and D. C. Heimbrook. 1993. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol. 13:7802–7812.
   PubMed Web of Science ®Google Scholar
• Johnson, D., K. Ohtani, and J. R. Nevins. 1994. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8:1514–1525.
   PubMed Web of Science ®Google Scholar
• Kaelin, W. G., Jr., M. E. Ewen, and D. M. Livingston. 1990. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol. Cell. Biol. 10:3761–3769.
   PubMed Web of Science ®Google Scholar
• Kaelin, W. G., W. Krek, W. R. Sellers, J. A. DeCaprio, F. Ajchanbaum, C. S. Fuchs, T. Chittenden, Y. Li, P. J. Farnham, M. A. Blanar, D. M. Livingston, and E. K. Flemington. 1992. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:351–364.
   PubMed Web of Science ®Google Scholar
• Krek, W., M. Ewen, S. Shirodkar, Z. Arany, W. Kaelin, and D. Livingston. 1994. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78:161–172.
   PubMed Web of Science ®Google Scholar
• Krek, W., D. M. Livingston, and S. Shirodkar. 1993. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science 262:1557–1560.
   PubMed Web of Science ®Google Scholar
• Lam, E. W.-F., and R. J. Watson. 1993. An E2F binding site mediates cell-cycle repression of mouse B-myb transcription. EMBO J. 12:2705–2713.
   PubMed Web of Science ®Google Scholar
• LaThangue, N. 1994. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108–114.
   PubMed Web of Science ®Google Scholar
• Lees, E., B. Faha, V. Dulic, S. Reed, and E. Harlow. 1992. Cyclin E/cdk2 and cyclin A/cdk-2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 6:1874–1885.
   PubMed Web of Science ®Google Scholar
• Lees, J. A., M. Saito, M. Vidal, M. Valentine, T. Look, E. Harlow, N. Dyson, and K. Helin. 1993. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 13:7813–7825.
   PubMed Web of Science ®Google Scholar
• Li, Y., C. Graham, S. Lacy, A. Duncan, and P. Whyte. 1993. The adenovirus E1A-associated 130kD protein is encoded by a member of the retinoblas-toma gene family and physically interacts with cyclins A and E. Genes Dev. 7:2366–2377.
   PubMed Web of Science ®Google Scholar
• Li, Y., J. E. Slansky, D. J. Myers, N. R. Drinkwater, W. G. Kaelin, and P. J. Farnham. 1994. Cloning, chromosomal location, and characterization of mouse E2F1. Mol. Cell. Biol. 14:1861–1869.
   PubMedGoogle Scholar
• Maione, R., G. Fimia, P. Holman, B. Schaffhausen, and P. Amati. 1994. Retinoblastoma antioncogene is involved in the inhibition of myogenesis by polyomavirus large T antigen. Cell Growth Differ. 5:231–237.
   PubMedGoogle Scholar
• Maione, R., G. M. Firmia, and P. Amati. 1992. Inhibition of in vitro myogenic differentiation by a polyomavirus early function. Oncogene 7:85–93.
   PubMedGoogle Scholar
• Mudryj, M., S. H. Devoto, S. Hiebert, T. Hunter, J. Pines, and J. R. Nevins. 1991. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65:1243–1253.
   PubMed Web of Science ®Google Scholar
• Mudryj, M., S. Hiebert, and J. R. Nevins. 1990. A role for the adenovirus-inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 9:2179–2184.
   PubMedGoogle Scholar
• Nevins, J. R. 1992. A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424–429.
   PubMed Web of Science ®Google Scholar
• Olson, E. N., and W. H. Klein. 1994. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev. 8:1–8.
   PubMed Web of Science ®Google Scholar
• Peterson, C., H. Gordon, Z. Hall, B. Paterson, and H. Blau. 1990. Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant. Cell 62:493–502.
   PubMedGoogle Scholar
• Qian, Y., C. Luckey, L. Horton, M. Esser, and D. J. Templeton. 1992. Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding. Mol. Cell. Biol. 12:5363–5372.
   PubMed Web of Science ®Google Scholar
• Qin, X.-Q., T. Chittenden, D. Livingston, and W. G. Kaelin. 1992. Identifi-cation of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 6:953–964.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Schneider, J. W., W. Gu, L. Zhu, V. Mahdavi, and B. Nadal-Ginard. 1994. Reversal of terminal differentiation mediated by p107 in Rb 2/2 muscle cells. Science 264:1467–1470.
   PubMed Web of Science ®Google Scholar
• Schwarz, J. K., S. H. Devoto, E. J. Smith, S. P. Chellapan, L. Jakoi, and J. R. Nevins. 1993. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J. 12:1013–1020.
   PubMed Web of Science ®Google Scholar
• Shan, B., C.-Y. Chang, D. Jones, and W.-H. Lee. 1994. The transcription factor E2F-1 mediates the autoregulation of RB gene expression. Mol. Cell. Biol. 14:299–309.
   PubMedGoogle Scholar
• Shan, B., X. Zhu, P.-L. Chen, T. Durfee, Y. Yang, D. Sharp, and W.-H. Lee. 1992. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12:5620–5631.
   PubMed Web of Science ®Google Scholar
• Shirodkar, S., M. Ewen, J. DeCaprio, D. Morgan, D. M. Livingston, and T. Chittenden. 1992. The transcription factor E2F interacts with the retinoblas-toma product and a p107-cyclin A complex in a cell-cycle regulated manner. Cell 68:157–166.
   PubMed Web of Science ®Google Scholar
• Sternberg, E. A., G. Spizz, W. M. Perry, D. Vizard, T. Weil, and E. N. Olson. 1988. Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene. Mol. Cell. Biol. 8:2896–2909.
   PubMedGoogle Scholar
• Thalmeier, K., R. Synovzik, R. Mertz, E. Winnacker, and M. Lipp. 1989. Nuclear factor E2F mediates basic transcription and trans-activation by E1A of the human MYC promoter. Genes Dev. 3:527–536.
   PubMedGoogle Scholar
• Webster, K. A., G. Muscat, and L. Kedes. 1988. Adenovirus E1a products suppress myogenic differentiation and inhibit transcription from muscle-specifc promoters. Nature (London) 332:553–557.
   PubMedGoogle Scholar
• Weintraub, H. 1993. The MyoD family and myogenesis: redundancy, networks and thresholds. Cell 75:1241–1244.
   PubMed Web of Science ®Google Scholar
• Weintraub, S., C. A. Prater, and D. C. Dean. 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature (London) 358:259–261.
   PubMed Web of Science ®Google Scholar
• Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67–75.
   PubMed Web of Science ®Google Scholar
• Xu, M., K.-A. Sheppard, C.-Y. Peng, A. S. Yee, and H. Piwnica-Worms. 1994. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. 14:8420–8431.
   PubMed Web of Science ®Google Scholar
• Yaffe, D., and O. Saxel. 1977. Serial passaging and differentiation of myo-genic cells isolated from dystrophic mouse muscle. Nature (London) 270: 725–727.
   PubMed Web of Science ®Google Scholar
• Yee, A. S., P. Raychaudhuri, L. Jakoi, and J. R. Nevins. 1989. The adeno-virus-inducible factor E2F stimulates transcription after specific DNA binding. Mol. Cell. Biol. 9:578–585.
   PubMedGoogle Scholar
• Yee, A. S., R. Reichel, I. Kovesdi, and J. R. Nevins. 1987. Promoter interaction of the E1A-inducible E2F and its potential role in the formation of a multi-component complex. EMBO J. 6:2061–2068.
   PubMed Web of Science ®Google Scholar
• Zamanian, M., and N. LaThangue. 1993. Transcriptional repression by the Rb-related protein p107. Mol. Biol. Cell 4:389–396.
   PubMed Web of Science ®Google Scholar
• Zhu, L., K. van den Heuvel, A. Fattaey, M. Ewen, D. M. Livingston, N. Dyson, and E. Harlow. 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7:1111–1125.
   PubMed Web of Science ®Google Scholar