2
Views
59
CrossRef citations to date
0
Altmetric
Research Article

A Myc-Associated Zinc Finger Protein Binding Site Is One of Four Important Functional Regions in the CD4 Promoter

, , , &
Pages 3179-3186 | Received 10 Jun 1994, Accepted 24 Mar 1995, Published online: 30 Mar 2023

REFERENCES

  • Ashfield, R., A. J. Stupakoff, S. A. Bossone, H. Brown, R. D. Campbell, K. B. Marcu, and N. J. Proudfoot. 1994. MAZ-dependent termination between closely spaced human complement genes. EMBO J. 13:5656–5667.
  • Asselin, C., A. Nepveu, and K. B. Marcu. 1989. Molecular requirements for transcriptional initiation of the murine c-myc gene. Oncogene 4:549–558.
  • Badiani, P., P. Corbella, D. Kioussis, J. Marvel, and K. Weston. 1994. Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev. 8:770–782.
  • Blum, M. D., G. T. Wong, K. M. Higgins, M. J. Sunshine, and E. Lacy. 1993. Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. J. Exp. Med. 177:1343–1358.
  • Bossone, S. A., C. Asselin, A. J. Patel, and K. B. Marcu. 1992. MAZ, a zinc finger, binds to a c-myc and C2 gene sequences regulating transcriptional initiation and termination. Proc. Natl. Acad. Sci. USA 89:7452–7456.
  • Chan, S. H., D. Cosgrove, C. Waltzinger, C. Benoist, and D. Mathis. 1993. Another view of the selective model of thymocyte selection. Cell 73:225–236.
  • Davis, C. B., N. Killeen, M. E. C. Crooks, D. Raulet, and D. R. Littman. 1993. Evidence for a stochastic mechanism of the differentiation of mature subsets of T lymphocytes. Cell 73:237–247.
  • De Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725–737.
  • Dufort, D., and A. Nepveu. 1994. The human Cut homeodomain protein represses transcription from the c-myc promoter. Mol. Cell. Biol. 14:4251–4257.
  • Fowlkes, B. J., and D. Pardoll. 1989. Molecular and cellular events of T cell development. Adv. Immunol. 44:207–264.
  • Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287–299.
  • Ghosh, D. 1992. TFD: the transcription factors database. Nucleic Acids Res. 20:2091–2093.
  • Gillespie, F. P., L. Doros, J. Vitale, C. Blackwell, J. Gosselin, B. W. Snyder, and S. C. Wadsworth. 1993. Tissue-specific expression of human CD4 in transgenic mice. Mol. Cell. Biol. 13:2952–2958.
  • Hanna, Z., C. Simard, A. LaPerriere, and P. Jolicoeur. 1994. Specific expression of the human CD4 gene in mature CD4+ CD8− and immature CD4+ CD8+ T cells and in macrophages of transgenic mice. Mol. Cell. Biol. 14:1084–1094.
  • Javahery, R., A. Khachi, K. Lo, B. Zenzie-Gregory, and S. T. Smale. 1994. DNA sequence requirements for transcriptional initiator activity in mammalian cells. Mol. Cell. Biol. 14:116–127.
  • Jones, N. C., P. W. Rigby, and E. B. Ziff. 1988. Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses. Genes Dev. 2:267–281.
  • Kadonaga, J. T., K. A. Jones, and R. Tjian. 1986. Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends Biol. Sci. 11:20–23.
  • Kennedy, G. C., and W. J. Rutter. 1992. Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heter-ologous cells. Proc. Natl. Acad. Sci. USA 89:11498–11502.
  • Killeen, N., S. Sawada, and D. R. Littman. 1993. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 12:1547–1553.
  • Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367–382.
  • Littman, D. R. 1987. The structure of the CD4 and CD8 genes. Annu. Rev. Immunol. 5:561–584.
  • Miller, H., C. Asselin, D. Dufort, J. Yang, K. Gupta, K. B. Marcu, and A. Nepveu. 1989. A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional block. Mol. Cell. Biol. 9:5340–5349.
  • Natesan, S., and M. Z. Gilman. 1993. DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes Dev. 7:2497–2509.
  • Nossal, G. J. V. 1994. Negative selection of lymphocytes. Cell 76:229–239.
  • Paillard, F., G. Sterkers, and C. Vaquero. 1990. Transcriptional and post-transcriptional regulation of TcR, CD4, and CD8 gene expression during activation of normal human T lymphocytes. EMBO J. 9:1867–1872.
  • Parnes, J. R. 1989. Molecular biology and function of CD4 and CD8. Adv. Immunol 44:265–311.
  • Patel, A., and K. B. Marcu. Unpublished data.
  • Pugh, B. F., and R. Tjian. 1991. Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev. 5:1935–1945.
  • Pyrc, J. J., K. H. Moberg, and D. J. Hall. 1992. Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter. Biochemistry 31:4102–4110.
  • Robey, E. A., B. J. Fowlkes, J. W. Gordon, D. Kioussis, H. von Boehmer, F. Ramsdell, and R. Axel. 1991. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64:99–107.
  • Salmon, P., A. Giovane, B. Wasylyk, and D. Klatzmann. 1993. Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins. Proc. Natl. Acad. Sci. USA 90:7739–7743.
  • Sawada, S., and D. R. Littman. 1991. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol. Cell. Biol. 11:5506–5515.
  • Sawada, S., and D. R. Littman. 1993. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13:5620–5628.
  • Sawada, S., J. D. Scarborough, N. Killeen, and D. R. Littman. 1994. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77:917–929.
  • Siu, G., S. M. Hedrick, M. L. Waterman, and K. A. Jones. Unpublished data.
  • Siu, G., A. L. Wurster, D. D. Duncan, T. M. Soliman, and S. M. Hedrick. 1994. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13:3570–3579.
  • Siu, G., A. L. Wurster, J. S. Lipsick, and S. M. Hedrick. 1992. Expression of the CD4 gene requires a Myb transcription factor. Mol. Cell. Biol. 12:1592–1604.
  • Stupakoff, A., S. Bossone, and K. B. Marcu. Unpublished data.
  • Swain, S. 1983. T cell subsets and the recognition of MHC class. Immunol. Rev. 74:129–142.
  • Takahama, Y., and A. Singer. 1992. Post-transcriptional regulation of early T cell development by T cell receptor signals. Science 258:1456–1462.
  • Thanos, D., and T. Maniatis. 1992. The high mobility group protein HMG I(Y) is required for NF-κB dependent virus induction of the human IFN-β gene. Cell 71:777–789.
  • Travis, A., A. Amsterdam, C. Belanger, and R. Grosschedl. 1991. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function. Genes Dev. 5:880–894.
  • von Boehmer, H. 1988. The developmental biology of T lymphocytes. Annu. Rev. Immunol. 6:309–326.
  • von Boehmer, H. 1994. Positive selection of lymphocytes. Cell 76:219–228.
  • von Boehmer, H., and P. Kisielow. 1993. Lymphocyte lineage commitment: instruction versus selection. Cell 73:207–208.
  • Waterman, M. L., W. H. Fischer, and K. A. Jones. 1991. A thymus-specific member of the HMG protein family regulates the human T cell receptor Ca enhancer. Genes Dev. 5:656–669.
  • Waterman, M. L., and K. A. Jones. 1990. Purification of TCF-1α, a T-cell-specific transcription factor that activates the T-cell receptor Cα gene enhancer in a context-dependent manner. New Biol. 2:621–636.
  • Wright, S., and J. M. Bishop. 1989. DNA sequence that mediates attenuation of transcription from the mouse protooncogene myc. Proc. Natl. Acad. Sci. USA 86:505–509.
  • Wu, L., R. Scollay, M. Egerton, M. Pearse, G. J. Spangrude, and K. Shortman. 1991. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature (London) 349:71–74.
  • Wurster, A. L., G. Siu, J. Leiden, and S. M. Hedrick. 1994. Elf-1 binds to a critical element in a second CD4 enhancer. Mol. Cell. Biol. 14:6452–6463.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.