REFERENCES
- Bell, S. P., R. Kobayashi, and B. Stillman. 1993. Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262:1844–1870.
- Blanco, L., A. Bernad, M. A. Blasco, and M. Salas. 1991. A general structure for DNA-dependent DNA polymerases. Gene 100:27–38.
- Bunz, F., R. Kobayashi, and B. Stillman. 1993. cDNAs encoding the large subunit of human replication factor C. Proc. Natl. Acad. Sci. USA 90:11014–11018.
- Bunz, F., and B. Stillman. Unpublished results.
- Burbelo, P. D., A. Utani, Z.-Q. Pan, and Y. Yamada. 1993. Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases. Proc. Natl. Acad. Sci. USA 90:11543–11547.
- Burgers, P. M. J. 1991. Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases δ and ε. J. Biol. Chem. 266:22698–22706.
- Cafferkey, R., P. R. Young, M. McLaughlin, D. J. Bergsma, Y. Koltin, G. M. Sathe, L. Faucette, W.-K. Eng, R. K. Johnson, and G. P. Livi. 1993. Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol. Cell. Biol. 13:6012–6023.
- Chen, M., Z.-Q. Pan, and J. Hurwitz. 1992. Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. Proc. Natl. Acad. Sci. USA 89:2516–2520.
- Chen, M., Z.-Q. Pan, and J. Hurwitz. 1992. Studies of the cloned 37-kDa subunit of activator 1 (replication factor C) of HeLa cells. Proc. Natl. Acad. Sci. USA 89:5211–5215.
- de Murcia, G., and J. M. de Murcia. 1994. Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem. Sci. 19:172–176.
- Dong, Z., R. Onrust, M. Skangalis, and M. O'Donnell. 1993. DNA polymerase III accessory proteins. J. Biol. Chem. 268:11758–11765.
- Eki, T., T. Matsumoto, Y. Murakami, and J. Hurwitz. 1992. The replication of DNA containing the simian virus 40 origin by the monopolymerase and dipolymerase systems. J. Biol. Chem. 267:7284–7294.
- Fien, K., and B. Stillman. 1992. Identification of replication factor C from Saccharomyces cerevisiae: a component of the leading-strand DNA replication complex. Mol. Cell. Biol. 12:155–163.
- Flower, A. M., and C. S. McHenry. 1986. The adjacent dnaZ and dnaX genes of Escherichia coli are contained within one continuous open reading frame. Nucleic Acids Res. 14:8091–8101.
- Helliwell, S. B., P. Wagner, J. Kunz, M. Deuter-Reinhard, R. Henriquez, and M. N. Hall. 1994. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologs in yeast. Mol. Biol. Cell 5:105–118.
- Howell, E. A., M. A. McAlear, D. Rose, and C. Holm. 1994. CDC44: a putative nucleotide-binding protein required for cell cycle progression that has homology to subunits of replication factor C. Mol. Cell. Biol. 14:255–267.
- Hurwitz, J. Personal communication.
- Ittel, M.-E., J.-M. Garnier, J.-M. Jeltsch, and C. P. Niedergang. 1991. Chicken poly(ADP-ribose) synthetase: complete deduced amino acid sequence and comparison with mammalian enzyme sequences. Gene 102:157–164.
- Jones, W. E. 1991. Tackling the protease problem in Saccharomyces cerevi-siae. Methods Enzymol. 194:428–453.
- Kouprina, N., A. Tsouladze, M. Koryabin, P. Hieter, F. Spencer, and V. Larionov. 1993. Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Yeast 9:11–19.
- Kovalic, D., J.-H. Kwak, and B. Weisblum. 1991. General method for direct cloning of DNA fragments generated by the polymerase chain reaction. Nucleic Acids Res. 19:4560.
- Krishna, T. S. R., X.-P. Kong, S. Gary, P. M. Burgers, and J. Kuriyan. 1994. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell 79:1233–1243.
- Lauer, G., E. A. Rudd, D. L. McKay, A. Ally, D. Ally, and K. Backman. 1991. Cloning, nucleotide sequence, and engineered expression of Thermus ther-mophilus DNA ligase, a homolog of Escherichia coli DNA ligase. J. Bacteriol. 173:5047–5053.
- Lee, S.-H., and J. Hurwitz. 1990. Mechanism of elongation of primed DNA by DNA polymerase d, proliferating cell nuclear antigen, and activator I. Proc. Natl. Acad. Sci. USA 87:5672–5676.
- Lee, S.-H., A. D. Kwong, Z.-Q. Pan, and J. Hurwitz. 1991. Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase δ J. Biol. Chem. 266:594–602.
- Li, X., and P. M. J. Burgers. 1994. Cloning and characterization of the essential Saccharomyces cerevisiae RFC4 gene encoding the 37-kDa subunit of replication factor C. J. Biol. Chem. 269:21880–21884.
- Li, X., and P. M. J. Burgers. 1994. Molecular cloning and expression of the Saccharomyces cerevisiae RFC3 gene, an essential component of replication factor C. Proc. Natl. Acad. Sci. USA 91:868–872.
- Li, X., B. L. Yoder, and P. M. J. Burgers. 1992. A Saccharomyces cerevisiae DNA helicase associated with replication factor C. J. Biol. Chem. 267:25321–25327.
- Linder, P., P. F. Lasko, M. Ashburner, P. Leroy, P. J. Nielsen, K. Nishi, J. Schnier, and P. P. Slonimski. 1989. Birth of the D-E-A-D box. Nature (London) 337:121–122.
- Lu, Y., and A. T. Riegel. 1994. The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 39 processing of mRNA. Gene 145:261–265.
- Luckow, B., F. Bunz, B. Stillman, P. Lichter, and G. Schütz. 1994. Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans. Mol. Cell. Biol. 14:1626–1634.
- Matsumoto, Y., K. Kim, and D. F. Bogenhagen. 1994. Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair. Mol. Cell. Biol. 14:6187–6197.
- McAlear, M. A., E. A. Howell, K. K. Espenshade, and C. Holm. 1994. Proliferating cell nuclear antigen (pol30) mutations suppress cdc44 mutations and identify potential regions of interaction between the two encoded proteins. Mol. Cell. Biol. 14:4390–4397.
- Moir, D., S. E. Stewart, B. C. Osmond, and D. Botstein. 1982. Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics 100:547–563.
- Nichols, A. F., and A. Sancar. 1992. Purification of PCNA as a nucleotide excision repair protein. Nucleic Acids Res. 20:3559–3564.
- Noskov, V., S. Maki, Y. Kawasaki, S.-H. Leem, B.-I. Ono, H. Araki, Y. Pavlov, and A. Sugino. 1994. The RFC2 gene encoding a subunit of replication factor C of Saccharomyces cerevisiae. Nucleic Acids Res. 22:1527–1535.
- O'Donnell, M., R. Onrust, F. B. Dean, M. Chen, and J. Hurwitz. 1993. Homology in accessory proteins of replicative polymerase-E. coli to humans. Nucleic Acids Res. 21:1–3.
- Ogas, J., B. J. Andrews, and I. Herskowitz. 1991. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Cell 66:1015–1026.
- Ogasawara, N., S. Nakai, and H. Yoshikawa. 1994. Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin. DNA Res. 1:1–14.
- Onrust, R., P. T. Stuckenberg, and M. O'Donnell. 1991. Analysis of the ATPase subassembly which initiates processive DNA synthesis by DNA polymerase III. J. Biol. Chem. 266:21681–21686.
- Pai, E. F., W. Kabsch, U. Krengel, K. C. Holmes, J. John, and A. Wittighofer. 1989. Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature (London) 341:209–214.
- Pai, E. F., U. Krengel, G. A. Petsko, R. S. Goody, W. Kabsch, and A. Wittighofer. 1990. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution: implications for the mechanism of GTP hydrolysis. EMBO J. 9:2351–2359.
- Pause, A., and N. Sonenberg. 1992. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J. 11:2643–2654.
- Podust, V. N., A. Georgaki, B. Strack, and U. Hübscher. 1992. Calf thymus RF-C as an essential component for DNA polymerase δ and ε holoenzymes function. Nucleic Acids Res. 20:4159–4165.
- Prelich, G., M. Kostura, D. R. Marshak, M. B. Mathews, and B. Stillman. 1987. The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro. Nature (London) 326:471–475.
- Seufert, W., and B. Futcher. Unpublished results.
- Sherman, F., and J. Hicks. 1991. Micromanipulation and dissection of asci. Methods Enzymol. 194:21–37.
- Shivji, M. K. K., M. K. Kenny, and R. D. Wood. 1992. Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69:367–374.
- Spencer, F., S. L. Gerring, C. Connelly, and P. Hieter. 1990. Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124:237–249.
- Spicer, E. K., N. G. Nossal, and K. R. Williams. 1984. Bacteriophage T4 gene 44 DNA polymerase accessory protein: sequence of gene 44 and its protein product. J. Biol. Chem. 259:15425–15432.
- Stillman, B. 1994. Smart machines at the DNA replication fork. Cell 78:725–728.
- Stukenberg, P. T., J. Turner, and M. O'Donnell. 1994. An explanation for lagging strand replication: polymerase hopping among DNA sliding clamps. Cell 78:877–887.
- Tsuchihashi, Z., and A. Kornberg. 1989. ATP interactions of the t and γ subunits of DNA polymerase III holoenzyme of Escherichia coli. J. Biol. Chem. 264:17790–17795.
- Tsurimoto, T., M. P. Fairman, and B. Stillman. 1989. Simian virus 40 DNA replication in vitro: identification of multiple stages of initiation. Mol. Cell. Biol. 9:3839–3849.
- Tsurimoto, T., T. Melendy, and B. Stillman. 1990. Sequential initiation of lagging and leading strand synthesis by two DNA polymerase complexes at the SV40 DNA replication origin. Nature (London) 346:534–539.
- Tsurimoto, T., and B. Stillman. 1989. Purification of a cellular replication factor, RF-C, that is required for coordinated synthesis of leading and lagging strands during simian virus 40 DNA replication in vitro. Mol. Cell. Biol. 9:609–619.
- Tsurimoto, T., and B. Stillman. 1990. Functions of replication factor C and proliferating cell nuclear antigen: functional similarity of DNA polymerase accessory proteins from human cells and bacteriophage T4. Proc. Natl. Acad. Sci. USA 87:1023–1027.
- Tsurimoto, T., and B. Stillman. 1991. Replication factors required for SV40 DNA replication in vitro. I. DNA structure specific recognition of a primer-template junction by eukaryotic DNA polymerases and their accessory factors. J. Biol. Chem. 266:1950–1960.
- Tsurimoto, T., and B. Stillman. 1991. Replication factors required for SV40 DNA replication in vitro. II. Switching of DNA polymerase α and δ during initiation of leading and lagging strand synthesis. J. Biol. Chem. 266:1961–1968.
- Uchida, K., T. Morita, T. Sato, T. Ogura, R. Yamashita, S. Noguchi, H. Suzuki, H. Nyunoya, M. Miwa, and T. Sugimura. 1987. Nucleotide sequence of a full-length cDNA for human fibroblast Poly(ADP-ribose) polymerase. Biochem. Biophys. Res. Commun. 148:617–622.
- Waga, S., and B. Stillman. 1994. Anatomy of a DNA replication fork re vealed by reconstitution of SV40 DNA replication in vitro. Nature (London) 369:207–212.
- Weinberg, D. H., K. L. Collins, P. Simancek, A. Russo, M. S. Old, D. M. Virshup, and T. J. Kelly. 1990. Reconstitution of simian virus 40 DNA replication with purified proteins. Proc. Natl. Acad. Sci. USA 87:8692–8696.
- Yin, K. C., A. Blinkowa, and J. R. Walker. 1986. E. coli dnaZX replication gene. Nucleic Acids Res. 14:6541–6549.
- Yoder, B. L., and P. M. J. Burgers. 1991. Saccharomyces cerevisiae replication factor C I. Purification and characterization of its ATPase activity. J. Biol. Chem. 266:22689–22697.
- Young, M. C., M. K. Reddy, and P. H. von Hippel. 1992. Structure and function of the bacteriophage T4 DNA polymerase holoenzyme. Biochemistry 31:8675–8690.