4
Views
37
CrossRef citations to date
0
Altmetric
Research Article

Two Distinct Regions in the 3′ Untranslated Region of Tumor Necrosis Factor Alpha mRNA Form Complexes with Macrophage Proteins

, &
Pages 5579-5590 | Received 07 May 1996, Accepted 17 Jul 1996, Published online: 29 Mar 2023

REFERENCES

  • Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1987. Current protocols in molecular biology. Greene Publishing Associates and Wiley-Interscience, New York.
  • Beutler, B. 1990. Regulation of cachectin biosynthesis occurs at multiple levels. Prog. Clin. Biol. Res. 349: 229–420.
  • Beutler, B., and T. Brown. 1991. A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines. J. Clin. Invest. 87: 1336–1344.
  • Beutler, B., and A. Cerami. 1994. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu. Rev. Biochem. 57: 505–518.
  • Bickel, M., Y. Iwai, D. H. Pluznik, and R. B. Cohen. 1992. Binding of sequence-specific proteins to the adenosine- plus uridine-rich sequences of the murine granulocyte/macrophage colony-stimulating factor mRNA. Proc. Natl. Acad. Sci. USA 89: 10001–10005.
  • Bohjanen, P. R., B. Petryniak, C. H. June, C. B. Thompson, and T. Lindsten. 1991. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA. Mol. Cell. Biol. 11: 3288–3295.
  • Bohjanen, P. R., B. Petryniak, C. H. June, C. B. Thompson, and T. Lindsten. 1992. AU RNA-binding factors differ in their binding specificities and affinities. J. Biol. Chem. 267: 6302–6309.
  • Brewer, G. 1991. An A+U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol. Cell. Biol. 11: 2460–2466.
  • Brewer, G., and J. Ross. 1989. Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component. Mol. Cell. Biol. 9: 1996–2006.
  • Camussi, G., E. Albano, C. Tetta, and F. Bussolino. 1991. The molecular action of tumor necrosis factor-alpha. Eur. J. Biochem. 202: 3–14.
  • Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and A. Cerami. 1986. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. USA 83: 1670–1674.
  • Cox, G., L. Gandino, E. Blasi, D. Radzioch, B. J. Mathieson, and L. Varesio. 1989. Heterogeneity of haematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver. J. Natl. Cancer Inst. 81: 1492–1496.
  • Dignam, J. D. 1990. Preparation of extracts from higher eucaryotes. Methods Enzymol. 182: 194–203.
  • Donis-Keller, H., A. M. Maxam, and W. Gilbert. 1977. Mapping adenines, guanines, and pyrimidines in RNA. Nucleic Acids Res. 4: 2527–2538.
  • Ehreman, K., L. Long, B. J. Wagner, and G. Brewer. 1994. Characterization of cDNA encoding the murine A+U-rich RNA-binding protein AUF1. Gene 149: 315–319.
  • Fields, A. P., G. R. Pettit, and W. S. May. 1988. Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C. J. Biol. Chem. 263: 8253–8260.
  • Gillis, P., and J. S. Malter. 1991. The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs. J. Biol. Chem. 266: 3172–3177.
  • Greenberg, M. E., and J. G. Belasco. 1993. Control of the decay of labile protooncogene and cytokine mRNAs, p. 199–218. In J. G. Belasco and G. Brawerman (ed.), Control of messenger RNA stability. Academic Press, Inc., San Diego, Calif.
  • Gurevich, V. V., I. D. Pokrovskaya, T. A. Obukhova, and S. A. Zozulya. 1991. Preparative in vitro mRNA synthesis using SP6 and T7 RNA polymerases. Anal. Biochem. 195: 207–213.
  • Hamilton, B. J., E. Nagy, J. S. Malter, B. A. Arrick, and W. F. Rigby. 1993. Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences. J. Biol. Chem. 268: 8881–8887.
  • Han, J., and B. Beutler. 1990. The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis. Eur. Cytokine Netw. 1: 71–75.
  • Han, J., T. Brown, and B. Beutler. 1990. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J. Exp. Med. 171: 465–475. (Erratum, 171:971-972.)
  • Han, J., G. Huez, and B. Beutler. 1991. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J. Immunol. 146: 1843–1848.
  • Han, J. H., B. Beutler, and G. Huez. 1991. Complex regulation of tumor necrosis factor mRNA turnover in lipopolysaccharide-activated macrophages. Biochim. Biophys. Acta 1090: 22–28.
  • Jackson, R. J. 1993. Cytoplasmic regulation of mRNA function: the importance of the 3′-untranslated region. Cell 74: 9–14.
  • Jacob, C. O. 1992. Tumor necrosis factor alpha in autoimmunity: pretty girl or old witch? Immunol. Today. 13: 122–125.
  • Jacob, C. O., and N. B. Tashman. 1993. Disruption in the AU motif of the mouse TNF-alpha 3′ UTR correlates with reduced TNF production by macrophages in vitro. Nucleic Acids Res. 21: 2761–2766.
  • Jochum, C., R. Voth, S. Rossol, K.-H. Meyer zum Buschenfelde, G. Hess, H. Will, H. C. Schroder, R. Steffen, and W. E. G. Müller. 1990. Immunosuppressive function of hepatitis B antigens in vitro: role of endoribonuclease V as one potential trans inactivator for cytokines in macrophages and human hepatoma cells. J. Virol. 64: 1956–1963.
  • Katz, D. A., N. G. Theodorakis, D. W. Cleveland, T. Lindsten, and C. B. Thompson. 1994. AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and thee cytoplasm. Nucleic Acids Res. 22: 238–246.
  • Kovacs, E. J., D. Radzioch, H. A. Young, and L. Varesio. 1988. Differential inhibition of IL-1 and TNF-α mRNA expression by agents which block second messenger pathways in murine macrophages. J. Immunol. 141: 3101–3105.
  • Kruys, V., K. Kemmer, A. Shakhov, V. Jongeneel, and B. Beutler. 1992. Constitutive activity of the tumor necrosis factor promoter is cancelled by the 3′ untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect. Proc. Natl. Acad. Sci. USA 89: 673–677.
  • Kruys, V., O. Marinx, G. Shaw, J. Deschamps, and G. Huez. 1989. Translational blockade imposed by cytokine-derived UA-rich sequences. Science 245: 852–854.
  • Lagnado, C. A., C. Y. Brown, and G. J. Goodall. 1994. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A) (U/A). Mol. Cell. Biol. 14: 7984–7995.
  • Malter, J. S. 1989. Identification of an AUUUA-specific messenger RNA binding protein. Science 246: 664–666.
  • Matic, M., and S. R. Simon. 1992. Effects of gamma interferon on release of tumor necrosis factor alpha from lipopolysaccharide-tolerant human monocyte-derived macrophages. Infect. Immun. 60: 3756–3762.
  • Müller, W. E. G., H. Slor, K. Pfeifer, P. Huhn, A. Bek, S. Orsulic, H. Ushijima, and H. C. Schroder. 1992. Association of AUUUA-binding protein with A+U-rich mRNA during nucleo-cytoplasmic transport. J. Mol. Biol. 226: 721–733.
  • Old, L. J. 1985. Tumor necrosis factor (TNF). Science 230: 630–632.
  • Ozols, J. 1990. Preparation of membrane fractions. Methods Enzymol. 182: 225–235.
  • Parida, S. K., and G. E. Grau. 1993. Role of TNF in immunopathology of leprosy. Res. Immunol. 144: 376–384.
  • Radzioch, D., T. Hudson, M. Boule, L. Barrera, J. W. Urbance, L. Varesio, and E. Skamene. 1991. Genetic resistance/susceptibility to mycobacteria: phenotypic expression in bone marrow derived macrophage lines. J. Leukocyte Biol. 50: 263–272.
  • Schiavi, S. C., J. G. Belasco, and M. E. Greenberg. 1992. Regulation of proto-oncogene mRNA stability. Biochim. Biophys. Acta 1114: 95–106.
  • Schroder, H. C., K. Dose, R. K. Zahn, and W. E. G. Müller. 1980. Isolation and characterization of the novel polyadenylate- and polyuridylate-degrading acid endoribonuclease V from calf thymus. J. Biol. Chem. 255: 5108–5112.
  • Shaw, G., and R. Kamen. 1988. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659–667.
  • Shyu, A. B., J. G. Belasco, and M. E. Greenberg. 1991. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 5: 221–331.
  • Standiford, T. J., and R. M. Strieter. 1992. TNF and IL-1 in sepsis: good cytokines gone bad [editorial comment]. J. Lab. Clin. Med. 120: 179–180.
  • Strieter, R. M., S. L. Kunkel, and R. C. Bone. 1993. Role of tumor necrosis factor-alpha in disease states and inflammation. Crit. Care Med. 21: S447–S463.
  • Sung, S. J., J. A. Walters, and S. M. Fu. 1992. Stimulation of tumor necrosis factor alpha production in human monocytes by inhibitors of protein phosphatase 1 and 2A. J. Exp. Med. 176: 897–901.
  • Ulich, T. R., S. S. Shin, and J. del Castillo. 1993. Haematologic effects of TNF. Res. Immunol. 144: 347–354.
  • Vakalopoulou, E., J. Schaack, and T. Shenk. 1991. A 32-kilodalton protein binds to AU-rich domains in the 3′-untranslated regions of rapidly degraded mRNAs. Mol. Cell. Biol. 11: 3355–3364.
  • Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10: 411–452.
  • You, Y., C. Y. Chen, and A. B. Shyu. 1992. U-rich sequence-binding proteins interacting with a 20-nucleotide U-rich sequence in the 3′ untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol. Cell. Biol. 12: 2931–2940.
  • Zhang, W., B. J. Wagner, K. Ehrenman, A. W. Schaefer, C. T. DeMaria, D. Crater, K. DeHaven, L. Long, and G. Brewer. 1993. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol. Cell. Biol. 13: 7652–7665.
  • Zubiaga, A. M., J. G. Belasco, and M. E. Greenberg. 1995. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15: 2219–2230.
  • Zuckerman, S. H., G. F. Evans, Y. M. Snyder, and W. D. Roeder. 1989. Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression. J. Immunol. 143: 1223–1227.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.