3pK, a New Mitogen-Activated Protein Kinase-Activated Protein Kinase Located in the Small Cell Lung Cancer Tumor Suppressor Gene Region

REFERENCES

• Allikmets, R. L., V. I. Kashuba, B. Pettersson, R. Gizatullin, T. Lebedeva, I. D. Kholodnyuk, V. M. Bannikov, N. Petrov, V. M. Zakharyev, G. Winberg, W. Modi, M. Dean, M. Uhlen, L. L. Kisselev, G. Klein, and E. R. Zabarovsky. 1994. Notl linking clones as a tool for joining physical and genetic maps of the human genome. Genomics 19:303–309.
   PubMedGoogle Scholar
• Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403–410.
   PubMed Web of Science ®Google Scholar
• Anderson, N. J., J. Muller, N. G. Tonks, and T. W. Sturgill. 1990. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature (London) 343:651–653.
   PubMed Web of Science ®Google Scholar
• Brauch, H., K. Tory, and F. Kotler. 1990. Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer. Genes Chromosomes Cancer 1:247–255.
   PubMedGoogle Scholar
• Brewster, J. L., J. De Valo, Jr., N. D. Dwyer, E. Winter, and M. C. Gustin. 1993. An osmol-sensing signal transduction pathway in yeast. Science 259:1760–1762.
   PubMed Web of Science ®Google Scholar
• Bronner, C. E., S. M. Baker, P. T. Morrison, G. Warren, L. G. Smith, M. K. Lescoe, M. Kane, C. Earabino, J. Lipford, A. Lindblom, P. Tannergard, R. J. Bollag, A. R. Godwin, D. C. Ward, M. Nordenskjold, R. Fishel, R. Kolodner, and R. M. Liskay. 1994. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (London) 368:258–261.
   PubMed Web of Science ®Google Scholar
• Bruder, J. T., G. Heidecker, and U. R. Rapp. 1992. Serum, TPA, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6:5454–5456.
   Google Scholar
• Chen, L. C., K. Matsumura, G. Deng, W. Kurisu, B. M. Ljung, M. I. Lerman, F. M. Waldman, and H. S. Smith. 1994. Deletion of 2 separate regions on chromosome 3p in breast cancers. Cancer Res. 54:3021–3024.
   PubMed Web of Science ®Google Scholar
• Chen, R. H., C. Sarnecki, and J. Blenis. 1992. Nuclear localization and regulation of ERK- and rsk-encoded protein kinases. Mol. Cell. Biol. 12:915–927.
   PubMed Web of Science ®Google Scholar
• Clarke-Lewis, I., J. S. Sanghera, and S. L. Pelick. 1991. Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase. J. Biol. Chem. 266:15180–15184.
   PubMedGoogle Scholar
• Crews, C. M., and R. L. Erikson. 1992. Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the ERK-1 gene product: relationship to the fission yeast byr1 gene product. Proc. Natl. Acad. Sci. USA 89:8205–8209.
   PubMed Web of Science ®Google Scholar
• Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Young, and J. C. Lee. 1995. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:229–233.
   PubMed Web of Science ®Google Scholar
• Daly, M. C., R.-H. Xiang, D. Buchhagen, C. H. Hensel, D. K. Garcia, A. M. Killary, J. D. Minna, and S. L. Naylor. 1993. A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity. Oncogene 8:1825–1832.
   PubMedGoogle Scholar
• Dent, P., A. Lavoinne, S. Naxielny, F. B. Caudwell, P. Watt, and P. Cohen. 1990. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature (London) 348:302–308.
   PubMed Web of Science ®Google Scholar
• Derijard, B., M. Hibi, I. H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. Jnk1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025–1037.
   PubMed Web of Science ®Google Scholar
• Devereaux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387–395.
   PubMed Web of Science ®Google Scholar
• Dingwall, C., and R. A. Laskey. 1991. Nuclear targeting sequences—a consensus? Trends Biochem. Sci. 16:478–481.
   Google Scholar
• Engel, K., K. Plath, and M. Geastel. 1993. The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 336:143–147.
   PubMed Web of Science ®Google Scholar
• Feng, D.-F., and R. F. Doolittle. 1987. A multiple sequence alignment using a simplification of the progressive alignment method. J. Mol. Evol. 35:351–360.
   Web of Science ®Google Scholar
• Freshney, N. W., L. Rawlinson, F. Guesdon, E. Jones, S. Cowly, J. Hsuan, and J. Sakiat Vala. 1994. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78:1039–1049.
   PubMed Web of Science ®Google Scholar
• Gaestel, M., W. Schroder, R. Benndorf, C. Lippmann, K. Buchner, F. Hucho, V. A. Erdmann, and H. Bielka. 1991. Identification of the phosphorylation sites of the murine small heat shock protein hsp25. J. Biol. Chem. 266:14721–14724.
   PubMedGoogle Scholar
• Gille, H., A. D. Sharrocks, and P. E. Shaw. 1992. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature (London) 358:414–417.
   PubMed Web of Science ®Google Scholar
• Gonzalez, F. A., D. L. Raden, and R. J. Davis. 1991. Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem. 266:22159–22163.
   PubMed Web of Science ®Google Scholar
• Gotoh, Y., E. Nishida, T. Yamashita, M. Hoshi, M. Kawakami, and H. Sakai. 1991. In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase. Nature (London) 349:251–254.
   PubMed Web of Science ®Google Scholar
• Gould, K. L., S. Moreno, D. J. Owen, D. J. Sazer, and P. Nurse. 1991. Phosphorylation at Thr 167 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J. 10:3297–3309.
   PubMed Web of Science ®Google Scholar
• Killary, A. M., M. E. Wolf, T. A. Giambernardi, and S. L. Naylor. 1992. Definition of a tumor suppressor locus within human chromosome 3p21-p22. Proc. Natl. Acad. Sci. USA 89:10877–10881.
   PubMed Web of Science ®Google Scholar
• Knauf, U., U. Jakob, K. Engel, J. Buchner, and M. Gaestel. 1994. Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperon properties and cellular thermoresistance. EMBO J. 13:54–60.
   PubMed Web of Science ®Google Scholar
• Kok, K., A. van den Berg, P. M. J. F. Veldhuis, A. Y. van der Veen, M. Franke, E. F. P. M. Shoenmakers, M. M. F. Hulsbeek, A. H. van der Hout, L. de Leij, W. van de Ven, and C. H. C. M. Buys. 1994. A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes. Cancer Res. 54:4183–4187.
   PubMed Web of Science ®Google Scholar
• Kovacs, G., R. Erlandsson, F. Boldog, S. Ingvarsson, R. Muller-Brechlin, G. Klein, and J. Sumegi. 1988. Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. Proc. Natl. Acad. Sci. USA 85:1571-1575.
   PubMed Web of Science ®Google Scholar
• Kyriakis, J. M., H. App, X. F. Zhang, P. Banerjee, D. Brautigan, U. R. Rapp, and J. Avruch. 1992. Raf-1 activates MAP kinase-kinase. Nature (London) 358:417–421.
   PubMed Web of Science ®Google Scholar
• Kyriakis, J. M., P. Banerjee, E. Nikolakaki, T. Dai, E. A. Rubie, M. F. Ahmad, J. Avruch, and J. R. Woodgett. 1994. The stress activated protein kinase subfamily of c-jun kinases. Nature (London) 369:156–160.
   PubMed Web of Science ®Google Scholar
• Lange-Carter, C. A., and G. Johnson. 1994. Ras dependent growth factor regulation of MEK kinase in PC12 cells. Science 265:1458–1461.
   PubMed Web of Science ®Google Scholar
• Latif, F., K. Tory, J. Gnarra, M. Yao, F.-M. Duh, M. L. Orcutt, T. Stackhouse, I. Kuzmin, W. Modi, L. Geil, L. Schmidt, F. Zhou, H. Li, M. H. Wei, F. Chen, G. Glenn, P. Choyke, M. W. McClellan, Y. Weng, D.-S. R. Duan, M. Dean, D. Glavac, F. M. Richards, P. A. Crossey, M. A. Ferguson-Smith, D. Le Paslier, I. Chumakov, D. Cohen, A. C. Chinault, E. Maher, W. M. Linehan, B. Zbar, and M. I. Lerman. 1993. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260:1317–1320.
   PubMed Web of Science ®Google Scholar
• Latif, F., K. Tory, W. S. Modi, S. L. Graziano, G. Gamble, J. Douglas, A. C. Heppell-Parton, P. H. Rabbitts, B. Zbar, and M. I. Lerman. 1992. Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: a strategy for cloning the putative tumor suppressor gene. Genes Chromosomes Cancer 5:119–127.
   PubMedGoogle Scholar
• Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, J. E. Stricler, M. M. McLaughlin, I. R. Siemens, S. M. Fisher, G. P. Livi, J. R. White, J. L. Adams, and P. R. Young. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature (London) 372:739–746.
   PubMed Web of Science ®Google Scholar
• Lincoln, A. L., M. Daly, and E. Lander. 1991. PRIMER: a computer program for automatically selecting PCR primers. Whitehead Institute Technical Report. Whitehead Institute, Cambridge, Mass.
   Google Scholar
• Lothe, R. A., S. D. Fossa, A. E. Steinwig, Y. Nakamura, R. White, A.-L. Borresen, and A. Brogger. 1989. Loss of 3p or 11p alleles is associated with testicular cancer tumors. Genomics 5:134–138.
   PubMedGoogle Scholar
• Lubinski, J., P. Hadaczek, J. Podolski, A. Toloczko, A. Sikorski, P. McCue, T. Druck, and K. Huebner. 1994. Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res. 54:3710–3713.
   PubMedGoogle Scholar
• McCormick, F. 1993. How receptors turn Ras on. Nature (London) 363:15–16.
   PubMed Web of Science ®Google Scholar
• Nakielny, S., P. Cohen, J. Wu, and T. Sturgill. 1992. MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. EMBO J. 11:2123–2129.
   PubMedGoogle Scholar
• Nemenoff, R. A., S. Winitz, N. X. Qian, V. Van Putten, G. L. Johnson, and L. E. Heasley. 1993. Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase. J. Biol. Chem. 268:1960–1964.
   PubMed Web of Science ®Google Scholar
• Papadopoulos, N., N. C. Nicolaides, Y. F. Wei, S. M. Ruben, K. C. Carter, C. A. Rosen, W. A. Haseltine, R. D. Fleischmann, C. M. Fraser, M. D. Adams, J. C. Venter, S. R. Hamilton, G. M. Peterson, P. Watson, H. T. Lynch, P. Peltomaki, J. P. Mecklin, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein. 1994. Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625–1629.
   PubMed Web of Science ®Google Scholar
• Pelech, S. L. 1993. Networking with protein kinases. Curr. Biol. 3:513–515.
   PubMedGoogle Scholar
• Rabbitts, P., J. Bergh, J. Douglas, F. Collins, and J. Waters. 1990. A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma. Genes Chromosomes Cancer 2:231–238.
   PubMedGoogle Scholar
• Rapp, U. R. 1991. Role of raf-1 serine/threonine protein kinase in growth factor signal transduction. Oncogene 6:495–500.
   PubMed Web of Science ®Google Scholar
• Rogge, R. D., C. A. Karlovick, and V. Banerjee. 1991. Genetic dissection of a neurodevelopmental pathway: son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell 64:39–48.
   PubMed Web of Science ®Google Scholar
• Rouse, J., P. Cohen, S. Trijon, M. Morange, A. A. Liamazares, D. Zamarillo, J. Hunt, and A. R. Nebreda. 1994. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase 2 and phosphorylation of the small heat shock proteins. Cell 78:1027–1037.
   PubMed Web of Science ®Google Scholar
• Seger, R., N. G. Ahn, T. G. Boulton, G. D. Yancopoulos, N. Panayotatos, E. Radziejewska, L. Ericsson, R. L. Bratlien, M. H. Cobb, and E. G. Krebs. 1991. Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc. Natl. Acad. Sci. USA 88:6142–6146.
   PubMed Web of Science ®Google Scholar
• Shoji, S., K. Titani, J. G. Demaille, and E. H. Fisher. 1979. Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3′:5′-monophosphate-dependent protein kinase. J. Biol. Chem. 254:6211–6214.
   PubMed Web of Science ®Google Scholar
• Stokoe, D., D. G. Campell, S. Nakielny, H. Hidaka, S. J. Leevers, C. Marshall, and P. Cohen. 1992. MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J. 11:3985–3994.
   PubMedGoogle Scholar
• Stokoe, D., B. Caudwell, P. T. Cohen, and P. Cohen. 1993. The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein-kinase-2. Biochem. J. 296:843–849.
   PubMedGoogle Scholar
• Stokoe, D., K. Engel, D. G. Capell, and M. Gaestel. 1992. Identification of MAPKAP kinase 2 as major enzyme responsible for the phosphorylation of the small mammalian heat shock protein. FEBS Lett. 313:307–313.
   PubMed Web of Science ®Google Scholar
• Sturgill, T. W., L. B. Ray, E. Erikson, and T. L. Maller. 1988. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature (London) 334:715–718.
   PubMed Web of Science ®Google Scholar
• Sutherland, C., D. G. Campbell, and P. Cohen. 1993. Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rsk mo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase. Eur. J. Biochem. 212:581–588.
   PubMedGoogle Scholar
• Treisman, R. 1994. Ternary complex factors: growth factor regulated transcriptional activators. Curr. Opin. Genet. Dev. 1:96–101.
   Google Scholar
• Trent, J. M. M., Y. Kaneko, and F. Mitelman. 1989. Report of the committee on structural chromosome changes in neoplasia: 10th International Workshop on Human Gene Mapping. Cytogenet. Cell Genet. 51:533–562.
   PubMedGoogle Scholar
• Troppmair, J., J. T. Bruder, H. Munoz, P. A. Lloyd, J. Kyriakis, P. Banerjee, J. Avruch, and U. R. Rapp. 1994. Mitogen-activated protein kinase/extra cellular signal regulated protein kinase activation by oncogenes serum and 12-o-tetradecanoyl phorbol-13-acetate requires raf and is necessary for transformation. J. Biol. Chem. 269:7030–7035.
   PubMedGoogle Scholar
• Vaillancourt, R. R., A. M. Gardner, and G. L. Johnson. 1994. B-raf dependent regulation of the MEK-1/mitogen activated protein kinase pathway in PC12 cells and regulation by cyclic AMP. Mol. Cell. Biol. 14:6522–6530.
   PubMedGoogle Scholar
• Wu, J., J. K. Harrison, P. Dent, K. R. Lynch, M. J. Weber, and T. W. Sturgill. 1993. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. Mol. Cell. Biol. 13:4539–4548.
   PubMedGoogle Scholar
• Yu, H., J. K. Chen, S. Feng, D. C. Dalgarno, A. W. Brauer, and S. L. Schreiber. 1994. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 76:933–945.
   PubMed Web of Science ®Google Scholar
• Zabarovsky, E. R., F. Boldog, R. Erlandsson, V. I. Kashuba, R. L. Allikmets, Z. Marcsek, L. L. Kisselev, E. J. Stanbridge, G. Klein, J. Sumegi, and G. Winberg. 1991. New strategy for mapping the human genome based on a novel procedure for construction of jumping libraries. Genomics 11:1030–1039.
   PubMedGoogle Scholar
• Zabarovsky, E. R., F. Boldog, T. Thompson, D. Scanlon, G. Winberg, Z. Marcsek, R. Erlandsson, E. J. Stanbridge, G. Klein, and J. Sumegi. 1990. Construction of a human chromosome 3 specific NotI linking library using a novel cloning procedure. Nucleic Acids Res. 18:6319–6324.
   PubMedGoogle Scholar
• Zbar, B., H. Brauch, C. Talmadge, and M. Linehan. 1987. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature (London) 327:721–724.
   PubMed Web of Science ®Google Scholar
• Zu, Y.-L., F. Wu, A. Gilchrist, Y. Ai, M. E. Labadia, and C.-K. Huang. 1994. The primary structure of a human MAP kinase activated protein kinase 2. Biochem. Biophys. Res. Commun. 200:1118–1124.
   PubMedGoogle Scholar