Drosophila Homologs of the Proto-Oncogene Product PEBP2/CBFβ Regulate the DNA-Binding Properties of Runt

REFERENCES

• Armstrong, A. P., A. A. Franklin, M. N. Uittenbogaard, H. A. Giebler, and J. K. Nyborg. 1993. Pleiotropic effect of human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors. Proc. Natl. Acad. Sci. USA 90:7303–7307.
   PubMed Web of Science ®Google Scholar
• Bae, S.-C., E. Ogawa, M. Maruyama, H. Oka, M. Satake, K. Shigesada, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and Y. Ito. 1994. PEBP2αB/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol. Cell. Biol. 14:3242–3252.
   PubMed Web of Science ®Google Scholar
• Bartel, P. L., C.-T. Chien, R. Sternglanz, and S. Fields. 1994. Using the two-hybrid system to detect protein-protein interactions, p. 153–179. In D. A. Hartley (ed.), Cellular interactions in development: a practical approach. Oxford University Press, New York.
   Google Scholar
• Breeden, L., and K. Nasmyth. 1985. Regulation of the yeast HO gene. Cold Spring Harbor Symp. Quant. Biol. 50:643–650.
   PubMedGoogle Scholar
• Chan, S. K., L. Jaffe, M. Capovilla, J. Botas, and R. S. Mann. 1994. The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78:603–615.
   PubMedGoogle Scholar
• Daga, A., J. E. Tighe, and F. Calabi. 1992. Leukaemia/Drosophila homology. Nature (London) 356:484.
   PubMed Web of Science ®Google Scholar
• Duffy, J. B., and J. P. Gergen. 1991. The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of sex-determining gene Sex-lethal. Genes Dev. 5:2176–2187.
   PubMed Web of Science ®Google Scholar
• Duffy, J. B., M. A. Kania, and J. P. Gergen. 1991. Expression and function of the Drosophila gene runt in early stages of neural development. Development 113:1223–1230.
   PubMedGoogle Scholar
• Elledge, S. Personal communication.
   Google Scholar
• Fields, S., and O.-K. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature (London) 340:245–246.
   PubMed Web of Science ®Google Scholar
• Gergen, J. P., and E. Wieschaus. 1985. The localized requirements for a gene affecting segmentation in Drosophila: analysis of larvae mosaic for runt. Dev. Biol. 109:321–335.
   PubMedGoogle Scholar
• Gergen, J. P., and E. Wieschaus. 1986. Dosage requirements for runt in the segmentation of Drosophila embryos. Cell 45:289–299.
   PubMedGoogle Scholar
• Giam, C.-Z., and Y.-L. Xu. 1989. HTLV-1 tax gene product activates transcription via pre-existing cellular factors and cAMP responsive element. J. Biol. Chem. 264:15236–15241.
   PubMed Web of Science ®Google Scholar
• Giese, K., J. Cox, and R. Grosschedl. 1992. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell 69:185–195.
   PubMed Web of Science ®Google Scholar
• Giese, K., C. Kingsley, J. R. Kirshner, and R. Grosshedl. 1995. Assembly and function of a TCRα enhancer complex is dependent of LEF-1 induced DNA bending and multiple protein-protein interactions. Genes Dev. 9:995–1008.
   PubMed Web of Science ®Google Scholar
• Grueneberg, D. A., S. Natesan, C. Alexandre, and M. Z. Gilman. 1992. Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science 257:1089–1095.
   PubMed Web of Science ®Google Scholar
• Gupta, S., and J. P. Gergen. Unpublished data.
   Google Scholar
• Hajra, A., P. P. Liu, Q. Wang, C. A. Kelley, T. Stacy, R. S. Adelstein, N. A. Speck, and F. S. Collins. 1995. The leukemic core binding factor β-smooth muscle myosin heavy chain (CBFβ-SMMHC) chimeric protein requires both CBFβ and myosin heavy chain domains for transformation of NIH 3T3 cells. Proc. Natl. Acad. Sci. USA 92:1926–1930.
   PubMedGoogle Scholar
• Hoffman, C. S., and F. Winston. 1987. A ten minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57:267–272.
   PubMed Web of Science ®Google Scholar
• Hsiang, Y. H., D. Spencer, S. Wang, N. A. Speck, and D. H. Raulet. 1993. The role ofviral ‘core’ motif-related sequences in regulating T cell receptor γ and δ gene expression. J. Immunol. 150:3905–3916.
   PubMed Web of Science ®Google Scholar
• Ingham, P., and J. P. Gergen. 1988. Interactions between the pair-rule genes runt, hairy, even-skipped, and fushi tarazu and the establishment of periodic pattern in the Drosophila embryo. Development 104(Suppl.):51–60.
   PubMedGoogle Scholar
• Kagoshima, H., K. Shigesada, K. Satake, Y. Ito, H. Miyoshi, M. Ohki, M. Pepling, and J. P. Gergen. 1993. The Runt domain identifies a new family of heteromeric transcriptional regulators. Trends Genet. 9:338–341.
   PubMedGoogle Scholar
• Kamachi, Y., E. Ogawa, M. Asano, S. Ishida, Y. Murakami, M. Satake, Y. Ito, and K. Shigesada. 1990. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J. Virol. 64:4808-4819.
   PubMed Web of Science ®Google Scholar
• Kania, M. A., A. S. Bonner, J. B. Duffy, and J. P. Gergen. 1990. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev. 4:1701–1713.
   PubMed Web of Science ®Google Scholar
• Kim, J., C. Zwieb, C. Wu, and S. Adhya. 1989. Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector. Gene 85:15–23.
   PubMed Web of Science ®Google Scholar
• Klingler, M., and J. P. Gergen. 1993. Regulation of runt transcription by Drosophila segmentation genes. Mech. Dev. 43:3–19.
   PubMedGoogle Scholar
• Levanon, D., V. Negreanu, Y. Bernstein, I. Bar-Am, L. Avivi, and Y. Groner. 1994. AML1, AML2 and AML3, the human members of the runt domain gene family: cDNA structure, expression, and chromosomal location. Genomics 23:425–432.
   PubMed Web of Science ®Google Scholar
• Liu, P., S. A. Tarlé, A. Hajra, D. F. Claxton, P. Marlton, M. Freedman, M. J. Siciliano, and F. S. Collins. 1993. Fusion between transcription factor CBFβ/ PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science 261:1041–1044.
   PubMed Web of Science ®Google Scholar
• Lu, J., M. Maruyama, M. Satake, S.-C. Bae, E. Ogawa, H. Kagoshima, K. Shigesada, and Y. Ito. 1995. Subcellular localization of the α and β subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF. Mol. Cell. Biol. 15:1651–1661.
   PubMed Web of Science ®Google Scholar
• Miyoshi, H., K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki. 1991. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. USA 88:10431–10434.
   PubMed Web of Science ®Google Scholar
• Nyborg, J. K., W. S. Dynan, I. S. Y. Chen, and W. Wachsman. 1988. Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression. Proc. Natl. Acad. Sci. USA 85:1457–1461.
   PubMedGoogle Scholar
• Ogawa, E., M. Inuzuka, M. Maruyama, M. Satake, M. M. Naito-Fujimoto, Y. Ito, and K. Shigesada. 1993. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194:314–331.
   PubMed Web of Science ®Google Scholar
• Ogawa, E., M. Maruyama, H. Kagoshima, M. Inuzuka, J. Lu, M. Satake, K. Shigesada, and Y. Ito. 1993. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc. Natl. Acad. Sci. USA 90:6859–6863.
   PubMed Web of Science ®Google Scholar
• Pepling, M. E., and J. P. Gergen. 1995. Conservation and function of the transcriptional regulatory protein Runt. Proc. Natl. Acad. Sci. USA 92:9087–9091.
   PubMedGoogle Scholar
• Prosser, H. M., D. Wotton, A. Geggone, J. Ghysdael, S. Wang, N. A. Speck, and M. J. Owen. 1992. A phorbol ester response element within the human T-cell receptor beta-chain enhancer. Proc. Natl. Acad. Sci. USA 89:9934–9938.
   PubMedGoogle Scholar
• Redondo, J. M., J. L. Pfohl, C. Hernandez-Munain, S. Wang, N. A. Speck, and M. S. Krangel. 1992. Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers. Mol. Cell. Biol. 12:4817–4823.
   PubMed Web of Science ®Google Scholar
• Sato, Y., M. Murai, J. Tsunoda, N. Komatsu, K. Muroi, M. Yoshida, K. Motoyoshi, S. Sakamoto, and Y. Miura. 1991. Second relapse of acute promyelocytic leukemia (ANLL-M3) with t(15;17) and t(1;3) (p36;q21). Cancer Genet. Cytogenet. 57:53–58.
   PubMedGoogle Scholar
• Schiestl, R. H., and R. D. Gietz. 1989. High efficiency transformation of intactyeast cells using single stranded nucleic acids as a carrier. Curr. Genet. 16:339–346.
   PubMed Web of Science ®Google Scholar
• Thompson, C. C., T. A. Brown, and S. L. McKnight. 1991. Convergence of ets- and Notch-related structural motifs in a heteromeric DNA-binding complex. Science 253:762–768.
   PubMed Web of Science ®Google Scholar
• Travis, A., A. Amsterdam, C. Belanger, and R. Grosschedl. 1991. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor a enhancer function. Genes Dev. 5:880–894.
   PubMed Web of Science ®Google Scholar
• Tsai, C., and J. P. Gergen. 1994. Gap gene properties of the pair-rule gene runt during Drosophila segmentation. Development 120:1671–1683.
   PubMedGoogle Scholar
• Tsai, C., and J. P. Gergen. 1995. Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy. Development 121:453–462.
   PubMedGoogle Scholar
• Vermaelen, K., J.-L. Michaux, A. Louwagie, and H. Van Den Berghe. 1983. Reciprocal translocation t(6;9)(p21;q33): a new characteristic chromosome anomaly in myeloid leukemias. Cancer Genet. Cytogenet. 10:125–131.
   PubMedGoogle Scholar
• Wang, S., and N. A. Speck. 1992. Purification of Core-binding factor, a protein that binds to the conserved core site in murine leukemia virus enhancers. Mol. Cell. Biol. 12:89–102.
   PubMedGoogle Scholar
• Wang, S., Q. Wang, B. E. Crute, I. N. Melnikova, S. R. Keller, and N. A. Speck. 1993. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer Core-binding factor. Mol. Cell. Biol. 13:3324–3339.
   PubMed Web of Science ®Google Scholar
• Waterman, M., W. Fischer, and K. Jones. 1991. A thymus-specific member of the HMG protein family regulates the human T cell receptor alpha enhancer. Genes Dev. 5:656–669.
   PubMed Web of Science ®Google Scholar
• Wotton, D., J. Ghysdael, S. Wang, N. A. Speck, and M. J. Owen. 1994. Cooperative binding of Ets-1 and Core binding factor to DNA. Mol. Cell. Biol. 14:840–850.
   PubMed Web of Science ®Google Scholar
• Wu, H.-M., and D. M. Crothers. 1984. The locus of sequence-directed and protein-induced DNA bending. Nature (London) 308:509–513.
   PubMed Web of Science ®Google Scholar
• Zhao, L. J., and C.-Z. Giam. 1992. Human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. Proc. Natl. Acad. Sci. USA 89:7070–7074.
   PubMed Web of Science ®Google Scholar